{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:18:20Z","timestamp":1783401500556,"version":"3.54.6"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s00520-025-09603-6","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T16:37:36Z","timestamp":1750178256000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of primary venous thromboembolism prophylaxis in hospitalized patients with primary brain tumors or secondary brain metastases"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0554-7588","authenticated-orcid":false,"given":"Katie","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0617-3941","authenticated-orcid":false,"given":"Emily","family":"Highsmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-8052","authenticated-orcid":false,"given":"Zhongya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5980-7309","authenticated-orcid":false,"given":"Katy M.","family":"Toale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"9603_CR1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12957-015-0592-8","volume":"13","author":"J Khalil","year":"2015","unstructured":"Khalil J, Bensaid B, Elkacemi H, Afif M, Bensaid Y, Kebdani T, Benjaafar N (2015) Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol 13:204. https:\/\/doi.org\/10.1186\/s12957-015-0592-8","journal-title":"World J Surg Oncol"},{"issue":"5","key":"9603_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/00005792-199909000-00001","volume":"78","author":"N Levitan","year":"1999","unstructured":"Levitan N, Dowlati A, Remick SC, Tahsildar HI, Sivinski LD, Beyth R, Rimm AA (1999) Rates of initial and recurrent thromboembolic disease among patients with malignancy versus those without malignancy. Risk analysis using Medicare claims data. Medicine (Baltimore) 78(5):285\u2013291. https:\/\/doi.org\/10.1097\/00005792-199909000-00001","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"9603_CR3","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1200\/JCO.19.01461","volume":"38","author":"NS Key","year":"2020","unstructured":"Key NS, Khorana AA, Kuderer NM, Bohlke K, Lee AYY, Arcelus JI, Wong SL, Balaban EP, Flowers CR, Francis CW, Gates LE, Kakkar AK, Levine MN, Liebman HA, Tempero MA, Lyman GH, Falanga A (2020) Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol 38(5):496\u2013520. https:\/\/doi.org\/10.1200\/JCO.19.01461","journal-title":"J Clin Oncol"},{"issue":"4","key":"9603_CR4","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1182\/bloodadvances.2020003442","volume":"5","author":"GH Lyman","year":"2021","unstructured":"Lyman GH, Carrier M, Ay C, Di Nisio M, Hicks LK, Khorana AA, Leavitt AD, Lee AY, Macbeth F, Morgan RL, Noble S, Sexton EA, Stenehjem D, Wiercioch W, Kahale LA, Alonso-Coello P (2021) American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer. Blood Adv 5(4):927\u2013974. https:\/\/doi.org\/10.1182\/bloodadvances.2020003442","journal-title":"Blood Adv"},{"key":"9603_CR5","unstructured":"Streiff MB, Holmstrom B, Angelini D, Ashrani A, Elshoury A, Fanikos J, et al. (Version 2.2019) National Comprehensive Cancer Network: Cancer-Associated Venous Thromboembolic Disease https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/vte.pdf. Accessed 5 December 2024"},{"issue":"1","key":"9603_CR6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.amjmed.2013.09.015","volume":"127","author":"M Carrier","year":"2014","unstructured":"Carrier M, Khorana AA, Moretto P, Le Gal G, Karp R, Zwicker JI (2014) Lack of evidence to support thromboprophylaxis in hospitalized medical patients with cancer. Am J Med 127(1):82\u20136.e1. https:\/\/doi.org\/10.1016\/j.amjmed.2013.09.015","journal-title":"Am J Med"},{"issue":"9","key":"9603_CR7","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s11864-023-01116-w","volume":"24","author":"RR Woods","year":"2023","unstructured":"Woods RR, Lesser GJ (2023) Management of thromboembolic disease in patients with primary and metastatic brain tumors. Curr Treat Options Oncol 24(9):1293\u20131303. https:\/\/doi.org\/10.1007\/s11864-023-01116-w","journal-title":"Curr Treat Options Oncol"},{"issue":"4","key":"9603_CR8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s11912-021-01178-9","volume":"24","author":"M Diaz","year":"2022","unstructured":"Diaz M, Jo J (2022) Venous thrombotic events and anticoagulation in brain tumor patients. Curr Oncol Rep 24(4):493\u2013500. https:\/\/doi.org\/10.1007\/s11912-021-01178-9","journal-title":"Curr Oncol Rep"},{"issue":"3","key":"9603_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1055\/s-0034-1370791","volume":"40","author":"JT Jo","year":"2014","unstructured":"Jo JT, Schiff D, Perry JR (2014) Thrombosis in brain tumors. Semin Thromb Hemost 40(3):325\u2013331. https:\/\/doi.org\/10.1055\/s-0034-1370791","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"9603_CR10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1056\/NEJMoa025313","volume":"349","author":"AY Lee","year":"2003","unstructured":"Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003) Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med 349(2):146\u2013153. https:\/\/doi.org\/10.1056\/NEJMoa025313","journal-title":"N Engl J Med"},{"issue":"4","key":"9603_CR11","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1182\/blood-2015-02-626788","volume":"126","author":"J Donato","year":"2015","unstructured":"Donato J, Campigotto F, Uhlmann EJ, Coletti E, Neuberg D, Weber GM, Zwicker JI (2015) Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study. Blood 126(4):494\u2013499. https:\/\/doi.org\/10.1182\/blood-2015-02-626788","journal-title":"Blood"},{"issue":"1","key":"9603_CR12","doi-asserted-by":"publisher","first-page":"101350","DOI":"10.1016\/j.beha.2022.101350","volume":"35","author":"V Iyengar","year":"2022","unstructured":"Iyengar V, Patell R, Zwicker J (2022) Challenges in anticoagulation for patients with brain tumors. Best Pract Res Clin Haematol 35(1):101350. https:\/\/doi.org\/10.1016\/j.beha.2022.101350","journal-title":"Best Pract Res Clin Haematol"},{"issue":"7","key":"9603_CR13","doi-asserted-by":"publisher","first-page":"e1001275","DOI":"10.1371\/journal.pmed.1001275","volume":"9","author":"F Horsted","year":"2012","unstructured":"Horsted F, West J, Grainge MJ (2012) Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. PLoS Med 9(7):e1001275. https:\/\/doi.org\/10.1371\/journal.pmed.1001275","journal-title":"PLoS Med"},{"issue":"2","key":"9603_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1023\/a:1008915202859","volume":"8","author":"AT Chan","year":"1999","unstructured":"Chan AT, Atiemo A, Diran LK, Licholai GP, McLaren Black P, Creager MA, Goldhaber SZ (1999) Venous thromboembolism occurs frequently in patients undergoing brain tumor surgery despite prophylaxis. J Thromb Thrombolysis 8(2):139\u2013142. https:\/\/doi.org\/10.1023\/a:1008915202859","journal-title":"J Thromb Thrombolysis"},{"issue":"3","key":"9603_CR15","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1160\/TH16-09-0680","volume":"117","author":"C Chai-Adisaksopha","year":"2017","unstructured":"Chai-Adisaksopha C, Linkins LA, Sy AL, Cheah M, Crowther MA, Iorio A (2017) Outcomes of low-molecular-weight heparin treatment for venous thromboembolism in patients with primary and metastatic brain tumours. Thromb Haemost 117(3):589\u2013594. https:\/\/doi.org\/10.1160\/TH16-09-0680","journal-title":"Thromb Haemost"},{"issue":"2","key":"9603_CR16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/1097-0142(19940115)73:2<493::aid-cncr2820730240>3.0.co;2-d","volume":"73","author":"D Schiff","year":"1994","unstructured":"Schiff D, DeAngelis LM (1994) Therapy of venous thromboembolism in patients with brain metastases. Cancer 73(2):493\u2013498. https:\/\/doi.org\/10.1002\/1097-0142(19940115)73:2<493::aid-cncr2820730240>3.0.co;2-d","journal-title":"Cancer"},{"issue":"3","key":"9603_CR17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s11239-007-0025-9","volume":"24","author":"AJ Ghanim","year":"2007","unstructured":"Ghanim AJ, Daskalakis C, Eschelman DJ, Kraft WK (2007) A five-year, retrospective, comparison review of survival in neurosurgical patients diagnosed with venous thromboembolism and treated with either inferior vena cava filters or anticoagulants. J Thromb Thrombolysis 24(3):247\u2013254. https:\/\/doi.org\/10.1007\/s11239-007-0025-9","journal-title":"J Thromb Thrombolysis"},{"key":"9603_CR18","doi-asserted-by":"publisher","first-page":"e934341","DOI":"10.12659\/MSM.934341","volume":"28","author":"ZY Wang","year":"2022","unstructured":"Wang ZY, Wan YD, Liu XZ, Wang H, Jiang GY, Yang B (2022) A single-center, randomized, double-blind study of 94 patients undergoing surgery for cerebral glioma to compare postoperative thromboprophylaxis with and without rivaroxaban. Med Sci Monit 28:e934341. https:\/\/doi.org\/10.12659\/MSM.934341","journal-title":"Med Sci Monit"},{"issue":"3","key":"9603_CR19","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s11060-016-2259-x","volume":"130","author":"N Alshehri","year":"2016","unstructured":"Alshehri N, Cote DJ, Hulou MM, Alghamdi A, Alshahrani A, Mekary RA, Smith TR (2016) Venous thromboembolism prophylaxis in brain tumor patients undergoing craniotomy: a meta-analysis. J Neurooncol 130(3):561\u2013570. https:\/\/doi.org\/10.1007\/s11060-016-2259-x","journal-title":"J Neurooncol"},{"issue":"4","key":"9603_CR20","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1007\/s11239-023-02780-3","volume":"55","author":"D Liu","year":"2023","unstructured":"Liu D, Song D, Ning W, Zhang X, Chen S, Zhang H (2023) Efficacy and safety of prophylaxis for venous thromboembolism in brain neoplasm patients undergoing neurosurgery: a systematic review and Bayesian network meta-analysis. J Thromb Thrombolysis 55(4):710\u2013720. https:\/\/doi.org\/10.1007\/s11239-023-02780-3","journal-title":"J Thromb Thrombolysis"},{"issue":"5","key":"9603_CR21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Fletchtner H, Fleishman SB, de Haes JC (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365\u2013376. https:\/\/doi.org\/10.1093\/jnci\/85.5.365","journal-title":"J Natl Cancer Inst"},{"key":"9603_CR22","doi-asserted-by":"publisher","first-page":"107602961983805","DOI":"10.1177\/1076029619838052","volume":"25","author":"M Cronin","year":"2019","unstructured":"Cronin M, Dengler N, Krauss ES, Segal A, Wei N, Daly M, Mota F, Caprini JA (2019) Completion of the Updated Caprini Risk Assessment Model (2013 Version). Clin Appl Thromb Hemost. 25:1076029619838052. https:\/\/doi.org\/10.1177\/1076029619838052","journal-title":"Clin Appl Thromb Hemost."},{"issue":"6","key":"9603_CR23","doi-asserted-by":"publisher","first-page":"e001152","DOI":"10.1161\/JAHA.114.001152","volume":"3","author":"D Rosenberg","year":"2014","unstructured":"Rosenberg D, Eichorn A, Alarcon M, McCullagh L, McGinn T, Spyropoulos AC (2014) External validation of the risk assessment model of the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) for medical patients in a tertiary health system. J Am Heart Assoc 3(6):e001152. https:\/\/doi.org\/10.1161\/JAHA.114.001152","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"9603_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1378\/chest.09-3081","volume":"139","author":"H Decousus","year":"2011","unstructured":"Decousus H, Tapson VF, Bergmann JF, Chong BH, Froehlich JB, Kakkar AK, Merli GJ, Monreal M, Nakamura M, Pavanello R, Pini M, Piovella F, Spencer FA, Spyropoulos AC, Turpie AG, Zotz RB, Fitzgerald G, Anderson FA (2011) Factors at admission associated with bleeding risk in medical patients: findings from the IMPROVE investigators. Chest 139(1):69\u201379. https:\/\/doi.org\/10.1378\/chest.09-3081","journal-title":"Chest"},{"issue":"11","key":"9603_CR25","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1111\/jth.13140","volume":"13","author":"S Kaatz","year":"2015","unstructured":"Kaatz S, Ahmad D, Spyropoulos AC, Schulman S (2015) Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH. J Thromb Haemost 13(11):2119\u20132126. https:\/\/doi.org\/10.1111\/jth.13140","journal-title":"J Thromb Haemost"},{"issue":"1","key":"9603_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.amjmed.2005.06.058","volume":"119","author":"PD Stein","year":"2006","unstructured":"Stein PD, Beemath A, Meyers FA, Skaf E, Sanchez J, Olson RE (2006) Incidence of venous thromboembolism in patients hospitalized with cancer. Am J Med 119(1):60\u201368. https:\/\/doi.org\/10.1016\/j.amjmed.2005.06.058","journal-title":"Am J Med"},{"issue":"16","key":"9603_CR27","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.1182\/bloodadvances.2022008086","volume":"6","author":"M Giustozzi","year":"2022","unstructured":"Giustozzi M, Proietti G, Becattini C, Roila F, Agnelli G, Mandal\u00e0 M (2022) ICH in primary or metastatic brain cancer patients with or without anticoagulant treatment: a systematic review and meta-analysis. Blood Adv 6(16):4873\u20134883. https:\/\/doi.org\/10.1182\/bloodadvances.2022008086","journal-title":"Blood Adv"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09603-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09603-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09603-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T04:03:07Z","timestamp":1753934587000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09603-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["9603"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09603-6","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]},"assertion":[{"value":"16 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"592"}}