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Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>HCT recipients had a median age of 59\u00a0years (IQR 48\u201366); 63% were male. Median time to HCT was 53\u00a0days (IQR 29\u201389), median follow-up was 279\u00a0days (IQR 183\u2013349). Severe periodontitis (\u2265\u20091 site with PPD\u2009\u2265\u20096\u00a0mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26\u00a0mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm<jats:sup>2<\/jats:sup> [95%CI 89;190] and 123 mm<jats:sup>2<\/jats:sup> [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00520-025-09654-9","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T01:15:25Z","timestamp":1750641325000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0446-9060","authenticated-orcid":false,"given":"Lucky L. 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