{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:54:34Z","timestamp":1755226474230,"version":"3.43.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s00520-025-09756-4","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:05:03Z","timestamp":1752491103000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of different photobiomodulation protocols on the prevention of chemotherapy-induced dysgeusia in breast cancer patients treated with Doxorubicin-Cyclophosphamide: a phase III, randomized, triple-blinded non-inferiority clinical trial"],"prefix":"10.1007","volume":"33","author":[{"given":"Cassia Emanuella N\u00f3brega","family":"Malta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Maria Fontes","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulianna Aparecida Vieira","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella Juli\u00e3o Alves","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lais Oliveira Castro","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Alves","family":"Crispim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Fernando Bastos","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Goberl\u00e2nio","family":"de Barros Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"issue":"3","key":"9756_CR1","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.3390\/ijms24032538","volume":"24","author":"BT Webber","year":"2023","unstructured":"Webber BT, Briata IM, DeCensi A et al (2023) Taste and smell disorders in cancer treatment: results from an integrative rapid systematic review. Int J Mol Sci 24(3):2538. https:\/\/doi.org\/10.3390\/ijms24032538","journal-title":"Int J Mol Sci"},{"issue":"3","key":"9756_CR2","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1007\/s00520-021-06642-7","volume":"30","author":"CEN Malta","year":"2022","unstructured":"Malta CEN, Matos Carlos ACA, Alencar MCM et al (2022) Photobiomodulation therapy prevents dysgeusia chemotherapy induced in breast cancer women treated with doxorubicin plus cyclophosphamide: a triple-blinded, randomized, placebo-controlled clinical trial. Support Care Cancer 30(3):2569\u20132580. https:\/\/doi.org\/10.1007\/s00520-021-06642-7","journal-title":"Support Care Cancer"},{"issue":"2","key":"9756_CR3","doi-asserted-by":"publisher","first-page":"e12633","DOI":"10.1111\/ecc.12633","volume":"26","author":"E Ponticelli","year":"2017","unstructured":"Ponticelli E, Clari M, Frigerio S et al (2017) Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study. Eur J Cancer Care 26(2):e12633. https:\/\/doi.org\/10.1111\/ecc.12633","journal-title":"Eur J Cancer Care"},{"issue":"22","key":"9756_CR4","doi-asserted-by":"publisher","first-page":"4505","DOI":"10.3390\/ijerph16224505","volume":"16","author":"M El Mobadder","year":"2019","unstructured":"El Mobadder M, Farhat F, El Mobadder W, Nammour S (2019) Photobiomodulation therapy in the treatment of oral mucositis, dysphagia, oral dryness, taste alteration, and burning mouth sensation due to cancer therapy: A case series. Int J Environ Res Public Health 16(22):4505. https:\/\/doi.org\/10.3390\/ijerph16224505","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"9756_CR5","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00520-021-06219-4","volume":"30","author":"CEN Malta","year":"2022","unstructured":"Malta CEN, de Lima Martins JO, Carlos ACA et al (2022) Risk factors for dysgeusia during chemotherapy for solid tumors: a retrospective cross-sectional study. Support Care Cancer 30(1):313\u2013325. https:\/\/doi.org\/10.1007\/s00520-021-06219-4","journal-title":"Support Care Cancer"},{"key":"9756_CR6","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s00520-016-3152-z","volume":"24","author":"JA Zecha","year":"2016","unstructured":"Zecha JA, Raber-Durlacher JE, Nair RG et al (2016) Low level laser therapy\/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations. Support Care Cancer 24:2781\u20132792. https:\/\/doi.org\/10.1007\/s00520-016-3152-z","journal-title":"Support Care Cancer"},{"key":"9756_CR7","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00520-019-04930-x","volume":"28","author":"S Pugnaloni","year":"2020","unstructured":"Pugnaloni S, Vignini A, Borroni F et al (2020) Modifications of taste sensitivity in cancer patients: a method for the evaluations of dysgeusia. Support Care Cancer 28:1173\u20131181. https:\/\/doi.org\/10.1007\/s00520-019-04930-x","journal-title":"Support Care Cancer"},{"issue":"2","key":"9756_CR8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.4103\/0976-500X.72352","volume":"1","author":"KF Schulz","year":"2010","unstructured":"Schulz KF, Altman DG, Moher DCONSORT (2010) statement: updated guidelines for reporting parallel group randomised trials. J Pharmacol Pharmacother 1(2):100\u2013107. https:\/\/doi.org\/10.4103\/0976-500X.72352","journal-title":"J Pharmacol Pharmacother"},{"key":"9756_CR9","doi-asserted-by":"publisher","unstructured":"Hannum ME, Koch RJ, Ramirez VA et al (2022) Taste loss as a distinct symptom of COVID-19: a systematic review and meta-analysis. Chem Senses 47:bjac001. https:\/\/doi.org\/10.1093\/chemse\/bjac001","DOI":"10.1093\/chemse\/bjac001"},{"issue":"11","key":"9756_CR10","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/lapl.201010060","volume":"7","author":"RDFZ Lizarelli","year":"2010","unstructured":"Lizarelli RDFZ, Miguel FAC, Freitas-Pontes KM et al (2010) Dentin hypersensitivity clinical study comparing LILT and LEDT keeping the same irradiation parameters. Laser Phys Lett 7(11):805\u2013811. https:\/\/doi.org\/10.1002\/lapl.201010060","journal-title":"Laser Phys Lett"},{"issue":"1","key":"9756_CR11","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","volume":"694","author":"M Navazesh","year":"1993","unstructured":"Navazesh M (1993) Methods for collecting saliva. Ann N Y Acad Sci 694(1):72\u201377. https:\/\/doi.org\/10.1111\/j.1749-6632.1993.tb18343.x","journal-title":"Ann N Y Acad Sci"},{"key":"9756_CR12","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1007\/s00784-018-02798-5","volume":"23","author":"AFM Albuquerque","year":"2019","unstructured":"Albuquerque AFM, Soares ECS, de Barros Silva PG et al (2019) Clinical investigation of gustatory and neurosensory alterations following mandibular third molar surgery: an observational prospective study. Clin Oral Investig 23:2941\u20132949. https:\/\/doi.org\/10.1007\/s00784-018-02798-5","journal-title":"Clin Oral Investig"},{"key":"9756_CR13","unstructured":"National Cancer Institute. Common Toxicity Criteria, Version 5.0 (2017) Available from: http:\/\/safetyprofiler-ctep.nci.nih.gov\/CTC\/CTC.aspx. Accessed March 2023."},{"issue":"2","key":"9756_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.oraloncology.2009.11.008","volume":"46","author":"JB Epstein","year":"2010","unstructured":"Epstein JB, Barasch A (2010) Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol 46(2):77\u201381. https:\/\/doi.org\/10.1016\/j.oraloncology.2009.11.008","journal-title":"Oral Oncol"},{"key":"9756_CR15","first-page":"196","volume-title":"Evaluation of Chemotherapeutic Agents","author":"DA Karnofsky","year":"1949","unstructured":"Karnofsky DA, Burchenal JH (1949) The Clinical Evaluation of Chemotherapeutic Agents in Cancer. In: MacLeod CM (ed) Evaluation of Chemotherapeutic Agents. Columbia University Press, New York, pp 196\u2013196"},{"key":"9756_CR16","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1590\/0102-311X00072013","volume":"30","author":"MF Silveira","year":"2014","unstructured":"Silveira MF, Mar\u00f4co JP, Freire RS et al (2014) Impact of oral health on physical and psychosocial dimensions: an analysis using structural equation modeling. Cad Saude Publica 30:1169\u20131182. https:\/\/doi.org\/10.1590\/0102-311X00072013","journal-title":"Cad Saude Publica"},{"key":"9756_CR17","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s00520-012-1551-3","volume":"21","author":"RM Speck","year":"2013","unstructured":"Speck RM, DeMichele A, Farrar JT et al (2013) Taste alteration in breast cancer patients treated with taxane chemotherapy: experience, effect, and coping strategies. Support Care Cancer 21:549\u2013555. https:\/\/doi.org\/10.1007\/s00520-012-1551-3","journal-title":"Support Care Cancer"},{"issue":"10","key":"9756_CR18","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1007\/s00520-023-08012-x","volume":"31","author":"M Hannon","year":"2023","unstructured":"Hannon M, Shaw A, Connolly M, Davies A (2023) Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications. Support Care Cancer 31(10):562. https:\/\/doi.org\/10.1007\/s00520-023-08012-x","journal-title":"Support Care Cancer"},{"key":"9756_CR19","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1007\/s12282-020-01089-w","volume":"27","author":"Y Denda","year":"2020","unstructured":"Denda Y, Niikura N, Satoh-Kuriwada S et al (2020) Taste alterations in patients with breast cancer following chemotherapy: a cohort study. Breast Cancer 27:954\u2013962. https:\/\/doi.org\/10.1007\/s12282-020-01089-w","journal-title":"Breast Cancer"},{"issue":"3","key":"9756_CR20","doi-asserted-by":"publisher","first-page":"e398","DOI":"10.4317\/medoral.26389","volume":"29","author":"PG Silva","year":"2024","unstructured":"Silva PG, Barreto GA, Carlos AC et al (2024) Dysgeusia increases the risk for death and other side effects during antineoplastic systemic treatment for solid tumors: a cross-sectional study. Med Oral Patol Oral Cir Bucal 29(3):e398\u2013e407. https:\/\/doi.org\/10.4317\/medoral.26389","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"177","key":"9756_CR21","doi-asserted-by":"publisher","first-page":"106318","DOI":"10.1016\/j.archoralbio.2025.106318","volume":"4","author":"AA Crispim","year":"2025","unstructured":"Crispim AA, Costa GAJ, Barreto GAV et al (2025) Influence of salivary tumor necrosis factor alpha (TNF-\u03b1) concentration in patients with dysgeusia induced by antineoplastic chemotherapy: A case-control study. Arch Oral Biol 4(177):106318. https:\/\/doi.org\/10.1016\/j.archoralbio.2025.106318","journal-title":"Arch Oral Biol"},{"issue":"3","key":"9756_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1159\/000513751","volume":"83","author":"B Chen","year":"2021","unstructured":"Chen B, Benzien C, Faria V et al (2021) Symptoms of depression in patients with chemosensory disorders. ORL 83(3):135\u2013143. https:\/\/doi.org\/10.1159\/000513751","journal-title":"ORL"},{"issue":"4","key":"9756_CR23","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.jpainsymman.2010.06.022","volume":"41","author":"TD Brisbois","year":"2011","unstructured":"Brisbois TD, de Kock IH, Watanabe SM, Baracos VE, Wismer WV (2011) Characterization of chemosensory alterations in advanced cancer reveals specific chemosensory phenotypes impacting dietary intake and quality of life. J Pain Symptom Manage 41(4):673\u2013683. https:\/\/doi.org\/10.1016\/j.jpainsymman.2010.06.022","journal-title":"J Pain Symptom Manage"},{"issue":"10","key":"9756_CR24","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.3390\/nu11102285","volume":"11","author":"AA Nolden","year":"2019","unstructured":"Nolden AA, Hwang LD, Boltong A, Reed DR (2019) Chemosensory changes from cancer treatment and their effects on patients\u2019 food behavior: a scoping review. Nutrients 11(10):2285. https:\/\/doi.org\/10.3390\/nu11102285","journal-title":"Nutrients"},{"key":"9756_CR25","doi-asserted-by":"publisher","unstructured":"Rydholm M, Strang P (2002) Physical and psychosocial impact of xerostomia in palliative cancer care: a qualitative interview study. Int J Palliat Nurs 8(7):318\u2013323. https:\/\/doi.org\/10.12968\/ijpn.2002.8.7.10671","DOI":"10.12968\/ijpn.2002.8.7.10671"},{"key":"9756_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpsycho.2023.01.010","volume":"186","author":"P Castellano","year":"2023","unstructured":"Castellano P, Gigli V, Ghezzi V et al (2023) Momentary gustative-olfactory sensitivity and tonic heart rate variability are independently associated with motivational behavior. Int J Psychophysiol 186:1\u20139. https:\/\/doi.org\/10.1016\/j.ijpsycho.2023.01.010","journal-title":"Int J Psychophysiol"},{"issue":"6","key":"9756_CR27","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.3390\/ijms24065358","volume":"24","author":"YJ Kim","year":"2023","unstructured":"Kim YJ (2023) Xerostomia and Its Cellular Targets. Int J Mol Sci 24(6):5358. https:\/\/doi.org\/10.3390\/ijms24065358","journal-title":"Int J Mol Sci"},{"key":"9756_CR28","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1007\/s00520-021-06066-3","volume":"29","author":"M Kaizu","year":"2021","unstructured":"Kaizu M, Komatsu H, Yamauchi H et al (2021) Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life. Support Care Cancer 29:5103\u20135114. https:\/\/doi.org\/10.1007\/s00520-021-06066-3","journal-title":"Support Care Cancer"},{"issue":"8","key":"9756_CR29","doi-asserted-by":"publisher","first-page":"6955","DOI":"10.1007\/s00520-022-07091-6","volume":"30","author":"R Pedersini","year":"2022","unstructured":"Pedersini R, Zamparini M, Bosio S et al (2022) Taste alterations during neo\/adjuvant chemotherapy and subsequent follow-up in breast cancer patients: A prospective single-center clinical study. Support Care Cancer 30(8):6955\u20136961. https:\/\/doi.org\/10.1007\/s00520-022-07091-6","journal-title":"Support Care Cancer"},{"issue":"12","key":"9756_CR30","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1111\/joor.12005","volume":"39","author":"JB Caputo","year":"2012","unstructured":"Caputo JB, Campos SS, Pereira SM et al (2012) Masticatory performance and taste perception in patients submitted to cancer treatment. J Oral Rehabil 39(12):905\u2013913. https:\/\/doi.org\/10.1111\/joor.12005","journal-title":"J Oral Rehabil"},{"issue":"2","key":"9756_CR31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1089\/pho.2017.4325","volume":"36","author":"BL Brzak","year":"2018","unstructured":"Brzak BL, Cigi\u0107 L, Bari\u010devi\u0107 M et al (2018) Different protocols of photobiomodulation therapy of hyposalivation. Photomed Laser Surg 36(2):78\u201382. https:\/\/doi.org\/10.1089\/pho.2017.4325","journal-title":"Photomed Laser Surg"},{"issue":"12","key":"9756_CR32","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.3390\/jcm11123414","volume":"11","author":"A Ferrandez-Pujante","year":"2022","unstructured":"Ferrandez-Pujante A, Pons-Fuster E, L\u00f3pez-Jornet P (2022) Efficacy of photobiomodulation in reducing symptomatology and improving the quality of life in patients with xerostomia and hyposalivation: A randomized controlled trial. J Clin Med 11(12):3414. https:\/\/doi.org\/10.3390\/jcm11123414","journal-title":"J Clin Med"},{"key":"9756_CR33","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3389\/fonc.2020.01255","volume":"10","author":"SY Tam","year":"2020","unstructured":"Tam SY, Tam VC, Ramkumar S et al (2020) Review on the cellular mechanisms of low-level laser therapy use in oncology. Front Oncol 10:1255. https:\/\/doi.org\/10.3389\/fonc.2020.01255","journal-title":"Front Oncol"},{"key":"9756_CR34","doi-asserted-by":"publisher","first-page":"927685","DOI":"10.3389\/fonc.2022.927685","volume":"12","author":"J Robijns","year":"2022","unstructured":"Robijns J, Nair RG, Lodewijckx J et al (2022) Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Front Oncol 12:927685. https:\/\/doi.org\/10.3389\/fonc.2022.927685","journal-title":"Front Oncol"},{"issue":"22","key":"9756_CR35","doi-asserted-by":"publisher","first-page":"8279","DOI":"10.1002\/cam4.3582","volume":"9","author":"RJ Bensadoun","year":"2020","unstructured":"Bensadoun RJ, Epstein JB, Nair RG et al (2020) Safety and efficacy of photobiomodulation therapy in oncology: A systematic review. Cancer Med 9(22):8279\u20138300. https:\/\/doi.org\/10.1002\/cam4.3582","journal-title":"Cancer Med"},{"key":"9756_CR36","doi-asserted-by":"publisher","unstructured":"De Menezes BC, Thebit MM, Bonela LAS et al (2021) Laser therapy as a preventive approach for oral mucositis in cancer patients undergoing chemotherapy: the potential role of superoxide dismutase. Asian Pac J Cancer Prev 22(10):3211. https:\/\/doi.org\/10.31557\/APJCP.2021.22.10.3211","DOI":"10.31557\/APJCP.2021.22.10.3211"},{"issue":"3","key":"9756_CR37","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1188\/18.ONF.342-353","volume":"45","author":"S Campagna","year":"2018","unstructured":"Campagna S, Gonella S, Sperlinga R (2018) Prevalence, severity, and self-reported characteristics of taste alterations in patients receiving chemotherapy. Oncol Nurs Forum 45(3):342\u2013353. https:\/\/doi.org\/10.1188\/18.ONF.342-353","journal-title":"Oncol Nurs Forum"},{"key":"9756_CR38","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00520-009-0590-x","volume":"17","author":"G Bovio","year":"2009","unstructured":"Bovio G, Montagna G, Bariani C, Baiardi P (2009) Upper gastrointestinal symptoms in patients with advanced cancer: relationship to nutritional and performance status. Support Care Cancer 17:1317\u20131324. https:\/\/doi.org\/10.1007\/s00520-009-0590-x","journal-title":"Support Care Cancer"},{"key":"9756_CR39","doi-asserted-by":"publisher","first-page":"5491188","DOI":"10.1155\/2021\/5491188","volume":"2021","author":"J Liu","year":"2021","unstructured":"Liu J, Lv C, Wu D et al (2021) Subjective taste and smell changes in conjunction with anxiety and depression are associated with symptoms in patients with functional constipation and irritable bowel syndrome. Gastroenterol Res Pract 2021:5491188. https:\/\/doi.org\/10.1155\/2021\/5491188","journal-title":"Gastroenterol Res Pract"},{"issue":"2","key":"9756_CR40","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1254\/jphs.11R08CP","volume":"118","author":"K Iwatsuki","year":"2012","unstructured":"Iwatsuki K, Uneyama H (2012) Sense of taste in the gastrointestinal tract. J Pharmacol Sci 118(2):123\u2013128. https:\/\/doi.org\/10.1254\/jphs.11R08CP","journal-title":"J Pharmacol Sci"},{"issue":"25","key":"9756_CR41","doi-asserted-by":"publisher","first-page":"7015","DOI":"10.1080\/10408398.2021.1909532","volume":"62","author":"B Wu","year":"2022","unstructured":"Wu B, Eldeghaidy S, Ayed C (2022) Mechanisms of umami taste perception: From molecular level to brain imaging. Crit Rev Food Sci Nutr 62(25):7015\u20137024. https:\/\/doi.org\/10.1080\/10408398.2021.1909532","journal-title":"Crit Rev Food Sci Nutr"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09756-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09756-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09756-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:05:05Z","timestamp":1752491105000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09756-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["9756"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09756-4","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"31 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted by ethical principles and guidelines. Informed consent was obtained upon admission to the institution (Hospital Haroldo Jua\u00e7aba\/Cear\u00e1 Cancer Institute). To protect patient confidentiality, information and data were anonymized and stored securely. The code of ethics for this study was no. l.4.879.342.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"692"}}