{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:29:51Z","timestamp":1789475391402,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00520-025-09822-x","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T10:56:57Z","timestamp":1754737017000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-5736","authenticated-orcid":false,"given":"Di\u011fdem","family":"Do\u011fan Akag\u00fcnd\u00fcz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-3711","authenticated-orcid":false,"given":"Perim Fatma","family":"T\u00fcrker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4979-3123","authenticated-orcid":false,"given":"Baran","family":"Akag\u00fcnd\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"issue":"1","key":"9822_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4235\/agmr.21.0144","volume":"26","author":"Y Choi","year":"2022","unstructured":"Choi Y, Kim N, Kim KW, Jo HH, Park J, Yoon H et al (2022) Gastric cancer in older patients: a retrospective study and literature review. Ann Geriatr Med Res 26(1):33","journal-title":"Ann Geriatr Med Res"},{"issue":"3","key":"9822_CR2","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249","journal-title":"CA Cancer J Clin"},{"key":"9822_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103841","volume":"181","author":"MJ L\u00f3pez","year":"2023","unstructured":"L\u00f3pez MJ, Carbajal J, Alfaro AL, Saravia LG, Zanabria D, Araujo JM et al (2023) Characteristics of gastric cancer around the world. Crit Rev Oncol Hematol 181:103841","journal-title":"Crit Rev Oncol Hematol"},{"issue":"16","key":"9822_CR4","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3748\/wjg.v29.i16.2452","volume":"29","author":"WJ Yang","year":"2023","unstructured":"Yang WJ, Zhao HP, Yu Y, Wang JH, Guo L, Liu JY et al (2023) Updates on global epidemiology, risk and prognostic factors of gastric cancer. World J Gastroenterol 29(16):2452","journal-title":"World J Gastroenterol"},{"issue":"1","key":"9822_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","volume":"16","author":"WL Guan","year":"2023","unstructured":"Guan WL, He Y, Xu RH (2023) Gastric cancer treatment: recent progress and future perspectives. J Hematol Oncol 16(1):57","journal-title":"J Hematol Oncol"},{"issue":"3","key":"9822_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41575-022-00703-w","volume":"20","author":"M Alsina","year":"2023","unstructured":"Alsina M, Arrazubi V, Diez M, Tabernero J (2023) Current developments in gastric cancer: from molecular profiling to treatment strategy. Nat Rev Gastroenterol Hepatol 20(3):155\u2013170","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"9822_CR7","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41467-022-35431-x","volume":"14","author":"S Li","year":"2023","unstructured":"Li S, Yu W, Xie F, Luo H, Liu Z, Lv W et al (2023) Neoadjuvant therapy with immune checkpoint blockade, antiangiogenesis, and chemotherapy for locally advanced gastric cancer. Nat Commun 14(1):8","journal-title":"Nat Commun"},{"issue":"5","key":"9822_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s10120-023-01404-2","volume":"26","author":"K Keywani","year":"2023","unstructured":"Keywani K, Borgstein ABJ, Eshuis WJ, Pape M, Versteeg KS, Derks S et al (2023) Neoadjuvant chemotherapy in older patients with gastric cancer undergoing surgery: a population-based cohort study. Gastric Cancer 26(5):763\u2013774","journal-title":"Gastric Cancer"},{"issue":"9","key":"9822_CR9","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1080\/01635581.2022.2059089","volume":"74","author":"Z Nikniaz","year":"2022","unstructured":"Nikniaz Z, Somi MH, Naghashi S (2022) Malnutrition and weight loss as prognostic factors in the survival of patients with gastric cancer. Nutr Cancer 74(9):3140\u20133145","journal-title":"Nutr Cancer"},{"issue":"12","key":"9822_CR10","doi-asserted-by":"publisher","first-page":"963","DOI":"10.20892\/j.issn.2095-3941.2023.0473","volume":"20","author":"C Song","year":"2023","unstructured":"Song C, Shi H (2023) Diagnosis of malnutrition in cancer patients. Cancer Biol Med 20(12):963","journal-title":"Cancer Biol Med"},{"issue":"3","key":"9822_CR11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/nu13030761","volume":"13","author":"D Meza-Valderrama","year":"2021","unstructured":"Meza-Valderrama D, Marco E, D\u00e1valos-Yerovi V, Muns MD, Tejero-S\u00e1nchez M, Duarte E et al (2021) Sarcopenia, malnutrition, and cachexia: adapting definitions and terminology of nutritional disorders in older people with cancer. Nutrients 13(3):761","journal-title":"Nutrients"},{"issue":"4","key":"9822_CR12","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.nut.2014.12.005","volume":"31","author":"F Bozzetti","year":"2015","unstructured":"Bozzetti F (2015) Why the oncologist should consider the nutritional status of the elderly cancer patient. Nutrition 31(4):590\u2013593","journal-title":"Nutrition"},{"issue":"6","key":"9822_CR13","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.clnu.2014.04.007","volume":"33","author":"NEP Deutz","year":"2014","unstructured":"Deutz NEP, Bauer JM, Barazzoni R, Biolo G, Boirie Y, Bosy-Westphal A et al (2014) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN expert group. Clin Nutr 33(6):929\u2013936","journal-title":"Clin Nutr"},{"issue":"4","key":"9822_CR14","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.clnu.2022.01.024","volume":"41","author":"D Volkert","year":"2022","unstructured":"Volkert D, Beck AM, Cederholm T, Cruz-Jentoft A, Hooper L, Kiesswetter E et al (2022) Espen practical guideline: clinical nutrition and hydration in geriatrics. Clin Nutr 41(4):958\u2013989","journal-title":"Clin Nutr"},{"issue":"11","key":"9822_CR15","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1038\/ejcn.2016.96","volume":"70","author":"SA Purcell","year":"2016","unstructured":"Purcell SA, Elliott SA, Baracos VE, Chu QSC, Prado CM (2016) Key determinants of energy expenditure in cancer and implications for clinical practice. Eur J Clin Nutr 70(11):1230\u20131238","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"9822_CR16","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1016\/j.clnu.2021.02.005","volume":"40","author":"M Muscaritoli","year":"2021","unstructured":"Muscaritoli M, Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H et al (2021) ESPEN practical guideline: clinical nutrition in cancer. Clin Nutr 40(5):2898\u20132913","journal-title":"Clin Nutr"},{"issue":"11","key":"9822_CR17","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1038\/s41430-020-0629-0","volume":"74","author":"AF Bullock","year":"2020","unstructured":"Bullock AF, Greenley SL, McKenzie GAG, Paton LW, Johnson MJ (2020) Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis. Eur J Clin Nutr 74(11):1519\u20131535","journal-title":"Eur J Clin Nutr"},{"issue":"5","key":"9822_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/jnci\/djr556","volume":"104","author":"C Baldwin","year":"2012","unstructured":"Baldwin C, Spiro A, Ahern R, Emery PW (2012) Oral nutritional interventions in malnourished patients with cancer: a systematic review and meta-analysis. J Natl Cancer Inst 104(5):371\u2013385","journal-title":"J Natl Cancer Inst"},{"key":"9822_CR19","first-page":"1","volume":"20","author":"O Le Saux","year":"2018","unstructured":"Le Saux O, Falandry C (2018) Toxicity of cancer therapies in older patients. Curr Oncol Rep 20:1\u201311","journal-title":"Curr Oncol Rep"},{"key":"9822_CR20","doi-asserted-by":"crossref","unstructured":"Guigoz Y, Vellas B, Garry PJ (1997) Mini nutritional assessment: a practical assessment tool for grading the nutritional state of elderly patients. 15\u201360","DOI":"10.1016\/S0899-9007(98)00171-3"},{"issue":"12","key":"9822_CR21","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","volume":"185","author":"S Katz","year":"1963","unstructured":"Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW (1963) Studies of illness in the aged: the index of ADL: a standardized measure of biological and psychosocial function. JAMA 185(12):914\u2013919","journal-title":"JAMA"},{"key":"9822_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton MP (1969) Assessment of older people; self-maintaining and instrumental activites of dialy living. Gerontologist 9:279\u2013286","journal-title":"Gerontologist"},{"issue":"5","key":"9822_CR23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365\u201376","journal-title":"J Natl Cancer Inst"},{"issue":"5","key":"9822_CR24","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373\u2013383","journal-title":"J Chronic Dis"},{"key":"9822_CR25","unstructured":"US Department of Health and Human Services\u00a0(2017)\u00a0Common terminology criteria for adverse events (CTCAE)"},{"issue":"5","key":"9822_CR26","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3390\/nu11051145","volume":"11","author":"SH Kim","year":"2019","unstructured":"Kim SH, Lee SM, Jeung HC, Lee IJ, Park JS, Song M et al (2019) The effect of nutrition intervention with oral nutritional supplements on pancreatic and bile duct cancer patients undergoing chemotherapy. Nutrients 11(5):1145","journal-title":"Nutrients"},{"issue":"11\u201312","key":"9822_CR27","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1016\/j.nut.2013.05.004","volume":"29","author":"A Uster","year":"2013","unstructured":"Uster A, Ruefenacht U, Ruehlin M, Pless M, Siano M, Haefner M et al (2013) Influence of a nutritional intervention on dietary intake and quality of life in cancer patients: a randomized controlled trial. Nutrition 29(11\u201312):1342\u20131349","journal-title":"Nutrition"},{"issue":"8","key":"9822_CR28","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/nu16081223","volume":"16","author":"T Pareja Sierra","year":"2024","unstructured":"Pareja Sierra T, H\u00fcnicken Torrez FL, Pablos Hern\u00e1ndez MC, L\u00f3pez Velasco R, Ort\u00e9s G\u00f3mez R, del CerveraD\u00edaz MC et al (2024) A prospective, observational study of the effect of a high-calorie, high-protein oral nutritional supplement with HMB in an old and malnourished or at-risk-of-malnutrition population with hip fractures: a FracNut study. Nutrients 16(8):1223","journal-title":"Nutrients"},{"issue":"3","key":"9822_CR29","first-page":"415","volume":"30","author":"H Zhang","year":"2021","unstructured":"Zhang H, Qiu Y, Zhang J, Ma Z, Amoah AN, Cao Y et al (2021) The effect of oral nutritional supplements on the nutritional status of community elderly people with malnutrition or risk of malnutrition. Asia Pac J Clin Nutr 30(3):415\u2013423","journal-title":"Asia Pac J Clin Nutr"},{"issue":"10","key":"9822_CR30","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.3390\/nu9101108","volume":"9","author":"M Zi\u0119tarska","year":"2017","unstructured":"Zi\u0119tarska M, Krawczyk-Lipiec J, Kraj L, Zaucha R, Ma\u0142gorzewicz S (2017) Chemotherapy-related toxicity, nutritional status and quality of life in precachectic oncologic patients with, or without, high protein nutritional support. A prospective, randomized study. Nutrients 9(10):1108","journal-title":"Nutrients"},{"issue":"12","key":"9822_CR31","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1001\/jamasurg.2018.1645","volume":"153","author":"EM Minnella","year":"2018","unstructured":"Minnella EM, Awasthi R, Loiselle SE, Agnihotram RV, Ferri LE, Carli F (2018) Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery: a randomized clinical trial. JAMA Surg 153(12):1081\u20131089","journal-title":"JAMA Surg"},{"issue":"3","key":"9822_CR32","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.jgo.2017.02.010","volume":"8","author":"C Kenis","year":"2017","unstructured":"Kenis C, Decoster L, Bastin J, Bode H, Van Puyvelde K, De Gr\u00e8ve J et al (2017) Functional decline in older patients with cancer receiving chemotherapy: a multicenter prospective study. J Geriatr Oncol 8(3):196\u2013205","journal-title":"J Geriatr Oncol"},{"issue":"5","key":"9822_CR33","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.14336\/AD.2018.1226","volume":"10","author":"TRL Lima","year":"2019","unstructured":"Lima TRL, Almeida VP, Ferreira AS, Guimar\u00e3es FS, Lopes AJ (2019) Handgrip strength and pulmonary disease in the elderly: what is the link? Aging Dis 10(5):1109","journal-title":"Aging Dis"},{"issue":"1","key":"9822_CR34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.radonc.2017.10.015","volume":"126","author":"E Cereda","year":"2018","unstructured":"Cereda E, Cappello S, Colombo S, Klersy C, Imarisio I, Turri A et al (2018) Nutritional counseling with or without systematic use of oral nutritional supplements in head and neck cancer patients undergoing radiotherapy. Radiother Oncol 126(1):81\u201388","journal-title":"Radiother Oncol"},{"key":"9822_CR35","doi-asserted-by":"publisher","unstructured":"Ozveren, Ahmet, et al\u00a0(2024) Alterations in muscle strength among patients with GI cancers receiving oral nutritional support as soon as malnutrition was detected: ONMUS study. J Clin Oncol 741\u2013741. https:\/\/doi.org\/10.1200\/JCO.2024.42.3_suppl.741","DOI":"10.1200\/JCO.2024.42.3_suppl.741"},{"issue":"6","key":"9822_CR36","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.surg.2018.05.017","volume":"164","author":"SH Kong","year":"2018","unstructured":"Kong SH, Lee HJ, Na JR, Kim WG, Han DS, Park SH et al (2018) Effect of perioperative oral nutritional supplementation in malnourished patients who undergo gastrectomy: a prospective randomized trial. Surgery 164(6):1263\u201370","journal-title":"Surgery"},{"key":"9822_CR37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00423-016-1527-8","volume":"402","author":"F Hatao","year":"2017","unstructured":"Hatao F, Chen KY, Wu JM, Wang MY, Aikou S, Onoyama H et al (2017) Randomized controlled clinical trial assessing the effects of oral nutritional supplements in postoperative gastric cancer patients. Langenbecks Arch Surg 402:203\u2013211","journal-title":"Langenbecks Arch Surg"},{"issue":"12","key":"9822_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121861","volume":"11","author":"RF Dunne","year":"2019","unstructured":"Dunne RF, Loh KP, Williams GR, Jatoi A, Mustian KM, Mohile SG (2019) Cachexia and sarcopenia in older adults with cancer: a comprehensive review. Cancers (Basel) 11(12):1861","journal-title":"Cancers (Basel)"},{"issue":"16","key":"9822_CR39","doi-asserted-by":"publisher","first-page":"6923","DOI":"10.1002\/cam4.2517","volume":"8","author":"E Cereda","year":"2019","unstructured":"Cereda E, Turri A, Klersy C, Cappello S, Ferrari A, Filippi AR et al (2019) Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy. Cancer Med 6932. https:\/\/doi.org\/10.1002\/cam4.2517","journal-title":"Cancer Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09822-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09822-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09822-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T03:03:49Z","timestamp":1758164629000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09822-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["9822"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09822-x","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]},"assertion":[{"value":"22 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"775"}}