{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:21:19Z","timestamp":1792167679931,"version":"4.4.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Patients with hematological malignancies frequently receive aggressive, poor-quality end-of-life care. In oncology, serious illness conversations conducted early in the illness trajectory, focusing on patients\u2019 goals, values, and priorities, have been associated with improved end-of-life care and decreased symptoms of anxiety and depression. Yet, evidence of such supportive interventions\u2019 impact in hematology remains limited. This study explores the association between receiving a serious illness conversation and the quality of end-of-life care and the timing of serious illness conversations in patients with hematological malignancies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Single-center retrospective quality improvement study. Data on receipt of serious illness conversations and end-of-life care (hospitalizations, specialized palliative care referrals, place of death, receipt of anticancer treatment) were extracted from electronic healthcare records. Logistic regression, adjusted for sex, age, and diagnosis examined the differences between patients who did and did not receive a serious illness conversation. The study included patients with hematological malignancies, who died between 2020 and 2022 and received anticancer treatment within the last 12\u00a0months at a university hospital in Denmark.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among 311 patients (median age 74\u00a0years, 43% female), 63 (20%) received a serious illness conversation. Patients receiving conversations had significantly higher odds of referral to specialized palliative care (OR 2.67, 95% CI [1.44; 4.91]) and lower odds of receiving anticancer treatment within 30\u00a0days (OR 0.19, 95% CI [0.10; 0.37]) and 14\u00a0days (OR 0.21, 95% CI [0.09; 0.46) before death.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Serious illness conversations are associated with reduced aggressive end-of-life anticancer treatment and increased referrals to specialized palliative care.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00520-025-09855-2","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T01:19:50Z","timestamp":1756257590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serious illness conversations and quality of end-of-life care in patients with hematological malignancies\u2014a retrospective quality improvement study"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-8702","authenticated-orcid":false,"given":"C\u00e6cilie Borregaard","family":"Myrh\u00f8j","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0873-7931","authenticated-orcid":false,"given":"Rachelle","family":"Bernacki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Bjerre-Bertelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-8759","authenticated-orcid":false,"given":"Juliet","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-5058","authenticated-orcid":false,"given":"Jenny","family":"Klintman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3040-8384","authenticated-orcid":false,"given":"Mary","family":"Jarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-206X","authenticated-orcid":false,"given":"Christoffer","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-5575","authenticated-orcid":false,"given":"Annika","family":"von Heymann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9145-5611","authenticated-orcid":false,"given":"Stine Novrup","family":"Clemmensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"9855_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-0323-4","volume":"10","author":"D Pulte","year":"2020","unstructured":"Pulte D, Jansen L, Brenner H (2020) Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century. 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