{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:30:36Z","timestamp":1788244236822,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","award":["2023JH2\/101700113"],"award-info":[{"award-number":["2023JH2\/101700113"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s00520-025-09998-2","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:04:57Z","timestamp":1760151897000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of combined adjuvant therapeutic drugs in modulating opioid dosage and pain status in cancer patients: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"33","author":[{"given":"Xiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Sheng","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"issue":"4","key":"9998_CR1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jatmed.2024.10.005","volume":"3","author":"MS Bodnar","year":"2024","unstructured":"Bodnar MS, Barber S, Jim HSL et al (2024) The role of ketamine and its enantiomer in managing depression and pain in cancer patients: a narrative review [J]. J Anesth Transl Med 3(4):155\u2013165","journal-title":"J Anesth Transl Med"},{"issue":"10","key":"9998_CR2","first-page":"CD012509","volume":"10","author":"C Els","year":"2017","unstructured":"Els C, Jackson TD, Kunyk D et al (2017) Adverse events associated with medium- and long-term use of opioids for chronic non-cancer pain: an overview of Cochrane reviews [J]. Cochrane Database Syst Rev 10(10):CD012509","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"9998_CR3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1200\/JCO.22.02198","volume":"41","author":"JA Paice","year":"2023","unstructured":"Paice JA, Bohlke K, Barton D et al (2023) Use of opioids for adults with pain from cancer or cancer treatment: ASCO guideline [J]. J Clin Oncol 41(4):914\u2013930","journal-title":"J Clin Oncol"},{"issue":"Suppl A","key":"9998_CR4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/eujp.2001.0281","volume":"5","author":"M Matoba","year":"2001","unstructured":"Matoba M (2001) Use of morphine and adjuvant drugs according to the condition [J]. Eur J Pain 5(Suppl A):59\u201362","journal-title":"Eur J Pain"},{"key":"9998_CR5","unstructured":"American Pain Society. Principles of Analgesic Use, 7th Ed. American Pain Society, Glenview, IL. 2016. ISBN-10: 157862173X"},{"issue":"5","key":"9998_CR6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/aas.13305","volume":"63","author":"H Taguchi","year":"2019","unstructured":"Taguchi H, Oishi K, Shingu K et al (2019) Intrathecal betamethasone for cancer pain: a study of its analgesic efficacy and safety [J]. Acta Anaesthesiol Scand 63(5):659\u2013667","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"9998_CR7","volume":"19","author":"L Zhang","year":"2024","unstructured":"Zhang L, Zhang H (2024) The efficacy of pregabalin for pain control after thoracic surgery: a meta-analysis. J Cardiothorac Surg 19(1):4","journal-title":"J Cardiothorac Surg"},{"issue":"15","key":"9998_CR8","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006463","volume":"96","author":"C Peng","year":"2017","unstructured":"Peng C, Li C, Qu J et al (2017) Gabapentin can decrease acute pain and morphine consumption in spinal surgery patients: a meta-analysis of randomized controlled trials. Medicine (Baltimore) 96(15):e6463","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"9998_CR9","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.bjps.2017.05.054","volume":"70","author":"AS Rai","year":"2017","unstructured":"Rai AS, Khan JS, Dhaliwal J et al (2017) Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: a systematic review and meta-analysis of randomized controlled trials[J]. J Plast Reconstr Aesthet Surg 70(10):1317\u20131328","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"7","key":"9998_CR10","first-page":"CD012638","volume":"7","author":"S Derry","year":"2017","unstructured":"Derry S, Wiffen PJ, Moore RA et al (2017) Oral nonsteroidal anti-inflammatory drugs (NSAIDs) for cancer pain in adults [J]. Cochrane Database Syst Rev 7(7):CD012638","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"9998_CR11","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s10147-017-1133-y","volume":"22","author":"Z Liu","year":"2017","unstructured":"Liu Z, Xu Y, Liu ZL (2017) Combined application of diclofenac and celecoxib with an opioid yields superior efficacy in metastatic bone cancer pain: a randomized controlled trial [J]. Int J Clin Oncol 22(5):980\u2013985","journal-title":"Int J Clin Oncol"},{"issue":"1","key":"9998_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00315271","volume":"44","author":"R Bj\u00f6rkman","year":"1993","unstructured":"Bj\u00f6rkman R, Ullman A, Hedner J (1993) Morphine-sparing effect of diclofenac in cancer pain [J]. Eur J Clin Pharmacol 44(1):1\u20135","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"9998_CR13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0885-3924(97)00005-5","volume":"14","author":"S Mercadante","year":"1997","unstructured":"Mercadante S, Sapio M, Caligara M (1997) Opioid-sparing effect of diclofenac in cancer pain. J Pain Symptom Manage 14(1):15\u201320","journal-title":"J Pain Symptom Manage"},{"key":"9998_CR14","volume":"76","author":"J Li","year":"2021","unstructured":"Li J, Luan F, Song J et al (2021) Clinical efficacy of controlled-release morphine tablets combined with celecoxib in pain management and the effects on WNK1 expression. Clinics 76:e1907","journal-title":"Clinics"},{"issue":"24","key":"9998_CR15","first-page":"10855","volume":"15","author":"TT Wu","year":"2014","unstructured":"Wu TT, Wang ZG, Ou WL et al (2014) Intravenous flurbiprofen axetil enhances the analgesic effect of opioids in patients with refractory cancer pain by increasing plasma beta-endorphin [J]. Asian Pac J Cancer Prev 15(24):10855\u201310860","journal-title":"Asian Pac J Cancer Prev"},{"issue":"2","key":"9998_CR16","first-page":"e57","volume":"13","author":"Z Dou","year":"2017","unstructured":"Dou Z, Jiang Z, Zhong J (2017) Efficacy and safety of pregabalin in patients with neuropathic cancer pain undergoing morphine therapy. Asia Pac J Clin Oncol 13(2):e57\u2013e64","journal-title":"Asia Pac J Clin Oncol"},{"issue":"5","key":"9998_CR17","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/cam4.3779","volume":"10","author":"J Dai","year":"2021","unstructured":"Dai J, Teng L, Zhao L et al (2021) The combined analgesic effect of pregabalin and morphine in the treatment of pancreatic cancer pain [J]. Cancer Med 10(5):1738\u20131744","journal-title":"Cancer Med"},{"issue":"12","key":"9998_CR18","first-page":"7611","volume":"29","author":"L Teng","year":"2021","unstructured":"Teng L, Dai J, Shao H et al (2021) Gabapentin enhances the antinociceptive effect of intrathecal morphine in refractory cancer pain patients. Support Care Cancer 29(12):7611\u20137616","journal-title":"Support Care Cancer"},{"issue":"1","key":"9998_CR19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/15360288.2018.1460436","volume":"32","author":"K Barghi","year":"2018","unstructured":"Barghi K, Edmonds KP, Ajayi TA et al (2018) Prescribing trends of palliative care team\u2019s use of dexamethasone for cancer-related pain [J]. J Pain Palliat Care Pharmacother 32(1):37\u201343","journal-title":"J Pain Palliat Care Pharmacother"},{"issue":"4","key":"9998_CR20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.clon.2008.12.010","volume":"21","author":"A Hird","year":"2009","unstructured":"Hird A, Zhang L, Holt T et al (2009) Dexamethasone for the prophylaxis of radiation-induced pain flare after palliative radiotherapy for symptomatic bone metastases: a phase II study. Clin Oncol (R Coll Radiol) 21(4):329\u2013335","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"2","key":"9998_CR21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/bjc.2012.593","volume":"108","author":"GR Lauretti","year":"2013","unstructured":"Lauretti GR, Rizzo CC, Mattos AL et al (2013) Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone [J]. Br J Cancer 108(2):259\u2013264","journal-title":"Br J Cancer"},{"issue":"3","key":"9998_CR22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/030089160208800310","volume":"88","author":"S Mercadante","year":"2002","unstructured":"Mercadante S, Arcuri E, Tirelli W (2002) Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study [J]. Tumori 88(3):239\u2013242","journal-title":"Tumori"},{"issue":"1","key":"9998_CR23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4314\/tjpr.v18i1.19","volume":"18","author":"C Di","year":"2019","unstructured":"Di C, Xu D (2019) Effect of concomitant administration of oxycontin and amitriptyline on patients with severe cancer pain and depression [J]. Trop J Pharm Res 18(1):129\u2013134","journal-title":"Trop J Pharm Res"},{"key":"9998_CR24","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2147\/CMAR.S290470","volume":"13","author":"C Su","year":"2021","unstructured":"Su C, Chen M, Chen G et al (2021) Practices and hindrances in cancer pain management: results of a national multi-cancer center survey among healthcare professionals in China [J]. Cancer Manag Res 13:1709\u20131717","journal-title":"Cancer Manag Res"},{"issue":"1","key":"9998_CR25","first-page":"41","volume":"52","author":"K Preti","year":"2024","unstructured":"Preti K, D\u2019Aoust R, Beeber AS et al (2024) Multimodal Interprofessional Adult Cancer Pain Management: An Integrative Review [J]. Oncol Nurs Forum 52(1):41\u201350","journal-title":"Oncol Nurs Forum"},{"key":"9998_CR26","doi-asserted-by":"crossref","first-page":"116686","DOI":"10.1016\/j.bcp.2024.116686","volume":"232","author":"W Kr\u00f3l","year":"2025","unstructured":"Kr\u00f3l W, Machelak W, Zieli\u0144ska M (2025) Positive allosteric modulation of \u00b5-opioid receptor\u2014a new possible approach in the pain management [J]? Biochem Pharmacol 232:116686","journal-title":"Biochem Pharmacol"},{"key":"9998_CR27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106961","volume":"197","author":"N Ramos-Gonzalez","year":"2023","unstructured":"Ramos-Gonzalez N, Paul B, Majumdar S (2023) IUPHAR themed review: opioid efficacy, bias, and selectivity. Pharmacol Res 197:106961","journal-title":"Pharmacol Res"},{"key":"9998_CR28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/JPR.S75160","volume":"8","author":"K Brune","year":"2015","unstructured":"Brune K, Patrignani P (2015) New insights into the use of currently available non-steroidal anti-inflammatory drugs. J Pain Res 8:105\u2013118","journal-title":"J Pain Res"},{"issue":"9","key":"9998_CR29","first-page":"e69028","volume":"16","author":"MU Mian","year":"2024","unstructured":"Mian MU, Afzal M, Butt AA et al (2024) Neuropharmacology of neuropathic pain: a systematic review [J]. Cureus 16(9):e69028","journal-title":"Cureus"},{"issue":"2","key":"9998_CR30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/joacp.JOACP_12_17","volume":"34","author":"SS Routray","year":"2018","unstructured":"Routray SS, Pani N, Mishra D et al (2018) Comparison of pregabalin with gabapentin as a preemptive analgesic in lumbar spine surgery [J]. J Anaesthesiol Clin Pharmacol 34(2):232\u2013236","journal-title":"J Anaesthesiol Clin Pharmacol"},{"issue":"5","key":"9998_CR31","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/ejh.14392","volume":"114","author":"A Perrot","year":"2025","unstructured":"Perrot A, Facon T, Plesner T et al (2025) Sustained improvement in health-related quality of life in transplant-ineligible newly diagnosed multiple myeloma treated with daratumumab, lenalidomide, and dexamethasone: MAIA final analysis of patient-reported outcomes. Eur J Haematol 114(5):883\u20139","journal-title":"Eur J Haematol"},{"key":"9998_CR32","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.2147\/JPR.S243435","volume":"13","author":"HS Smith","year":"2020","unstructured":"Smith HS, Laufer A, Wallace MS (2020) The role of adjunctive agents in opioid analgesia. J Pain Res 13:1209\u20131222","journal-title":"J Pain Res"},{"issue":"5","key":"9998_CR33","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s11912-022-01245-9","volume":"24","author":"MI Johnson","year":"2022","unstructured":"Johnson MI, Davis MP (2022) Non-opioid adjuvant analgesics in cancer pain management. Curr Oncol Rep 24(5):595\u2013605","journal-title":"Curr Oncol Rep"},{"key":"9998_CR34","volume":"215","author":"Y Wang","year":"2022","unstructured":"Wang Y, Wang H, Li W (2022) Novel insights into GABAergic mechanisms in neuropathic pain. Neuropharmacology 215:109171","journal-title":"Neuropharmacology"},{"key":"9998_CR35","volume":"908","author":"JR Silva","year":"2021","unstructured":"Silva JR, Aley KO (2021) Histamine receptor antagonists in pain modulation: an updated review. Eur J Pharmacol 908:174358","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"9998_CR36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1177\/0269216310378546","volume":"25","author":"MI Bennett","year":"2011","unstructured":"Bennett MI (2011) Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review. Palliat Med 25(5):553\u2013559","journal-title":"Palliat Med"},{"issue":"15","key":"9998_CR37","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S1470-2045(15)00199-0","volume":"16","author":"E Chow","year":"2015","unstructured":"Chow E, Meyer RM, Ding K et al (2015) Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: a double-blind, randomized placebo-controlled, phase 3 trial. Lancet Oncol 16(15):1463\u20131472","journal-title":"Lancet Oncol"},{"issue":"6","key":"9998_CR38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2165\/11534590-000000000-00000","volume":"33","author":"MM Tielemans","year":"2010","unstructured":"Tielemans MM, Eikendal T, Jansen JB et al (2010) Identification of NSAID users at risk for gastrointestinal complications: a systematic review of current guidelines and consensus agreements. Drug Saf 33(6):443\u2013453","journal-title":"Drug Saf"},{"key":"9998_CR39","unstructured":"U.S. Food and Drug Administration. FDA drug safety communication: FDA strengthens warning that non-aspirin NSAIDs (NSAIDs) can cause heart attacks or strokes. 2015. Accessed 12.20.2024."},{"key":"9998_CR40","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1009950","volume":"13","author":"J Hahn","year":"2022","unstructured":"Hahn J, Jo Y, Yoo SH et al (2022) Risk of major adverse events associated with gabapentinoid and opioid combination therapy: a systematic review and meta-analysis. Front Pharmacol 13:1009950","journal-title":"Front Pharmacol"},{"issue":"2 Suppl","key":"9998_CR41","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.36076\/ppj.2008\/11\/S133","volume":"11","author":"AM Trescot","year":"2008","unstructured":"Trescot AM, Datta S, Lee M et al (2008) Opioid pharmacology [J]. Pain Physician 11(2 Suppl):S133\u2013S153","journal-title":"Pain Physician"},{"issue":"12","key":"9998_CR42","doi-asserted-by":"crossref","first-page":"e1003876","DOI":"10.1371\/journal.pmed.1003876","volume":"18","author":"T Gomes","year":"2021","unstructured":"Gomes T, Greaves S, van den Brink W et al (2021) Gabapentinoids, opioids, and the risk of opioid-related death: a population-based nested case-control study. PLoS Med 18(12):e1003876","journal-title":"PLoS Med"},{"issue":"6","key":"9998_CR43","first-page":"1699","volume":"89","author":"KM Moksnes","year":"2023","unstructured":"Moksnes KM, Dale O, Rosland JH et al (2023) How to switch from morphine to methadone in cancer pain? A systematic review and critical assessment of previously published conversion methods. Br J Clin Pharmacol 89(6):1699\u20131715","journal-title":"Br J Clin Pharmacol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09998-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-09998-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-09998-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T19:06:10Z","timestamp":1763406370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-09998-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["9998"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-09998-2","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"18 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"931"}}