{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:23:02Z","timestamp":1772119382487,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"NCI Early-Stage Surgeon Scientist Program (ESSP) NIH\/NCI P30 CCSG Supplement Grant","award":["GR023102"],"award-info":[{"award-number":["GR023102"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To correlate genitourinary exam (GU) findings to patient-reported sexual dysfunction in female cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included female cancer patients seen at a South Florida sexual health after cancer program. GU anatomy abnormalities and patient-reported sexual dysfunction were evaluated by Adapted Vulvovaginal Exam Score (AVES) and the\u00a0Female Sexual Function Index (FSFI), respectively. Multivariate analyses compared, FSFI scores between patients with AVES\u2009&gt;\u20093 vs. 0\u20133, (AVES\u2009&gt;\u20093 corresponds to more abnormal GU exam). Adjusted odds ratio (aOR) and 95% confidence intervals (95% CI) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AVES was calculated for 162 female patients treated between 2020\u20132022. Median age was 46; 57% were Hispanic, and 79% had breast cancer. Common symptoms included vaginal dryness (55%) and dyspareunia (45%). Of 108 women with FSFI scores, 97% met criteria for female sexual dysfunction (FSD). 23% were found to have vaginal stenosis, and 42% had a narrowed vaginal introitus. Those with AVES\u2009&gt;\u20093 had significantly lower FSFI lubrication, orgasm, satisfaction, and pain domain scores. Any endocrine therapy use was associated with worse AVES scores (aOR 0.20, 95% CI 0.05\u20130.80, p\u2009=\u20090.024), an association strongest with aromatase inhibitor (AIs) use. Low satisfaction scores\u2009&lt;\u20093.6 were nearly three times more likely to have abnormal GU exams (aOR\u2009=\u20092.81; 95% CI: 1.03\u20137.65; p\u2009=\u20090.044).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FSD in female cancer survivors is associated with previously unreported GU exam changes that can limit or prevent sexual activity through pain and worsened sexual satisfaction. Ongoing work evaluates targeted interventions to improve symptoms and quality of life for this growing survivor population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-025-10046-2","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:17:42Z","timestamp":1763003862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["More than just \u201cvaginal dryness\u201d: sexual dysfunction correlates with genitourinary anatomy changes in female cancer survivors"],"prefix":"10.1007","volume":"33","author":[{"given":"Erin","family":"Kobiella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjana","family":"Satish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fay","family":"Pon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia","family":"Jueng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Shields","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Curran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tizeta","family":"Wolde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica F.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Greenseid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tulay","family":"Koru-Sengul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Penedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin E","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"10046_CR1","volume-title":"Cancer Treatment & Survivorship Facts & Figures 2022\u20132024","author":"American Cancer Society","year":"2022","unstructured":"American Cancer Society (2022) Cancer Treatment & Survivorship Facts & Figures 2022\u20132024. 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The research was conducted in accordance with the ethical standards set forth by the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study. Only de-identified patient data is included in the present study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Dr. Rojas has received speaker honoraria from Pacira Pharmaceuticals (2023) for a presentation highlighting perioperative multimodal analgesia strategies and has served in an advisory role for Merck and Novartis (2024). Dr. Rojas receives funding from the NCI Early-Stage Surgeon Scientist Program (ESSP) NIH\/NCI P30 CCSG Supplement Grant (AWD-005240 | GR023102), 2023\u20132026.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"1056"}}