{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:14:28Z","timestamp":1788315268920,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00520-025-10122-7","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:18:38Z","timestamp":1762377518000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Opioid use in patients aged 90\u00a0years or older with terminal cancer in a palliative care unit: a single-center retrospective observational study"],"prefix":"10.1007","volume":"33","author":[{"given":"Ryota","family":"Yanaizumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0443-5007","authenticated-orcid":false,"given":"Yusuke","family":"Nagamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuri","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shino","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kuroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"10122_CR1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.61919","volume":"16","author":"Y Ishikawa","year":"2024","unstructured":"Ishikawa Y, Ishikawa E, Ishikawa K (2024) Postoperative course and supportive care in very elderly cecum cancer patients. Cureus 16:e61919. https:\/\/doi.org\/10.7759\/cureus.61919","journal-title":"Cureus"},{"key":"10122_CR2","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.jgo.2020.02.006","volume":"11","author":"CJ Presley","year":"2020","unstructured":"Presley CJ, Canavan M, Wang SY, Feder SL, Kapo J, Saphire ML, Sheinfeld E, Kent EE, Davidoff AJ (2020) Severe functional limitation due to pain & emotional distress and subsequent receipt of prescription medications among older adults with cancer. J Geriatr Oncol 11:960\u2013968. https:\/\/doi.org\/10.1016\/j.jgo.2020.02.006","journal-title":"J Geriatr Oncol"},{"key":"10122_CR3","unstructured":"Statistics Bureau of Japan. Japan statistical yearbook. https:\/\/www.stat.go.jp\/english\/data\/nenkan\/69nenkan\/index.html. Accessed 30 April 2025."},{"key":"10122_CR4","first-page":"93","volume":"21","author":"K Mystakidou","year":"2007","unstructured":"Mystakidou K, Parpa E, Tsilika E, Pathiaki M, Galanos A, Vlahos L (2007) Comparison of pain quality descriptors in cancer patients with nociceptive and neuropathic pain. In Vivo 21:93\u201397","journal-title":"In Vivo"},{"key":"10122_CR5","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1002\/1097-0142(19920915)70:6<1616::aid-cncr2820700630>3.0.co;2-7","volume":"70","author":"RK Portenoy","year":"1992","unstructured":"Portenoy RK, Miransky J, Thaler HT, Hornung J, Bianchi C, Cibas-Kong I, Feldhamer E, Lewis F, Matamoros I, Sugar MZ et al (1992) Pain in ambulatory patients with lung or colon cancer. Prevalence, characteristics, and effect. Cancer 70:1616\u20131624. https:\/\/doi.org\/10.1002\/1097-0142(19920915)70:6%3c1616::aid-cncr2820700630%3e3.0.co;2-7","journal-title":"Cancer"},{"key":"10122_CR6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.cger.2015.01.006","volume":"31","author":"TJ Smith","year":"2015","unstructured":"Smith TJ (2015) Symptom management in the older adult: 2015 update. Clin Geriatr Med 31:155\u2013175. https:\/\/doi.org\/10.1016\/j.cger.2015.01.006","journal-title":"Clin Geriatr Med"},{"key":"10122_CR7","unstructured":"WHO Guidelines Approved by the Guidelines Review Committee (2018) WHO Guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents. World Health Organization, Geneva"},{"key":"10122_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jpainsymman.2021.09.001","volume":"63","author":"M Tatokoro","year":"2022","unstructured":"Tatokoro M, Matsuo N (2022) The impact of aging on symptom prevalence and management in terminally ill patients with cancer. J Pain Symptom Manage 63:251\u2013259. https:\/\/doi.org\/10.1016\/j.jpainsymman.2021.09.001","journal-title":"J Pain Symptom Manage"},{"key":"10122_CR9","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1089\/jpm.2011.0308","volume":"14","author":"NM Rashidi","year":"2011","unstructured":"Rashidi NM, Zordan RD, Flynn E, Philip JA (2011) The care of the very old in the last three days of life. J Palliat Med 14:1339\u20131344. https:\/\/doi.org\/10.1089\/jpm.2011.0308","journal-title":"J Palliat Med"},{"key":"10122_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jpainsymman.2013.02.016","volume":"47","author":"A Van Lancker","year":"2014","unstructured":"Van Lancker A, Velghe A, Van Hecke A, Verbrugghe M, Van Den Noortgate N, Grypdonck M, Verhaeghe S, Bekkering G, Beeckman D (2014) Prevalence of symptoms in older cancer patients receiving palliative care: a systematic review and meta-analysis. J Pain Symptom Manage 47:90\u2013104. https:\/\/doi.org\/10.1016\/j.jpainsymman.2013.02.016","journal-title":"J Pain Symptom Manage"},{"key":"10122_CR11","unstructured":"Yokohama city. Population by age of city and ward (in Japanese). https:\/\/www.city.yokohama.lg.jp\/city-info\/yokohamashi\/tokei-chosa\/portal\/jinko\/nenrei\/suikei.html. Accessed 30 April 2025."},{"key":"10122_CR12","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1089\/jpm.2018.0141","volume":"21","author":"D Baik","year":"2018","unstructured":"Baik D, Russell D, Jordan L, Dooley F, Bowles KH, Masterson Creber RM (2018) Using the palliative performance scale to estimate survival for patients at the end of life: a systematic review of the literature. J Palliat Med 21:1651\u20131661. https:\/\/doi.org\/10.1089\/jpm.2018.0141","journal-title":"J Palliat Med"},{"key":"10122_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1089\/pmr.2021.0037","volume":"2","author":"H Sumimoto","year":"2021","unstructured":"Sumimoto H, Hayashi K, Kimura Y, Nishikawa A, Hattori S, Hasegawa C, Morii H, Teramoto K, Morita S, Daigo Y (2021) Factors associated with cancer-related pain requiring high-dose opioid use in palliative cancer patients. Palliat Med Rep 2:237\u2013241. https:\/\/doi.org\/10.1089\/pmr.2021.0037","journal-title":"Palliat Med Rep"},{"key":"10122_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","volume":"335","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP (2007) Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 335:806\u2013808. https:\/\/doi.org\/10.1136\/bmj.39335.541782.AD","journal-title":"BMJ"},{"key":"10122_CR15","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/ijc.33232","volume":"148","author":"S Pilleron","year":"2021","unstructured":"Pilleron S, Soto-Perez-de-Celis E, Vignat J, Ferlay J, Soerjomataram I, Bray F, Sarfati D (2021) Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050. Int J Cancer 148:601\u2013608. https:\/\/doi.org\/10.1002\/ijc.33232","journal-title":"Int J Cancer"},{"key":"10122_CR16","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1089\/jpm.2013.0625","volume":"17","author":"T Morita","year":"2014","unstructured":"Morita T, Kuriya M, Miyashita M, Sato K, Eguchi K, Akechi T (2014) Symptom burden and achievement of good death of elderly cancer patients. J Palliat Med 17:887\u2013893. https:\/\/doi.org\/10.1089\/jpm.2013.0625","journal-title":"J Palliat Med"},{"key":"10122_CR17","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1001\/jama.285.7.925","volume":"285","author":"J Lynn","year":"2001","unstructured":"Lynn J (2001) Perspectives on care at the close of life. Serving patients who may die soon and their families: the role of hospice and other services. JAMA 285:925\u2013932. https:\/\/doi.org\/10.1001\/jama.285.7.925","journal-title":"JAMA"},{"key":"10122_CR18","unstructured":"Japanese Society for Palliative Medicine (2018) A practical guide for refractory suffering and palliative sedation therapy in advanced cancer patients. Kanehara & Co., Ltd, Tokyo. (in Japanese)"},{"key":"10122_CR19","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1007\/s00520-015-2988-y","volume":"24","author":"S Mercadante","year":"2016","unstructured":"Mercadante S, Aielli F, Masedu F, Valenti M, Verna L, Porzio G (2016) Age differences in the last week of life in advanced cancer patients followed at home. Support Care Cancer 24:1889\u20131895. https:\/\/doi.org\/10.1007\/s00520-015-2988-y","journal-title":"Support Care Cancer"},{"key":"10122_CR20","doi-asserted-by":"publisher","unstructured":"Choi H, Hwang W (2024) Anesthetic approaches and their impact on cancer recurrence and metastasis: a comprehensive review. Cancers (Basel) 16. https:\/\/doi.org\/10.3390\/cancers16244269","DOI":"10.3390\/cancers16244269"},{"key":"10122_CR21","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1017\/s1478951524000294","volume":"22","author":"JN S\u00e1nchez-D\u00e1vila","year":"2024","unstructured":"S\u00e1nchez-D\u00e1vila JN, Ver\u00e1stegui EL, Pe\u00f1a-Nieves A, Allende-P\u00e9rez SR (2024) Integration of the geriatric palliative care in oncological care of elderly patient with cancer. Palliat Support Care 22:792\u2013800. https:\/\/doi.org\/10.1017\/s1478951524000294","journal-title":"Palliat Support Care"},{"key":"10122_CR22","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520987726","volume":"49","author":"R Yanaizumi","year":"2021","unstructured":"Yanaizumi R, Nagamine Y, Harada S, Kojima K, Tazawa T, Goto T (2021) Prevalence of neuropathic pain in terminally ill patients with cancer admitted to a general ward: a prospective observational study. J Int Med Res 49:300060520987726. https:\/\/doi.org\/10.1177\/0300060520987726","journal-title":"J Int Med Res"},{"key":"10122_CR23","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1002\/npr2.12448","volume":"44","author":"M Hasegawa-Moriyama","year":"2024","unstructured":"Hasegawa-Moriyama M, Morioka Y, Hiroi S, Naya N, Suzuki Y, Koretaka Y, Hara E, Abe H, Uchida K, Sumitani M (2024) High prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: combined database study and nationwide questionnaire survey in Japan. Neuropsychopharmacol Rep 44:502\u2013511. https:\/\/doi.org\/10.1002\/npr2.12448","journal-title":"Neuropsychopharmacol Rep"}],"updated-by":[{"DOI":"10.1007\/s00520-025-10225-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000}}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10122-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-10122-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10122-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:31:22Z","timestamp":1765949482000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-10122-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10122"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-10122-7","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00520-025-10225-1","URL":"https:\/\/doi.org\/10.1007\/s00520-025-10225-1","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving human participants performed in this study were in accordance with the ethical standards of the institutional and\/or national research committee and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by the ethics committee of the Seirei Yokohama Hospital (2024\u2013017, August 23, 2024), Yokohama, Japan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The requirement for written informed consent was waived due to the retrospective nature of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consent to publication of this article\u00a0in Supportive Care in Cancer.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1018"}}