{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:35:50Z","timestamp":1768422950870,"version":"3.49.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Grant for Implementation of Advanced Medicine"},{"name":"Grant for Research Advancement on Palliative Medicine, Japanese Society for Palliative Medicine","award":["No. 192"],"award-info":[{"award-number":["No. 192"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00520-025-10170-z","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:25:54Z","timestamp":1764325554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Establishing the minimal important change for Patient Assessment of Constipation Quality of Life\u00a0questionnaire for the prevention of opioid-induced constipation in patients with cancer pain"],"prefix":"10.1007","volume":"33","author":[{"given":"Takahiro","family":"Higashibata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Oyamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Kessoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuhiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"10170_CR1","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1093\/pm\/pnw255","volume":"18","author":"S M\u00fcller-Lissner","year":"2017","unstructured":"M\u00fcller-Lissner S, Bassotti G, Coffin B et al (2017) Opioid-induced constipation and bowel dysfunction: a clinical guideline. Pain Med 18:1837\u20131863. https:\/\/doi.org\/10.1093\/pm\/pnw255","journal-title":"Pain Med"},{"key":"10170_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/2050640618818305","volume":"7","author":"AD Farmer","year":"2019","unstructured":"Farmer AD, Drewes AM, Chiarioni G et al (2019) Pathophysiology and management of opioid-induced constipation: European expert consensus statement. United Eur Gastroenterol J 7:7\u201320. https:\/\/doi.org\/10.1177\/2050640618818305","journal-title":"United Eur Gastroenterol J"},{"key":"10170_CR3","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.jpainsymman.2010.02.019","volume":"40","author":"F Hjalte","year":"2010","unstructured":"Hjalte F, Berggren AC, Bergendahl H, Hjortsberg C (2010) The direct and indirect costs of opioid-induced constipation. J Pain Symptom Manage 40:696\u2013703. https:\/\/doi.org\/10.1016\/j.jpainsymman.2010.02.019","journal-title":"J Pain Symptom Manage"},{"key":"10170_CR4","doi-asserted-by":"publisher","first-page":"iv111","DOI":"10.1093\/annonc\/mdy148","volume":"29","author":"PJ Larkin","year":"2018","unstructured":"Larkin PJ, Cherny NI, La Carpia D et al (2018) Diagnosis, assessment and management of constipation in advanced cancer: ESMO clinical practice guidelines. Ann Oncol 29:iv111\u2013iv125. https:\/\/doi.org\/10.1093\/annonc\/mdy148","journal-title":"Ann Oncol"},{"key":"10170_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00520-019-05016-4","volume":"28","author":"A Davies","year":"2020","unstructured":"Davies A, Leach C, Caponero R et al (2020) MASCC recommendations on the management of constipation in patients with advanced cancer. Support Care Cancer 28:23\u201333. https:\/\/doi.org\/10.1007\/s00520-019-05016-4","journal-title":"Support Care Cancer"},{"key":"10170_CR6","doi-asserted-by":"publisher","first-page":"4206","DOI":"10.1200\/JCO.24.00381","volume":"42","author":"J Hamano","year":"2024","unstructured":"Hamano J, Higashibata T, Kessoku T et al (2024) Naldemedine for opioid-induced constipation in patients with cancer: a multicenter, double-blind, randomized, placebo-controlled trial. J Clin Oncol 42:4206\u20134217. https:\/\/doi.org\/10.1200\/JCO.24.00381","journal-title":"J Clin Oncol"},{"key":"10170_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/147323001103900106","volume":"39","author":"MA Ueberall","year":"2011","unstructured":"Ueberall MA, M\u00fcller-Lissner S, Buschmann-Kramm C, Bosse B (2011) The bowel function index for evaluating constipation in pain patients: definition of a reference range for a non- constipated population of pain patients. J Int Med Res 39:41\u201350. https:\/\/doi.org\/10.1177\/147323001103900106","journal-title":"J Int Med Res"},{"key":"10170_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1080\/00365520510012208","volume":"40","author":"P Marquis","year":"2005","unstructured":"Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O (2005) Development and validation of the patient assessment of constipation quality of life questionnaire. Scand J Gastroenterol 40:540\u2013551. https:\/\/doi.org\/10.1080\/00365520510012208","journal-title":"Scand J Gastroenterol"},{"key":"10170_CR9","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/17474124.2020.1708718","volume":"14","author":"I Aziz","year":"2020","unstructured":"Aziz I, Whitehead WE, Palsson OS, T\u00f6rnblom H, Simr\u00e9n M (2020) An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Rev Gastroenterol Hepatol 14:39\u201346. https:\/\/doi.org\/10.1080\/17474124.2020.1708718","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"10170_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13226689","volume":"13","author":"G Varrassi","year":"2024","unstructured":"Varrassi G, Casale G, De Marinis MG et al (2024) Improving diagnosis and management of opioid-induced constipation (OIC) in clinical practice: an Italian expert opinion. J Clin Med 13. https:\/\/doi.org\/10.3390\/jcm13226689","journal-title":"J Clin Med"},{"key":"10170_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.ejpain.2005.03.008","volume":"10","author":"R Slappendel","year":"2006","unstructured":"Slappendel R, Simpson K, Dubois D, Keininger DL (2006) Validation of the PAC-SYM questionnaire for opioid-induced constipation in patients with chronic low back pain. Eur J Pain 10:209\u2013217. https:\/\/doi.org\/10.1016\/j.ejpain.2005.03.008","journal-title":"Eur J Pain"},{"key":"10170_CR12","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1093\/annonc\/mdy118","volume":"29","author":"N Katakami","year":"2018","unstructured":"Katakami N, Harada T, Murata T (2018) Randomized phase III and extension studies\u202f: efficacy and impacts on quality of life of naldemedine in subjects with opioid-induced constipation and cancer. Ann Oncol 29:1461\u20131467. https:\/\/doi.org\/10.1093\/annonc\/mdy118","journal-title":"Ann Oncol"},{"key":"10170_CR13","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.2147\/JPR.S282738","volume":"14","author":"M Camilleri","year":"2021","unstructured":"Camilleri M, Hale M, Morlion B, Tack J, Webster L, Wild J (2021) Naldemedine improves patient-reported outcomes of opioid-induced constipation in patients with chronic non-cancer pain in the COMPOSE phase 3 studies. J Pain Res 14:2179\u20132189. https:\/\/doi.org\/10.2147\/JPR.S282738","journal-title":"J Pain Res"},{"key":"10170_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225736","volume":"13","author":"R Ostan","year":"2021","unstructured":"Ostan R, Gambino G, Malavasi I et al (2021) Can naloxegol therapy improve quality of life in patients with advanced cancer? Cancers (Basel) 13. https:\/\/doi.org\/10.3390\/cancers13225736","journal-title":"Cancers (Basel)"},{"key":"10170_CR15","doi-asserted-by":"publisher","first-page":"16323","DOI":"10.3748\/wjg.v20.i43.16323","volume":"20","author":"CM Marciniak","year":"2014","unstructured":"Marciniak CM, Toledo S, Lee J et al (2014) Lubiprostone vs senna in postoperative orthopedic surgery patients with opioid-induced constipation: a double-blind, active-comparator trial. World J Gastroenterol 20:16323\u201316333. https:\/\/doi.org\/10.3748\/wjg.v20.i43.16323","journal-title":"World J Gastroenterol"},{"key":"10170_CR16","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.1007\/s00520-022-06947-1","volume":"30","author":"D Yildirim","year":"2022","unstructured":"Yildirim D, Kocatepe V, Talu GK (2022) The efficacy of acupressure in managing opioid-induced constipation in patients with cancer: a single-blind randomized controlled trial. Support Care Cancer 30:5201\u20135210. https:\/\/doi.org\/10.1007\/s00520-022-06947-1","journal-title":"Support Care Cancer"},{"key":"10170_CR17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1177\/1534735417734910","volume":"17","author":"HD Zhu","year":"2018","unstructured":"Zhu HD, Gong Z, Hu BW, Wei QL, Kong J, Peng CB (2018) The efficacy and safety of transcutaneous acupoint interferential current stimulation for cancer pain patients with opioid-induced constipation: a prospective randomized controlled study. Integr Cancer Ther 17:437\u2013443. https:\/\/doi.org\/10.1177\/1534735417734910","journal-title":"Integr Cancer Ther"},{"key":"10170_CR18","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1097\/j.pain.0000000000001174","volume":"159","author":"LR Webster","year":"2018","unstructured":"Webster LR, Nalamachu S, Morlion B et al (2018) Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study. Pain 159:987\u2013994. https:\/\/doi.org\/10.1097\/j.pain.0000000000001174","journal-title":"Pain"},{"key":"10170_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/IJPC.IJPC_187_20","volume":"27","author":"S Mishra","year":"2021","unstructured":"Mishra S, Singh R, Satapathy S, Bhatnagar S (2021) Validity and reliability of the Hindi version of the patient assessment of constipation quality of life questionnaire in cancer patients on opioids for pain management at tertiary care center, India. Indian J Palliat Care 27:95\u201398. https:\/\/doi.org\/10.4103\/IJPC.IJPC_187_20","journal-title":"Indian J Palliat Care"},{"key":"10170_CR20","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3111\/13696990903430481","volume":"12","author":"AM Rentz","year":"2009","unstructured":"Rentz AM, Yu R, M\u00fcller-Lissner S, Leyendecker P (2009) Validation of the bowel function index to detect clinically meaningful changes in opioid-induced constipation. J Med Econ 12:371\u2013383. https:\/\/doi.org\/10.3111\/13696990903430481","journal-title":"J Med Econ"},{"key":"10170_CR21","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1007\/s11136-021-02925-y","volume":"30","author":"CB Terwee","year":"2021","unstructured":"Terwee CB, Peipert JD, Chapman R et al (2021) Minimal important change (MIC): a conceptual clarification and systematic review of MIC estimates of PROMIS measures. Qual Life Res 30:2729\u20132754. https:\/\/doi.org\/10.1007\/s11136-021-02925-y","journal-title":"Qual Life Res"},{"key":"10170_CR22","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.cgh.2021.05.004","volume":"20","author":"J Tack","year":"2022","unstructured":"Tack J, Camilleri M, Hale M et al (2022) Establishing minimal clinically important differences in quality of life measures in opioid-induced constipation. Clin Gastroenterol Hepatol 20:855\u2013863. https:\/\/doi.org\/10.1016\/j.cgh.2021.05.004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10170_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2022.100967","volume":"29","author":"T Higashibata","year":"2022","unstructured":"Higashibata T, Hamano J, Kessoku T et al (2022) Rationale and design of a multicenter, double-blinded, randomized, placebo-controlled trial to investigate the effects of naldemedine on opioid-induced constipation for patients with cancer pain: a study protocol. Contemp Clin Trials Commun 29. https:\/\/doi.org\/10.1016\/j.conctc.2022.100967","journal-title":"Contemp Clin Trials Commun"},{"key":"10170_CR24","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.1002\/cam4.2341","volume":"8","author":"A Tokoro","year":"2019","unstructured":"Tokoro A, Imai H, Fumita S et al (2019) Incidence of opioid-induced constipation in Japanese patients with cancer pain: a prospective observational cohort study. Cancer Med 8:4883\u20134891. https:\/\/doi.org\/10.1002\/cam4.2341","journal-title":"Cancer Med"},{"key":"10170_CR25","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.jcf.2024.07.013","volume":"23","author":"M Lee","year":"2024","unstructured":"Lee M, Sathe M, Moshiree B et al (2024) Estimating minimal clinically important difference (MCID) for gastrointestinal symptoms in cystic fibrosis. J Cyst Fibros 23:991\u2013999. https:\/\/doi.org\/10.1016\/j.jcf.2024.07.013","journal-title":"J Cyst Fibros"},{"key":"10170_CR26","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00535-013-0825-y","volume":"49","author":"H Nomura","year":"2014","unstructured":"Nomura H, Agatsuma T, Mimura T (2014) Validity and reliability of the Japanese version of the Patient Assessment of Constipation Quality of Life questionnaire. J Gastroenterol 49:667\u2013673. https:\/\/doi.org\/10.1007\/s00535-013-0825-y","journal-title":"J Gastroenterol"},{"key":"10170_CR27","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1007\/s11136-014-0886-2","volume":"24","author":"L Neri","year":"2015","unstructured":"Neri L, Conway PM, Basilisco G (2015) Confirmatory factor analysis of the patient assessment of constipation-symptoms (PAC-SYM) among patients with chronic constipation. Qual Life Res 24:1597\u20131605. https:\/\/doi.org\/10.1007\/s11136-014-0886-2","journal-title":"Qual Life Res"},{"key":"10170_CR28","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/apt.14349","volume":"46","author":"Y Yiannakou","year":"2017","unstructured":"Yiannakou Y, Tack J, Piessevaux H et al (2017) The PAC-SYM questionnaire for chronic constipation: defining the minimal important difference. Aliment Pharmacol Ther 46:1103\u20131111. https:\/\/doi.org\/10.1111\/apt.14349","journal-title":"Aliment Pharmacol Ther"},{"key":"10170_CR29","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jaip.2016.04.022","volume":"4","author":"JA Bernstein","year":"2016","unstructured":"Bernstein JA, Mauger DT (2016) The minimally clinically important difference (MCID): what difference does it make? The Journal of Allergy and Clinical Immunology: In Practice 4:689\u2013690. https:\/\/doi.org\/10.1016\/j.jaip.2016.04.022","journal-title":"The Journal of Allergy and Clinical Immunology: In Practice"},{"key":"10170_CR30","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1007\/s00586-024-08369-5","volume":"33","author":"AM Klukowska","year":"2024","unstructured":"Klukowska AM, Vandertop WP, Schr\u00f6der ML, Staartjes VE (2024) Calculation of the minimum clinically important difference (MCID) using different methodologies: case study and practical guide. Eur Spine J 33:3388\u20133400. https:\/\/doi.org\/10.1007\/s00586-024-08369-5","journal-title":"Eur Spine J"},{"key":"10170_CR31","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1007\/s11136-018-1798-3","volume":"27","author":"CAC Prinsen","year":"2018","unstructured":"Prinsen CAC, Mokkink LB, Bouter LM et al (2018) Cosmin guideline for systematic reviews of patient-reported outcome measures. Qual Life Res 27:1147\u20131157. https:\/\/doi.org\/10.1007\/s11136-018-1798-3","journal-title":"Qual Life Res"},{"key":"10170_CR32","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejca.2005.06.022","volume":"42","author":"M Groenvold","year":"2006","unstructured":"Groenvold M, Petersen MA, Aaronson NK et al (2006) The development of the EORTC QLQ-C15-PAL: a shortened questionnaire for cancer patients in palliative care. Eur J Cancer 42:55\u201364. https:\/\/doi.org\/10.1016\/j.ejca.2005.06.022","journal-title":"Eur J Cancer"},{"key":"10170_CR33","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1185\/03007995.2012.657301","volume":"28","author":"P Ducrotte","year":"2012","unstructured":"Ducrotte P, Causse C (2012) The bowel function index: a new validated scale for assessing opioid-induced constipation. Curr Med Res Opin 28:457\u2013466. https:\/\/doi.org\/10.1185\/03007995.2012.657301","journal-title":"Curr Med Res Opin"},{"issue":"2","key":"10170_CR34","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jclinepi.2007.03.012","volume":"61","author":"D Revicki","year":"2008","unstructured":"Revicki D, Hays RD, Cella D, Sloan J (2008) Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes. J Clin Epidemiol 61(2):102\u2013109. https:\/\/doi.org\/10.1016\/j.jclinepi.2007.03.012","journal-title":"J Clin Epidemiol"},{"key":"10170_CR35","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/aje\/kwj063","volume":"163","author":"NJ Perkins","year":"2006","unstructured":"Perkins NJ, Schisterman EF (2006) The inconsistency of \u201coptimal\u201d cut-points using two criteria based on the receiver operating characteristic curve. Am J Epidemiol 163:670\u2013675. https:\/\/doi.org\/10.1093\/aje\/kwj063","journal-title":"Am J Epidemiol"},{"key":"10170_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-1055-z","volume":"16","author":"A Ousmen","year":"2018","unstructured":"Ousmen A, Touraine C, Deliu N, Cottone F et al (2018) Distribution- and anchor-based methods to determine the minimally important difference on patient-reported outcome questionnaires in oncology: a structured review. Health Qual Life Outcomes 16. https:\/\/doi.org\/10.1186\/s12955-018-1055-z","journal-title":"Health Qual Life Outcomes"},{"key":"10170_CR37","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jclinepi.2017.06.009","volume":"89","author":"R Jayadevappa","year":"2017","unstructured":"Jayadevappa R, Cook R, Chhatre S (2017) Minimal important difference to infer changes in health-related quality of life\u2014a systematic review. J Clin Epidemiol 89:188\u2013198. https:\/\/doi.org\/10.1016\/j.jclinepi.2017.06.009","journal-title":"J Clin Epidemiol"},{"key":"10170_CR38","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1111\/j.1365-2982.2009.01408.x","volume":"22","author":"D Dubois","year":"2010","unstructured":"Dubois D, Gilet H, Viala-Danten M, Tack J (2010) Psychometric performance and clinical meaningfulness of the patient assessment of constipation - quality of life questionnaire in prucalopride (RESOLOR\u00ae) trials for chronic constipation. Neurogastroenterol Motil 22:e54-63. https:\/\/doi.org\/10.1111\/j.1365-2982.2009.01408.x","journal-title":"Neurogastroenterol Motil"},{"key":"10170_CR39","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1023\/A:1015276414526","volume":"11","author":"D Cella","year":"2002","unstructured":"Cella D, Hahn EA, Dineen K (2002) Meaningful change in cancer-specific quality of life scores: differences between improvement and worsening. Qual Life Res 11:207\u2013221. https:\/\/doi.org\/10.1023\/A:1015276414526","journal-title":"Qual Life Res"},{"key":"10170_CR40","doi-asserted-by":"publisher","first-page":"675","DOI":"10.2522\/ptj.20100229","volume":"91","author":"Y Wang","year":"2011","unstructured":"Wang Y, Hart DL, Stratford PW, Mioduski JE (2011) Baseline dependency of minimal clinically important improvement. Phys Ther 91:675\u2013688. https:\/\/doi.org\/10.2522\/ptj.20100229","journal-title":"Phys Ther"},{"key":"10170_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-023-02157-3","volume":"21","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Xi X, Huang Y (2023) The anchor design of anchor-based method to determine the minimal clinically important difference: a systematic review. Health Qual Life Outcomes 21. https:\/\/doi.org\/10.1186\/s12955-023-02157-3","journal-title":"Health Qual Life Outcomes"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10170-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-10170-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10170-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:24:37Z","timestamp":1768375477000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-10170-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10170"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-10170-z","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"8 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1146"}}