{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:32:45Z","timestamp":1765949565697,"version":"3.48.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00520-025-10188-3","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:43:36Z","timestamp":1763750616000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of symptom clusters and sentinel symptoms in preoperative patients with oral and maxillofacial cancers: A cross-sectional study"],"prefix":"10.1007","volume":"33","author":[{"given":"Qin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haili","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"10188_CR1","doi-asserted-by":"publisher","unstructured":"Xiao BL, Zhang W, Chen G (2023) Extracellular vesicles and oral tumor immunity. Stomatology 43: 769\u201374. https:\/\/doi.org\/10.13591\/j.cnki.kqyx.2023.09.001","DOI":"10.13591\/j.cnki.kqyx.2023.09.001"},{"key":"10188_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/coa.12502","volume":"41","author":"TM Govers","year":"2016","unstructured":"Govers TM, Schreuder WH, Klop WM, Grutters JP, Rovers MM, Merkx MA, Takes RP (2016) Quality of life after different procedures for regional control in oral cancer patients: cross-sectional survey. Clin Otolaryngol 41:228\u2013233. https:\/\/doi.org\/10.1111\/coa.12502","journal-title":"Clin Otolaryngol"},{"key":"10188_CR3","doi-asserted-by":"publisher","unstructured":"Division of Oral and Maxillofacial Oncology, Chinese Society of Oral and Maxillofacial Surgery 2010 The protocol of treatment guideline for oral and maxillofacial malignant neoplasms Chin J Pract Stomatol 03 395 403 https:\/\/doi.org\/10.3969\/j.issn.1674-1595.2010.07.004","DOI":"10.3969\/j.issn.1674-1595.2010.07.004"},{"key":"10188_CR4","doi-asserted-by":"publisher","unstructured":"An Q, Guo P, Yuan YB, Zhang JX (2021) Preoperative anxiety in patients with oral and maxillofacial tumors and analysis of influencing factors. J Inte Psychiat 48: 532\u2013535. https:\/\/doi.org\/10.13479\/j.cnki.jip.2021.03.041","DOI":"10.13479\/j.cnki.jip.2021.03.041"},{"key":"10188_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2023.104044","volume":"45","author":"PFA Pichardo","year":"2024","unstructured":"Pichardo PFA, Desiato VM, Hellums RN, Altman KW, Purdy NC, Haugen T (2024) Depression and anxiety in patients with head and neck cancer undergoing free flap reconstruction. Am J Otolaryngol 45:104044. https:\/\/doi.org\/10.1016\/j.amjoto.2023.104044","journal-title":"Am J Otolaryngol"},{"key":"10188_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3760\/cma.j.issn.1673-0860.2018.01.005","volume":"53","author":"L Li","year":"2018","unstructured":"Li L, Wang BQ, Gao TH, Tian J (2018) Assessment of psychological status of inpatients with head and neck cancer before surgery. Chin J Otorhinolaryngol Head Neck Surg 53:21\u201326. https:\/\/doi.org\/10.3760\/cma.j.issn.1673-0860.2018.01.005","journal-title":"Chin J Otorhinolaryngol Head Neck Surg"},{"key":"10188_CR7","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s12877-023-03923-0","volume":"23","author":"KL Yang","year":"2023","unstructured":"Yang KL, Detroyer E, Van Grootven B, Tuand K, Zhao DN, Rex S, Milisen K (2023) Association between preoperative anxiety and postoperative delirium in older patients: a systematic review and meta-analysis. BMC Geriatr 23:198. https:\/\/doi.org\/10.1186\/s12877-023-03923-0","journal-title":"BMC Geriatr"},{"key":"10188_CR8","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.arth.2019.10.022","volume":"35","author":"J Xu","year":"2020","unstructured":"Xu J, Twiggs J, Parker D, Negus J (2020) The association between anxiety, depression, and locus of control with patient outcomes following total knee arthroplasty. J Arthroplasty 35:720\u2013724. https:\/\/doi.org\/10.1016\/j.arth.2019.10.022","journal-title":"J Arthroplasty"},{"key":"10188_CR9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.bja.2023.10.015","volume":"132","author":"D Chen","year":"2024","unstructured":"Chen D, Yang H, Yang L, Tang Y, Zeng H, He J, Chen W, Qu Y, Hu Y, Xu Y, Liu D, Song H, Li Q (2024) Preoperative psychological symptoms and chronic postsurgical pain: analysis of the prospective China surgery and anaesthesia cohort study. Br J Anaesth 132:359\u2013371. https:\/\/doi.org\/10.1016\/j.bja.2023.10.015","journal-title":"Br J Anaesth"},{"key":"10188_CR10","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1302\/0301-620x.105b5.Bjj-2022-1123.R1","volume":"105-B","author":"JR Harmer","year":"2023","unstructured":"Harmer JR, Wyles CC, Duong SQ, Iii RJM, Maradit-Kremers H, Abdel MP (2023) Depression and anxiety are associated with an increased risk of infection, revision, and reoperation following total hip or knee arthroplasty. Bone Joint J 105-B:526\u2013533. https:\/\/doi.org\/10.1302\/0301-620x.105b5.Bjj-2022-1123.R1","journal-title":"Bone Joint J"},{"key":"10188_CR11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.4103\/2347-5625.311003","volume":"8","author":"T Khamboon","year":"2021","unstructured":"Khamboon T, Pakanta I (2021) Intervention for symptom cluster management of fatigue, loss of appetite, and anxiety among patients with lung cancer undergoing chemotherapy. Asia Pac J Oncol Nurs 8:267\u2013275. https:\/\/doi.org\/10.4103\/2347-5625.311003","journal-title":"Asia Pac J Oncol Nurs"},{"key":"10188_CR12","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1177\/1049909110364048","volume":"27","author":"J Kirkova","year":"2010","unstructured":"Kirkova J, Walsh D, Aktas A, Davis MP (2010) Cancer symptom clusters: old concept but new data. Am J Hosp Palliat Care 27:282\u2013288. https:\/\/doi.org\/10.1177\/1049909110364048","journal-title":"Am J Hosp Palliat Care"},{"key":"10188_CR13","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.soncn.2016.08.001","volume":"32","author":"A Barsevick","year":"2016","unstructured":"Barsevick A (2016) Defining the symptom cluster: how far have we come? Semin Oncol Nurs 32:334\u2013350. https:\/\/doi.org\/10.1016\/j.soncn.2016.08.001","journal-title":"Semin Oncol Nurs"},{"key":"10188_CR14","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw253","volume":"109","author":"C Miaskowski","year":"2017","unstructured":"Miaskowski C, Barsevick A, Berger A, Casagrande R, Grady PA, Jacobsen P, Kutner J, Patrick D, Zimmerman L, Xiao C, Matocha M, Marden S (2017) Advancing symptom science through symptom cluster research: expert panel proceedings and recommendations. J Natl Cancer Inst 109:djw253. https:\/\/doi.org\/10.1093\/jnci\/djw253","journal-title":"J Natl Cancer Inst"},{"key":"10188_CR15","doi-asserted-by":"publisher","unstructured":"Kim HJ, McGuire DB, Tulman L, Barsevick AM (2005) Symptom clusters: concept analysis and clinical implications for cancer nursing. Cancer Nurs 28:270\u2013282; quiz 283\u2013284. https:\/\/doi.org\/10.1097\/00002820-200507000-00005","DOI":"10.1097\/00002820-200507000-00005"},{"issue":"3","key":"10188_CR16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1200\/jco.22.02051","volume":"41","author":"S Bhatia","year":"2023","unstructured":"Bhatia S, Landier W (2023) Symptom clusters in childhood cancer survivors. J Clinic Oncol 41(3):439\u201342. https:\/\/doi.org\/10.1200\/jco.22.02051","journal-title":"J Clinic Oncol"},{"key":"10188_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1177\/10547738231191655","volume":"32","author":"JL Larson","year":"2023","unstructured":"Larson JL, Zhou W, Veliz PT, Smith S (2023) Symptom clusters in adults with post-COVID-19: a cross-sectional survey. Clin Nurs Res 32:1071\u20131080. https:\/\/doi.org\/10.1177\/10547738231191655","journal-title":"Clin Nurs Res"},{"key":"10188_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.apnr.2018.11.003","volume":"45","author":"BA Jenkins","year":"2019","unstructured":"Jenkins BA, Athilingam P, Jenkins RA (2019) Symptom clusters in chronic obstructive pulmonary disease: a systematic review. Appl Nurs Res 45:23\u201329. https:\/\/doi.org\/10.1016\/j.apnr.2018.11.003","journal-title":"Appl Nurs Res"},{"key":"10188_CR19","doi-asserted-by":"publisher","unstructured":"He R, Hou DQ (2024) Correlation between perioperative symptom clusters and quality of life in patients with oral and maxillofacial neoplasms. Chin J Oral Maxillofac Surg 22: 446\u2013454. https:\/\/doi.org\/10.19438\/j.cjoms.2024.05.006","DOI":"10.19438\/j.cjoms.2024.05.006"},{"key":"10188_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2023.151407","volume":"39","author":"A Mathew","year":"2023","unstructured":"Mathew A, Lockwood MB, Steffen A, Tirkey AJ, Pavamani SP, Patil CL, Doorenbos AZ (2023) Symptom cluster experiences of patients operated for oral cancer: a mixed methods study. Semin Oncol Nurs 39:151407. https:\/\/doi.org\/10.1016\/j.soncn.2023.151407","journal-title":"Semin Oncol Nurs"},{"key":"10188_CR21","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00520-024-08600-5","volume":"32","author":"Y Luo","year":"2024","unstructured":"Luo Y, Mao D, Zhang L, Yang Z, Miao J, Zhang L (2024) Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer. Support Care Cancer 32:385. https:\/\/doi.org\/10.1007\/s00520-024-08600-5","journal-title":"Support Care Cancer"},{"key":"10188_CR22","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1002\/pon.4883","volume":"27","author":"K Kwekkeboom","year":"2018","unstructured":"Kwekkeboom K, Zhang Y, Campbell T, Coe CL, Costanzo E, Serlin RC, Ward S (2018) Randomized controlled trial of a brief cognitive-behavioral strategies intervention for the pain, fatigue, and sleep disturbance symptom cluster in advanced cancer. Psychooncology 27:2761\u20132769. https:\/\/doi.org\/10.1002\/pon.4883","journal-title":"Psychooncology"},{"key":"10188_CR23","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/nuf.12684","volume":"57","author":"LH Nguyen","year":"2022","unstructured":"Nguyen LH, Nguyen HTH (2022) Symptom clusters: revisiting the concept in nursing care for cancer patients. Nurs Forum 57:469\u2013472. https:\/\/doi.org\/10.1111\/nuf.12684","journal-title":"Nurs Forum"},{"key":"10188_CR24","doi-asserted-by":"publisher","first-page":"E425","DOI":"10.1188\/11.Onf.E425-e435","volume":"38","author":"JK Brown","year":"2011","unstructured":"Brown JK, Cooley ME, Chernecky C, Sarna L (2011) A symptom cluster and sentinel symptom experienced by women with lung cancer. Oncol Nurs Forum 38:E425-435. https:\/\/doi.org\/10.1188\/11.Onf.E425-e435","journal-title":"Oncol Nurs Forum"},{"key":"10188_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3969\/j.issn.1674-0904.2024.03.010","volume":"37","author":"Y Liu","year":"2024","unstructured":"Liu Y, Zeng Y, Lv JX, Jiang QH, Yin L (2024) Research progress of sentinel symptoms in cancer patients. J Cancer Control Treat 37:259\u2013263. https:\/\/doi.org\/10.3969\/j.issn.1674-0904.2024.03.010","journal-title":"J Cancer Control Treat"},{"key":"10188_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3761\/j.issn.0254-1769.2024.02.001","volume":"59","author":"JS Ma","year":"2024","unstructured":"Ma JS, Wang AP, Wang YJ, Li W, Liu YX (2024) Intervention study of lung cancer patients undergoing postoperative chemotherapy based on sentinel symptoms. Chin J Nurs 59:133\u2013141. https:\/\/doi.org\/10.3761\/j.issn.0254-1769.2024.02.001","journal-title":"Chin J Nurs"},{"key":"10188_CR27","doi-asserted-by":"publisher","unstructured":"Rosenthal DI, Mendoza TR, Chambers MS, Asper JA, Gning I, Kies MS, Weber RS, Lewin JS, Garden AS, Ang KK, X SW, Cleeland CS (2007) Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module. Head Neck 29:923\u2013931. https:\/\/doi.org\/10.1002\/hed.20602","DOI":"10.1002\/hed.20602"},{"key":"10188_CR28","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/1097-0142(20001001)89:7<1634::aid-cncr29>3.0.co;2-v","volume":"89","author":"CS Cleeland","year":"2000","unstructured":"Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, Engstrom MC (2000) Assessing symptom distress in cancer patients: the M.D Anderson Symptom Inventory. Cancer 89:1634\u20131646. https:\/\/doi.org\/10.1002\/1097-0142(20001001)89:7%3c1634::aid-cncr29%3e3.0.co;2-v","journal-title":"Cancer"},{"key":"10188_CR29","doi-asserted-by":"publisher","first-page":"626","DOI":"10.3761\/j.issn.0254-1769.2010.07.020","volume":"45","author":"Y Han","year":"2010","unstructured":"Han Y, Zhang MF, Zhang JE (2010) Symptom distress during and after radiation therapy in patients with nasopharyngeal carcinoma. Chin J Nurs 45:626\u2013628. https:\/\/doi.org\/10.3761\/j.issn.0254-1769.2010.07.020","journal-title":"Chin J Nurs"},{"key":"10188_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF02291575","volume":"39","author":"HF Kaiser","year":"1974","unstructured":"Kaiser HF (1974) An index of factorial simplicity. Psychometrika 39:31\u201336. https:\/\/doi.org\/10.1007\/BF02291575","journal-title":"Psychometrika"},{"key":"10188_CR31","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1207\/s15327906mbr0403_8","volume":"4","author":"S Tobias","year":"1969","unstructured":"Tobias S, Carlson JE (1969) Brief report: Bartlett\u2019s test of sphericity and chance findings in factor analysis. Multivar Behav Res 4:375\u2013377. https:\/\/doi.org\/10.1207\/s15327906mbr0403_8","journal-title":"Multivar Behav Res"},{"key":"10188_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7275\/jyj1-4868","volume":"10","author":"AB Costello","year":"2005","unstructured":"Costello AB, Osborne J (2005) Best practices in exploratory factor analysis: four recommendations for getting the most from your analysis. Pract Assess Res Eval 10:1\u20139. https:\/\/doi.org\/10.7275\/jyj1-4868","journal-title":"Pract Assess Res Eval"},{"key":"10188_CR33","volume-title":"IBM SPSS modeler 18.0 a definitive guide to data mining","author":"HB Zhang","year":"2019","unstructured":"Zhang HB (2019) IBM SPSS modeler 18.0 a definitive guide to data mining. Posts & Telecom Press, Beijing"},{"key":"10188_CR34","doi-asserted-by":"publisher","first-page":"828","DOI":"10.3761\/j.issn.0254-1769.2024.07.009","volume":"59","author":"MZ Liu","year":"2024","unstructured":"Liu MZ, An R, Wu ZT, Gao F, Chen WF (2024) A network analysis and nursing implications of core symptoms and symptom clusters in head and neck cancer patients. Chin J Nurs 59:828\u2013834. https:\/\/doi.org\/10.3761\/j.issn.0254-1769.2024.07.009","journal-title":"Chin J Nurs"},{"key":"10188_CR35","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3322\/caac.21157","volume":"62","author":"JB Epstein","year":"2012","unstructured":"Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L, Popplewell L, Maghami E (2012) Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin 62:400\u2013422. https:\/\/doi.org\/10.3322\/caac.21157","journal-title":"CA Cancer J Clin"},{"key":"10188_CR36","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1177\/154405910708600605","volume":"86","author":"JB Epstein","year":"2007","unstructured":"Epstein JB, Elad S, Eliav E, Jurevic R, Benoliel R (2007) Orofacial pain in cancer: part II\u2013clinical perspectives and management. J Dent Res 86:506\u2013518. https:\/\/doi.org\/10.1177\/154405910708600605","journal-title":"J Dent Res"},{"key":"10188_CR37","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1177\/154405910708600604","volume":"86","author":"R Benoliel","year":"2007","unstructured":"Benoliel R, Epstein J, Eliav E, Jurevic R, Elad S (2007) Orofacial pain in cancer: part I\u2013mechanisms. J Dent Res 86:491\u2013505. https:\/\/doi.org\/10.1177\/154405910708600604","journal-title":"J Dent Res"},{"key":"10188_CR38","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00520-010-0827-8","volume":"18","author":"SB Jensen","year":"2010","unstructured":"Jensen SB, Pedersen AM, Vissink A, Andersen E, Brown CG, Davies AN, Dutilh J, Fulton JS, Jankovic L, Lopes NN, Mello AL, Muniz LV, Murdoch-Kinch CA, Nair RG, Nape\u00f1as JJ, Nogueira-Rodrigues A, Saunders D, Stirling B, von B\u00fcltzingsl\u00f6wen I, Weikel DS, Elting LS, Spijkervet FK, Brennan MT (2010) A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer 18:1039\u20131060. https:\/\/doi.org\/10.1007\/s00520-010-0827-8","journal-title":"Support Care Cancer"},{"key":"10188_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2021.151215","volume":"37","author":"A Mathew","year":"2021","unstructured":"Mathew A, Tirkey AJ, Li H, Steffen A, Lockwood MB, Patil CL, Doorenbos AZ (2021) Symptom clusters in head and neck cancer: a systematic review and conceptual model. Semin Oncol Nurs 37:151215. https:\/\/doi.org\/10.1016\/j.soncn.2021.151215","journal-title":"Semin Oncol Nurs"},{"issue":"23","key":"10188_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.16460\/j.issn1008-9969.2019.23.006","volume":"26","author":"ZH Na","year":"2019","unstructured":"Na ZH, Jin-xia SO, Hong-qiao WA, Jing ZH, Yong-long JI, Yuan-yuan WA, Hui-hui SU (2019) Changes of symptom clusters among nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy: a longitudinal study. J Nurs 26(23):6\u201310. https:\/\/doi.org\/10.16460\/j.issn1008-9969.2019.23.006","journal-title":"J Nurs"},{"key":"10188_CR41","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1016\/j.jpainsymman.2018.01.008","volume":"55","author":"KL Kwekkeboom","year":"2018","unstructured":"Kwekkeboom KL, Tostrud L, Costanzo E, Coe CL, Serlin RC, Ward SE, Zhang Y (2018) The role of inflammation in the pain, fatigue, and sleep disturbance symptom cluster in advanced cancer. J Pain Symptom Manage 55:1286\u20131295. https:\/\/doi.org\/10.1016\/j.jpainsymman.2018.01.008","journal-title":"J Pain Symptom Manage"},{"key":"10188_CR42","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.mehy.2015.01.002","volume":"84","author":"K Tobias","year":"2015","unstructured":"Tobias K, Rosenfeld B, Pessin H, Breitbart W (2015) Measuring sickness behavior in the context of pancreatic cancer. Med Hypotheses 84:231\u2013237. https:\/\/doi.org\/10.1016\/j.mehy.2015.01.002","journal-title":"Med Hypotheses"},{"key":"10188_CR43","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1200\/jco.2007.10.7805","volume":"26","author":"AH Miller","year":"2008","unstructured":"Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR (2008) Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol 26:971\u2013982. https:\/\/doi.org\/10.1200\/jco.2007.10.7805","journal-title":"J Clin Oncol"},{"key":"10188_CR44","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nrc2507","volume":"8","author":"B Seruga","year":"2008","unstructured":"Seruga B, Zhang H, Bernstein LJ, Tannock IF (2008) Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer 8:887\u2013899. https:\/\/doi.org\/10.1038\/nrc2507","journal-title":"Nat Rev Cancer"},{"key":"10188_CR45","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/SPC.0b013e32835dabe3","volume":"7","author":"LJ Wood","year":"2013","unstructured":"Wood LJ, Weymann K (2013) Inflammation and neural signaling: etiologic mechanisms of the cancer treatment-related symptom cluster. Curr Opin Support Palliat Care 7:54\u201359. https:\/\/doi.org\/10.1097\/SPC.0b013e32835dabe3","journal-title":"Curr Opin Support Palliat Care"},{"key":"10188_CR46","doi-asserted-by":"publisher","first-page":"E24","DOI":"10.1097\/ncc.0000000000000625","volume":"42","author":"X Zhang","year":"2019","unstructured":"Zhang X, Wang Q, Zhang X, Wu X, Wang Q, Hong J (2019) A cognitive-behavioral intervention for the symptom clusters of Chinese patients with gastrointestinal tract cancer undergoing chemotherapy: a pilot study. Cancer Nurs 42:E24-e31. https:\/\/doi.org\/10.1097\/ncc.0000000000000625","journal-title":"Cancer Nurs"},{"key":"10188_CR47","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jpainsymman.2016.08.005","volume":"53","author":"RR Reich","year":"2017","unstructured":"Reich RR, Lengacher CA, Alinat CB, Kip KE, Paterson C, Ramesar S, Han HS, Ismail-Khan R, Johnson-Mallard V, Moscoso M, Budhrani-Shani P, Shivers S, Cox CE, Goodman M, Park J (2017) Mindfulness-based stress reduction in post-treatment breast cancer patients: immediate and sustained effects across multiple symptom clusters. J Pain Symptom Manage 53:85\u201395. https:\/\/doi.org\/10.1016\/j.jpainsymman.2016.08.005","journal-title":"J Pain Symptom Manage"},{"key":"10188_CR48","unstructured":"Deng W (2015) The study of symptom clusters and their factors among head and neck cancer patients during the treatment. Dissertation, Chongqing Medical University."},{"key":"10188_CR49","doi-asserted-by":"publisher","first-page":"102318","DOI":"10.1016\/j.ejon.2023.102318","volume":"64","author":"L Wei","year":"2023","unstructured":"Wei L, Lv F, Luo C, Fang Y (2023) Study on sentinel symptoms and influencing factors of postoperative chemotherapy in patients with gastric cancer. Eur J Oncol Nurs 64:102318. https:\/\/doi.org\/10.1016\/j.ejon.2023.102318","journal-title":"Eur J Oncol Nurs"},{"key":"10188_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100278","volume":"26","author":"K Gupta","year":"2021","unstructured":"Gupta K, Walton R, Kataria SP (2021) Chemotherapy-induced nausea and vomiting: pathogenesis, recommendations, and new trends. Cancer Treat Res Commun 26:100278. https:\/\/doi.org\/10.1016\/j.ctarc.2020.100278","journal-title":"Cancer Treat Res Commun"},{"key":"10188_CR51","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cein.2004.05.001","volume":"8","author":"JP Richmond","year":"2004","unstructured":"Richmond JP, Wright ME (2004) Review of the literature on constipation to enable development of a constipation risk assessment scale. Clin Eff Nurs 8:11\u201325. https:\/\/doi.org\/10.1016\/j.cein.2004.05.001","journal-title":"Clin Eff Nurs"},{"key":"10188_CR52","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjab011","author":"D Gaillard","year":"2021","unstructured":"Gaillard D, Barlow LA (2021) A mechanistic overview of taste bud maintenance and impairment in cancer therapies. Chem Senses. https:\/\/doi.org\/10.1093\/chemse\/bjab011","journal-title":"Chem Senses"},{"key":"10188_CR53","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s005200100279","volume":"9","author":"TB Comeau","year":"2001","unstructured":"Comeau TB, Epstein JB, Migas C (2001) Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer 9:575\u2013580. https:\/\/doi.org\/10.1007\/s005200100279","journal-title":"Support Care Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10188-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-10188-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10188-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:31:45Z","timestamp":1765949505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-10188-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10188"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-10188-3","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"type":"print","value":"0941-4355"},{"type":"electronic","value":"1433-7339"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"22 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Shandong Provincial Hospital Affiliated to Shandong First Medical University (SWYX: NO.2024\u20131013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All the authors approved the final paper for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1109"}}