{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:10:48Z","timestamp":1769037048471,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior , Brasil","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305654\/2023-3"],"award-info":[{"award-number":["305654\/2023-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00520-025-10246-w","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:26:32Z","timestamp":1765452392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ozone therapy as an adjunctive strategy for MRONJ in oncology patients: A systematic review and meta-analysis"],"prefix":"10.1007","volume":"34","author":[{"given":"Mailon Cury","family":"Carneiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia Fran\u00e7a","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Carvalho","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Lopes","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo S\u00e9rgio","family":"da Silva Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"10246_CR1","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/s0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61:1115\u20131117. https:\/\/doi.org\/10.1016\/s0278-2391(03)00720-1","journal-title":"J Oral Maxillofac Surg"},{"key":"10246_CR2","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","volume":"80","author":"SL Ruggiero","year":"2022","unstructured":"Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D (2022) American Association of Oral and Maxillofacial Surgeons\u2019 position paper on medication-related osteonecrosis of the jaws\u20142022 update. J Oral Maxillofac Surg 80:920\u2013943. https:\/\/doi.org\/10.1016\/j.joms.2022.02.008","journal-title":"J Oral Maxillofac Surg"},{"key":"10246_CR3","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1200\/JCO.19.01186","volume":"37","author":"N Yarom","year":"2019","unstructured":"Yarom N, Shapiro CL, Peterson DE, Van Poznak CH, Bohlke K, Ruggiero SL et al (2019) Medication-related osteonecrosis of the jaw: MASCC\/ISOO\/ASCO clinical practice guideline. J Clin Oncol 37:2270\u20132290. https:\/\/doi.org\/10.1200\/JCO.19.01186","journal-title":"J Clin Oncol"},{"key":"10246_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012432.pub3","author":"NH Beth-Tasdogan","year":"2022","unstructured":"Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O, Peter JU (2022) Interventions for managing medication-related osteonecrosis of the jaw. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD012432.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"10246_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13687","author":"Q Wen","year":"2021","unstructured":"Wen Q, Liu D, Wang X, Zhang Y, Fang S, Qiu X et al (2021) A systematic review of ozone therapy for treating chronically refractory wounds and ulcers. Int Wound J. https:\/\/doi.org\/10.1111\/iwj.13687","journal-title":"Int Wound J"},{"key":"10246_CR6","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.arcmed.2005.08.006","volume":"37","author":"VA Bocci","year":"2006","unstructured":"Bocci VA (2006) Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 37:425\u2013435. https:\/\/doi.org\/10.1016\/j.arcmed.2005.08.006","journal-title":"Arch Med Res"},{"key":"10246_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/08977194.2019.1643339","volume":"37","author":"CD Soares","year":"2019","unstructured":"Soares CD, Morais TML, Ara\u00fajo RMFG, Meyer PF, Oliveira EAF, Silva RMV et al (2019) Effects of subcutaneous injection of ozone during wound healing in rats. Growth Factors 37:95\u2013103. https:\/\/doi.org\/10.1080\/08977194.2019.1643339","journal-title":"Growth Factors"},{"key":"10246_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/273475","volume":"2014","author":"J Zhang","year":"2014","unstructured":"Zhang J, Guan M, Xie C, Luo X, Zhang Q, Xue Y (2014) Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. Oxid Med Cell Longev 2014:273475. https:\/\/doi.org\/10.1155\/2014\/273475","journal-title":"Oxid Med Cell Longev"},{"key":"10246_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1177\/1091581809360069","volume":"29","author":"V Travagli","year":"2010","unstructured":"Travagli V, Zanardi I, Bernini P, Nepi S, Tenori L, Bocci V (2010) Effects of ozone blood treatment on the metabolite profile of human blood. Int J Toxicol 29:165\u2013174. https:\/\/doi.org\/10.1177\/1091581809360069","journal-title":"Int J Toxicol"},{"key":"10246_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/0962935062000197083","volume":"13","author":"V Bocci","year":"2004","unstructured":"Bocci V (2004) Ozone as janus: this controversial gas can be either toxic or medically useful. Mediators Inflamm 13:3\u201311. https:\/\/doi.org\/10.1080\/0962935062000197083","journal-title":"Mediators Inflamm"},{"key":"10246_CR11","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1111\/jop.12151","volume":"43","author":"J Bagan","year":"2014","unstructured":"Bagan J, S\u00e1ez GT, Tormos MC, Gavalda-Esteve C, Bagan L, Leopoldo-Rodado M et al (2014) Oxidative stress in bisphosphonate-related osteonecrosis of the jaws. J Oral Pathol Med 43:371\u2013377. https:\/\/doi.org\/10.1111\/jop.12151","journal-title":"J Oral Pathol Med"},{"key":"10246_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1590\/1413-785220182601179926","volume":"26","author":"A Bilge","year":"2018","unstructured":"Bilge A, \u00d6zt\u00fcrk \u00d6, Adali Y, \u00dcstebay S, Bilge A, \u00d6zt\u00fcrk \u00d6 et al (2018) Could ozone treatment be a promising alternative for osteomyelitis? An experimental study. Acta Ortop Bras 26:67\u201371. https:\/\/doi.org\/10.1590\/1413-785220182601179926","journal-title":"Acta Ortop Bras"},{"key":"10246_CR13","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.jss.2011.06.029","volume":"171","author":"E Oguz","year":"2011","unstructured":"Oguz E, Ekinci S, Eroglu M, Bilgic S, Koca K, Durusu M et al (2011) Evaluation and comparison of the effects of hyperbaric oxygen and ozonized oxygen as adjuvant treatments in an experimental osteomyelitis model. J Surg Res 171:e61\u2013e68. https:\/\/doi.org\/10.1016\/j.jss.2011.06.029","journal-title":"J Surg Res"},{"key":"10246_CR14","doi-asserted-by":"publisher","first-page":"030006052199953","DOI":"10.1177\/0300060521999530","volume":"49","author":"T Yasheng","year":"2021","unstructured":"Yasheng T, Mijiti A, Yushan M, Liu Z, Liu Y, Yusufu A (2021) Ozonated water lavage and physiological saline irrigation combined with vacuum-sealed drainage in the treatment of 18 cases of chronic osteomyelitis. J Int Med Res 49:0300060521999530. https:\/\/doi.org\/10.1177\/0300060521999530","journal-title":"J Int Med Res"},{"key":"10246_CR15","doi-asserted-by":"crossref","unstructured":"Koo TK, Li MY (2016) A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research. J Chiropr Med 15:155\u2013163. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4913118\/","DOI":"10.1016\/j.jcm.2016.02.012"},{"key":"10246_CR16","doi-asserted-by":"publisher","unstructured":"Moola S, Munn Z, Tufunaru C, Aromataris E, Sears K, Sfetc R, et al (2024) Systematic reviews of Aetiology and risk. JBI eBooks. https:\/\/doi.org\/10.46658\/JBIMES-24-06","DOI":"10.46658\/JBIMES-24-06"},{"key":"10246_CR17","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/joor.12785","volume":"46","author":"H Polmann","year":"2019","unstructured":"Polmann H, Domingos FL, Melo G, Stuginski-Barbosa J, da Guerra ENS, Porporatti AL et al (2019) Association between sleep bruxism and anxiety symptoms in adults: A systematic review. J Oral Rehabil 46:482\u2013491. https:\/\/doi.org\/10.1111\/joor.12785","journal-title":"J Oral Rehabil"},{"key":"10246_CR18","first-page":"1741","volume":"16","author":"A Agrillo","year":"2012","unstructured":"Agrillo A, Filiaci F, Ramieri V, Riccardi E, Quarato D, Rinna C et al (2012) Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy. Eur Rev Med Pharmacol Sci 16:1741\u20131747","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10246_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185307","volume":"11","author":"O Di Fede","year":"2022","unstructured":"Di Fede O, Del Gaizo C, Panzarella V, La Mantia G, Tozzo P, Di Grigoli A et al (2022) Ozone infiltration for osteonecrosis of the jaw therapy: a case series. J Clin Med 11:5307","journal-title":"J Clin Med"},{"key":"10246_CR20","doi-asserted-by":"publisher","first-page":"9094","DOI":"10.26355\/eurrev_202009_22855","volume":"24","author":"F Goker","year":"2020","unstructured":"Goker F, Donati G, Grecchi F, Sparaco A, Ghezzi M, Rania V et al (2020) Treatment of BRONJ with ozone\/oxygen therapy and debridement with piezoelectric surgery. Eur Rev Med Pharmacol Sci 24:9094\u20139103. https:\/\/doi.org\/10.26355\/eurrev_202009_22855","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10246_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jbo.2012.08.001","volume":"1","author":"CI Ripamonti","year":"2012","unstructured":"Ripamonti CI, Maniezzo M, Boldini S, Pessi MA, Mariani L, Cislaghi E (2012) Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates\u2014preliminary data. J Bone Oncol 1:81\u201387","journal-title":"J Bone Oncol"},{"key":"10246_CR22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.oraloncology.2011.01.002","volume":"47","author":"CI Ripamonti","year":"2011","unstructured":"Ripamonti CI, Cislaghi E, Mariani L, Maniezzo M (2011) Efficacy and safety of medical ozone (O3) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: preliminary results of a phase I-II study. Oral Oncol 47:185\u2013190","journal-title":"Oral Oncol"},{"key":"10246_CR23","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s10006-024-01246-x","volume":"28","author":"F Goker","year":"2024","unstructured":"Goker F, Donati G, Gallo F, Sparaco A, Rania V, Busa A et al (2024) Ozone infiltration as an adjunctive treatment to piezoelectric surgery in the management of medication-related osteonecrosis of the jaws: case series of 29 patients. Oral Maxillofac Surg 28:1197\u20131207. https:\/\/doi.org\/10.1007\/s10006-024-01246-x","journal-title":"Oral Maxillofac Surg"},{"key":"10246_CR24","doi-asserted-by":"crossref","unstructured":"Pereira-Silva M, Hadad H, de Jesus LK, de Freitas Santana Oliveira ME, de Almeida JM, N\u00edmia HH, et al (2024) Ozone therapy effect in medication-related osteonecrosis of the jaw as prevention or treatment: microtomographic, confocal laser microscopy and histomorphometric analysis. Clin Oral Investig 28:151. https:\/\/pubmed.ncbi.nlm.nih.gov\/38360985\/","DOI":"10.1007\/s00784-024-05547-z"},{"key":"10246_CR25","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.1007\/s00784-021-03951-3","volume":"25","author":"CGJ Monteiro","year":"2021","unstructured":"Monteiro CGJ, Vieira EM, Emerick C, Azevedo RS, Pascoal VA, Homsi N et al (2021) Ozonated oil effect for prevention of medication-related osteonecrosis of the jaw (MRONJ) in rats undergoing zoledronic acid therapy. Clin Oral Investig 25:6653\u20136659","journal-title":"Clin Oral Investig"},{"key":"10246_CR26","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.oraloncology.2014.08.016","volume":"50","author":"K Rupel","year":"2014","unstructured":"Rupel K, Ottaviani G, Gobbo M, Contardo L, Tirelli G, Vescovi P et al (2014) A systematic review of therapeutical approaches in bisphosphonates-related osteonecrosis of the jaw (BRONJ). Oral Oncol 50:1049\u20131057","journal-title":"Oral Oncol"},{"key":"10246_CR27","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1089\/photob.2022.0084","volume":"40","author":"P Razavi","year":"2022","unstructured":"Razavi P, Jafari A, Vescovi P, Fekrazad R (2022) Efficacy of adjunctive photobiomodulation in the management of medication-related osteonecrosis of the jaw: a systematic review. Photobiomodul Photomed Laser Surg 40:777\u2013791. https:\/\/doi.org\/10.1089\/photob.2022.0084","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"10246_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59050972","volume":"59","author":"A Scribante","year":"2023","unstructured":"Scribante A, Ghizzoni M, Pellegrini M, Pulicari F, Spadari F (2023) Laser devices and autologous platelet concentrates in prevention and treatment of medication-related osteonecrosis of the jaws: a systematic review. Medicina (Kaunas) 59:972","journal-title":"Medicina (Kaunas)"},{"key":"10246_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08388-4","author":"A Abdolrahmani","year":"2024","unstructured":"Abdolrahmani A, Epstein JB, Samim F (2024) Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management. Support Care Cancer. https:\/\/doi.org\/10.1007\/s00520-024-08388-4","journal-title":"Support Care Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10246-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-10246-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10246-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:47:37Z","timestamp":1768985257000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-10246-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,11]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10246"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-10246-w","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,11]]},"assertion":[{"value":"26 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval and informed consent were waived for this study, as it constituted a systematic review and meta-analysis of previously published, publicly available data and did not involve human participants directly.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"25"}}