{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:10:44Z","timestamp":1769037044106,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Clinical Research Project of Zhongshan Hospital","award":["ZSLCYJ202367"],"award-info":[{"award-number":["ZSLCYJ202367"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00520-025-10275-5","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:17:13Z","timestamp":1766089033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom network in patients with colorectal cancer during the perioperative period"],"prefix":"10.1007","volume":"34","author":[{"given":"Mingming","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiujun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"issue":"3","key":"10275_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10275_CR2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","volume":"72","author":"E Morgan","year":"2023","unstructured":"Morgan E, Arnold M, Gini A et al (2023) Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 72(2):338\u2013344. https:\/\/doi.org\/10.1136\/gutjnl-2022-327736","journal-title":"Gut"},{"issue":"4","key":"10275_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/ans.0000000000000423","volume":"45","author":"CS Harris","year":"2022","unstructured":"Harris CS, Dodd M, Kober KM et al (2022) Advances in conceptual and methodological issues in symptom cluster research: a 20-year perspective. ANS Adv Nurs Sci 45(4):309\u2013322. https:\/\/doi.org\/10.1097\/ans.0000000000000423","journal-title":"ANS Adv Nurs Sci"},{"issue":"1","key":"10275_CR4","doi-asserted-by":"publisher","first-page":"32079","DOI":"10.1038\/s41598-024-83755-z","volume":"14","author":"C You","year":"2024","unstructured":"You C, Xie G, Lin S et al (2024) Temporal relationship between symptom cluster and quality of life in rectal cancer patients after laparoscopic anus-preserving surgery. Sci Rep 14(1):32079. https:\/\/doi.org\/10.1038\/s41598-024-83755-z","journal-title":"Sci Rep"},{"issue":"1","key":"10275_CR5","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/cam4.4904","volume":"12","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Sun Y, Kuang Y et al (2023) Contemporaneous symptom networks of multidimensional symptom experiences in cancer survivors: a network analysis. Cancer Med 12(1):663\u2013673. https:\/\/doi.org\/10.1002\/cam4.4904","journal-title":"Cancer Med"},{"issue":"3","key":"10275_CR6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/cac2.12639","volume":"45","author":"F Wang","year":"2025","unstructured":"Wang F, Chen G, Zhang Z et al (2025) The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update. Cancer Commun (Lond) 45(3):332\u2013379. https:\/\/doi.org\/10.1002\/cac2.12639","journal-title":"Cancer Commun (Lond)"},{"key":"10275_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-025-01773-w","author":"G Lv","year":"2025","unstructured":"Lv G, Qin R, Zhao X et al (2025) Network structure and temporal stability of symptoms during perioperative period among gastrointestinal cancer patients. J Cancer Surviv. https:\/\/doi.org\/10.1007\/s11764-025-01773-w","journal-title":"J Cancer Surviv"},{"issue":"6","key":"10275_CR8","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.chest.2024.12.013","volume":"167","author":"C Gauld","year":"2025","unstructured":"Gauld C, Grasman R, Bailly S (2025) Usefulness of cross-lagged panel models for clinical research. Chest 167(6):1537\u20131540. https:\/\/doi.org\/10.1016\/j.chest.2024.12.013","journal-title":"Chest"},{"issue":"1","key":"10275_CR9","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1186\/s12885-018-4923-3","volume":"18","author":"C O'Gorman","year":"2018","unstructured":"O\u2019Gorman C, Stack J, O\u2019Ceilleachair A et al (2018) Colorectal cancer survivors: an investigation of symptom burden and influencing factors. BMC Cancer 18(1):1022. https:\/\/doi.org\/10.1186\/s12885-018-4923-3","journal-title":"BMC Cancer"},{"issue":"11","key":"10275_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7330","volume":"13","author":"L Song","year":"2024","unstructured":"Song L, Su Z, He Y et al (2024) Association between anxiety, depression, and symptom burden in patients with advanced colorectal cancer: a multicenter cross-sectional study. Cancer Med 13(11):e7330. https:\/\/doi.org\/10.1002\/cam4.7330","journal-title":"Cancer Med"},{"issue":"2","key":"10275_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/nhs.70122","volume":"27","author":"J Shi","year":"2025","unstructured":"Shi J, Luo J, Liu Y et al (2025) Symptom clusters and sentinel symptoms in patients with colorectal cancer: a network analysis. Nurs Health Sci 27(2):e70122. https:\/\/doi.org\/10.1111\/nhs.70122","journal-title":"Nurs Health Sci"},{"issue":"1","key":"10275_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-08288-z","volume":"32","author":"B Shang","year":"2023","unstructured":"Shang B, Bian Z, Luo C et al (2023) Exploring the dynamics of perioperative symptom networks in colorectal cancer patients: a cross-lagged panel network analysis. Support Care Cancer 32(1):62. https:\/\/doi.org\/10.1007\/s00520-023-08288-z","journal-title":"Support Care Cancer"},{"key":"10275_CR13","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jad.2025.02.071","volume":"377","author":"P Zhang","year":"2025","unstructured":"Zhang P, Sun C, Zhu Z et al (2025) Depressive symptoms changes in the new-onset stroke patients: a cross-lagged panel network analysis. J Affect Disord 377:198\u2013205. https:\/\/doi.org\/10.1016\/j.jad.2025.02.071","journal-title":"J Affect Disord"},{"key":"10275_CR14","doi-asserted-by":"crossref","unstructured":"Cleeland CS, Mendoza TR, Wang XS et al (2000) Assessing symptom distress in cancer patients: the M.D. Anderson Symptom Inventory. Cancer 89(7):1634\u20131646. https:\/\/doi.org\/10.1002\/1097-0142(20001001)89:7<1634::aid-cncr29>3.0.co;2-v","DOI":"10.1002\/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V"},{"key":"10275_CR15","doi-asserted-by":"publisher","unstructured":"He X, Chen J, Zhang L et al (2024) Identifying the factors affecting financial toxicity status in patients with middle and advanced colorectal cancer: a cross-sectional study. Front Public Health 121421314. https:\/\/doi.org\/10.3389\/fpubh.2024.1421314","DOI":"10.3389\/fpubh.2024.1421314"},{"issue":"6","key":"10275_CR16","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s00520-025-09600-9","volume":"33","author":"J Zhang","year":"2025","unstructured":"Zhang J, He Q, Wang M et al (2025) Core symptoms in patients with colorectal cancer receiving chemotherapy: a network analysis. Support Care Cancer 33(6):532. https:\/\/doi.org\/10.1007\/s00520-025-09600-9","journal-title":"Support Care Cancer"},{"key":"10275_CR17","unstructured":"Gu M (2019) Development and application of the Colorectal Cancer Module based on M D Anderson Symptom Inventory, Shanghai University of Traditional Chinese Medicine"},{"issue":"5","key":"10275_CR18","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jpainsymman.2007.11.011","volume":"36","author":"HJ Kim","year":"2008","unstructured":"Kim HJ, Barsevick AM, Tulman L et al (2008) Treatment-related symptom clusters in breast cancer: a secondary analysis. J Pain Symptom Manage 36(5):468\u2013479. https:\/\/doi.org\/10.1016\/j.jpainsymman.2007.11.011","journal-title":"J Pain Symptom Manage"},{"key":"10275_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.120082","volume":"392","author":"MY Chen","year":"2026","unstructured":"Chen MY, Sun HL, Zhang Q et al (2026) Depression in older adults: longitudinal study findings from a national survey in China. J Affect Disord 392:120082. https:\/\/doi.org\/10.1016\/j.jad.2025.120082","journal-title":"J Affect Disord"},{"issue":"5","key":"10275_CR20","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1192\/bjp.2023.8","volume":"222","author":"AF Martin","year":"2023","unstructured":"Martin AF, Maughan B, Konac D et al (2023) Mother and father depression symptoms and child emotional difficulties: a network model. Br J Psychiatry 222(5):204\u2013211. https:\/\/doi.org\/10.1192\/bjp.2023.8","journal-title":"Br J Psychiatry"},{"issue":"1","key":"10275_CR21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12875-021-01452-6","volume":"22","author":"K Holtedahl","year":"2021","unstructured":"Holtedahl K, Borgquist L, Donker GA et al (2021) Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort study of diagnostic accuracy in primary care. BMC Fam Pract 22(1):148. https:\/\/doi.org\/10.1186\/s12875-021-01452-6","journal-title":"BMC Fam Pract"},{"key":"10275_CR22","doi-asserted-by":"publisher","unstructured":"Zhao CY, Shi WH, Wen ZQ et al (2024) An Evidence-Based Medical Review on Promoting Gastrointestinal Function Recovery After Colorectal Cancer Surgery. J Multidiscip Healthc 171343\u20131362. https:\/\/doi.org\/10.2147\/jmdh.S449891","DOI":"10.2147\/jmdh.S449891"},{"issue":"6","key":"10275_CR23","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1007\/s11136-025-03946-7","volume":"34","author":"W Qi","year":"2025","unstructured":"Qi W, Zhou R, Qiu Q et al (2025) Relationship between core symptoms, function, and quality of life in colorectal cancer patients: a network analysis. Qual Life Res 34(6):1723\u20131734. https:\/\/doi.org\/10.1007\/s11136-025-03946-7","journal-title":"Qual Life Res"},{"issue":"7","key":"10275_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304121","volume":"19","author":"N Gao","year":"2024","unstructured":"Gao N, Yu Z, Fan Y et al (2024) Impact of negative emotions on upper gastrointestinal diseases: a Mendel randomization study. PLoS ONE 19(7):e0304121. https:\/\/doi.org\/10.1371\/journal.pone.0304121","journal-title":"PLoS ONE"},{"issue":"2","key":"10275_CR25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/jop.13512","volume":"53","author":"D Paudel","year":"2024","unstructured":"Paudel D, Uehara O, Giri S et al (2024) Transcriptomic analysis of the submandibular gland under psychological stress condition. J Oral Pathol Med 53(2):150\u2013158. https:\/\/doi.org\/10.1111\/jop.13512","journal-title":"J Oral Pathol Med"},{"issue":"3","key":"10275_CR26","doi-asserted-by":"publisher","first-page":"100087","DOI":"10.1016\/j.soi.2024.100087","volume":"1","author":"L Judy","year":"2024","unstructured":"Judy L, Nazanin K, Elad S et al (2024) Anxiety and depression are common in surgical oncology patients: results of a prospective cohort study. Surgical Oncol Insight 1(3):100087\u2013100087. https:\/\/doi.org\/10.1016\/j.soi.2024.100087","journal-title":"Surgical Oncol Insight"},{"issue":"10","key":"10275_CR27","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1002\/ueg2.12658","volume":"12","author":"AHC Gielen","year":"2024","unstructured":"Gielen AHC (2024) Guideline for the assessment and management of gastrointestinal symptoms following colorectal surgery-A UEG\/ESCP\/EAES\/ESPCG\/ESPEN\/ESNM\/ESSO collaboration. Part I-sequelae to oncological diseases. United Eur Gastroenterol J 12(10):1489\u20131506. https:\/\/doi.org\/10.1002\/ueg2.12658","journal-title":"United Eur Gastroenterol J"},{"issue":"1","key":"10275_CR28","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1186\/s12876-021-02035-6","volume":"21","author":"Y Liu","year":"2021","unstructured":"Liu Y, He W, Yang J et al (2021) The effects of preoperative intestinal dysbacteriosis on postoperative recovery in colorectal cancer surgery: a prospective cohort study. BMC Gastroenterol 21(1):446. https:\/\/doi.org\/10.1186\/s12876-021-02035-6","journal-title":"BMC Gastroenterol"},{"issue":"10","key":"10275_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-024-08903-7","volume":"32","author":"D Fernandes","year":"2024","unstructured":"Fernandes D, Nelson D, Ortega M et al (2024) Non-gastrointestinal symptom burden following colorectal cancer treatment-a systematic review. Support Care Cancer 32(10):699. https:\/\/doi.org\/10.1007\/s00520-024-08903-7","journal-title":"Support Care Cancer"},{"issue":"1","key":"10275_CR30","doi-asserted-by":"publisher","first-page":"E55","DOI":"10.1097\/ncc.0000000000001280","volume":"48","author":"K Wang","year":"2025","unstructured":"Wang K, Diao M, Yang Z et al (2025) Identification of core symptom cluster in patients with digestive cancer: a network analysis. Cancer Nurs 48(1):E55-e63. https:\/\/doi.org\/10.1097\/ncc.0000000000001280","journal-title":"Cancer Nurs"},{"issue":"5","key":"10275_CR31","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s44220-025-00415-5","volume":"3","author":"PZ Grimes","year":"2025","unstructured":"Grimes PZ, Murray AL, Smith K et al (2025) Network temperature as a metric of stability in depression symptoms across adolescence. Nat Ment Health 3(5):548\u2013557. https:\/\/doi.org\/10.1038\/s44220-025-00415-5","journal-title":"Nat Ment Health"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10275-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-025-10275-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-025-10275-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:47:14Z","timestamp":1768985234000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-025-10275-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10275"],"URL":"https:\/\/doi.org\/10.1007\/s00520-025-10275-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"20 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has been approved by the Zhongshan Hospital Ethics Committee (B2024-102R) and written informed consent has been obtained from the participants. All procedures were performed in accordance with the Declaration of Helsinki and the Ethical Guidelines for Clinical Research Involving Human Subjects in China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}