{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T21:01:34Z","timestamp":1771275694332,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["5M-2021-23683816"],"award-info":[{"award-number":["5M-2021-23683816"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00520-026-10374-x","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T02:13:11Z","timestamp":1769566391000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The functional recovery trajectory in patients undergoing lower limb salvage surgery for bone tumour: an observational study"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-9927","authenticated-orcid":false,"given":"Mattia","family":"Morri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alida","family":"Abbruzzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Meneghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora","family":"Raffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-6617","authenticated-orcid":false,"given":"Lisa","family":"Berti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-0576","authenticated-orcid":false,"given":"Davide","family":"Donati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"10374_CR1","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.clon.2017.04.001","volume":"29","author":"C Gerrand","year":"2017","unstructured":"Gerrand C, Furtado S (2017) Issues of survivorship and rehabilitation in soft tissue sarcoma. Clin Oncol (R Coll Radiol) 29:538\u2013545. https:\/\/doi.org\/10.1016\/j.clon.2017.04.001","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10374_CR2","first-page":"706","volume":"90","author":"A Asavamongkolkul","year":"2007","unstructured":"Asavamongkolkul A, Waikakul S, Phimolsarnti R et al (2007) Endoprosthetic reconstruction for malignant bone and soft-tissue tumors. J Med Assoc Thai 90:706\u2013717","journal-title":"J Med Assoc Thai"},{"key":"10374_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2023.101944","volume":"48","author":"ML Johansen","year":"2023","unstructured":"Johansen ML, Eriksrud O, Thorkildsen J et al (2023) Muscle strength characteristics following megaprosthetic knee reconstruction for bone sarcoma. Surg Oncol 48:101944. https:\/\/doi.org\/10.1016\/j.suronc.2023.101944","journal-title":"Surg Oncol"},{"key":"10374_CR4","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1007\/s00402-012-1542-3","volume":"132","author":"I Qadir","year":"2012","unstructured":"Qadir I, Umer M, Baloch N (2012) Functional outcome of limb salvage surgery with mega-endoprosthetic reconstruction for bone tumors. Arch Orthop Trauma Surg 132:1227\u20131232. https:\/\/doi.org\/10.1007\/s00402-012-1542-3","journal-title":"Arch Orthop Trauma Surg"},{"key":"10374_CR5","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1302\/0301-620X.102B6.BJJ-2020-0004","volume":"102-B","author":"S Gupta","year":"2020","unstructured":"Gupta S, Griffin AM, Gundle K et al (2020) Long-term outcome of iliosacral resection without reconstruction for primary bone tumours. Bone Jt J 102-B:779\u2013787. https:\/\/doi.org\/10.1302\/0301-620X.102B6.BJJ-2020-0004","journal-title":"Bone Jt J"},{"key":"10374_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05282-x","volume":"19","author":"Y Luo","year":"2024","unstructured":"Luo Y, Sheng H, Zhou Y et al (2024) Clinical efficacy on the reconstruction of bone defects using modular hemipelvic prosthesis in patients with pelvic tumors. J Orthop Surg Res 19:812. https:\/\/doi.org\/10.1186\/s13018-024-05282-x","journal-title":"J Orthop Surg Res"},{"key":"10374_CR7","doi-asserted-by":"publisher","first-page":"4531","DOI":"10.1080\/09638288.2021.1900409","volume":"44","author":"NM AlDossary","year":"2022","unstructured":"AlDossary NM, Ostler C, Donovan-Hall M, Metcalf CD (2022) Non-oncological outcomes following limb salvage surgery in patients with knee sarcoma: a scoping review. Disabil Rehabil 44:4531\u20134545. https:\/\/doi.org\/10.1080\/09638288.2021.1900409","journal-title":"Disabil Rehabil"},{"key":"10374_CR8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/09638288.2018.1520929","volume":"42","author":"GM Hobusch","year":"2020","unstructured":"Hobusch GM, Cernakova M, Puchner SE et al (2020) Sports activity after soft tissue sarcoma of the lower extremity. Disabil Rehabil 42:14\u201319. https:\/\/doi.org\/10.1080\/09638288.2018.1520929","journal-title":"Disabil Rehabil"},{"key":"10374_CR9","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1080\/09638288.2022.2101696","volume":"45","author":"L Fernandes","year":"2023","unstructured":"Fernandes L, Villadsen A, Holm CE et al (2023) Work ability and physical activity after major bone sarcoma resection and reconstruction with tumour prosthesis of the lower extremities. A cross-sectional study. Disabil Rehabil 45:2597\u20132603. https:\/\/doi.org\/10.1080\/09638288.2022.2101696","journal-title":"Disabil Rehabil"},{"key":"10374_CR10","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.ejso.2014.03.015","volume":"40","author":"TNK Kwong","year":"2014","unstructured":"Kwong TNK, Furtado S, Gerrand C (2014) What do we know about survivorship after treatment for extremity sarcoma? A systematic review. Eur J Surg Oncol 40:1109\u20131124. https:\/\/doi.org\/10.1016\/j.ejso.2014.03.015","journal-title":"Eur J Surg Oncol"},{"key":"10374_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/23809000.2016.1203725","volume":"1","author":"J Stevenson","year":"2016","unstructured":"Stevenson J, Tsagkozis P, Grimer R (2016) Functional and quality of life outcomes in bone sarcoma following amputation, rotationplasty or limb-salvage. Expert Rev Qual Life Cancer Care 1:303\u2013312. https:\/\/doi.org\/10.1080\/23809000.2016.1203725","journal-title":"Expert Rev Qual Life Cancer Care"},{"key":"10374_CR12","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/pon.5349","volume":"29","author":"SC Zambrano","year":"2020","unstructured":"Zambrano SC, Koll\u00e1r A, Bernhard J (2020) Experiences of return to work after treatment for extremital soft tissue or bone sarcoma: between distraction and leaving the disease behind. Psychooncology 29:781\u2013787. https:\/\/doi.org\/10.1002\/pon.5349","journal-title":"Psychooncology"},{"key":"10374_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13237023","volume":"13","author":"C Galluccio","year":"2024","unstructured":"Galluccio C, Germanotta M, Valeri S et al (2024) Soft tissue sarcoma with lower limb impairment: development of a specific rehabilitation protocol based on demolitive and reconstructive surgery types. J Clin Med 13:7023. https:\/\/doi.org\/10.3390\/jcm13237023","journal-title":"J Clin Med"},{"key":"10374_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3322\/caac.21639","volume":"71","author":"NL Stout","year":"2021","unstructured":"Stout NL, Santa Mina D, Lyons KD et al (2021) A systematic review of rehabilitation and exercise recommendations in oncology guidelines. CA Cancer J Clin 71:149\u2013175. https:\/\/doi.org\/10.3322\/caac.21639","journal-title":"CA Cancer J Clin"},{"key":"10374_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.17116\/kurort20209703153","volume":"97","author":"TI Grushina","year":"2020","unstructured":"Grushina TI, Teplyakov VV (2020) Physiotherapy in early rehabilitation of patients with bone sarcomas after arthroplasty of large bones and joints. Vopr Kurortol Fizioter Lech Fiz Kult 97:53\u201359. https:\/\/doi.org\/10.17116\/kurort20209703153","journal-title":"Vopr Kurortol Fizioter Lech Fiz Kult"},{"key":"10374_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-019-1271-z","volume":"43","author":"M Morri","year":"2019","unstructured":"Morri M, Vigna D, Raffa D et al (2019) Effect of game based balance exercises on rehabilitation after knee surgery: a controlled observational study. J Med Syst 43:141. https:\/\/doi.org\/10.1007\/s10916-019-1271-z","journal-title":"J Med Syst"},{"key":"10374_CR17","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/978-1-4419-0284-9_20","volume":"152","author":"M Punzalan","year":"2009","unstructured":"Punzalan M, Hyden G (2009) The role of physical therapy and occupational therapy in the rehabilitation of pediatric and adolescent patients with osteosarcoma. Cancer Treat Res 152:367\u2013384. https:\/\/doi.org\/10.1007\/978-1-4419-0284-9_20","journal-title":"Cancer Treat Res"},{"key":"10374_CR18","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1080\/08880018.2024.2353360","volume":"41","author":"F Rossi","year":"2024","unstructured":"Rossi F, Botti S, Morri M et al (2024) The Italian consensus conference on the role of rehabilitation for children and adolescents with leukemia, central nervous system tumors, and bone cancer, part 2: general principles for the rehabilitation treatment of motor function impairments. Pediatr Hematol Oncol 41:346\u2013366. https:\/\/doi.org\/10.1080\/08880018.2024.2353360","journal-title":"Pediatr Hematol Oncol"},{"key":"10374_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-023-06315-y","volume":"24","author":"HW van Kouswijk","year":"2023","unstructured":"van Kouswijk HW, van Keeken HG, Ploegmakers JJW et al (2023) Therapeutic validity and effectiveness of exercise interventions after lower limb-salvage surgery for sarcoma: a systematic review. BMC Musculoskelet Disord 24:216. https:\/\/doi.org\/10.1186\/s12891-023-06315-y","journal-title":"BMC Musculoskelet Disord"},{"key":"10374_CR20","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1002\/jso.23830","volume":"111","author":"K Tobias","year":"2015","unstructured":"Tobias K, Gillis T (2015) Rehabilitation of the sarcoma patient-enhancing the recovery and functioning of patients undergoing management for extremity soft tissue sarcomas. J Surg Oncol 111:615\u2013621. https:\/\/doi.org\/10.1002\/jso.23830","journal-title":"J Surg Oncol"},{"key":"10374_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.hemonc.2013.09.001","volume":"6","author":"A Shehadeh","year":"2013","unstructured":"Shehadeh A, Dahleh ME, Salem A et al (2013) Standardization of rehabilitation after limb salvage surgery for sarcomas improves patients\u2019 outcome. Hematol Oncol Stem Cell Ther 6:105\u2013111. https:\/\/doi.org\/10.1016\/j.hemonc.2013.09.001","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"10374_CR22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1701\/1960.21306","volume":"106","author":"M Lopresti","year":"2015","unstructured":"Lopresti M, Rancati J, Farina E et al (2015) Rehabilitation pathway after knee arthroplasty with mega prosthesis in osteosarcoma. Recenti Prog Med 106:385\u2013392. https:\/\/doi.org\/10.1701\/1960.21306","journal-title":"Recenti Prog Med"},{"key":"10374_CR23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s43465-023-01092-1","volume":"58","author":"L Andreani","year":"2024","unstructured":"Andreani L, Ipponi E, Falcinelli F et al (2024) Proximal femur megaprostheses in orthopedic oncology: evaluation of a standardized post-operative rehabilitation protocol. Indian J Orthop 58:323\u2013329. https:\/\/doi.org\/10.1007\/s43465-023-01092-1","journal-title":"Indian J Orthop"},{"key":"10374_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11222984","volume":"11","author":"L Andreani","year":"2023","unstructured":"Andreani L, Ipponi E, Falcinelli F et al (2023) Distal femur megaprostheses in orthopedic oncology: evaluation of a standardized post-operative rehabilitation protocol. Healthcare 11:2984. https:\/\/doi.org\/10.3390\/healthcare11222984","journal-title":"Healthcare"},{"key":"10374_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17182951","volume":"17","author":"FF Brzeszczy\u0144ski","year":"2025","unstructured":"Brzeszczy\u0144ski FF, Karpi\u0144ski M, Brzeszczy\u0144ski MA et al (2025) Rehabilitation protocols and functional outcomes in oncological patients treated with modular megaprosthesis: a systematic review. Cancers (Basel) 17:2951. https:\/\/doi.org\/10.3390\/cancers17182951","journal-title":"Cancers (Basel)"},{"key":"10374_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12916","volume":"27","author":"M Morri","year":"2018","unstructured":"Morri M, Raffa D, Barbieri M et al (2018) Compliance and satisfaction with intensive physiotherapy treatment during chemotherapy in patients with bone tumours and evaluation of related prognostic factors: an observational study. Eur J Cancer Care (Engl) 27:e12916. https:\/\/doi.org\/10.1111\/ecc.12916","journal-title":"Eur J Cancer Care (Engl)"},{"key":"10374_CR27","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/pri.97","volume":"2","author":"L Brosseau","year":"1997","unstructured":"Brosseau L, Tousignant M, Budd J et al (1997) Intratester and intertester reliability and criterion validity of the parallelogram and universal goniometers for active knee flexion in healthy subjects. Physiother Res Int 2:150\u2013166. https:\/\/doi.org\/10.1002\/pri.97","journal-title":"Physiother Res Int"},{"key":"10374_CR28","doi-asserted-by":"publisher","unstructured":"Compston A (2010) Aids to the investigation of peripheral nerve injuries. Medical research council: nerve injuries research committee. His Majesty\u2019s Stationery Office: 1942; pp. 48 (iii) and 74 figures and 7 diagrams; with aids to the examination of the peripheral nervous system. By Michael O\u2019Brien for the Guarantors of Brain. Saunders Elsevier: 2010; pp. [8] 64 and 94 Figures. Brain 133:2838\u20132844. https:\/\/doi.org\/10.1093\/brain\/awq270","DOI":"10.1093\/brain\/awq270"},{"key":"10374_CR29","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","volume":"39","author":"D Podsiadlo","year":"1991","unstructured":"Podsiadlo D, Richardson S (1991) The timed \u201cup & go\u201d: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 39:142\u2013148. https:\/\/doi.org\/10.1111\/j.1532-5415.1991.tb01616.x","journal-title":"J Am Geriatr Soc"},{"key":"10374_CR30","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/BF00540024","volume":"5","author":"AM Davis","year":"1996","unstructured":"Davis AM, Wright JG, Williams JI et al (1996) Development of a measure of physical function for patients with bone and soft tissue sarcoma. Qual Life Res 5:508\u2013516. https:\/\/doi.org\/10.1007\/BF00540024","journal-title":"Qual Life Res"},{"key":"10374_CR31","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1111\/ans.12895","volume":"85","author":"QD Shao","year":"2015","unstructured":"Shao QD, Yan X, Sun JY, Xu TM (2015) Internal hemipelvectomy with reconstruction for primary pelvic neoplasm: a systematic review. ANZ J Surg 85:553\u2013560. https:\/\/doi.org\/10.1111\/ans.12895","journal-title":"ANZ J Surg"},{"key":"10374_CR32","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.17.00072","volume":"6","author":"RJ Wilson","year":"2018","unstructured":"Wilson RJ, Freeman TH, Halpern JL et al (2018) Surgical outcomes after limb-sparing resection and reconstruction for pelvic sarcoma: a systematic review. JBJS Rev 6:e10. https:\/\/doi.org\/10.2106\/JBJS.RVW.17.00072","journal-title":"JBJS Rev"},{"key":"10374_CR33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.2147\/PROM.S130183","volume":"10","author":"CC Andrews","year":"2019","unstructured":"Andrews CC, Siegel G, Smith S (2019) Rehabilitation to improve the function and quality of life of soft tissue and bony sarcoma patients. Patient Relat Outcome Meas 10:417\u2013425. https:\/\/doi.org\/10.2147\/PROM.S130183","journal-title":"Patient Relat Outcome Meas"},{"key":"10374_CR34","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.3390\/curroncol29100600","volume":"29","author":"AM Gazendam","year":"2022","unstructured":"Gazendam AM, Schneider P, Heels-Ansdell D et al (2022) Predictors of functional recovery among musculoskeletal oncology patients undergoing lower extremity endoprosthetic reconstruction. Curr Oncol 29:7598\u20137606. https:\/\/doi.org\/10.3390\/curroncol29100600","journal-title":"Curr Oncol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10374-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10374-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10374-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:02:56Z","timestamp":1771272176000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10374-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10374"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10374-x","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"15 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the Ethics Committee of the Vast Area of Central Emilia with protocol no. 111\/2024\/Oss\/IOR. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"136"}}