{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:41:25Z","timestamp":1776238885733,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Kocaeli"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Although survival rates in childhood cancer have improved with more effective, risk-adapted multimodal  treatments, oral mucositis remains one of the most common treatment-related oral complications. This study  evaluated the impact of an oral mucositis care protocol on the severity of mucositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective randomized controlled study was conducted with 30 pediatric oncology patients aged 6 to 18\u00a0years. The sample included children with hematologic malignancies (predominantly acute lymphoblastic leukemia) and solid tumors. The data were collected using a descriptive information form, the Children\u2019s International Mucositis Evaluation Scale (ChIMES), and the WHO Oral Mucositis Grading Scale. Standard care was applied to the control group. For the intervention group, an oral care protocol was prepared, and the patients received training. The oral care intervention was applied for 14\u00a0days and monitored by the researcher. The patients were monitored for oral mucositis on Days 0, 3, 7, and 14. Those in the intervention group received a calendar for documenting their oral care practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ChIMES scores showed a significant difference between the groups and were lower in the intervention group (\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20090.010;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). The WHO scale results revealed significant differences between the groups on Day 7 (\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u2009\u22123.106;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and Day 14 (\n                      <jats:italic>Z<\/jats:italic>\n                      \u2009=\u2009\u22122.841;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At the end of the study, the severity of mucositis was lower in the patients who received the oral mucositis care protocol. It is recommended that a standardized oral care protocol specific to children be developed and that education on oral mucositis care be provided to children and their parents from the beginning of hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov (Identifier: NCT06711315; Registration date: 29 November 2024).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10393-8","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:21:49Z","timestamp":1774070509000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of oral mucositis management based on MASCC\/ISOO guidelines in pediatric oncology patients: a randomized controlled trial"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-6949","authenticated-orcid":false,"given":"Z\u00fcbeyde Ezgi","family":"Er\u00e7elik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9074-2646","authenticated-orcid":false,"given":"Birg\u00fcl","family":"Erdo\u011fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-3390","authenticated-orcid":false,"given":"Naime","family":"Altay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"10393_CR1","unstructured":"Pan American Health Organization (2024) International childhood cancer day 2024. https:\/\/www.paho.org\/en\/campaigns\/international-childhood-cancer-day-2024#:~:text=%2D%20February%2015%20%2D,the%20survivors%2C%20and%20their%20families. 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No. 2023-695). All procedures were conducted in accordance with the principles of the Declaration of Helsinki. Written and verbal informed consent was obtained from all participants prior to their inclusion in the study. Participants were informed that they could withdraw from the study at any stage without providing a reason. Clinical Trial Registration number is NCT06711315 (Registration Date: 29.11.2024).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"349"}}