{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:02:14Z","timestamp":1773270134690,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Italian Ministry of Health \u2013 Ricerca Corrente"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00520-026-10476-6","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:11:49Z","timestamp":1772179909000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidisciplinary approach to bone metastases: a single center experience in a tertiary cancer center"],"prefix":"10.1007","volume":"34","author":[{"given":"Chiara","family":"Pittarello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Brunello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelina","family":"Lamberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Zovato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Formaglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Galuppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Krengli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugo","family":"Nena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Ruggieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Pozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Pintacuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Pittaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Aldegheri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Ballestrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Roma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Guarneri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Falci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-9249","authenticated-orcid":false,"given":"Marco","family":"Maruzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"10476_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3618","author":"J Fornetti","year":"2018","unstructured":"Fornetti J, Welm A, Stewart SA (2018) Understanding the bone in cancer metastasis. J Bone Miner Res. https:\/\/doi.org\/10.1002\/jbmr.3618","journal-title":"J Bone Miner Res"},{"key":"10476_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115783","author":"C Ryan","year":"2022","unstructured":"Ryan C, Stoltzfus KC, Horn S et al (2022) Epidemiology of bone metastases. Bone. https:\/\/doi.org\/10.1016\/j.bone.2020.115783","journal-title":"Bone"},{"key":"10476_CR3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2019","author":"P Cl\u00e9zardin","year":"2021","unstructured":"Cl\u00e9zardin P, Coleman R, Puppo M et al (2021) Bone metastasis: mechanisms, therapies, and biomarkers. Physiol Rev. https:\/\/doi.org\/10.1152\/physrev.00012.2019","journal-title":"Physiol Rev"},{"key":"10476_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28050290","author":"S Tsukamoto","year":"2021","unstructured":"Tsukamoto S, Kido A, Tanaka Y et al (2021) Current overview of treatment for metastatic bone disease. Curr Oncol. https:\/\/doi.org\/10.3390\/curroncol28050290","journal-title":"Curr Oncol"},{"key":"10476_CR5","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2017.715","author":"C Pulido","year":"2017","unstructured":"Pulido C, Vendrell I, Ferreira AR et al (2017) Bone metastasis risk factors in breast cancer. Ecancermedicalscience. https:\/\/doi.org\/10.3332\/ecancer.2017.715","journal-title":"Ecancermedicalscience"},{"key":"10476_CR6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.65.7270","author":"S Halabi","year":"2016","unstructured":"Halabi S, Kelly WC, Ma H et al (2016) Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer. J Clin Oncol. https:\/\/doi.org\/10.1200\/jco.2015.65.7270","journal-title":"J Clin Oncol"},{"key":"10476_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99726-7","author":"B Zengel","year":"2021","unstructured":"Zengel B, Kilic M, Tasli F et al (2021) Breast cancer patients with isolated bone metastases and oligometastatic bone disease show different survival outcomes. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-99726-7","journal-title":"Sci Rep"},{"key":"10476_CR8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-06-0931","author":"R Coleman","year":"2006","unstructured":"Coleman R (2006) Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. https:\/\/doi.org\/10.1158\/1078-0432.ccr-06-0931","journal-title":"Clin Cancer Res"},{"key":"10476_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.019","author":"R Coleman","year":"2020","unstructured":"Coleman R, Hadji P, Body JJ et al (2020) Bone health in cancer: ESMO clinical practice guidelines. Ann Oncol. https:\/\/doi.org\/10.1016\/j.annonc.2020.07.019","journal-title":"Ann Oncol"},{"key":"10476_CR10","unstructured":"AIOM (2024), Linee guida Metastasi ossee e salute dell\u2019osso https:\/\/www.aiom.it\/linee-guida-aiom-2024-metastasi-ossee-e-salute-dellosso\/ Accessed 20 Aug 2025"},{"key":"10476_CR11","unstructured":"ASCO (2025) Guidelines Multidisciplinary Approaches to Evaluation and Management of Bone Metastases https:\/\/dailynews.ascopubs.org\/do\/multidisciplinary-approaches-evaluation-and-management-bone-metastases Accessed 20 Aug 2025"},{"key":"10476_CR12","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2013.0215","author":"JR Gralow","year":"2013","unstructured":"Gralow JR, Biermann JS, Farooki A et al (2013) NCCN Task Force Report: bone health in cancer care. J Natl Compr Canc Netw. https:\/\/doi.org\/10.6004\/jnccn.2013.0215","journal-title":"J Natl Compr Canc Netw"},{"issue":"2","key":"10476_CR13","first-page":"121","volume":"10","author":"T Ibrahim","year":"2013","unstructured":"Ibrahim T, Mercatali L, Amadori D (2013) Bone and cancer: the osteoncology. Clin Cases Miner Bone Metab 10(2):121\u2013123","journal-title":"Clin Cases Miner Bone Metab"},{"key":"10476_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10060156","author":"T Kimura","year":"2018","unstructured":"Kimura T (2018) Multidisciplinary approach for bone metastasis: a review. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers10060156","journal-title":"Cancers (Basel)"},{"key":"10476_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-4635-5","author":"A Bongiovanni","year":"2019","unstructured":"Bongiovanni A, Recine F, Fausti V et al (2019) Ten-year experience of the multidisciplinary Osteoncology Center. Support Care Cancer. https:\/\/doi.org\/10.1007\/s00520-019-4635-5","journal-title":"Support Care Cancer"},{"key":"10476_CR16","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000180401.06919.a5","author":"Y Tokuhashi","year":"2005","unstructured":"Tokuhashi Y, Matsuzaki H, Oda H et al (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). https:\/\/doi.org\/10.1097\/01.brs.0000180401.06919.a5","journal-title":"Spine (Phila Pa 1976)"},{"key":"10476_CR17","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.s220976","author":"R Berardi","year":"2020","unstructured":"Berardi R, Morgese F, Rinaldi S et al (2020) Benefits and limitations of a multidisciplinary approach in cancer patient management. Cancer Manag Res. https:\/\/doi.org\/10.2147\/cmar.s220976","journal-title":"Cancer Manag Res"},{"key":"10476_CR18","doi-asserted-by":"publisher","DOI":"10.48286\/aro.2024.86","author":"I Bisceglia","year":"2024","unstructured":"Bisceglia I, Marinelli F, Morabito F et al (2024) Multidisciplinary approach in oncology: enhancing patient outcomes through collaborative care. Ann Oncol Res. https:\/\/doi.org\/10.48286\/aro.2024.86","journal-title":"Ann Oncol Res"},{"key":"10476_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.102124","author":"M Dadzie","year":"2024","unstructured":"Dadzie M, Yarney J, Nyantakyi A et al (2024) A bright future for multidisciplinary approach to cancer care in the setting of limited resource. Transl Oncol. https:\/\/doi.org\/10.1016\/j.tranon.2024.102124","journal-title":"Transl Oncol"},{"key":"10476_CR20","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198412273112604","author":"LZ Rubenstein","year":"1984","unstructured":"Rubenstein LZ, Josephson KR, Wieland GD et al (1984) Effectiveness of a geriatric evaluation unit - a randomize clinical trial. N Engl J Med. https:\/\/doi.org\/10.1056\/nejm198412273112604","journal-title":"N Engl J Med"},{"key":"10476_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00085","author":"M Taberna","year":"2020","unstructured":"Taberna M, Gil Moncayo F, Jan\u00e9-Salas E et al (2020) The multidisciplinary team (MDT) approach and quality of care. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2020.00085","journal-title":"Front Oncol"},{"key":"10476_CR22","doi-asserted-by":"publisher","DOI":"10.1200\/edbk_236857","author":"P Selby","year":"2019","unstructured":"Selby P, Popescu R, Lawler M et al (2019) The value and future developments of multidisciplinary team cancer care. Am Soc Clin Oncol Educ Book. https:\/\/doi.org\/10.1200\/edbk_236857","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10476_CR23","doi-asserted-by":"publisher","DOI":"10.1177\/030089160909500304","author":"T Ibrahim","year":"2009","unstructured":"Ibrahim T, Flamini E, Fabbri L et al (2009) Multidisciplinary approach to the treatment of bone metastases: osteo-oncology center, a new organizational model. Tumori. https:\/\/doi.org\/10.1177\/030089160909500304","journal-title":"Tumori"},{"key":"10476_CR24","unstructured":"Registro Tumori Veneto https:\/\/gecoopendata.registrotumoriveneto.it\/incidenza.php Accessed 20 Aug 2025"},{"key":"10476_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24896","author":"T Ibrahim","year":"2010","unstructured":"Ibrahim T, Flamini E, Mercatali L et al (2010) Pathogenesis of osteoblastic bone metastases from prostate cancer. Cancer. https:\/\/doi.org\/10.1002\/cncr.24896","journal-title":"Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10476-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10476-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10476-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:44:36Z","timestamp":1773215076000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10476-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10476"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10476-6","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"21 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study has been performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Istituto Oncologico Veneto (23Jan2023).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"256"}}