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Primary outcomes were recruitment\/retention and cancer-related fatigue level. Quality of life was a secondary aim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Women with Stage 0\u20133 breast cancer between 18\u201370\u00a0years who scored\u2009\u2265\u20094\/10 on the One-Item Fatigue Scale, completed chemotherapy and\/or radiation within 5\u00a0years, and did not have chronic fatigue, were randomly assigned to eHealth intervention (eHealth) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918) or control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924). Cancer-related fatigue and quality of life were measured before and after intervention using the Brief Fatigue Inventory and the Functional Assessment Cancer Therapy-General.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Social media was an effective way to recruit participants into this study; however, more participants in the eHealth group dropped out than the control group. Both\u00a0groups' fatigue scores significantly decreased over time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). eHealth decreases in fatigue reached a minimally clinically important difference (2.25), but control did not (1.3). Quality of life significantly improved in the eHealth group compared to the control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multi-modal cancer-related fatigue eHealth intervention appears to clinically reduce fatigue and improve quality of life among women with breast cancer.<\/jats:p>\n                    <jats:p>\n                      US Clinical Trial Register NCT05868187. Date registered: 2\u20137-2023.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicalgrials.gov\" ext-link-type=\"uri\">www.clinicalgrials.gov<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10477-5","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T09:31:33Z","timestamp":1772098293000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CanRestoreFunction: Cancer-related fatigue management eHealth intervention- a pilot pragmatic randomized-control trial"],"prefix":"10.1007","volume":"34","author":[{"given":"Anne B.","family":"Fleischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Insana","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Wen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"issue":"1","key":"10477_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025, (in eng). 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