{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:41:00Z","timestamp":1776238860568,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00520-026-10526-z","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:31:58Z","timestamp":1772811118000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of a clinical nurse specialist-led early palliative care initiative for patients with advanced pancreatic cancer"],"prefix":"10.1007","volume":"34","author":[{"given":"Sangyang","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Lelond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Daeninck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina A.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"issue":"11","key":"10526_CR1","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1093\/jnci\/djac158","volume":"114","author":"L Gallicchio","year":"2022","unstructured":"Gallicchio L, Devasia TP, Tonorezos E, Mollica MA, Mariotto A (2022) Estimation of the number of individuals living with metastatic cancer in the United States. J Natl Cancer Inst 114(11):1476\u20131483. https:\/\/doi.org\/10.1093\/jnci\/djac158","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"10526_CR2","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.jpainsymman.2020.04.027","volume":"60","author":"L Radbruch","year":"2020","unstructured":"Radbruch L, De Lima L, Knaul F, Wenk R, Ali Z, Bhatnaghar S, Blanchard C, Bruera E, Buitrago R, Burla C, Callaway M, Munyoro EC, Centeno C, Cleary J, Connor S, Davaasuren O, Downing J, Foley K, Goh C, Gomez-Garcia W, Harding R, Khan QT, Larkin P, Leng M, Luyirika E, Marston J, Moine S, Osman H, Pettus K, Puchalski C, Rajagopal MR, Spence D, Spruijt O, Venkateswaran C, Wee B, Woodruff R, Yong J, Pastrana T (2020) Redefining palliative care-a new consensus-based definition. J Pain Symptom Manage 60(4):754\u2013764. https:\/\/doi.org\/10.1016\/j.jpainsymman.2020.04.027","journal-title":"J Pain Symptom Manage"},{"issue":"8","key":"10526_CR3","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1056\/NEJMoa1000678","volume":"363","author":"JS Temel","year":"2010","unstructured":"Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363(8):733\u2013742. https:\/\/doi.org\/10.1056\/NEJMoa1000678","journal-title":"N Engl J Med"},{"issue":"1","key":"10526_CR4","doi-asserted-by":"publisher","first-page":"e183","DOI":"10.1200\/OP.21.00299","volume":"18","author":"H Seow","year":"2022","unstructured":"Seow H, Barbera LC, McGrail K, Burge F, Guthrie DM, Lawson B, Chan KKW, Peacock SJ, Sutradhar R (2022) Effect of early palliative care on end-of-life health care costs: a population-based, propensity score-matched cohort study. JCO Oncol Pract 18(1):e183\u2013e192. https:\/\/doi.org\/10.1200\/OP.21.00299","journal-title":"JCO Oncol Pract"},{"issue":"4","key":"10526_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07709-3","volume":"31","author":"CA Kim","year":"2023","unstructured":"Kim CA, Lelond S, Daeninck PJ, Rabbani R, Lix L, McClement S, Chochinov HM, Goldenberg BA (2023) The impact of early palliative care on the quality of life of patients with advanced pancreatic cancer: the IMPERATIVE case-crossover study. Support Care Cancer 31(4):250. https:\/\/doi.org\/10.1007\/s00520-023-07709-3","journal-title":"Support Care Cancer"},{"issue":"19","key":"10526_CR6","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1200\/JCO.24.00542","volume":"42","author":"JJ Sanders","year":"2024","unstructured":"Sanders JJ, Temin S, Ghoshal A, Alesi ER, Ali ZV, Chauhan C, Cleary JF, Epstein AS, Firn JI, Jones JA, Litzow MR, Lundquist D, Mardones MA, Nipp RD, Rabow MW, Rosa WE, Zimmermann C, Ferrell BR (2024) Palliative care for patients with cancer: ASCO guideline update. J Clin Oncol 42(19):2336\u20132357. https:\/\/doi.org\/10.1200\/JCO.24.00542","journal-title":"J Clin Oncol"},{"issue":"10","key":"10526_CR7","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.40977","volume":"7","author":"SJ Mah","year":"2024","unstructured":"Mah SJ, Carter Ramirez DM, Schnarr K, Eiriksson LR, Gayowsky A, Seow H (2024) Timing of palliative care, end-of-life quality indicators, and health resource utilization. JAMA Netw Open 7(10):e2440977. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.40977","journal-title":"JAMA Netw Open"},{"issue":"11","key":"10526_CR8","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","volume":"74","author":"L Rahib","year":"2014","unstructured":"Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM (2014) Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 74(11):2913\u20132921. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-0155","journal-title":"Cancer Res"},{"issue":"4","key":"10526_CR9","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.3390\/curroncol28040244","volume":"28","author":"S Lelond","year":"2021","unstructured":"Lelond S, Ward J, Lambert PJ, Kim CA (2021) Symptom burden of patients with advanced pancreas cancer (APC): a provincial cancer institute observational study. Curr Oncol 28(4):2789\u20132800. https:\/\/doi.org\/10.3390\/curroncol28040244","journal-title":"Curr Oncol"},{"issue":"22","key":"10526_CR10","doi-asserted-by":"publisher","first-page":"3927","DOI":"10.1002\/cncr.32423","volume":"125","author":"GT Moffat","year":"2019","unstructured":"Moffat GT, Epstein AS, O\u2019Reilly EM (2019) Pancreatic cancer-a disease in need: optimizing and integrating supportive care. Cancer 125(22):3927\u20133935. https:\/\/doi.org\/10.1002\/cncr.32423","journal-title":"Cancer"},{"issue":"5","key":"10526_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/COC.0000000000000802","volume":"44","author":"J Bevins","year":"2021","unstructured":"Bevins J, Bhulani N, Goksu SY, Sanford NN, Gao A, Ahn C, Paulk ME, Terauchi S, Pruitt SL, Tavakkoli A, Rhodes RL, Kazmi SMA, Beg MS (2021) Early palliative care is associated with reduced emergency department utilization in pancreatic cancer. Am J Clin Oncol 44(5):181\u2013186. https:\/\/doi.org\/10.1097\/COC.0000000000000802","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10526_CR12","doi-asserted-by":"publisher","first-page":"e291","DOI":"10.1016\/j.cllc.2019.02.002","volume":"20","author":"E Feld","year":"2019","unstructured":"Feld E, Singhi EK, Phillips S, Huang LC, Shyr Y, Horn L (2019) Palliative care referrals for advanced non-small-cell lung cancer (NSCLC): patient and provider attitudes and practices. Clin Lung Cancer 20(3):e291\u2013e298. https:\/\/doi.org\/10.1016\/j.cllc.2019.02.002","journal-title":"Clin Lung Cancer"},{"key":"10526_CR13","doi-asserted-by":"publisher","unstructured":"Nitecki R, Diver EJ, Kamdar MM, Boruta DM 2nd, Del Carmen MC, Clark RM, Goodman A, Schorge JO, Growdon WB (2018) Patterns of palliative care referral in ovarian cancer: a single institution 5\u202fyear retrospective analysis. Gynecol Oncol 148(3):521\u2013526. https:\/\/doi.org\/10.1016\/j.ygyno.2018.01.018","DOI":"10.1016\/j.ygyno.2018.01.018"},{"issue":"3","key":"10526_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-025-09193-3","volume":"33","author":"S Lelond","year":"2025","unstructured":"Lelond S, Kim CA (2025) Advanced practice nurse-led early palliative care: a novel model for improved access to care. Support Care Cancer 33(3):168. https:\/\/doi.org\/10.1007\/s00520-025-09193-3","journal-title":"Support Care Cancer"},{"issue":"1","key":"10526_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-025-01712-7","volume":"4","author":"CE Kircher","year":"2025","unstructured":"Kircher CE, Hanna TP, Tranmer J, Goldie CE, Ross-White A, Moulton E, Flegal J, Goldie CL (2025) Defining \u201cearly palliative care\u201d for adults diagnosed with a life-limiting illness: a scoping review. BMC Palliat Care 4(1):93. https:\/\/doi.org\/10.1186\/s12904-025-01712-7","journal-title":"BMC Palliat Care"},{"key":"10526_CR16","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2020-002578","volume":"19","author":"S Ahmed","year":"2020","unstructured":"Ahmed S, Naqvi SF, Sinnarajah A, McGhan G, Simon J, Santana M (2020) Patient and caregiver experiences with advanced cancer care: a qualitative study informing the development of an early palliative care pathway. BMJ Support Palliat Care 19:bmjspcare-2020-002578. https:\/\/doi.org\/10.1136\/bmjspcare-2020-002578","journal-title":"BMJ Support Palliat Care"},{"issue":"4","key":"10526_CR17","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1177\/0269216317690098","volume":"31","author":"P May","year":"2017","unstructured":"May P, Garrido MM, Cassel JB, Kelley AS, Meier DE, Normand C, Smith TJ, Morrison RS (2017) Cost analysis of a prospective multi-site cohort study of palliative care consultation teams for adults with advanced cancer: where do cost-savings come from? Palliat Med 31(4):378\u2013386. https:\/\/doi.org\/10.1177\/0269216317690098","journal-title":"Palliat Med"},{"issue":"12","key":"10526_CR18","doi-asserted-by":"publisher","first-page":"10408","DOI":"10.3390\/curroncol30120758","volume":"11","author":"G Chaput","year":"2023","unstructured":"Chaput G (2023) Oncology workforce crisis: let\u2019s work smarter, not harder. Curr Oncol 11(12):10408\u201310409. https:\/\/doi.org\/10.3390\/curroncol30120758","journal-title":"Curr Oncol"},{"issue":"1","key":"10526_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-024-00568-0","volume":"10","author":"S Ahmed","year":"2024","unstructured":"Ahmed S, Simon J, Biondo P, Slobogian V, Shirt L, King S, Paolucci A, Pabani A, Hao D, Bossio E, Cross R, Monds T, Nieuwenhuis J, Sinnarajah A (2024) Acceptability of automatic referrals to supportive and palliative care by patients living with advanced lung cancer: qualitative interviews and a co-design process. Res Involv Engagem 10(1):36. https:\/\/doi.org\/10.1186\/s40900-024-00568-0","journal-title":"Res Involv Engagem"},{"issue":"6","key":"10526_CR20","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jogc.2021.03.005","volume":"43","author":"MC Cusimano","year":"2021","unstructured":"Cusimano MC, Sajewycz K, Harle I, Giroux J, Hanna T, Willing S, Martin V, Francis JA (2021) Acceptability and feasibility of early palliative care among women with advanced epithelial ovarian cancer: a randomized controlled pilot study. J Obstet Gynaecol Can 43(6):707\u2013715. https:\/\/doi.org\/10.1016\/j.jogc.2021.03.005","journal-title":"J Obstet Gynaecol Can"},{"issue":"11","key":"10526_CR21","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1089\/jpm.2019.0314","volume":"22","author":"JD Henderson","year":"2019","unstructured":"Henderson JD, Boyle A, Herx L, Alexiadis A, Barwich D, Connidis S, Lysecki D, Sinnarajah A (2019) Staffing a specialist palliative care service, a team-based approach: expert consensus white paper. J Palliat Med 22(11):1318\u20131323. https:\/\/doi.org\/10.1089\/jpm.2019.0314","journal-title":"J Palliat Med"},{"issue":"7","key":"10526_CR22","doi-asserted-by":"publisher","first-page":"780","DOI":"10.6004\/jnccn.2021.0033","volume":"19","author":"M Dans","year":"2021","unstructured":"Dans M, Kutner JS, Agarwal R, Baker JN, Bauman JR, Beck AC, Campbell TC, Carey EC, Case AA, Dalal S, Doberman DJ, Epstein AS, Fecher L, Jones J, Kapo J, Lee RT, Loggers ET, McCammon S, Mitchell W, Ogunseitan AB, Portman DG, Ramchandran K, Sutton L, Temel J, Teply ML, Terauchi SY, Thomas J, Walling AM, Zachariah F, Bergman MA, Ogba N, Campbell M (2021) NCCN guidelines\u00ae insights: palliative care, version 2.2021. J Natl Compr Canc Netw 19(7):780\u2013788. https:\/\/doi.org\/10.6004\/jnccn.2021.0033","journal-title":"J Natl Compr Canc Netw"},{"issue":"1","key":"10526_CR23","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1200\/JCO.2016.70.1474","volume":"35","author":"BR Ferrell","year":"2017","unstructured":"Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, Firn JI, Paice JA, Peppercorn JM, Phillips T, Stovall EL, Zimmermann C, Smith TJ (2017) Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35(1):96\u2013112. https:\/\/doi.org\/10.1200\/JCO.2016.70.1474","journal-title":"J Clin Oncol"},{"issue":"8","key":"10526_CR24","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1177\/1049909118765405","volume":"35","author":"A Habibi","year":"2018","unstructured":"Habibi A, Wu SP, Gorovets D, Sansosti A, Kryger M, Beaudreault C, Chung WY, Shelton G, Silverman J, Lowy J, Kondziolka D (2018) Early palliative care for patients with brain metastases decreases inpatient admissions and need for imaging studies. Am J Hosp Palliat Care 35(8):1069\u20131075. https:\/\/doi.org\/10.1177\/1049909118765405","journal-title":"Am J Hosp Palliat Care"},{"issue":"13","key":"10526_CR25","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1200\/JCO.2014.58.6362","volume":"33","author":"MA Bakitas","year":"2015","unstructured":"Bakitas MA, Tosteson TD, Li Z, Lyons KD, Hull JG, Li Z, Dionne-Odom JN, Frost J, Dragnev KH, Hegel MT, Azuero A, Ahles TA (2015) Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol 33(13):1438\u20131445. https:\/\/doi.org\/10.1200\/JCO.2014.58.6362","journal-title":"J Clin Oncol"},{"key":"10526_CR26","doi-asserted-by":"publisher","DOI":"10.1177\/1178224216688887","volume":"10","author":"P Hawley","year":"2017","unstructured":"Hawley P (2017) Barriers to access to palliative care. Palliat Care Res Treat 10:1178224216688887. https:\/\/doi.org\/10.1177\/1178224216688887","journal-title":"Palliat Care Res Treat"},{"issue":"6","key":"10526_CR27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1037\/hea0000489","volume":"36","author":"M Hoerger","year":"2017","unstructured":"Hoerger M, Perry LM, Gramling R, Epstein RM, Duberstein PR (2017) Does educating patients about the Early Palliative Care Study increase preferences for outpatient palliative cancer care? Findings from Project EMPOWER. Health Psychol 36(6):538\u2013548. https:\/\/doi.org\/10.1037\/hea0000489","journal-title":"Health Psychol"},{"issue":"12","key":"10526_CR28","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1001\/jamainternmed.2014.5271","volume":"174","author":"RE Bernacki","year":"2014","unstructured":"Bernacki RE, Block SD (2014) Communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med 174(12):1994\u20132003. https:\/\/doi.org\/10.1001\/jamainternmed.2014.5271","journal-title":"JAMA Intern Med"},{"issue":"5","key":"10526_CR29","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/0284186X.2023.2212410","volume":"62","author":"SUA Gill","year":"2023","unstructured":"Gill SUA, Hollegaard S, Sch\u00f8nnemann KR (2023) Implementation of early palliative care in an oncologic outpatient clinic - an observational study of the first year. Acta Oncol 62(5):522\u2013527. https:\/\/doi.org\/10.1080\/0284186X.2023.2212410","journal-title":"Acta Oncol"},{"issue":"1","key":"10526_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00520-019-04811-3","volume":"28","author":"D Hui","year":"2020","unstructured":"Hui D, Anderson L, Tang M, Park M, Liu D, Bruera E (2020) Examination of referral criteria for outpatient palliative care among patients with advanced cancer. Support Care Cancer 28(1):295\u2013301. https:\/\/doi.org\/10.1007\/s00520-019-04811-3","journal-title":"Support Care Cancer"},{"issue":"6","key":"10526_CR31","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1002\/cncr.34044","volume":"128","author":"JN Dionne-Odom","year":"2022","unstructured":"Dionne-Odom JN, Azuero A, Taylor RA, Dosse C, Bechthold AC, Currie E, Reed RD, Harrell ER, Engler S, Ejem DB, Ivankova NV, Martin MY, Rocque GB, Williams GR, Bakitas MA (2022) A lay navigator-led, early palliative care intervention for African American and rural family caregivers of individuals with advanced cancer (Project Cornerstone): results of a pilot randomized trial. Cancer 128(6):1321\u20131330. https:\/\/doi.org\/10.1002\/cncr.34044","journal-title":"Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10526-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10526-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10526-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:41:20Z","timestamp":1776235280000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10526-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10526"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10526-z","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"assertion":[{"value":"19 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the University of Manitoba Health Research Ethics Board in accordance with the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans\u2013TCPS 2 (2022).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable (quality improvement, retrospective study).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"287"}}