{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:18:01Z","timestamp":1778685481376,"version":"3.51.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006260","name":"Technion - Israel Institute of Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006260","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to explore integrative oncology (IO) across the Middle East, examine how international IO leaders promote IO in the Middle East, and assess how the Middle East contributes to the development of IO globally. This narrative review employed a structured literature search and descriptive analytic approach, using multiple databases, predefined keywords, varied study designs, and multilingual sources. It was conducted by a multi-disciplinary team of clinicians, researchers, and medical educators from ten Middle Eastern countries (Cyprus, Egypt, Iran, Israel, Jordan, Morocco, Palestine, Sudan, Turkey, and United Arab Emirates) and global IO\/palliative leaders from South America, India, China, Europe, and the USA, providing a real-life implementation perspective. The collaborative IO model of care ensures safe and effective traditional and herbal medicine practices, with a culturally-sensitive approach respecting health beliefs. Middle Eastern and international IO participants discuss how they can benefit from each other, drawing from Middle-East Research Group in Integrative Oncology (MERGIO) activities in clinical practice, research, and medical education. Important themes derived from the review include the potential for IO to advance patient-centered care, effectively improve quality of life-related concerns, ensure a safe therapeutic environment, and overcome accessibility- and disparity-related barriers. IO treatments should be provided by trained multi-disciplinary teams of integrative physicians and practitioners, within culturally-adapted multi-modal programs and a receptive national and regional healthcare policy. Research utilizing pragmatic methodologies reflects real-world IO practice, with IO prioritized in medical education providing students and healthcare professionals with high-quality clinical and research training across the Middle East.<\/jats:p>","DOI":"10.1007\/s00520-026-10647-5","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:45:14Z","timestamp":1776840314000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative oncology in clinical practice, research, and education: Middle-Eastern and global perspectives"],"prefix":"10.1007","volume":"34","author":[{"given":"Eran","family":"Ben-Arye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tido","family":"von Schoen-Angerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Rassouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclbeyaz","family":"Can","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Hablas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suha","family":"Omran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Stylianou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak Rita","family":"Hajji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil Arun","family":"Nijhawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtisam","family":"Ghrayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla","family":"Gafer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Toledano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Bonucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ghelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Fuller-Shavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rammanohar","family":"Puthiyedath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"10647_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/349040","volume":"2012","author":"H Zaid","year":"2012","unstructured":"Zaid H, Silbermann M, Ben-Arye E, Saad B (2012) Greco-arab and islamic herbal-derived anticancer modalities: from tradition to molecular mechanisms. Evid Based Complement Alternat Med 2012:349040. https:\/\/doi.org\/10.1155\/2012\/349040","journal-title":"Evid Based Complement Alternat Med"},{"issue":"8","key":"10647_CR2","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s11920-024-01515-2","volume":"26","author":"E Ben-Arye","year":"2024","unstructured":"Ben-Arye E, Lopez G, Rassouli M, Ortiz M, Cramer H, Samuels N (2024) Cross-cultural patient counseling and communication in the integrative medicine setting: respecting the patient\u2019s health belief model of care. Curr Psychiatry Rep 26(8):422\u2013434. https:\/\/doi.org\/10.1007\/s11920-024-01515-2","journal-title":"Curr Psychiatry Rep"},{"key":"10647_CR3","doi-asserted-by":"publisher","unstructured":"Ben-Arye E, Samuels N, Daher M, Turker I, Nimri O, Rassouli M, Silbermann M (2017) Integrating complementary and traditional practices in Middle-Eastern supportive cancer care. J Natl Cancer Inst Monogr 2017(52). https:\/\/doi.org\/10.1093\/jncimonographs\/lgx016","DOI":"10.1093\/jncimonographs\/lgx016"},{"key":"10647_CR4","doi-asserted-by":"publisher","unstructured":"Witt CM, Balneaves LG, Cardoso MJ, Cohen L, Greenlee H, Johnstone P, K\u00fcc\u00fck \u00d6, Mailman J, Mao JJ (2017) A comprehensive definition for integrative oncology. J Natl Cancer Inst Monogr 2017(52). https:\/\/doi.org\/10.1093\/jncimonographs\/lgx012","DOI":"10.1093\/jncimonographs\/lgx012"},{"issue":"25","key":"10647_CR5","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1200\/JCO.2018.79.2721","volume":"36","author":"GH Lyman","year":"2018","unstructured":"Lyman GH, Greenlee H, Bohlke K, Bao T, DeMichele AM, Deng GE, Fouladbakhsh JM, Gil B, Hershman DL, Mansfield S, Mussallem DM, Mustian KM, Price E, Rafte S, Cohen L (2018) Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline. J Clin Oncol 36(25):2647\u20132655. https:\/\/doi.org\/10.1200\/JCO.2018.79.2721","journal-title":"J Clin Oncol"},{"issue":"34","key":"10647_CR6","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.1200\/JCO.22.01357","volume":"40","author":"JJ Mao","year":"2022","unstructured":"Mao JJ, Ismaila N, Bao T, Barton D, Ben-Arye E, Garland EL, Greenlee H, Leblanc T, Lee RT, Lopez AM, Loprinzi C, Lyman GH, MacLeod J, Master VA, Ramchandran K, Wagner LI, Walker EM, Bruner DW, Witt CM, Bruera E (2022) Integrative medicine for pain management in oncology: Society for Integrative Oncology-ASCO guideline. J Clin Oncol 40(34):3998\u20134024. https:\/\/doi.org\/10.1200\/JCO.22.01357","journal-title":"J Clin Oncol"},{"issue":"28","key":"10647_CR7","doi-asserted-by":"publisher","first-page":"4562","DOI":"10.1200\/JCO.23.00857","volume":"41","author":"LE Carlson","year":"2023","unstructured":"Carlson LE, Ismaila N, Addington EL, Asher GN, Atreya C, Balneaves LG, Bradt J, Fuller-Shavel N, Goodman J, Hoffman CJ, Huston A, Mehta A, Paller CJ, Richardson K, Seely D, Siwik CJ, Temel JS, Rowland JH (2023) Integrative oncology care of symptoms of anxiety and depression in adults with cancer: Society for Integrative Oncology-ASCO guideline. J Clin Oncol 41(28):4562\u20134591. https:\/\/doi.org\/10.1200\/JCO.23.00857","journal-title":"J Clin Oncol"},{"issue":"20","key":"10647_CR8","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1200\/JCO.24.00541","volume":"42","author":"JE Bower","year":"2024","unstructured":"Bower JE, Lacchetti C, Alici Y, Barton DL, Bruner D, Canin BE, Escalante CP, Ganz PA, Garland SN, Gupta S, Jim H, Ligibel JA, Loh KP, Peppone L, Tripathy D, Yennu S, Zick S, Mustian K (2024) Management of fatigue in adult survivors of cancer: ASCO-Society for Integrative Oncology guideline update. J Clin Oncol 42(20):2456\u20132487. https:\/\/doi.org\/10.1200\/JCO.24.00541","journal-title":"J Clin Oncol"},{"issue":"2","key":"10647_CR9","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3322\/caac.21706","volume":"72","author":"JJ Mao","year":"2022","unstructured":"Mao JJ, Pillai GG, Andrade CJ, Ligibel JA, Basu P, Cohen L, Khan IA, Mustian KM, Puthiyedath R, Dhiman KS, Lao L, Ghelman R, C\u00e1ceres Guido P, Lopez G, Gallego-Perez DF, Salicrup LA (2022) Integrative oncology: addressing the global challenges of cancer prevention and treatment. CA Cancer J Clin 72(2):144\u2013164. https:\/\/doi.org\/10.3322\/caac.21706","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"10647_CR10","doi-asserted-by":"publisher","first-page":"418","DOI":"10.4300\/JGME-D-22-00481.1","volume":"14","author":"J Sukhera","year":"2022","unstructured":"Sukhera J (2022) Narrative reviews in medical education: key steps for researchers. J Grad Med Educ 14(4):418\u2013419. https:\/\/doi.org\/10.4300\/JGME-D-22-00481.1","journal-title":"J Grad Med Educ"},{"key":"10647_CR11","unstructured":"Ben-Arye E (2014) Integrating complementary medicine in cancer supportive care across the Middle East: challenges and opportunities. In: Palliative Care to the Cancer Patient: The Middle East as a Model to Emerging Countries, Silbermann M, Ed., Nova Science Publishers NY, pp.77\u201397"},{"issue":"3","key":"10647_CR12","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1177\/1534735418764839","volume":"17","author":"I Shalom-Sharabi","year":"2018","unstructured":"Shalom-Sharabi I, Frenkel M, Caspi O, Bar-Sela G, Toledano M, Samuels N, Schiff E, Ben-Arye E (2018) Integrative oncology in supportive cancer care in Israel. Integr Cancer Ther 17(3):697\u2013706. https:\/\/doi.org\/10.1177\/1534735418764839","journal-title":"Integr Cancer Ther"},{"issue":"2","key":"10647_CR13","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/annonc\/mdt554","volume":"25","author":"E Ben-Arye","year":"2014","unstructured":"Ben-Arye E, Massalha E, Bar-Sela G, Silbermann M, Agbarya A, Saad B, Lev E, Schiff E (2014) Stepping from traditional to integrative medicine: perspectives of Israeli-Arab patients on complementary medicine\u2019s role in cancer care. Ann Oncol 25(2):476\u2013480. https:\/\/doi.org\/10.1093\/annonc\/mdt554","journal-title":"Ann Oncol"},{"issue":"5","key":"10647_CR14","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.jpainsymman.2014.09.014","volume":"49","author":"E Ben-Arye","year":"2015","unstructured":"Ben-Arye E, Schiff E, Silbermann M, Agbarya A, Bar-Sela G (2015) Perceptions of complementary medicine integration in supportive cancer care of Arabs and Jews in Israel: a cross-cultural study. J Pain Symptom Manage 49(5):871\u2013877. https:\/\/doi.org\/10.1016\/j.jpainsymman.2014.09.014","journal-title":"J Pain Symptom Manage"},{"issue":"5","key":"10647_CR15","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.jpainsymman.2014.10.006","volume":"49","author":"E Ben-Arye","year":"2015","unstructured":"Ben-Arye E, Hamadeh AM, Schiff E, Jamous RM, Dagash J, Jamous RM, Agbarya A, Bar-Sela G, Massalha E, Silbermann M, Ali-Shtayeh MS (2015) Compared perspectives of Arab patients in Palestine and Israel on the role of complementary medicine in cancer care. J Pain Symptom Manage 49(5):878\u2013884. https:\/\/doi.org\/10.1016\/j.jpainsymman.2014.10.006","journal-title":"J Pain Symptom Manage"},{"issue":"2","key":"10647_CR16","doi-asserted-by":"publisher","first-page":"136","DOI":"10.14525\/JJNR.v2i2.06","volume":"2","author":"S Omran","year":"2023","unstructured":"Omran S, Barakat H (2023) Jordanian patients\u2019 perspectives of the role of complementary medicine in the treatment of cancer. Jordan J Nurs Res 2(2):136\u2013146. https:\/\/doi.org\/10.14525\/JJNR.v2i2.06","journal-title":"Jordan J Nurs Res"},{"issue":"2","key":"10647_CR17","doi-asserted-by":"publisher","DOI":"10.5812\/ijcm.89916","volume":"12","author":"AS Farahani","year":"2019","unstructured":"Farahani AS, Salmani N, Khoshnazar TSK, Karami M, Hatamipour K, Yazdani S, Pourazarhagh P, Rassouli M (2019) The perspective of cancer patients on the use of complementary medicine. Int J Cancer Manag 12(2):e89916. https:\/\/doi.org\/10.5812\/ijcm.89916","journal-title":"Int J Cancer Manag"},{"key":"10647_CR18","doi-asserted-by":"publisher","first-page":"e2618","DOI":"10.32113\/wcrj_20237_2618","volume":"10","author":"G Can","year":"2023","unstructured":"Can G, Sekerci A, AkyuzOzdemir F, Egeli D, NurAkbas M, SumbulSekerci B, Akcakaya A (2023) Psychometric validation of the Turkish version of the questionnaire on the integration of complementary and alternative medicine in oncological treatment. WCRJ 10:e2618. https:\/\/doi.org\/10.32113\/wcrj_20237_2618","journal-title":"WCRJ"},{"issue":"9","key":"10647_CR19","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1007\/s00520-015-2619-7","volume":"23","author":"E Ben-Arye","year":"2015","unstructured":"Ben-Arye E, Schiff E, Mutafoglu K, Omran S, Hajjar R, Charalambous H, Dweikat T, Ghrayeb I, Sela GB, Turker I, Hassan A, Hassan E, Popper-Giveon A, Saad B, Nimri O, Kebudi R, Dagash J, Silbermann M (2015) Integration of complementary medicine in supportive cancer care: survey of health-care providers\u2019 perspectives from 16 countries in the Middle East. Support Care Cancer 23(9):2605\u20132612. https:\/\/doi.org\/10.1007\/s00520-015-2619-7","journal-title":"Support Care Cancer"},{"issue":"5","key":"10647_CR20","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s00432-016-2120-9","volume":"142","author":"E Ben-Arye","year":"2016","unstructured":"Ben-Arye E, Popper-Giveon A, Samuels N, Mutafoglu K, Schiff E, Omran S, Charalambous H, Dweikat T, Ghrayeb I, Turker I, Hassan A, Hassan E, Nimri O, Kebudi R, Silbermann M (2016) Communication and integration: a qualitative analysis of perspectives among Middle Eastern oncology healthcare professionals on the integration of complementary medicine in supportive cancer care. J Cancer Res Clin Oncol 142(5):1117\u20131126. https:\/\/doi.org\/10.1007\/s00432-016-2120-9","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"10647_CR21","doi-asserted-by":"publisher","first-page":"151444","DOI":"10.1016\/j.soncn.2023.151444","volume":"39","author":"A ShirinabadiFarahani","year":"2023","unstructured":"ShirinabadiFarahani A, Ashrafizadeh H, KhoubbinKhoshnazar TAS, Mehrnoush N, Karami M, Khademi F, EshaghianDorcheh A, Ebrahimloee S, KoohiRostamkalaee Z, Rassouli M (2023) Barriers to applying integrative oncology from the perspective of the care providers in Iran: a mixed-methods study. Semin Oncol Nurs 39(4):151444. https:\/\/doi.org\/10.1016\/j.soncn.2023.151444","journal-title":"Semin Oncol Nurs"},{"issue":"3","key":"10647_CR22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.14525\/JJNR.v2i3.02","volume":"2","author":"S Omran","year":"2023","unstructured":"Omran S, Qadri Z, Shahrour G (2023) Integration of complementary medicine in supportive cancer care: survey of healthcare providers\u2019 perspectives. Jordan J Nurs Res 2(3):169\u2013182. https:\/\/doi.org\/10.14525\/JJNR.v2i3.02","journal-title":"Jordan J Nurs Res"},{"issue":"4","key":"10647_CR23","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/cncr.29796","volume":"122","author":"E Ben-Arye","year":"2016","unstructured":"Ben-Arye E, Samuels N, Goldstein LH, Mutafoglu K, Omran S, Schiff E, Charalambous H, Dweikat T, Ghrayeb I, Bar-Sela G, Turker I, Hassan A, Hassan E, Saad B, Nimri O, Kebudi R, Silbermann M (2016) Potential risks associated with traditional herbal medicine use in cancer care: a study of Middle Eastern oncology health care professionals. Cancer 122(4):598\u2013610. https:\/\/doi.org\/10.1002\/cncr.29796","journal-title":"Cancer"},{"issue":"6","key":"10647_CR24","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1634\/theoncologist.2017-0490","volume":"23","author":"E Ben-Arye","year":"2018","unstructured":"Ben-Arye E, Bonucci M, Daher M, Kebudi R, Saad B, Breitkreuz T, Rassouli M, Rossi E, Gafer N, Nimri O, Hablas M, Kienle GS, Samuels N, Silbermann M (2018) Refugees in conflict: creating a bridge between traditional and conventional health belief models. Oncologist 23(6):693\u2013696. https:\/\/doi.org\/10.1634\/theoncologist.2017-0490","journal-title":"Oncologist"},{"issue":"2","key":"10647_CR25","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jpainsymman.2020.08.004","volume":"61","author":"E Ben-Arye","year":"2021","unstructured":"Ben-Arye E, Portalupi E, Keshet Y, Bonucci M, Can G, Kading Y, Samuels N, Livas M, Gressel O, Silbermann M, Breitkreuz T (2021) Enhancing palliative care with mindful touch: impact of a manual and movement therapy training program in an international multidisciplinary integrative oncology setting. J Pain Symptom Manage 61(2):229\u2013236. https:\/\/doi.org\/10.1016\/j.jpainsymman.2020.08.004","journal-title":"J Pain Symptom Manage"},{"key":"10647_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ejon.2016.10.007","volume":"26","author":"T Tsitsi","year":"2017","unstructured":"Tsitsi T, Charalambous A, Papastavrou E, Raftopoulos V (2017) Effectiveness of a relaxation intervention (progressive muscle relaxation and guided imagery techniques) to reduce anxiety and improve mood of parents of hospitalized children with malignancies: a randomized controlled trial in Republic of Cyprus and Greece. Eur J Oncol Nurs 26:9\u201318. https:\/\/doi.org\/10.1016\/j.ejon.2016.10.007","journal-title":"Eur J Oncol Nurs"},{"issue":"12","key":"10647_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.31326","volume":"71","author":"A Farrag","year":"2024","unstructured":"Farrag A, Alqudimat MR, Hassan FAA (2024) Family strategies for managing childhood cancer: using traditional and complementary medicine in Southern Egypt. Pediatr Blood Cancer 71(12):e31326. https:\/\/doi.org\/10.1002\/pbc.31326","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"10647_CR28","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3109\/08880018.2012.669026","volume":"29","author":"M Abdulrhman","year":"2012","unstructured":"Abdulrhman M, Elbarbary NS, Ahmed Amin D, Saeid Ebrahim R (2012) Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol 29(3):285\u2013292. https:\/\/doi.org\/10.3109\/08880018.2012.669026","journal-title":"Pediatr Hematol Oncol"},{"issue":"6","key":"10647_CR29","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1177\/1078155219897294","volume":"26","author":"AA Hagag","year":"2020","unstructured":"Hagag AA, Badraia IM, El-Shehaby WA, Mabrouk MM (2020) Protective role of black seed oil in doxorubicin-induced cardiac toxicity in children with acute lymphoblastic leukemia. J Oncol Pharm Pract 26(6):1397\u20131406. https:\/\/doi.org\/10.1177\/1078155219897294","journal-title":"J Oncol Pharm Pract"},{"key":"10647_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2024.102644","volume":"39","author":"M Yousefi","year":"2024","unstructured":"Yousefi M, Reihani H, Heydari M, Nasimi Doost Azgomi R, Hashempur MH (2024) Complementary and alternative medicine use among cancer patients in Iran: a systematic review. Prev Med Rep 39:102644. https:\/\/doi.org\/10.1016\/j.pmedr.2024.102644","journal-title":"Prev Med Rep"},{"issue":"5","key":"10647_CR31","first-page":"143","volume":"13","author":"M Bordbar","year":"2023","unstructured":"Bordbar M, Vahidifar M, Zarshenas MM, Haghpanah S, Zareifar S, Shahriari M, Zekavat OR, Karimi M, Fathpour G, Zargaran A, Shakibazad N (2023) The efficacy of Allium ampeloprasum L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial. Am J Blood Res 13(5):143\u2013151","journal-title":"Am J Blood Res"},{"issue":"11","key":"10647_CR32","doi-asserted-by":"publisher","first-page":"e1614","DOI":"10.1200\/OP.21.00156","volume":"17","author":"M Miladinia","year":"2021","unstructured":"Miladinia M, Voss JG, Molavynejad S, Malehi AS, Zarea K, Nouri EM, Ahmadzadeh A (2021) Slow-stroke back massage compared with music therapy for leukemia-related pain and fatigue: a randomized controlled trial. JCO Oncol Pract 17(11):e1614\u2013e1621. https:\/\/doi.org\/10.1200\/OP.21.00156","journal-title":"JCO Oncol Pract"},{"issue":"1","key":"10647_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/jehp.jehp_147_14","volume":"6","author":"M Shahriari","year":"2017","unstructured":"Shahriari M, Dehghan M, Pahlavanzadeh S, Hazini A (2017) Effects of progressive muscle relaxation, guided imagery and deep diaphragmatic breathing on quality of life in elderly with breast or prostate cancer. J Educ Health Promot 6(1):1. https:\/\/doi.org\/10.4103\/jehp.jehp_147_14","journal-title":"J Educ Health Promot"},{"issue":"1","key":"10647_CR34","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00520-021-06413-4","volume":"30","author":"E Khezri","year":"2022","unstructured":"Khezri E, Bagheri-Saveh MI, Kalhor MM, Rahnama M, Roshani D, Salehi K (2022) Nursing care based on the Support-Based Spiritual Care Model increases hope among women with breast cancer in Iran. Support Care Cancer 30(1):423\u2013429. https:\/\/doi.org\/10.1007\/s00520-021-06413-4","journal-title":"Support Care Cancer"},{"issue":"20","key":"10647_CR35","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1002\/cncr.34422","volume":"128","author":"E Ben-Arye","year":"2022","unstructured":"Ben-Arye E, Hausner D, Samuels N, Gamus D, Lavie O, Tadmor T, Gressel O, Agbarya A, Attias S, David A, Schiff E (2022) Impact of acupuncture and integrative therapies on chemotherapy-induced peripheral neuropathy: a multicentered, randomized controlled trial. Cancer 128(20):3641\u20133652. https:\/\/doi.org\/10.1002\/cncr.34422","journal-title":"Cancer"},{"issue":"6","key":"10647_CR36","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1002\/cncr.34542","volume":"129","author":"E Ben-Arye","year":"2023","unstructured":"Ben-Arye E, Segev Y, Galil G, Marom I, Gressel O, Stein N, Hirsh I, Samuels N, Schmidt M, Schiff E, Lurie I, Lavie O (2023) Acupuncture during gynecological oncology surgery: a randomized controlled trial assessing the impact of integrative therapies on perioperative pain and anxiety. Cancer 129(6):908\u2013919. https:\/\/doi.org\/10.1002\/cncr.34542","journal-title":"Cancer"},{"key":"10647_CR37","doi-asserted-by":"publisher","unstructured":"Samuels N, Gressel-Raz O, Peled N, Stein N, Granot I, Ben-Arye E (2024) Identifying factors associated with disparities in accessing an Integrative Oncology program. J Pain Symptom Manage S0885\u20133924(24)01191\u20136. https:\/\/doi.org\/10.1016\/j.jpainsymman.2024.11.022","DOI":"10.1016\/j.jpainsymman.2024.11.022"},{"issue":"2","key":"10647_CR38","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1136\/spcare-2022-004117","volume":"14","author":"E Ben-Arye","year":"2024","unstructured":"Ben-Arye E, Tapiro Y, Baruch R, Tal A, Shulman B, Gressel O, Israeli P, Dagash J, Yosipovich A, Shalom Sharabi I, Zimmermann P, Samuels N (2024) Integrative oncology for palliative care nurses: pre-post training evaluation. BMJ Support Palliat Care 14(2):178\u2013182. https:\/\/doi.org\/10.1136\/spcare-2022-004117","journal-title":"BMJ Support Palliat Care"},{"issue":"4","key":"10647_CR39","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ctcp.2010.05.001","volume":"16","author":"FU Afifi","year":"2010","unstructured":"Afifi FU, Wazaify M, Jabr M, Treish E (2010) The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan. Complement Ther Clin Pract 16(4):208\u2013212. https:\/\/doi.org\/10.1016\/j.ctcp.2010.05.001","journal-title":"Complement Ther Clin Pract"},{"issue":"3","key":"10647_CR40","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1365-2648.2010.05517.x","volume":"67","author":"MR Al-Qudimat","year":"2011","unstructured":"Al-Qudimat MR, Rozmus CL, Farhan N (2011) Family strategies for managing childhood cancer: using complementary and alternative medicine in Jordan. J Adv Nurs 67(3):591\u2013597. https:\/\/doi.org\/10.1111\/j.1365-2648.2010.05517.x","journal-title":"J Adv Nurs"},{"issue":"2","key":"10647_CR41","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ctcp.2013.01.002","volume":"19","author":"A Al-Omari","year":"2013","unstructured":"Al-Omari A, Al-Qudimat M, Abu Hmaidan A, Zaru L (2013) Perception and attitude of Jordanian physicians towards complementary and alternative medicine (CAM) use in oncology. Complement Ther Clin Pract 19(2):70\u201376. https:\/\/doi.org\/10.1016\/j.ctcp.2013.01.002","journal-title":"Complement Ther Clin Pract"},{"issue":"1","key":"10647_CR42","doi-asserted-by":"publisher","first-page":"E38","DOI":"10.1097\/NCC.0000000000001159","volume":"47","author":"R Ibdah","year":"2024","unstructured":"Ibdah R, Zeilani R, Atout M (2024) Jordanian nurses\u2019 perspectives of spirituality and spiritual care: a qualitative study. Cancer Nurs 47(1):E38\u2013E46. https:\/\/doi.org\/10.1097\/NCC.0000000000001159","journal-title":"Cancer Nurs"},{"issue":"1","key":"10647_CR43","doi-asserted-by":"publisher","first-page":"64","DOI":"10.2174\/1871526515666150320161440","volume":"15","author":"AA Hagag","year":"2015","unstructured":"Hagag AA, AbdElaal AM, Elfaragy MS, Hassan SM, Elzamarany EA (2015) Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia. Infect Disord Drug Targets 15(1):64\u201371. https:\/\/doi.org\/10.2174\/1871526515666150320161440","journal-title":"Infect Disord Drug Targets"},{"issue":"4","key":"10647_CR44","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s13149-013-0308-7","volume":"106","author":"I Tazi","year":"2013","unstructured":"Tazi I, Nafil H, Mahmal L, Harif M, Khouchani M, Saadi Z, Belbaraka R, Elomrani A, Tahri A (2013) Les m\u00e9decines alternatives et compl\u00e9mentaires chez les patients canc\u00e9reux en cours de traitement \u00e0 Marrakech, Maroc\u202f: \u00e9tude prospective [Complementary medicine in cancer patients under treatment in Marrakech, Morocco: a prospective study]. Bull Soc Pathol Exot 106(4):278\u2013285. https:\/\/doi.org\/10.1007\/s13149-013-0308-7","journal-title":"Bull Soc Pathol Exot"},{"key":"10647_CR45","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jep.2016.04.038","volume":"187","author":"MS Ali-Shtayeh","year":"2016","unstructured":"Ali-Shtayeh MS, Jamous RM, Salameh NM, Jamous RM, Hamadeh AM (2016) Complementary and alternative medicine use among cancer patients in Palestine with special reference to safety-related concerns. J Ethnopharmacol 187:104\u2013122. https:\/\/doi.org\/10.1016\/j.jep.2016.04.038","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"10647_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09649-3","volume":"22","author":"AA Koni","year":"2022","unstructured":"Koni AA, Nazzal MA, Suwan BA, Sobuh SS, Abuhazeem NT, Salman AN, Salameh HT, Amer R, Zyoud SH (2022) A comprehensive evaluation of potentially significant drug-drug, drug-herb, and drug-food interactions among cancer patients receiving anticancer drugs. BMC Cancer 22(1):547. https:\/\/doi.org\/10.1186\/s12885-022-09649-3","journal-title":"BMC Cancer"},{"issue":"6","key":"10647_CR47","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1159\/000345462","volume":"7","author":"G Can","year":"2012","unstructured":"Can G, Demir M, Aydiner A (2012) Complementary and alternative therapies used by Turkish breast cancer patients undergoing chemotherapy. Breast Care (Basel) 7(6):471\u2013475. https:\/\/doi.org\/10.1159\/000345462","journal-title":"Breast Care (Basel)"},{"key":"10647_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2024.102646","volume":"71","author":"N Izgu","year":"2024","unstructured":"Izgu N, Metin ZG, Eroglu H, Semerci R, Pars H (2024) Impact of spiritual interventions in individuals with cancer: a systematic review and meta-analysis. Eur J Oncol Nurs 71:102646. https:\/\/doi.org\/10.1016\/j.ejon.2024.102646","journal-title":"Eur J Oncol Nurs"},{"issue":"2","key":"10647_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2022.100676","volume":"14","author":"JT Arnold","year":"2023","unstructured":"Arnold JT (2023) Integrating ayurvedic medicine into cancer research programs part 1: Ayurveda background and applications. J Ayurveda Integr Med 14(2):100676. https:\/\/doi.org\/10.1016\/j.jaim.2022.100676","journal-title":"J Ayurveda Integr Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10647-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10647-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10647-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:48:21Z","timestamp":1778683701000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10647-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10647"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10647-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"22 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Participation in this manuscript was voluntary. Due to political constraints, no submission to the Ethics Review Board was feasible.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Participation in this study was voluntary and verified by participants\u2019 consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consented for publication of the present manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"453"}}