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We aimed to investigate unmet information and support needs and quality of life in a German cohort of relatives of metastatic breast cancer (mBC) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between July 2022 and August 2023, adults with mBC were included in the BRE-BY-MED \u201cBreast Cancer Care in Bavaria for Patients with Metastatic Disease\u201d cohort study (DRKS00026601) at the University Hospital W\u00fcrzburg. Relatives of these patients completed a questionnaire on unmet support and information needs at the 3-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      75.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) of the relatives had at least one unmet support need, mostly observed in the categories \u201cmedical information about the relative\u2019s illness\u201d (54.5%) and \u201ccontact person who coordinates the treatment\/aftercare\u201d (42.4%). 45.5% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915) of the relatives had at least one information need, with the highest needs in the categories \u201cthe likely course of the disease in the relative\u201d (39.4%) and \u201chow to deal with the treatment side effects\u201d (36.4%). In 72.7% and 88.0% of the relatives, respectively, there was evidence for severe depressive or anxiety symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Dedicated support programmes for relatives of patients with mBC should be developed, targeting their unmet support and information needs regarding the disease, treatments, side effects, prognosis, and aftercare. Furthermore, physicians should be aware of actively involving mBC patients\u2019 relatives in the disease and treatment process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10672-4","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:14:14Z","timestamp":1776410054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unmet support and information needs of relatives of patients with advanced or metastatic breast cancer: results of the BRE-BY-MED study"],"prefix":"10.1007","volume":"34","author":[{"given":"Lilly Sophia","family":"Brandstetter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Grau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"L\u00f6ffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"M\u00fcller-Reiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Salmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens-Peter","family":"Reese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Heuschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"W\u00f6ckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"issue":"Suppl 7","key":"10672_CR1","doi-asserted-by":"publisher","first-page":"vii11","DOI":"10.1093\/annonc\/mds232","volume":"23","author":"F Cardoso","year":"2012","unstructured":"Cardoso F, Harbeck N, Fallowfield L, Kyriakides S, Senkus E (2012) Locally recurrent or metastatic breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. 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All methods of the study were fully approved by the ethics committee of the Medical Faculty of the University Wuerzburg (reference number 137\/21). Written informed consent was obtained from all patients. As no person-related data were collected from the relatives and the survey was anonymous, no informed consent was required. The responsible data protection officer accepted the data management concept.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"438"}}