{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:58:50Z","timestamp":1781060330479,"version":"3.54.1"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00520-026-10707-w","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:58:28Z","timestamp":1778043508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The potential of bee products in clinical trials focused on the side effects of radiotherapy and chemotherapy used for cancer treatment"],"prefix":"10.1007","volume":"34","author":[{"given":"Shaden A. M.","family":"Khalifa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida A. Abd","family":"El-Wahed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamer","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Daglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haged H.","family":"El-Seedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Sabit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Coghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham R.","family":"El-Seedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"10707_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71:209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"10707_CR2","doi-asserted-by":"publisher","unstructured":"Soussain C, Ricard D, Fike JR et al (2009)\u00a0CNS complications of radiotherapy and chemotherapy. Lancet 374:1639\u20131651. https:\/\/doi.org\/10.1016\/S0140-6736(09)61299-X","DOI":"10.1016\/S0140-6736(09)61299-X"},{"key":"10707_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/eurjhf\/hfq213","volume":"13","author":"T Eschenhagen","year":"2011","unstructured":"Eschenhagen T, Force T, Ewer MS et al (2011) Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 13:1\u201310. https:\/\/doi.org\/10.1093\/eurjhf\/hfq213","journal-title":"Eur J Heart Fail"},{"key":"10707_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1053\/j.seminoncol.2005.03.009","volume":"32","author":"F-M Kong","year":"2005","unstructured":"Kong F-M, Haken RT, Eisbruch A, Lawrence TS (2005) Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis, Semin. Semin Oncol 32:42\u201354. https:\/\/doi.org\/10.1053\/j.seminoncol.2005.03.009","journal-title":"Semin Oncol"},{"key":"10707_CR5","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1007\/s12094-010-0553-1","volume":"12","author":"M L\u00f3pez Rodr\u00edguez","year":"2010","unstructured":"L\u00f3pez Rodr\u00edguez M, Mart\u00edn Mart\u00edn M, Cerezo Padellano L et al (2010) Gastrointestinal toxicity associated to radiation therapy. Clin Transl Oncol 12:554\u2013561. https:\/\/doi.org\/10.1007\/s12094-010-0553-1","journal-title":"Clin Transl Oncol"},{"key":"10707_CR6","doi-asserted-by":"publisher","unstructured":"Clermont T, LeBlanc AK, Adams WH et al (2012) Radiotherapy-induced myelosuppression in dogs: 103 cases (2002\u20132006). Vet Comp Oncol 10:24\u201332. https:\/\/doi.org\/10.1111\/j.1476-5829.2011.00271.x","DOI":"10.1111\/j.1476-5829.2011.00271.x"},{"key":"10707_CR7","doi-asserted-by":"publisher","unstructured":"Campbell AC, Hersey P, MacLennan ICM et al (1973) Immunosuppressive consequences of radiotherapy and chemotherapy in patients with acute lymphoblastic leukaemia. Br Med J 2:385\u2013388. https:\/\/doi.org\/10.1136\/bmj.2.5863.385","DOI":"10.1136\/bmj.2.5863.385"},{"key":"10707_CR8","unstructured":"Joshi M, Sodhi KS, Pandey R et al (2014) Cancer chemotherapy and hepatotoxicity: an update. J Pharm Res 4:2976\u20132984"},{"key":"10707_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/medicina55020025","volume":"55","author":"G Daug\u0117lait\u0117","year":"2019","unstructured":"Daug\u0117lait\u0117 G, U\u017ekuraityt\u0117 K, Jagelavi\u010dien\u0117 E, Filipauskas A (2019) Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis. Medicina (B. Aires) 55:25\u201338","journal-title":"Medicina (B. Aires)"},{"key":"10707_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.899782","volume":"12","author":"M Zhang","year":"2022","unstructured":"Zhang M, Yang H, Xu C et al (2022) Risk factors for anthracycline-induced cardiotoxicity in breast cancer treatment: a meta-analysis. Front Oncol 12:899782. https:\/\/doi.org\/10.3389\/fonc.2022.899782","journal-title":"Front Oncol"},{"key":"10707_CR11","doi-asserted-by":"crossref","unstructured":"Lazzari G, Montagna A, Andrea BD et al (2024) Breast cancer adjuvant radiotherapy and chemotherapy sequencing: sequential, concomitant, or what else? A comprehensive review of the adjuvant combinations journey. J Clin Med 13:6252","DOI":"10.20944\/preprints202409.0412.v1"},{"key":"10707_CR12","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s12033-023-01032-2","volume":"66","author":"SF Kashani","year":"2024","unstructured":"Kashani SF, Abedini Z, Darehshouri AF, Jazi K, Bereimipour A, Malekraeisi MA, Javanshir HT, Mahmoodzadeh H, Hadjilooei F (2024) Investigation of molecular mechanisms of S-1, docetaxel and cisplatin in gastric cancer with a history of Helicobacter pylori. Infect Mol Biotechnol 66:1303\u20131313","journal-title":"Infect Mol Biotechnol"},{"key":"10707_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0331979","volume":"20","author":"L Wang","year":"2025","unstructured":"Wang L, Zhao H, Yang K et al (2025) Assessing the real-world safety of docetaxel for non-small cell lung cancer: insights from a comprehensive analysis of FAERS data. PLoS One 20:e0331979. https:\/\/doi.org\/10.1371\/journal.pone.0331979","journal-title":"PLoS One"},{"key":"10707_CR14","doi-asserted-by":"crossref","unstructured":"Gupta RK, Stangaciu S (2014) Apitherapy: holistic healing through the honeybee and bee products in countries with poor healthcare system. In: Beekeeping for poverty alleviation and livelihood security. Springer, Dordrecht, pp 413\u2013446","DOI":"10.1007\/978-94-017-9199-1_15"},{"key":"10707_CR15","first-page":"136","volume":"12","author":"AG Hegazi","year":"2012","unstructured":"Hegazi AG (2012) Medical importance of bee products. Uludag Aricilik Derg 12:136\u2013146","journal-title":"Uludag Aricilik Derg"},{"key":"10707_CR16","first-page":"81","volume":"1","author":"A Ahuja","year":"2010","unstructured":"Ahuja A, Ahuja V (2010) Apitherapy\u2013a sweet approach to dental diseases-Part I: honey. J Adv Dent Res Innov 1:81\u201386","journal-title":"J Adv Dent Res Innov"},{"key":"10707_CR17","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3390\/nu15071614","volume":"15","author":"J Moskwa","year":"2023","unstructured":"Moskwa J, Naliwajko SK (2023) Bee products and colorectal cancer\u2014active components and mechanism of action. Nutrients 15:1614\u20131640","journal-title":"Nutrients"},{"key":"10707_CR18","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.acthis.2009.06.001","volume":"112","author":"HS Vatansever","year":"2010","unstructured":"Vatansever HS, Sorkun K, Gurhan SID, Ozdal-Kurt F, Turkoz E, Gencay O, Salih B (2010) Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines. Acta Histochem 112:546\u2013556. https:\/\/doi.org\/10.1016\/j.acthis.2009.06.001","journal-title":"Acta Histochem"},{"key":"10707_CR19","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.etap.2008.01.008","volume":"26","author":"M Motomura","year":"2008","unstructured":"Motomura M, Kwon KM, Suh S-J et al (2008) Propolis induces cell cycle arrest and apoptosis in human leukemic U937 cells through Bcl-2\/Bax regulation. Environ Toxicol Pharmacol 26:61\u201367. https:\/\/doi.org\/10.1016\/j.etap.2008.01.008","journal-title":"Environ Toxicol Pharmacol"},{"key":"10707_CR20","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1248\/bpb.27.727","volume":"27","author":"K Aso","year":"2004","unstructured":"Aso K, Kanno S, Tadano T et al (2004) Inhibitory effect of propolis on the growth of human leukemia U937. Biol Pharm Bull 27:727\u2013730. https:\/\/doi.org\/10.1248\/bpb.27.727","journal-title":"Biol Pharm Bull"},{"key":"10707_CR21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5603\/FHC.2012.0004","volume":"50","author":"D Sawicka","year":"2012","unstructured":"Sawicka D, Car H, Borawska M, Nikli\u0144ski J (2012) The anticancer activity of propolis. Folia Histochem Cytobiol 50:25\u201337. https:\/\/doi.org\/10.5603\/FHC.2012.0004","journal-title":"Folia Histochem Cytobiol"},{"key":"10707_CR22","first-page":"9","volume":"79","author":"MAM Salleh","year":"2017","unstructured":"Salleh MAM, Eshak Z, Ismail WIW (2017) Acacia honey induces apoptosis in human breast adenocarcinoma cell lines (MCF-7). Jurnal Teknol 79:9\u201316","journal-title":"Jurnal Teknol"},{"key":"10707_CR23","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3390\/ijms18030613","volume":"18","author":"S Afrin","year":"2017","unstructured":"Afrin S, Forbes-Hernandez TY, Gasparrini M et al (2017) Strawberry-tree honey induces growth inhibition of human colon cancer cells and increases ROS generation: a comparison with Manuka honey. Int J Mol Sci 18:613\u2013641. https:\/\/doi.org\/10.3390\/ijms18030613","journal-title":"Int J Mol Sci"},{"key":"10707_CR24","doi-asserted-by":"publisher","unstructured":"Ghashm AA, Othman NH, Khattak MN et al (2010) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. BMC Complement Altern Med 10:49\u201356. https:\/\/doi.org\/10.1186\/1472-6882-10-49","DOI":"10.1186\/1472-6882-10-49"},{"key":"10707_CR25","doi-asserted-by":"crossref","unstructured":"Hakim L, Alias E, Makpol S et al (2014) Gelam honey and ginger potentiate the anti cancer effect of 5-FU against HCT 116 colorectal cancer cells. Asian Pacific J Cancer Prev 15:4651\u20134657","DOI":"10.7314\/APJCP.2014.15.11.4651"},{"key":"10707_CR26","doi-asserted-by":"publisher","unstructured":"Waheed M, Hussain MB, Javed A et al (2019) Honey and cancer: a mechanistic review. Clin Nutr 38:2499\u20132503. https:\/\/doi.org\/10.1016\/j.clnu.2018.12.019","DOI":"10.1016\/j.clnu.2018.12.019"},{"key":"10707_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1271\/bbb.60453","volume":"71","author":"M Nakaya","year":"2007","unstructured":"Nakaya M, Onda H, Sasaki K et al (2007) Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Biosci Biotechnol Biochem 71:253\u2013255. https:\/\/doi.org\/10.1271\/bbb.60453","journal-title":"Biosci Biotechnol Biochem"},{"key":"10707_CR28","doi-asserted-by":"publisher","unstructured":"Mohammadi Abandansari R, Parsian H, Kazerouni F et al (2018) Effect of simultaneous treatment with royal jelly and doxorubicin on the survival of the prostate cancer cell line (pc3): an in vitro study. Int J Cancer Manag 11:e13780. https:\/\/doi.org\/10.5812\/ijcm.13780","DOI":"10.5812\/ijcm.13780"},{"key":"10707_CR29","doi-asserted-by":"publisher","unstructured":"Gismondi A, Trionfera E, Canuti L et al (2017) Royal jelly lipophilic fraction induces antiproliferative effects on SH-SY5Y human neuroblastoma cells. Oncol Rep 38:1833\u20131844. https:\/\/doi.org\/10.3892\/or.2017.5851","DOI":"10.3892\/or.2017.5851"},{"key":"10707_CR30","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3390\/toxins13110810","volume":"13","author":"AAA El-Wahed","year":"2021","unstructured":"El-Wahed AAA, Khalifa SAM, Elashal MH et al (2021) Cosmetic applications of bee venom. Toxins (Basel) 13:810\u2013819. https:\/\/doi.org\/10.3390\/toxins13110810","journal-title":"Toxins (Basel)"},{"key":"10707_CR31","doi-asserted-by":"publisher","unstructured":"Khalifa SAM, Elshafiey EH, Shetaia AA et al (2021) Overview of bee pollination and its economic value for crop production. Insects 12:688\u2013703. https:\/\/doi.org\/10.3390\/insects12080688","DOI":"10.3390\/insects12080688"},{"key":"10707_CR32","doi-asserted-by":"crossref","unstructured":"El-Seedi H, Eid N, Abd El-Wahed AA et al (2022) Honey bee products: preclinical and clinical studies of their anti-inflammatory and immunomodulatory properties. Front Nutr 8:761267\u2013761285","DOI":"10.3389\/fnut.2021.761267"},{"key":"10707_CR33","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1080\/14786419.2016.1239088","volume":"31","author":"B Bueno-Silva","year":"2017","unstructured":"Bueno-Silva B, Marsola A, Ikegaki M et al (2017) The effect of seasons on Brazilian red propolis and its botanical source: chemical composition and antibacterial activity. Nat Prod Res 31:1318\u20131324","journal-title":"Nat Prod Res"},{"key":"10707_CR34","doi-asserted-by":"crossref","unstructured":"Anjum SI, Ullah A, Khan KA, et al (2019) Composition and functional properties of propolis (bee glue): a review. Saudi J Biol Sci 26:1695\u20131703","DOI":"10.1016\/j.sjbs.2018.08.013"},{"key":"10707_CR35","doi-asserted-by":"publisher","unstructured":"Elumalai P, Muninathan N, Megalatha ST et al (2022) An insight into anticancer effect of propolis and its constituents: a review of molecular mechanisms. Evidence-based Complement Altern Med 2022:1\u201313. https:\/\/doi.org\/10.1155\/2022\/5901191","DOI":"10.1155\/2022\/5901191"},{"key":"10707_CR36","doi-asserted-by":"crossref","unstructured":"Isidorov VA, Maslowiecka J, Szoka L et al (2022) Chemical composition and biological activity of Argentinian propolis of four species of stingless bees. Molecules 27:7686","DOI":"10.3390\/molecules27227686"},{"key":"10707_CR37","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1007\/s12016-012-8322-2","volume":"44","author":"GC Chan","year":"2013","unstructured":"Chan GC, Cheung K, Sze DM (2013) The immunomodulatory and anticancer properties of propolis. Clin Rev Allergy Immunol 44:262\u2013273. https:\/\/doi.org\/10.1007\/s12016-012-8322-2","journal-title":"Clin Rev Allergy Immunol"},{"key":"10707_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111895","volume":"141","author":"D Campoccia","year":"2021","unstructured":"Campoccia D, Ravaioli S, Santi S et al (2021) Exploring the anticancer effects of standardized extracts of poplar-type propolis: in vitro cytotoxicity toward cancer and normal cell lines. Biomed Pharmacother 141:111895. https:\/\/doi.org\/10.1016\/j.biopha.2021.111895","journal-title":"Biomed Pharmacother"},{"key":"10707_CR39","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jrras.2016.06.001","volume":"9","author":"SA Ebeid","year":"2016","unstructured":"Ebeid SA, Abd El Moneim NA, El-Benhawy SA et al (2016) Assessment of the radioprotective effect of propolis in breast cancer patients undergoing radiotherapy. New perspective for an old honey bee product. J Radiat Res Appl Sci 9:431\u2013440. https:\/\/doi.org\/10.1016\/j.jrras.2016.06.001","journal-title":"J Radiat Res Appl Sci"},{"key":"10707_CR40","doi-asserted-by":"publisher","first-page":"100385","DOI":"10.1016\/j.hermed.2020.100385","volume":"23","author":"N Darvishi","year":"2020","unstructured":"Darvishi N, Yousefinejad V, Akbari ME et al (2020) Antioxidant and anti-inflammatory effects of oral propolis in patients with breast cancer treated with chemotherapy: a randomized controlled trial. J Herb Med 23:100385\u2013100391. https:\/\/doi.org\/10.1016\/j.hermed.2020.100385","journal-title":"J Herb Med"},{"key":"10707_CR41","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.rpor.2020.09.012","volume":"25","author":"F Dastan","year":"2020","unstructured":"Dastan F, Ameri A, Dodge S et al (2020) Efficacy and safety of propolis mouthwash in management of radiotherapy induced oral mucositis; a randomized, double blind clinical trial. Rep Pract Oncol Radiother 25:969\u2013973","journal-title":"Rep Pract Oncol Radiother"},{"key":"10707_CR42","doi-asserted-by":"publisher","first-page":"226","DOI":"10.15171\/joddd.2016.036","volume":"10","author":"H Eslami","year":"2016","unstructured":"Eslami H, Pouralibaba F, Falsafi P et al (2016) Efficacy of Hypozalix spray and propolis mouthwash for prevention of chemotherapy-induced oral mucositis in leukemic patients: a double-blind randomized clinical trial. J Dent Res Dent Clin Dent Prospects 10:226\u2013233. https:\/\/doi.org\/10.15171\/joddd.2016.036","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"10707_CR43","first-page":"3611","volume":"17","author":"MH AkhavanKarbassi","year":"2016","unstructured":"AkhavanKarbassi MH, Yazdi MF, Ahadian H, SadrAbad MJ (2016) Randomized doubleblind placebocontrolled trial of propolis for oral mucositis in patients receiving chemotherapy for head and neck cancer. Asian Pac J Cancer Prev 17:3611\u20133614","journal-title":"Asian Pac J Cancer Prev"},{"key":"10707_CR44","doi-asserted-by":"publisher","DOI":"10.17795\/ijcp-4019","volume":"8","author":"AJ Bolouri","year":"2015","unstructured":"Bolouri AJ, Pakfetrat A, Tonkaboni A et al (2015) Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: a triple-blind, randomized, placebo-controlled trial. Int J Cancer Manag 8:e4019. https:\/\/doi.org\/10.17795\/ijcp-4019","journal-title":"Int J Cancer Manag"},{"key":"10707_CR45","unstructured":"Hamzah MH, Mohamad I, Musa MY et al (2022) Propolis mouthwash for preventing radiotherapy-induced mucositis in patients with nasopharyngeal carcinoma: a randomized control trial. Med J Malaysia 77:462\u2013467"},{"key":"10707_CR46","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12757","volume":"26","author":"M Piredda","year":"2017","unstructured":"Piredda M, Facchinetti G, Biagioli V et al (2017) Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: a pilot randomised controlled trial. Eur J Cancer Care (Engl) 26:e12757. https:\/\/doi.org\/10.1111\/ecc.12757","journal-title":"Eur J Cancer Care (Engl)"},{"key":"10707_CR47","doi-asserted-by":"publisher","first-page":"E255","DOI":"10.1097\/NCC.0000000000001212","volume":"47","author":"S \u00c7akmak","year":"2024","unstructured":"\u00c7akmak S, Nural N (2024) Efficacy of propolis in the prevention of oral mucositis in patients undergoing high-dose chemotherapy. A randomized controlled trial. Cancer Nurs 47:E255-268","journal-title":"Cancer Nurs"},{"key":"10707_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.973255","volume":"13","author":"PM Fernandes","year":"2022","unstructured":"Fernandes PM, Rosalen PL, Fernandes DT et al (2022) Brazilian organic propolis for prevention and treatment of radiation-related oral acute toxicities in head and neck cancer patients: A double-blind randomized clinical trial. Front Pharmacol 13:973255. https:\/\/doi.org\/10.3389\/fphar.2022.973255","journal-title":"Front Pharmacol"},{"key":"10707_CR49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41405-021-00068-3","volume":"7","author":"R Nakao","year":"2021","unstructured":"Nakao R, Ueno T (2021) Effects of oral moisturizing gel containing propolis following head and neck radiotherapy: Randomized controlled pilot trial. BDJ Open 7:12\u201318. https:\/\/doi.org\/10.1038\/s41405-021-00068-3","journal-title":"BDJ Open"},{"key":"10707_CR50","doi-asserted-by":"publisher","unstructured":"Zheng Y-Z, Deng G, Liang Q et al (2017) Antioxidant activity of quercetin and its glucosides from propolis: a theoretical study. Sci Rep 7:7543\u20137555. https:\/\/doi.org\/10.1038\/s41598-017-08024-8","DOI":"10.1038\/s41598-017-08024-8"},{"key":"10707_CR51","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jep.2013.06.004","volume":"149","author":"MC B\u00fafalo","year":"2013","unstructured":"B\u00fafalo MC, Ferreira I, Costa G et al (2013) Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-\u03baB and MAPK activation in macrophages. J Ethnopharmacol 149:84\u201392. https:\/\/doi.org\/10.1016\/j.jep.2013.06.004","journal-title":"J Ethnopharmacol"},{"key":"10707_CR52","doi-asserted-by":"publisher","first-page":"359","DOI":"10.2174\/1574884709666140205210051","volume":"9","author":"V Noronha","year":"2014","unstructured":"Noronha V, Araujo G, Gomes R et al (2014) Mucoadhesive propolis gel for prevention of radiation-induced oral mucositis. Curr Clin Pharmacol 9:359\u2013364. https:\/\/doi.org\/10.2174\/1574884709666140205210051","journal-title":"Curr Clin Pharmacol"},{"key":"10707_CR53","doi-asserted-by":"publisher","unstructured":"Kooshyar MM, Mozafari PM, Amirchaghmaghi M et al (2017) A randomized placebo-controlled double blind clinical trial of quercetin in the prevention and treatment of chemotherapy-induced oral mucositis. J Clin Diagnostic Res 11:46\u201350. https:\/\/doi.org\/10.7860\/JCDR\/2017\/23975.9571","DOI":"10.7860\/JCDR\/2017\/23975.9571"},{"key":"10707_CR54","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1080\/01635581.2021.1988118","volume":"74","author":"SH Davoodi","year":"2022","unstructured":"Davoodi SH, Yousefinejad V, Ghaderi B et al (2022) Oral propolis, nutritional status and quality of life with chemotherapy for breast cancer: A randomized, double-blind clinical trial. Nutr Cancer 74:2029\u20132037. https:\/\/doi.org\/10.1080\/01635581.2021.1988118","journal-title":"Nutr Cancer"},{"key":"10707_CR55","unstructured":"Trial C The effect of honey on xerostomia and oral mucositis (AC-H). https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01465308 Accessed 14 August 2022"},{"key":"10707_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252111724","volume":"25","author":"S Martinotti","year":"2024","unstructured":"Martinotti S, Bonsignore G, Ranzato E (2024) Understanding the anticancer properties of honey. Int J Mol Sci 25:11724","journal-title":"Int J Mol Sci"},{"key":"10707_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.focha.2024.100731","volume":"4","author":"RJ Mongi","year":"2024","unstructured":"Mongi RJ (2024) Influence of botanical origin and geographical zones on physicochemical properties, mineral contents and consumer acceptance of honey in Tanzania. Food Chem Adv 4:100731. https:\/\/doi.org\/10.1016\/j.focha.2024.100731","journal-title":"Food Chem Adv"},{"key":"10707_CR58","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/MJT.0b013e318293b09b","volume":"21","author":"ZH Israili","year":"2014","unstructured":"Israili ZH (2014) Antimicrobial properties of honey. Am J Ther 21:304\u2013323","journal-title":"Am J Ther"},{"key":"10707_CR59","doi-asserted-by":"publisher","first-page":"913","DOI":"10.7150\/ijbs.3697","volume":"8","author":"OO Erejuwa","year":"2012","unstructured":"Erejuwa OO, Sulaiman SA, Wahab MSA (2012) Honey-a novel antidiabetic agent. Int J Biol Sci 8:913\u2013934. https:\/\/doi.org\/10.7150\/ijbs.3697","journal-title":"Int J Biol Sci"},{"key":"10707_CR60","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/829070","volume":"2013","author":"S Ahmed","year":"2013","unstructured":"Ahmed S, Othman NH (2013) Honey as a potential natural anticancer agent: a review of its mechanisms. Evid Based Complement Altern Med 2013:829070. https:\/\/doi.org\/10.1155\/2013\/829070","journal-title":"Evid Based Complement Altern Med"},{"key":"10707_CR61","doi-asserted-by":"publisher","unstructured":"da Silva IAA, da Silva TMS, Camara CA et al (2013) Phenolic profile, antioxidant activity and palynological analysis of stingless bee honey from Amazonas, Northern Brazil. Food Chem 141:3552\u20133558. https:\/\/doi.org\/10.1016\/j.foodchem.2013.06.072","DOI":"10.1016\/j.foodchem.2013.06.072"},{"key":"10707_CR62","doi-asserted-by":"crossref","unstructured":"Khurshid A, Saeed A, H\u00f6kelek T et al (2022) Experimental and hirshfeld surface investigations for unexpected aminophenazone cocrystal formation under thiourea reaction conditions via possible enamine assisted rearrangement. Crystals 12:608\u2013631","DOI":"10.3390\/cryst12050608"},{"key":"10707_CR63","doi-asserted-by":"publisher","unstructured":"EL-Kholy WM, Hassan HA, Nour SE et al (2009)\u00a0Hepatoprotective effects of Nigella sativa and bees\u2019 honey on hepatotoxicity induced by administration of sodium nitrite and sunset yellow.\u00a0Faseb J 23:733.2-733.2. https:\/\/doi.org\/10.1096\/fasebj.23.1_supplement.733.2","DOI":"10.1096\/fasebj.23.1_supplement.733.2"},{"key":"10707_CR64","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.19082\/2475","volume":"8","author":"B Mofid","year":"2016","unstructured":"Mofid B, Rezaeizadeh H, Termos A et al (2016) Effect of processed honey and royal jelly on cancer-related fatigue: a double-blind randomized clinical trial. Electron Physician 8:2475\u20132482. https:\/\/doi.org\/10.19082\/2475","journal-title":"Electron Physician"},{"key":"10707_CR65","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3109\/08880018.2012.669026","volume":"29","author":"M Abdulrhman","year":"2012","unstructured":"Abdulrhman M, Samir El Barbary N, Ahmed Amin D, Saeid Ebrahim R (2012) Honey and a mixture of honey, beeswax, and olive oilpropolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol 29:285\u2013292. https:\/\/doi.org\/10.3109\/08880018.2012.669026","journal-title":"Pediatr Hematol Oncol"},{"key":"10707_CR66","doi-asserted-by":"publisher","unstructured":"Raeessi MA, Raeessi N, Panahi Y et al (2014) \u201cCoffee plus honey\u201d versus \u201ctopical steroid\u201d in the treatment of chemotherapy-induced oral mucositis: a randomised controlled trial. BMC Complement Altern Med 14:293. https:\/\/doi.org\/10.1186\/1472-6882-14-293","DOI":"10.1186\/1472-6882-14-293"},{"key":"10707_CR67","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/02841860600781799","volume":"45","author":"M Moolenaar","year":"2006","unstructured":"Moolenaar M, Louwrens Poorter R, Van Der Toorn PPG et al (2006) The effect of honey compared to conventional treatment on healing of radiotherapy-induced skin toxicity in breast cancer patients [2]. Acta Oncol (Madr) 45:623\u2013624. https:\/\/doi.org\/10.1080\/02841860600781799","journal-title":"Acta Oncol (Madr)"},{"key":"10707_CR68","doi-asserted-by":"publisher","unstructured":"Charalambous M, Raftopoulos V, Paikousis L et al (2018) The effect of the use of thyme honey in minimizing radiation-induced oral mucositis in head and neck cancer patients: a randomized controlled trial. Eur J Oncol Nurs 34:89\u201397. https:\/\/doi.org\/10.1016\/j.ejon.2018.04.003","DOI":"10.1016\/j.ejon.2018.04.003"},{"key":"10707_CR69","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ctim.2016.09.018","volume":"29","author":"H Kobya Bulut","year":"2016","unstructured":"Kobya Bulut H, G\u00fcd\u00fcc\u00fc T\u00fcfekci F (2016) Honey prevents oral mocositis in children undergoing chemotherapy: a quasi-experimental study with a control group. Complement Ther Med 29:132\u2013140. https:\/\/doi.org\/10.1016\/j.ctim.2016.09.018","journal-title":"Complement Ther Med"},{"key":"10707_CR70","unstructured":"Clinical trial. Therapeutic effect of luteolin natural extract versus its nanoparticles on tongue squamous cell carcinoma cell line. https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03288298 Accessed 14 Aug 2022"},{"key":"10707_CR71","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1039\/c8fo00164b","volume":"9","author":"S Afrin","year":"2018","unstructured":"Afrin S, Giampieri F, Gasparrini M et al (2018) The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. Food Funct 9:2145\u20132157. https:\/\/doi.org\/10.1039\/c8fo00164b","journal-title":"Food Funct"},{"key":"10707_CR72","doi-asserted-by":"crossref","unstructured":"Spilioti E, Jaakkola M, Tolonen T et al (2014) Phenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece. PLoS One 9:e94860","DOI":"10.1371\/journal.pone.0094860"},{"key":"10707_CR73","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.1111\/ijfs.14253","volume":"54","author":"P Hempattarasuwan","year":"2019","unstructured":"Hempattarasuwan P, Settachaimongkon S, Duangmal K (2019) Impact of botanical source and processing conditions on physicochemical properties and antioxidant activity of honey in the northern part of Thailand. Int J Food Sci Technol 54:3185\u20133195. https:\/\/doi.org\/10.1111\/ijfs.14253","journal-title":"Int J Food Sci Technol"},{"key":"10707_CR74","unstructured":"Shehata IAA (2016) The evaluation of phenolic constituents as markers to differentiate between clover and alfalfa honeys collected from different regions of Egypt. Middle East J Appl Sci 6:610\u2013615"},{"key":"10707_CR75","doi-asserted-by":"publisher","unstructured":"Motallebnejad M, Akram S, Moghadamnia A et al (2008) The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract 9:40\u201347. https:\/\/doi.org\/10.5005\/jcdp-9-3-40","DOI":"10.5005\/jcdp-9-3-40"},{"key":"10707_CR76","doi-asserted-by":"publisher","unstructured":"Bardy J, Molassiotis A, Ryder WD et al (2012) A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg 50:221\u2013226. https:\/\/doi.org\/10.1016\/j.bjoms.2011.03.005","DOI":"10.1016\/j.bjoms.2011.03.005"},{"key":"10707_CR77","unstructured":"Ebrahimi M, Allahyari A, Ebrahimi M et al (2016) Effects of dietary honey andardehcombination on chemotherapy-induced gastrointestinal and infectious complications in patients with acute myeloid leukemia: a double-blind randomized clinical trial. Iran J Pharm Res IJPR 15:661\u2013668"},{"key":"10707_CR78","doi-asserted-by":"publisher","unstructured":"Cho HK, Jeong YM, Lee HS et al (2015) Effects of honey on oral mucositis in patients with head and neck cancer: a meta-analysis. Laryngoscope 125:2085\u20132092. https:\/\/doi.org\/10.1002\/lary.25233","DOI":"10.1002\/lary.25233"},{"key":"10707_CR79","doi-asserted-by":"publisher","unstructured":"Co JL, Mejia MBA, Que JC, Dizon JMR (2014) Effectiveness of honey on radiation\u2010induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: a meta\u2010analysis and systematic review of literature. Head Neck 36:1119\u20131128. https:\/\/doi.org\/10.1002\/HED","DOI":"10.1002\/HED"},{"key":"10707_CR80","doi-asserted-by":"publisher","unstructured":"Yang C, Gong G, Jin E et al (2019) Topical application of honey in the management of chemo\/radiotherapy-induced oral mucositis: a systematic review and network meta-analysis. Int J Nurs Stud 89:80\u201387. https:\/\/doi.org\/10.1016\/j.ijnurstu.2018.08.007","DOI":"10.1016\/j.ijnurstu.2018.08.007"},{"key":"10707_CR81","doi-asserted-by":"publisher","unstructured":"Lima ICG da S, de F\u00e1tima Souto Maior L, Gueiros LAM et al (2021) Clinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis. Clin Oral Investig 25:4115\u20134124. https:\/\/doi.org\/10.1007\/s00784-020-03743-1","DOI":"10.1007\/s00784-020-03743-1"},{"key":"10707_CR82","unstructured":"Clinical trial. The use of candy and honey in decreasing salivary gland damage following radioiodine therapy for thyroid cancer. https:\/\/www.clinicaltrials.gov\/ct2\/show\/study\/NCT01833650\u00a0 Accessed 14 Aug 2022"},{"key":"10707_CR83","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.ijrobp.2016.11.022","volume":"97","author":"SE Fogh","year":"2017","unstructured":"Fogh SE, Deshmukh S, Berk LB et al (2017) A randomized phase 2 trial of prophylactic Manuka honey for the reduction of chemoradiation therapy\u2013induced esophagitis during the treatment of lung cancer: results of NRG Oncology RTOG 1012. Int J Radiat Oncol Biol Phys 97:786\u2013796. https:\/\/doi.org\/10.1016\/j.ijrobp.2016.11.022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10707_CR84","unstructured":"Clinical trial. Manuka honey in preventing esophagitis-related pain in patients receiving chemotherapy and radiation therapy for lung cancer. https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01262560 Accessed 14 Aug 2022"},{"key":"10707_CR85","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s00520-013-2031-0","volume":"22","author":"P Hawley","year":"2014","unstructured":"Hawley P, Hovan A, McGahan CE, Saunders D (2014) A randomized placebo-controlled trial of Manuka honey for radiation-induced oral mucositis. Support Care Cancer 22:751\u2013761. https:\/\/doi.org\/10.1007\/s00520-013-2031-0","journal-title":"Support Care Cancer"},{"key":"10707_CR86","unstructured":"Clinical trial. A randomized placebo-controlled trial of manuka honey for oral mucositis due to radiation therapy for cancer. https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00615420 Accessed 14 August 2022"},{"key":"10707_CR87","unstructured":"Clinical trial. The effect of honey on xerostomia and oral mucositis (AC-H). https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01465308 Accessed 14 Aug 2022"},{"key":"10707_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejon.2017.01.001","volume":"27","author":"A Charalambous","year":"2017","unstructured":"Charalambous A, Lambrinou E, Katodritis N et al (2017) The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: a\u00a0feasibility randomized control trial. Eur J Oncol Nurs 27:1\u20138. https:\/\/doi.org\/10.1016\/j.ejon.2017.01.001","journal-title":"Eur J Oncol Nurs"},{"key":"10707_CR89","unstructured":"Clinical trial. The effects of honey on febrile neutropenia in children with acute lymphoblastic leukemia. https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02272673 Accessed 14 Aug 2022"},{"key":"10707_CR90","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ctim.2016.01.009","volume":"25","author":"M Abdulmaksoud","year":"2016","unstructured":"Abdulmaksoud M, Alsaeed A, Abdelmaksoud S et al (2016) Effect of honey on febrile neutropenia in children with acute lymphoblastic leukemia: a randomized crossover open-labeled study. Complement Ther Med 25:98\u2013103. https:\/\/doi.org\/10.1016\/j.ctim.2016.01.009","journal-title":"Complement Ther Med"},{"key":"10707_CR91","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.ijom.2010.05.014","volume":"39","author":"B Khanal","year":"2010","unstructured":"Khanal B, Baliga M, Uppal N (2010) Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg 39:1181\u20131185. https:\/\/doi.org\/10.1016\/j.ijom.2010.05.014","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10707_CR92","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5861024","volume":"2017","author":"SK Al Jaouni","year":"2017","unstructured":"Al Jaouni SK, Al Muhayawi MS, Hussein A et al (2017) Effects of honey on oral mucositis among pediatric cancer patients undergoing chemo\/radiotherapy treatment at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia. Evid Based Complement Alternat Med 2017:5861024. https:\/\/doi.org\/10.1155\/2017\/5861024","journal-title":"Evid Based Complement Alternat Med"},{"key":"10707_CR93","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1017\/S0022215108002478","volume":"123","author":"UM Rashad","year":"2009","unstructured":"Rashad UM, Al-Gezawy SM, El-Gezawy E, Azzaz AN (2009) Honey as topical prophylaxis against radiochemotherapy-induced mucositis in head and neck cancer. J Laryngol Otol 123:223\u2013228. https:\/\/doi.org\/10.1017\/S0022215108002478","journal-title":"J Laryngol Otol"},{"key":"10707_CR94","doi-asserted-by":"publisher","unstructured":"Khanjani pour-fard-pachekenari A, Rahmani A, Ghahramanian A et al (2019) The effect of an oral care protocol and honey mouthwash on mucositis in acute myeloid leukemia patients undergoing chemotherapy: a single-blind clinical trial. Clin Oral Investig 23:1811\u20131821. https:\/\/doi.org\/10.1007\/s00784-018-2621-9","DOI":"10.1007\/s00784-018-2621-9"},{"key":"10707_CR95","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s00520-003-0443-y","volume":"11","author":"BM Biswal","year":"2003","unstructured":"Biswal BM, Zakaria A, Ahmad NM (2003) Topical application of honey in the management of radiation mucositis. A preliminary study. Support Care Cancer 11:242\u2013248. https:\/\/doi.org\/10.1007\/s00520-003-0443-y","journal-title":"Support Care Cancer"},{"key":"10707_CR96","doi-asserted-by":"publisher","first-page":"268","DOI":"10.4103\/0973-1075.164892","volume":"21","author":"S Samdariya","year":"2015","unstructured":"Samdariya S, Lewis S, Kauser H, Ahmed I (2015) A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients. ndian J Palliat Care 21:268\u2013273. https:\/\/doi.org\/10.4103\/0973-1075.164892","journal-title":"ndian J Palliat Care"},{"key":"10707_CR97","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116023","volume":"25","author":"N Or\u0161oli\u0107","year":"2024","unstructured":"Or\u0161oli\u0107 N, Jazvin\u0161\u0107ak Jembrek M (2024) Royal jelly: biological action and health benefits. Int J Mol Sci 25:6023. https:\/\/doi.org\/10.3390\/ijms25116023","journal-title":"Int J Mol Sci"},{"key":"10707_CR98","doi-asserted-by":"crossref","unstructured":"Xue X, Wu L, Wang K (2017) Chemical composition of royal jelly BT-bee products-chemical and biological properties. In: Alvarez-Suarez JM (ed). Springer International Publishing, Cham, pp 181\u2013190","DOI":"10.1007\/978-3-319-59689-1_8"},{"key":"10707_CR99","doi-asserted-by":"publisher","DOI":"10.1080\/23311932.2024.2348253","volume":"10","author":"F Khalfan Saeed Alwali Alkindi","year":"2024","unstructured":"Khalfan Saeed Alwali Alkindi F, El-Keblawy A, Lamghari Ridouane F, Bano Mirza S (2024) Factors influencing the quality of royal jelly and its components: a review. Cogent Food Agric 10:2348253. https:\/\/doi.org\/10.1080\/23311932.2024.2348253","journal-title":"Cogent Food Agric"},{"key":"10707_CR100","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.biopha.2018.07.089","volume":"106","author":"RS Almeer","year":"2018","unstructured":"Almeer RS, Alarifi S, Alkahtani S et al (2018) The potential hepatoprotective effect of royal jelly against cadmium chloride-induced hepatotoxicity in mice is mediated by suppression of oxidative stress and upregulation of Nrf2 expression. Biomed Pharmacother 106:1490\u20131498. https:\/\/doi.org\/10.1016\/j.biopha.2018.07.089","journal-title":"Biomed Pharmacother"},{"key":"10707_CR101","doi-asserted-by":"publisher","unstructured":"Hattori N, Ohta S, Sakamoto T et al (2011) Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated mice. Evidence-based Complement Altern Med 2011:26. https:\/\/doi.org\/10.1093\/ecam\/nep029","DOI":"10.1093\/ecam\/nep029"},{"key":"10707_CR102","doi-asserted-by":"publisher","first-page":"e105073","DOI":"10.1371\/journal.pone.0105073","volume":"9","author":"Y Kashima","year":"2014","unstructured":"Kashima Y, Kanematsu S, Asai S et al (2014) Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly. PLoS One 9:e105073\u2013e105084. https:\/\/doi.org\/10.1371\/journal.pone.0105073","journal-title":"PLoS One"},{"key":"10707_CR103","doi-asserted-by":"publisher","first-page":"11447","DOI":"10.1021\/jf802494e","volume":"56","author":"J-R Liu","year":"2008","unstructured":"Liu J-R, Yang Y-C, Shi L-S, Peng C-C (2008) Antioxidant properties of royal jelly associated with larval age and time of harvest. J Agric Food Chem 56:11447\u201311452. https:\/\/doi.org\/10.1021\/jf802494e","journal-title":"J Agric Food Chem"},{"key":"10707_CR104","doi-asserted-by":"publisher","unstructured":"Guo J, Wang Z, Chen Y et al (2021) Active components and biological functions of royal jelly. J Funct Foods 82:104514. https:\/\/doi.org\/10.1016\/j.jff.2021.104514","DOI":"10.1016\/j.jff.2021.104514"},{"key":"10707_CR105","doi-asserted-by":"publisher","unstructured":"Miyata Y, Araki K, Ohba K et al (2020) Oral intake of royal jelly improves anti\u2011cancer effects and suppresses adverse events of molecular targeted therapy by regulating TNF\u2011&alpha; and TGF\u2011&beta; in renal cell carcinoma: a preliminary study based on a randomized double\u2011blind clinical trial Cor. Mol Clin Oncol 13:29\u201336. https:\/\/doi.org\/10.3892\/mco.2020.2099","DOI":"10.3892\/mco.2020.2099"},{"key":"10707_CR106","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/974967","volume":"2014","author":"K Yamauchi","year":"2014","unstructured":"Yamauchi K, Kogashiwa Y, Moro Y, Kohno N (2014) Effect of topical application of royal jelly on chemoradiotherapy-induced mucositis in head and neck cancer: a preliminary study. Int J Otolaryngol 2014:974967. https:\/\/doi.org\/10.1155\/2014\/974967","journal-title":"Int J Otolaryngol"},{"key":"10707_CR107","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/medicines6010002","volume":"6","author":"K Araki","year":"2018","unstructured":"Araki K, Miyata Y, Ohba K et al (2018) Oral intake of royal jelly has protective effects against tyrosine kinase inhibitor-induced toxicity in patients with renal cell carcinoma: a randomized, double-blinded, placebo-controlled trial. Medicines (Basel) 6:2\u201312. https:\/\/doi.org\/10.3390\/medicines6010002","journal-title":"Medicines (Basel)"},{"key":"10707_CR108","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/HNP.0000000000000033","volume":"28","author":"\u00d6 Erdem","year":"2014","unstructured":"Erdem \u00d6, G\u00fcng\u00f6rm\u00fc\u015f Z (2014) The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. Holist Nurs Pract 28:242\u2013246. https:\/\/doi.org\/10.1097\/HNP.0000000000000033","journal-title":"Holist Nurs Pract"},{"key":"10707_CR109","first-page":"43","volume":"8","author":"T Yuno","year":"2020","unstructured":"Yuno T, Miyata Y, Mukae Y et al (2020) Mechanisms underlying the inhibition of tyrosine kinase inhibitor-induced anorexia and fatigue by royal jelly in renal cell carcinoma patients and the correlation between macrophage colony stimulating factor and inflammatory mediator. Med Sci (Basel) 8:43\u201353","journal-title":"Med Sci (Basel)"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10707-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10707-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10707-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:28:40Z","timestamp":1781058520000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10707-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":109,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10707"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10707-w","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"27 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"505"}}