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Participants were allocated to either CCP or CCP plus a home-based functional Effort Re-education Programme. Functionality (Barthel Index) was the primary outcome. Secondary outcomes included dyspnoea severity (mMRC), general performance status (ECOG), and caregiver burden (Zarit scale). Assessments were performed at discharge (baseline), 15\u00a0days, and one month post-discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients receiving ERP showed significantly greater improvements in functionality compared with the control group (mean change:\u2009+\u200920.3 vs.\u2009+\u20096.6 points; p\u2009&lt;\u20090.001). Significant between-group differences were also observed for dyspnoea (p\u2009=\u20090.002), performance status (p\u2009&lt;\u20090.001), and caregiver burden (p\u2009&lt;\u20090.001). No hospital readmissions were recorded in the intervention group during follow-up. Length of hospital stay was shorter in the intervention group prior to discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A home-based Effort Re-education Programme initiated at hospital discharge significantly improves functional outcomes, respiratory symptoms, and caregiver burden in oncology patients, supporting its integration into discharge planning and continuity-of-care models.<\/jats:p>\n                    <jats:p>The clinical trial was registered in ClinicalTrials.gov (NCT06035263). Registration Date: 2023\u201311-01; 04:11\u00a0h.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10725-8","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:52:23Z","timestamp":1777495943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a Functional Intervention with Home Follow-Up on Respiratory Symptoms and Functionality in Oncology Patients: A Randomised Clinical Trial"],"prefix":"10.1007","volume":"34","author":[{"given":"Eduado J.","family":"Fernandez-Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Sanchez-Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Fonseca-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Rihuete-Galve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jes\u00fas Cruz","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"8","key":"10725_CR1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/jnci\/84.8.575","volume":"84","author":"E Tchekmedyian","year":"1992","unstructured":"Tchekmedyian E, Gotay CC, Korn EL, McCabe MS, Moore TD, Cheson BD (1992) Quality-of-life assessment in cancer treatment protocols: research issues in protocol development. 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