{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:58:55Z","timestamp":1781060335176,"version":"3.54.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00520-026-10731-w","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:01:54Z","timestamp":1778122914000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of novel systemic cancer therapies on osseointegration and dental implant outcomes: a systematic review"],"prefix":"10.1007","volume":"34","author":[{"given":"Gunjan","family":"Chouksey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpana","family":"Parihar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"10731_CR1","first-page":"10","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025. CA Cancer J Clin 75:10","journal-title":"CA Cancer J Clin"},{"key":"10731_CR2","volume":"27","author":"B Garc\u00eda-Ch\u00edas","year":"2019","unstructured":"Garc\u00eda-Ch\u00edas B, Figuero E, Castelo-Fern\u00e1ndez B, Cebri\u00e1n-Carretero JL, Cerero-Lapiedra R (2019) Prevalence of oral side effects of chemotherapy and its relationship with periodontal risk: a cross-sectional study. Support Care Cancer 27:3479","journal-title":"Support Care Cancer"},{"key":"10731_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s40729-021-00373-4","volume":"7","author":"E Schiegnitz","year":"2021","unstructured":"Schiegnitz E, M\u00fcller LK, Sagheb K, Theis L, Cagiran V, K\u00e4mmerer PW et al (2021) Clinical long-term and patient-reported outcomes of dental implants in oral cancer patients. Int J Implant Dent 7:93","journal-title":"Int J Implant Dent"},{"key":"10731_CR4","volume":"10","author":"J Paul","year":"2024","unstructured":"Paul J, Mitchell AP, Kesselheim AS, Rome BN (2024) Overlapping and non-overlapping indications for checkpoint inhibitors in the US. JAMA Oncol 10:e241234","journal-title":"JAMA Oncol"},{"key":"10731_CR5","doi-asserted-by":"publisher","first-page":"738","DOI":"10.3390\/cancers12030738","volume":"12","author":"RK Vaddepally","year":"2020","unstructured":"Vaddepally RK, Kharel P, Pandey R, Garje R, Chandra AB (2020) Review of indications of FDA-approved immune checkpoint inhibitors per NCCN guidelines with the level of evidence. Cancers (Basel) 12:738","journal-title":"Cancers (Basel)"},{"key":"10731_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113365","volume":"143","author":"MA Hossain","year":"2024","unstructured":"Hossain MA (2024) A comprehensive review of immune checkpoint inhibitors for cancer treatment. Int Immunopharmacol 143:113365","journal-title":"Int Immunopharmacol"},{"key":"10731_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1307860","volume":"14","author":"L Wang","year":"2024","unstructured":"Wang L, Liu WQ, Broussy S, Han B, Fang H (2024) Recent advances of anti-angiogenic inhibitors targeting VEGF\/VEGFR axis. Front Pharmacol 14:1307860","journal-title":"Front Pharmacol"},{"key":"10731_CR8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.2174\/2772432817666220607114559","volume":"19","author":"A Mohammadi","year":"2024","unstructured":"Mohammadi A, Dehkordi NR, Mahmoudi S, Rafeie N, Sabri H, Valizadeh M et al (2024) Effects of drugs and chemotherapeutic agents on dental implant osseointegration: a narrative review. Curr Rev Clin Exp Pharmacol 19:42","journal-title":"Curr Rev Clin Exp Pharmacol"},{"key":"10731_CR9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71","journal-title":"BMJ"},{"key":"10731_CR10","doi-asserted-by":"publisher","unstructured":"Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, Currie M, Qureshi R, Mattis P, Lisy K, Mu P-F (2020) Systematic reviews of etiology and risk. In Aromataris\u00a0E, Munn\u00a0Z (Eds.), JBI Manual for evidence synthesis. Adelaide, Australia: Joanna Briggs Institute. https:\/\/doi.org\/10.46658\/JBIMES-20-08","DOI":"10.46658\/JBIMES-20-08"},{"key":"10731_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1902\/cap.2016.160050","volume":"7","author":"DR Dixon","year":"2017","unstructured":"Dixon DR, Yassin A (2017) Oral effects and early implant survival results after imatinib discontinuation therapy for chronic myelogenous leukemia: a case report. Clin Adv Periodontics 7:115","journal-title":"Clin Adv Periodontics"},{"key":"10731_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-019-0188-0","volume":"5","author":"G Maluf","year":"2019","unstructured":"Maluf G, Caldas RJ, Fregnani ER, da Silva Santos PS (2019) A rare case of bevacizumab-related osteonecrosis of the jaw associated with dental implants. Int J Implant Dent 5:34","journal-title":"Int J Implant Dent"},{"key":"10731_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8093293","volume":"2020","author":"F Bennardo","year":"2020","unstructured":"Bennardo F, Buffone C, Muraca D, Antonelli A, Giudice A (2020) Medication-related osteonecrosis of the jaw with spontaneous hemimaxilla exfoliation: report of a case in metastatic renal cancer patient under multidrug therapy. Case Rep Med 2020:8093293","journal-title":"Case Rep Med"},{"key":"10731_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6141493","volume":"2020","author":"E Emami","year":"2020","unstructured":"Emami E, de Grandmont P, Menassa M, Audy N, Durand R (2020) Anti-vascular endothelial growth factors as a potential risk for implant failure: a clinical report. Case Rep Med 2020:6141493","journal-title":"Case Rep Med"},{"key":"10731_CR15","doi-asserted-by":"publisher","first-page":"111","DOI":"10.11607\/ijp.6329","volume":"33","author":"K Morita","year":"2020","unstructured":"Morita K, Tsuka H, Kuremoto KC, Tsuga K (2020) Oral implant treatment for a patient undergoing molecularly targeted drug therapy for chronic myelocytic leukemia: a case report. Int J Prosthodont 33:111","journal-title":"Int J Prosthodont"},{"key":"10731_CR16","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1563\/aaid-joi-D-21-00155","volume":"48","author":"N Ueda","year":"2022","unstructured":"Ueda N, Imada M, Kato Y, Okuda N, Nakaue K, Horita S et al (2022) Bevacizumab-associated implant presence-triggered osteonecrosis: a case report and literature review. J Oral Implantol 48:325","journal-title":"J Oral Implantol"},{"key":"10731_CR17","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/aej.12893","volume":"50","author":"AC Rocha","year":"2024","unstructured":"Rocha AC, Mota ME, Lima RC, Pereira NF, Alves FA, Moreira MS (2024) Peri-implant medication-related osteonecrosis of the jaw mimicking endodontic disease in a cancer patient: a case report. Aust Endod J 50:709","journal-title":"Aust Endod J"},{"key":"10731_CR18","unstructured":"Thomson RJ, Moshirfar M, Ronquillo Y (2025) Tyrosine kinase inhibitors. In: StatPearls [Internet]. Treasure Island (FL). StatPearls Publishing"},{"issue":"3","key":"10731_CR19","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.taap.2015.10.008","volume":"289","author":"CP Liao","year":"2015","unstructured":"Liao CP, Prabhu KS, Paulson RF, Jollow DJ (2015) Adverse impacts of tyrosine kinase inhibitors on wound healing and angiogenesis. Toxicol Appl Pharmacol 289(3):474\u2013484. https:\/\/doi.org\/10.1016\/j.taap.2015.10.008","journal-title":"Toxicol Appl Pharmacol"},{"key":"10731_CR20","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.biopha.2018.02.056","volume":"100","author":"B Al-Jandan","year":"2018","unstructured":"Al-Jandan B, Marei HF, Abuohashish H, Zakaria O, Al-Mahalawy H (2018) Effects of sunitinib targeted chemotherapy on the osseointegration of titanium implants. Biomed Pharmacother 100:433","journal-title":"Biomed Pharmacother"},{"key":"10731_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12424","volume":"42","author":"A Al Subaie","year":"2015","unstructured":"Al Subaie A, Eimar H, Abdallah MN, Durand R, Feine J, Tamimi F, Emami E (2015) Anti-VEGFs hinder bone healing and implant osseointegration in rat tibiae. J Clin Periodontol 42:688","journal-title":"J Clin Periodontol"},{"key":"10731_CR22","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bone.2016.06.013","volume":"91","author":"K Hu","year":"2016","unstructured":"Hu K, Olsen BR (2016) The roles of vascular endothelial growth factor in bone repair and regeneration. Bone 91:30\u201338. https:\/\/doi.org\/10.1016\/j.bone.2016.06.013","journal-title":"Bone"},{"issue":"8Suppl","key":"10731_CR23","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1600-051X.2008.01274.x","volume":"35","author":"NU Zitzmann","year":"2008","unstructured":"Zitzmann NU, Berglundh T (2008) Definition and prevalence of peri\u2010implant diseases. J Clin Periodontol 35(8Suppl):286\u2013291. https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01274.x","journal-title":"J Clin Periodontol"},{"issue":"9","key":"10731_CR24","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/ni.3535","volume":"7","author":"A Terashima","year":"2016","unstructured":"Terashima A, Okamoto K, Nakashima T, Akira S, Takayanagi H (2016) Sepsis-induced osteoblast ablation causes immunodeficiency. Nat Immunol 7(9):1043\u20131053. https:\/\/doi.org\/10.1038\/ni.3535","journal-title":"Nat Immunol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10731-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10731-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10731-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:29:29Z","timestamp":1781058569000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10731-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10731"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10731-w","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"1 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This study is a systematic review of previously published literature and did not involve any direct interaction with human participants, human tissue, or identifiable personal data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"511"}}