{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:54:32Z","timestamp":1791741272851,"version":"4.3.4"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Sleep disturbance (\u201cinsomnia\u201d) is common in patients with advanced cancer receiving specialist palliative care. The aim of this scoping review was to determine the clinical relevance of sleep disturbance in this cohort of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Standard methodology was employed, and four databases were searched from inception (Medline, CINAHL, Embase, and APA PsycInfo). Hand searching of relevant sources was also undertaken. Included studies needed to have a sleep focus, and to utilise a validated sleep assessment tool (and\/or objective measure of sleep quality).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen studies met the criteria for inclusion. The studies highlight that sleep disturbance is associated with a range of physical symptoms (e.g. fatigue, drowsiness), a variety of psychological problems (e.g. anxiety, depression), impaired quality of life, and reduced overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sleep disturbance is an \u201corphan\u201d symptom, and the results of this scoping review suggest that it deserves much greater attention. Indeed, healthcare professionals should screen all palliative care patients for the problem and, when identified, perform a thorough assessment and initiate an appropriate treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10738-3","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:55:08Z","timestamp":1778183708000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The clinical relevance of sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer receiving palliative care: a scoping review"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2918-287X","authenticated-orcid":false,"given":"Shauna","family":"Munir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-0641","authenticated-orcid":false,"given":"Eva","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0834-5372","authenticated-orcid":false,"given":"Faith Precious","family":"Omeokwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4207-4799","authenticated-orcid":false,"given":"Andrew Neil","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"10738_CR1","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2023","unstructured":"American Academy of Sleep Medicine (2023) International classification of sleep disorders, 3rd ed, text revision. American Academy of Sleep Medicine, Darien, IL","edition":"3rd ed, text re"},{"key":"10738_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.5664\/jcsm.6470","volume":"13","author":"MJ Sateia","year":"2017","unstructured":"Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med 13:307\u2013349. https:\/\/doi.org\/10.5664\/jcsm.6470","journal-title":"J Clin Sleep Med"},{"key":"10738_CR3","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1177\/10547738221092146","volume":"31","author":"M Al Maqbali","year":"2022","unstructured":"Al Maqbali M, Al Sinani M, Alsayed A, Gleason AM (2022) Prevalence of sleep disturbance in patients with cancer: a systematic review and meta-analysis. Clin Nurs Res 31:1107\u20131123. https:\/\/doi.org\/10.1177\/10547738221092146","journal-title":"Clin Nurs Res"},{"key":"10738_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.856235","volume":"16","author":"A Berisha","year":"2022","unstructured":"Berisha A, Shutkind K, Borniger JC (2022) Sleep disruption and cancer: chicken or the egg? Front Neurosci 16:856235. https:\/\/doi.org\/10.3389\/fnins.2022.856235","journal-title":"Front Neurosci"},{"key":"10738_CR5","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1007\/s00520-021-06767-9","volume":"30","author":"A Divani","year":"2022","unstructured":"Divani A, Heidari ME, Ghavampour N, Parouhan A, Ahmadi S, Narimani Charan O, Shahsavari H (2022) Effect of cancer treatment on sleep quality in cancer patients: a systematic review and meta-analysis of Pittsburgh Sleep Quality Index. Support Care Cancer 30:4687\u20134697. https:\/\/doi.org\/10.1007\/s00520-021-06767-9","journal-title":"Support Care Cancer"},{"key":"10738_CR6","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jpainsymman.2015.06.018","volume":"50","author":"S Mercadante","year":"2015","unstructured":"Mercadante S, Aielli F, Adile C, Ferrera P, Valle A, Cartoni C, Pizzuto M, Caruselli A, Parsi R, Cortegiani A, Masedu F, Valenti M, Ficorella C, Porzio G (2015) Sleep disturbances in patients with advanced cancer in different palliative care settings. J Pain Symptom Manage 50:786\u2013792. https:\/\/doi.org\/10.1016\/j.jpainsymman.2015.06.018","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14163933","volume":"14","author":"G Jakobsen","year":"2022","unstructured":"Jakobsen G, Gjeilo KH, Hjermstad MJ, Klepstad P (2022) An update on prevalence, assessment, and risk factors for sleep disturbances in patients with advanced cancer\u2014implications for health care providers and clinical research. Cancers (Basel) 14:3933. https:\/\/doi.org\/10.3390\/cancers14163933","journal-title":"Cancers (Basel)"},{"key":"10738_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1017\/S1478951516001024","volume":"15","author":"KF Maltby","year":"2017","unstructured":"Maltby KF, Sanderson CR, Lobb EA, Phillips JL (2017) Sleep disturbances in caregivers of patients with advanced cancer: a systematic review. Palliat Support Care 15:125\u2013140. https:\/\/doi.org\/10.1017\/S1478951516001024","journal-title":"Palliat Support Care"},{"key":"10738_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1136\/bmjspcare-2014-000835","volume":"9","author":"S Thomas","year":"2019","unstructured":"Thomas S, Walsh D, Aktas A (2019) Systematic bias in cancer patient-reported outcomes: symptom \u2018orphans\u2019 and \u2018champions.\u2019 BMJ Support Palliat Care 9:67\u201374. https:\/\/doi.org\/10.1136\/bmjspcare-2014-000835","journal-title":"BMJ Support Palliat Care"},{"key":"10738_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000933","volume":"5","author":"D Santini","year":"2020","unstructured":"Santini D, Armento G, Giusti R, Ferrara M, Moro C, Fulfaro F, Bossi P, Arena F, Ripamonti CI, ESMO Guidelines Committee (2020) Management of orphan symptoms: ESMO clinical practice guidelines for diagnosis and treatment. ESMO Open 5:e000933. https:\/\/doi.org\/10.1136\/esmoopen-2020-000933","journal-title":"ESMO Open"},{"key":"10738_CR11","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1177\/02692163241269705","volume":"38","author":"MB Hansen","year":"2024","unstructured":"Hansen MB, Rojas-Concha L, Petersen MA, Adsersen M, Groenvold M (2024) Differences in palliative care needs between cancer patients and non-cancer patients at the start of specialized palliative care: a nationwide register-based study. Palliat Med 38:1021\u20131032. https:\/\/doi.org\/10.1177\/02692163241269705","journal-title":"Palliat Med"},{"key":"10738_CR12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jpainsymman.2017.11.026","volume":"55","author":"P Good","year":"2018","unstructured":"Good P, Pinkerton R, Bowler S, Craig J, Hardy J (2018) Impact of opioid therapy on sleep and respiratory patterns in adults with advanced cancer receiving palliative care. J Pain Symptom Manage 55:962\u2013967. https:\/\/doi.org\/10.1016\/j.jpainsymman.2017.11.026","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1240284","volume":"13","author":"C Gouldthorpe","year":"2023","unstructured":"Gouldthorpe C, Power J, Davies A (2023) Circadian rhythm disorders in patients with advanced cancer: a scoping review. Front Oncol 13:1240284. https:\/\/doi.org\/10.3389\/fonc.2023.1240284","journal-title":"Front Oncol"},{"key":"10738_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/1364557032000119616","volume":"8","author":"H Arksey","year":"2005","unstructured":"Arksey H, O\u2019Malley L (2005) Scoping studies: towards a methodological framework. Int J Soc Res Methodol 8:19\u201332. https:\/\/doi.org\/10.1080\/1364557032000119616","journal-title":"Int J Soc Res Methodol"},{"key":"10738_CR15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1097\/XEB.0000000000000277","volume":"19","author":"MDJ Peters","year":"2021","unstructured":"Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, McInerney P, Godfrey CM, Khalil H (2021) Updated methodological guidance for the conduct of scoping reviews. JBI Evid Implement 19:3\u201310. https:\/\/doi.org\/10.1097\/XEB.0000000000000277","journal-title":"JBI Evid Implement"},{"key":"10738_CR16","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jclinepi.2020.03.016","volume":"123","author":"J McGowan","year":"2020","unstructured":"McGowan J, Straus S, Moher D, Langlois EV, O\u2019Brien KK, Horsley T, Aldcroft A, Zarin W, Garitty CM, Hempel S, Lillie E, Tun\u00e7alp \u00d6, Tricco AC (2020) Reporting scoping reviews\u2014PRISMA ScR extension. J Clin Epidemiol 123:177\u2013179. https:\/\/doi.org\/10.1016\/j.jclinepi.2020.03.016","journal-title":"J Clin Epidemiol"},{"key":"10738_CR17","unstructured":"National Cancer Institute. https:\/\/www.cancer.gov\/. Accessed 1 Oct 2025."},{"key":"10738_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15143551","volume":"5","author":"C Gouldthorpe","year":"2023","unstructured":"Gouldthorpe C, Power J, Taylor A, Davies A (2023) Specialist palliative care for patients with cancer: more than end-of-life care. Cancers (Basel) 5:3551. https:\/\/doi.org\/10.3390\/cancers15143551","journal-title":"Cancers (Basel)"},{"key":"10738_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14521","volume":"75","author":"S Mercadante","year":"2021","unstructured":"Mercadante S, Valle A, Cartoni C, Pizzuto M (2021) Insomnia in patients with advanced lung cancer admitted to palliative care services. Int J Clin Pract 75:e14521. https:\/\/doi.org\/10.1111\/ijcp.14521","journal-title":"Int J Clin Pract"},{"key":"10738_CR20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1136\/bmjspcare-2018-001505","volume":"10","author":"MS Bernatchez","year":"2020","unstructured":"Bernatchez MS, Savard J, Aubin M, Ivers H (2020) Correlates of disrupted sleep-wake variables in patients with advanced cancer. BMJ Support Palliat Care 10:55\u201363. https:\/\/doi.org\/10.1136\/bmjspcare-2018-001505","journal-title":"BMJ Support Palliat Care"},{"key":"10738_CR21","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1007\/s00520-019-04998-5","volume":"28","author":"G Jakobsen","year":"2020","unstructured":"Jakobsen G, Engstr\u00f8m M, Thron\u00e6s M, L\u00f8hre ET, Kaasa S, Fayers P, Hjermstad MJ, Klepstad P (2020) Sleep quality in hospitalized patients with advanced cancer: an observational study using self-reports of sleep and actigraphy. Support Care Cancer 28:2015\u20132023. https:\/\/doi.org\/10.1007\/s00520-019-04998-5","journal-title":"Support Care Cancer"},{"key":"10738_CR22","first-page":"333","volume":"24","author":"G Sar\u0131cam","year":"2019","unstructured":"Sar\u0131cam G, Kahveci K, Akdogan D (2019) Prevalence of neurological symptoms in palliative care cancer patients: a retrospective study. Neurol Asia 24:333\u2013341","journal-title":"Neurol Asia"},{"key":"10738_CR23","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1017\/S1478951517000815","volume":"16","author":"MS Bernatchez","year":"2018","unstructured":"Bernatchez MS, Savard J, Savard MH, Aubin M, Ivers H (2018) Sleep-wake difficulties in community-dwelling cancer patients receiving palliative care: subjective and objective assessment. Palliat Support Care 16:756\u2013766. https:\/\/doi.org\/10.1017\/S1478951517000815","journal-title":"Palliat Support Care"},{"key":"10738_CR24","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/bmjspcare-2017-001363","volume":"7","author":"AN Davies","year":"2017","unstructured":"Davies AN, Patel SD, Gregory A, Lee B (2017) Observational study of sleep disturbances in advanced cancer. BMJ Support Palliat Care 7:435\u2013440. https:\/\/doi.org\/10.1136\/bmjspcare-2017-001363","journal-title":"BMJ Support Palliat Care"},{"key":"10738_CR25","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00520-016-3524-4","volume":"25","author":"S Mercadante","year":"2017","unstructured":"Mercadante S, Adile C, Ferrera P, Masedu F, Valenti M, Aielli F (2017) Sleep disturbances in advanced cancer patients admitted to a supportive\/palliative care unit. Support Care Cancer 25:1301\u20131306. https:\/\/doi.org\/10.1007\/s00520-016-3524-4","journal-title":"Support Care Cancer"},{"key":"10738_CR26","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1136\/bmjspcare-2015-000847","volume":"7","author":"S Yennurajalingam","year":"2017","unstructured":"Yennurajalingam S, Balachandran D, Pedraza Cardozo SL, Berg EA, Chisholm GB, Reddy A, DeLa Cruz V, Williams JL, Bruera E (2017) Patient-reported sleep disturbance in advanced cancer: frequency, predictors and screening performance of the Edmonton Symptom Assessment System sleep item. BMJ Support Palliat Care 7:274\u2013280. https:\/\/doi.org\/10.1136\/bmjspcare-2015-000847","journal-title":"BMJ Support Palliat Care"},{"key":"10738_CR27","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1177\/1049909113485804","volume":"31","author":"MP Davis","year":"2014","unstructured":"Davis MP, Khoshknabi D, Walsh D, Lagman R, Platt A (2014) Insomnia in patients with advanced cancer. Am J Hosp Palliat Care 31:365\u2013373. https:\/\/doi.org\/10.1177\/1049909113485804","journal-title":"Am J Hosp Palliat Care"},{"key":"10738_CR28","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.jpainsymman.2010.07.015","volume":"41","author":"M Delgado-Guay","year":"2011","unstructured":"Delgado-Guay M, Yennurajalingam S, Parsons H, Palmer JL, Bruera E (2011) Association between self-reported sleep disturbance and other symptoms in patients with advanced cancer. J Pain Symptom Manage 41:819\u2013827. https:\/\/doi.org\/10.1016\/j.jpainsymman.2010.07.015","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR29","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/00207590802194226","volume":"44","author":"K Mystakidou","year":"2009","unstructured":"Mystakidou K, Parpa E, Tsilika E, Galanos A, Vlahos L (2009) Does quality of sleep mediate the effect of depression on hopelessness? Int J Psychol 44:282\u2013289. https:\/\/doi.org\/10.1080\/00207590802194226","journal-title":"Int J Psychol"},{"key":"10738_CR30","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1177\/0269216308098088","volume":"23","author":"K Mystakidou","year":"2009","unstructured":"Mystakidou K, Parpa E, Tsilika E, Gennatas C, Galanos A, Vlahos L (2009b) How is sleep quality affected by the psychological and symptom distress of advanced cancer patients? Palliat Med 23:46\u201353. https:\/\/doi.org\/10.1177\/0269216308098088","journal-title":"Palliat Med"},{"key":"10738_CR31","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.jpsychores.2006.11.008","volume":"62","author":"K Mystakidou","year":"2007","unstructured":"Mystakidou K, Parpa E, Tsilika E, Pathiaki M, Patiraki E, Galanos A, Vlahos L (2007) Sleep quality in advanced cancer patients. J Psychosom Res 62:527\u2013533. https:\/\/doi.org\/10.1016\/j.jpsychores.2006.11.008","journal-title":"J Psychosom Res"},{"key":"10738_CR32","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/sleep\/30.6.737","volume":"30","author":"K Mystakidou","year":"2007","unstructured":"Mystakidou K, Parpa E, Tsilika E, Pathiaki M, Gennatas K, Smyrniotis V, Vassiliou I (2007) The relationship of subjective sleep quality, pain, and quality of life in advanced cancer patients. Sleep 30:737\u2013742. https:\/\/doi.org\/10.1093\/sleep\/30.6.737","journal-title":"Sleep"},{"key":"10738_CR33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2190\/0509-7332-388N-566W","volume":"37","author":"K Mystakidou","year":"2007","unstructured":"Mystakidou K, Parpa E, Tsilika E, Pathiaki M, Galanos A, Vlahos L (2007c) Depression, hopelessness, and sleep in cancer patients\u2019 desire for death. Int J Psychiatry Med 37:201\u2013211. https:\/\/doi.org\/10.2190\/0509-7332-388N-566W","journal-title":"Int J Psychiatry Med"},{"key":"10738_CR34","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jpainsymman.2016.10.357","volume":"53","author":"N Gough","year":"2017","unstructured":"Gough N, Koffman J, Ross JR, Riley J, Judson I (2017) Symptom burden in advanced soft-tissue sarcoma. J Pain Symptom Manage 53:588\u2013597. https:\/\/doi.org\/10.1016\/j.jpainsymman.2016.10.357","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR35","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.1016\/S2352-3026(15)00111-8","volume":"2","author":"TW LeBlanc","year":"2015","unstructured":"LeBlanc TW, Smith JM, Currow DC (2015) Symptom burden of haematological malignancies as death approaches in a community palliative care service: a retrospective cohort study of a consecutive case series. Lancet Haematol 2:e334\u2013e338. https:\/\/doi.org\/10.1016\/S2352-3026(15)00111-8","journal-title":"Lancet Haematol"},{"key":"10738_CR36","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/pon.1122","volume":"16","author":"T Akechi","year":"2007","unstructured":"Akechi T, Okuyama T, Akizuki N, Shimizu K, Inagaki M, Fujimori M, Shima Y, Furukawa TA, Uchitomi Y (2007) Associated and predictive factors of sleep disturbance in advanced cancer patients. Psychooncology 16:888\u2013894. https:\/\/doi.org\/10.1002\/pon.1122","journal-title":"Psychooncology"},{"key":"10738_CR37","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1177\/0269216321998558","volume":"35","author":"DC Currow","year":"2021","unstructured":"Currow DC, Davis W, Connolly A, Krishnan A, Wong A, Webster A, Barnes-Harris MM, Daveson B, Ekstr\u00f6m M (2021) Sleeping-related distress in a palliative care population: a national, prospective, consecutive cohort. Palliat Med 35:1663\u20131670. https:\/\/doi.org\/10.1177\/0269216321998558","journal-title":"Palliat Med"},{"key":"10738_CR38","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.jpainsymman.2003.09.010","volume":"27","author":"H Hugel","year":"2004","unstructured":"Hugel H, Ellershaw JE, Cook L, Skinner J, Irvine C (2004) The prevalence, key causes and management of insomnia in palliative care patients. J Pain Symptom Manage 27:316\u2013321. https:\/\/doi.org\/10.1016\/j.jpainsymman.2003.09.010","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/1472-684X-13-40","volume":"13","author":"A Renom-Guiteras","year":"2014","unstructured":"Renom-Guiteras A, Planas J, Farriols C, Mojal S, Miralles R, Silvent MA, Ruiz-Ripoll AI (2014) Insomnia among patients with advanced disease during admission in a palliative care unit: a prospective observational study on its frequency and association with psychological, physical and environmental factors. BMC Palliat Care 13:40. https:\/\/doi.org\/10.1186\/1472-684X-13-40","journal-title":"BMC Palliat Care"},{"key":"10738_CR40","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1017\/S1478951518000779","volume":"17","author":"S Yennurajalingam","year":"2019","unstructured":"Yennurajalingam S, Barla SR, Arthur J, Chisholm GB, Bruera E (2019) Frequency and characteristics of drowsiness, somnolence, or daytime sleepiness in patients with advanced cancer. Palliat Support Care 17:459\u2013463. https:\/\/doi.org\/10.1017\/S1478951518000779","journal-title":"Palliat Support Care"},{"key":"10738_CR41","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1177\/1049909115603055","volume":"33","author":"AR Rodrigues","year":"2016","unstructured":"Rodrigues AR, Trufelli DC, Fonseca F, de Paula LC, Giglio AD (2016) Fatigue in patients with advanced terminal cancer correlates with inflammation, poor quality of life and sleep, and anxiety\/depression. Am J Hosp Palliat Care 33:942\u2013947. https:\/\/doi.org\/10.1177\/1049909115603055","journal-title":"Am J Hosp Palliat Care"},{"key":"10738_CR42","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1089\/jpm.2017.0032","volume":"20","author":"M Warth","year":"2017","unstructured":"Warth M, Kessler J, Bardenheuer HJ (2017) Insomnia and autonomic function predict well-being in patients receiving palliative care. J Palliat Med 20:1395\u20131399. https:\/\/doi.org\/10.1089\/jpm.2017.0032","journal-title":"J Palliat Med"},{"key":"10738_CR43","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/JGP.0b013e3182487680","volume":"20","author":"CG Slatore","year":"2012","unstructured":"Slatore CG, Goy ER, O\u02bchearn DJ, Boudreau EA, O\u02bcMalley JP, Peters D, Ganzini L (2012) Sleep quality and its association with delirium among veterans enrolled in hospice. Am J Geriatr Psychiatry 20:317\u2013326. https:\/\/doi.org\/10.1097\/JGP.0b013e3182487680","journal-title":"Am J Geriatr Psychiatry"},{"key":"10738_CR44","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1177\/02692163211065278","volume":"36","author":"I Featherstone","year":"2022","unstructured":"Featherstone I, Sheldon T, Johnson M, Woodhouse R, Boland JW, Hosie A, Lawlor P, Russell G, Bush S, Siddiqi N (2022) Risk factors for delirium in adult patients receiving specialist palliative care: a systematic review and meta-analysis. Palliat Med 36:254\u2013267. https:\/\/doi.org\/10.1177\/02692163211065278","journal-title":"Palliat Med"},{"key":"10738_CR45","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1017\/S1478951520001066","volume":"19","author":"L Ascencio-Huertas","year":"2021","unstructured":"Ascencio-Huertas L, Allende-P\u00e9rez SR, Pastrana T (2021) Associated factors of distress in patients with advanced cancer: a retrospective study. Palliat Support Care 19:447\u2013456. https:\/\/doi.org\/10.1017\/S1478951520001066","journal-title":"Palliat Support Care"},{"key":"10738_CR46","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951525000136","volume":"23","author":"G \u00c7amc\u0131","year":"2025","unstructured":"\u00c7amc\u0131 G, O\u011fuz S, Oktay \u00d6, Ayd\u0131n \u00d6 (2025) Sleep quality, anxiety, and depression in palliative care patients. Palliat Support Care 23:e60. https:\/\/doi.org\/10.1017\/S1478951525000136","journal-title":"Palliat Support Care"},{"key":"10738_CR47","doi-asserted-by":"publisher","first-page":"e859","DOI":"10.3928\/02793695-20040801-05","volume":"13","author":"F Liu","year":"2024","unstructured":"Liu F, Peng W, Zhou R, Huang X, Yang H, Wen M, Zhang L, Tong F, Yang D, Jiang L, Yi L, Liu X (2024) Desire for hastened death in advanced cancer: cross-sectional study in China. BMJ Support Palliat Care 13:e859\u2013e862. https:\/\/doi.org\/10.3928\/02793695-20040801-05","journal-title":"BMJ Support Palliat Care"},{"key":"10738_CR48","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3928\/02793695-20040801-05","volume":"42","author":"G Birkholz","year":"2004","unstructured":"Birkholz G, Gibson JM, Clements PT (2004) Dying patients\u2019 thoughts of ending their lives: a pilot study of rural New Mexico. J Psychosoc Nurs Ment Health Serv 42:34\u201344. https:\/\/doi.org\/10.3928\/02793695-20040801-05","journal-title":"J Psychosoc Nurs Ment Health Serv"},{"key":"10738_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-023-01261-x","volume":"22","author":"Y Yang","year":"2023","unstructured":"Yang Y, Zhao X, Cui M, Wang Y (2023) Dimensions of spiritual well-being in relation to physical and psychological symptoms: a cross-sectional study of advanced cancer patients admitted to a palliative care unit. BMC Palliat Care 22:137. https:\/\/doi.org\/10.1186\/s12904-023-01261-x","journal-title":"BMC Palliat Care"},{"key":"10738_CR50","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1089\/jpm.2011.0086","volume":"14","author":"JM Giesinger","year":"2011","unstructured":"Giesinger JM, Wintner LM, Oberguggenberger AS, Gamper EM, Fiegl M, Denz H, Kemmler G, Zabernigg A, Holzner B (2011) Quality of life trajectory in patients with advanced cancer during the last year of life. J Palliat Med 14:904\u2013912. https:\/\/doi.org\/10.1089\/jpm.2011.0086","journal-title":"J Palliat Med"},{"key":"10738_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222988","volume":"14","author":"MN Verkissen","year":"2019","unstructured":"Verkissen MN, Hjermstad MJ, Van Belle S, Kaasa S, Deliens L, Pardon K (2019) Quality of life and symptom intensity over time in people with cancer receiving palliative care: results from the international European Palliative Care Cancer Symptom study. PLoS One 14:e0222988. https:\/\/doi.org\/10.1371\/journal.pone.0222988","journal-title":"PLoS One"},{"key":"10738_CR52","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.sleep.2016.06.041","volume":"32","author":"KP Collins","year":"2017","unstructured":"Collins KP, Geller DA, Antoni M, Donnell DM, Tsung A, Marsh JW, Burke L, Penedo F, Terhorst L, Kamarck TW, Greene A, Buysse DJ, Steel JL (2017) Sleep duration is associated with survival in advanced cancer patients. Sleep Med 32:208\u2013212. https:\/\/doi.org\/10.1016\/j.sleep.2016.06.041","journal-title":"Sleep Med"},{"key":"10738_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020503","volume":"15","author":"SD Patel","year":"2023","unstructured":"Patel SD, Davies A, Laing E, Wu H, Mendis J, Dijk DJ (2023) Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study. Cancers (Basel) 15:503. https:\/\/doi.org\/10.3390\/cancers15020503","journal-title":"Cancers (Basel)"},{"key":"10738_CR54","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1136\/bmjspcare-2015-000896","volume":"6","author":"A Aktas","year":"2016","unstructured":"Aktas A, Walsh D, Hauser K, Rybicki L (2016) Should we cluster patients or symptoms? The myth of symptom clusters based on \u2018depression, insomnia, pain\u2019 and \u2018depression, fatigue, pain.\u2019 BMJ Support Palliat Care 6:210\u2013218. https:\/\/doi.org\/10.1136\/bmjspcare-2015-000896","journal-title":"BMJ Support Palliat Care"},{"key":"10738_CR55","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jpainsymman.2010.10.266","volume":"42","author":"A Jim\u00e9nez","year":"2011","unstructured":"Jim\u00e9nez A, Madero R, Alonso A, Mart\u00ednez-Mar\u00edn V, Vilches Y, Mart\u00ednez B, Feliu M, D\u00edaz L, Espinosa E, Feliu J (2011) Symptom clusters in advanced cancer. J Pain Symptom Manage 42:24\u201331. https:\/\/doi.org\/10.1016\/j.jpainsymman.2010.10.266","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR56","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jpainsymman.2013.10.027","volume":"48","author":"ST Dong","year":"2014","unstructured":"Dong ST, Butow PN, Costa DS, Lovell MR, Agar M (2014) Symptom clusters in patients with advanced cancer: a systematic review of observational studies. J Pain Symptom Manage 48:411\u2013450. https:\/\/doi.org\/10.1016\/j.jpainsymman.2013.10.027","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR57","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.jpainsymman.2009.04.025","volume":"38","author":"J Gibbins","year":"2009","unstructured":"Gibbins J, McCoubrie R, Kendrick AH, Senior-Smith G, Davies AN, Hanks GW (2009) Sleep-wake disturbances in patients with advanced cancer and their family carers. J Pain Symptom Manage 38:860\u2013870. https:\/\/doi.org\/10.1016\/j.jpainsymman.2009.04.025","journal-title":"J Pain Symptom Manage"},{"key":"10738_CR58","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-025-09550-2","volume":"33","author":"S Munir","year":"2025","unstructured":"Munir S, Connolly M, Davies AN (2025) Non-pharmacological interventions for sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer: a scoping review. Support Care Cancer 33:486. https:\/\/doi.org\/10.1007\/s00520-025-09550-2","journal-title":"Support Care Cancer"},{"key":"10738_CR59","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-025-10202-8","volume":"33","author":"S Ryan","year":"2025","unstructured":"Ryan S, Munir S, Davies A (2025) Pharmacological interventions for sleep disturbance (\u201cinsomnia\u201d) in patients with advanced cancer receiving specialist palliative care: a scoping review. Support Care Cancer 33:1124. https:\/\/doi.org\/10.1007\/s00520-025-10202-8","journal-title":"Support Care Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10738-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10738-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10738-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:28:33Z","timestamp":1781058513000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10738-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,7]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10738"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10738-3","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,7]]},"assertion":[{"value":"31 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N\/A.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"516"}}