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Overall HRQoL was comparable between childhood cancer survivors and controls, whilst adult cancer survivors reported better HRQoL than controls. Over 50% of child and adult cancer survivors reported meaningful reductions in overall HRQoL compared to perfect health (i.e. EQ-5D-5L index\u2009&lt;\u20090.92). Childhood survivors reported more mobility and activity limitations on the EQ-5D-5L domains compared to controls, whilst adult survivors reported fewer self-care issues. Childhood survivors' poorer HRQoL was significantly associated with cancer diagnosis and treatment, greater health issues, lower resilience, and smoking history. Adult survivors' poorer HRQoL was associated with older age, lower education, fewer health issues, lower resilience, and less physical activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides a comprehensive examination of HRQoL among Australian cancer survivors, shedding light on age-specific differences and the multifaceted nature of associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for cancer survivors<\/jats:title>\n                    <jats:p>Factors associated with HRQoL highlight modifiable opportunities for targeted survivorship care interventions that may improve survivors\u2019 long-term coping and adaptation, as well as broader physical health after cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10775-y","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:45:05Z","timestamp":1778741105000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors associated with health-related quality of life in survivors of childhood-onset and adult-onset cancer compared to controls"],"prefix":"10.1007","volume":"34","author":[{"given":"Madeleine","family":"Rhodes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Signorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Donoghoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana K.","family":"McLoone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Anazodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula M.","family":"Sansom-Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Darlington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha C.","family":"Sodergren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Fardell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"10775_CR1","doi-asserted-by":"publisher","DOI":"10.25816\/ye05-nm50","volume-title":"Cancer in Australia 2021","author":"Australian Institute of Health Welfare","year":"2021","unstructured":"AIHW (Australian Institute of Health and Welfare) (2021) Cancer in Australia 2021, AIHW, Australian Government. https:\/\/doi.org\/10.25816\/ye05-nm50. 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