{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:33:08Z","timestamp":1791678788570,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the association between salivary inflammatory mediators and oral dryness during oral mucositis development in patients with cancer undergoing chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study (time-stratified sampling) enrolled adult patients undergoing chemotherapy or chemoradiotherapy at Niigata University Medical and Dental Hospital (November 2021\u2013August 2023). Sample size was determined a priori from a pilot study. Oral mucosal status was graded using the World Health Organization oral toxicity scale, and oral moisture was measured (dryness\u2009&lt;\u200928). Unstimulated whole saliva was analyzed for interleukins (IL)-1\u03b2, IL-6, IL-8, IL-10, IL-12p70, tumor necrosis factor (TNF), prostaglandin E2, and vascular endothelial growth factor via cytometric bead array and enzyme-linked immunosorbent assay. Clinical data included demographics, treatment, and days post-chemotherapy (0\u20137, 8\u201314,\u2009\u2265\u200915). TNF and IL-10 were independently associated with oral dryness; cutoffs were median levels in patients with grade 0 mucositis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 162 patients, 56 (34.6%) had oral dryness. Dryness was associated with higher neutrophil counts (median: 3.23 vs. 3.00\u2009\u00d7\u200910\n                      <jats:sup>3<\/jats:sup>\n                      \/\u00b5L;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). C-reactive protein levels increased, and neutrophil counts decreased 8\u201314\u00a0days post-chemotherapy. Multivariate analysis showed that TNF\u2009&gt;\u20094.7\u00a0pg\/mL was inversely associated (OR\u2009=\u20090.27; 95% CI\u2009=\u20090.11\u20130.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0058), whereas IL-10\u2009&gt;\u20092.8\u00a0pg\/mL was positively associated (OR\u2009=\u20093.17; 95% CI\u2009=\u20091.30\u20137.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) with dryness. Sampling at 8\u201314\u00a0days post-chemotherapy predicted dryness (OR\u2009=\u20095.16; 95% CI\u2009=\u20091.32\u201320.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salivary TNF and IL-10 levels and sampling timing after CT were associated with oral dryness, suggesting temporal changes in salivary inflammatory mediators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10796-7","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T13:28:26Z","timestamp":1779974906000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between salivary inflammatory mediators and oral dryness during chemotherapy in patients with cancer: a cohort study"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-0210","authenticated-orcid":false,"given":"Anna","family":"Kiyomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-2065","authenticated-orcid":false,"given":"Kensuke","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Kanemaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Tomihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitsugu","family":"Ohuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munetoshi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"10796_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00354","volume":"8","author":"M Cinausero","year":"2017","unstructured":"Cinausero M, Aprile G, Ermacora P et al (2017) New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury. 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