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Patients with taste change were compared to non-affected patients with respect to gender, age, transplant type, previous chemotherapy, conditioning regimen(s), oral mucositis, pre-HCT salivary flow, oral hygiene status and, in allogeneic HCT recipients, chronic oral graft-versus-host disease (GVHD). Distress from taste change was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During hospitalization, taste change was reported by over one-third (81\/238) of patients to an open question on oral symptoms; of these, 41% reported taste change as their worst\/most bothersome oral symptom. To a specific question on distress due to taste change, 76% of all patients reported some level of distress. Taste change from previous chemotherapy and full intensity conditioning were risk factors for severe taste change during hospitalization. At three months, allogeneic transplant patients reported a higher rate of severe taste change compared to autologous transplant patients. Increased age predicted severe taste change at 6 and 12-month follow-up. At twelve months, 13.1% of patients reported distress from taste change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirmed taste change as a common clinical complaint post-HCT. Taste change remained a significant issue for a small subset of patients at 12 months. Further research is required to develop effective preventive and management strategies for this common oral side-effect post-HCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10831-7","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:23:47Z","timestamp":1780467827000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal assessment and predictors of subjective taste change after hematopoietic cell transplantation (HCT)"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-5281","authenticated-orcid":false,"given":"Allan J.","family":"Hovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-4335","authenticated-orcid":false,"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3088-1550","authenticated-orcid":false,"given":"Bengt","family":"Hass\u00e9us","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-8390","authenticated-orcid":false,"given":"Judith E.","family":"Raber-Durlacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-7554","authenticated-orcid":false,"given":"Marie-Charlotte","family":"Huysmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-2798","authenticated-orcid":false,"given":"Alexa M. 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Approval was obtained from the Ethical Review Boards at each study site. Sweden: Regional Ethical Review Board in Gothenburg (513\u201310, T939-16); Charlotte: Wake Forest School of Medicine Institutional Review Board (IRB00080071); Vancouver: BC Cancer Agency Research Ethics Board (BCCA REB # H11-02350, BCCA REB # H15-02350); Amsterdam and Nijmegen: Medical Ethical Research Committee, Amsterdam university medical center location AMC (NL52117.018.15), registered in the Dutch Trial Register June 17, 2015 (NL 5645). The approval granted in Amsterdam was validated by the IRB of Radboud UMC in Nijmegen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"605"}}