{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:21Z","timestamp":1784012841874,"version":"3.55.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00520-026-10894-6","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:10:32Z","timestamp":1781867432000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Folic acid deficiency in cancer therapy: a review of chemotherapy-induced malabsorption and supportive care strategies"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-1121","authenticated-orcid":false,"given":"Sachin V.","family":"Tembhurne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9982-890X","authenticated-orcid":false,"given":"Payal M.","family":"Kate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"10894_CR1","doi-asserted-by":"publisher","DOI":"10.31083\/j.jmcm0501001","author":"G Jansen","year":"2022","unstructured":"Jansen G (2022) Folate supplementations for methotrexate therapies in cancer and arthritis: rationales revisited. J Mol Clin Med. https:\/\/doi.org\/10.31083\/j.jmcm0501001","journal-title":"J Mol Clin Med"},{"key":"10894_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/hemato3010002","author":"M Visentin","year":"2019","unstructured":"Visentin M, Zhao R, Goldman ID (2019) The antifolates. Hemato. https:\/\/doi.org\/10.3390\/hemato3010002","journal-title":"Hemato"},{"key":"10894_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-018-0237-y","author":"Y-I Kim","year":"2018","unstructured":"Kim Y-I (2018) Folate and its impact on cancer risk. Curr Nutr Rep. https:\/\/doi.org\/10.1007\/s13668-018-0237-y","journal-title":"Curr Nutr Rep"},{"key":"10894_CR4","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.206599","author":"RL Bailey","year":"2015","unstructured":"Bailey RL, Stover PJ, McNulty H, Fenech MF, Gregory JF, Mills JL, Pfeiffer CM, Fazili Z, Zhang M, Ueland PM, Berry RJ (2015) Biomarkers of nutrition for development\u2014folate review. J Nutr. https:\/\/doi.org\/10.3945\/jn.114.206599","journal-title":"J Nutr"},{"key":"10894_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109190","author":"L Wu","year":"2019","unstructured":"Wu L, Hu X, Song M et al (2019) Vitamin A supplementation alleviates methotrexate-induced intestinal injury by regulating gut microbiota. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2019.109190","journal-title":"Biomed Pharmacother"},{"key":"10894_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03164-x","author":"GF Ali","year":"2024","unstructured":"Ali GF, Hassanein EHM, Mohamed WR (2024) Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-024-03164-x","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10894_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.104061","volume":"188","author":"NRK Zwart","year":"2023","unstructured":"Zwart NRK et al (2023) Folate, folic acid, and chemotherapy-induced toxicities: a systematic literature review. Crit Rev Oncol Hematol 188:104061. https:\/\/doi.org\/10.1016\/j.critrevonc.2023.104061","journal-title":"Crit Rev Oncol Hematol"},{"issue":"11","key":"10894_CR8","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3390\/ph15111388","volume":"15","author":"B Stefanelli","year":"2022","unstructured":"Stefanelli B, Bassi S, Spinelli GP et al (2022) Concomitant administration of capecitabine and folate supplements: need to encourage medication reconciliation. Pharmaceuticals (Basel) 15(11):1388. https:\/\/doi.org\/10.3390\/ph15111388","journal-title":"Pharmaceuticals (Basel)"},{"key":"10894_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00062.x","author":"CM Ulrich","year":"2008","unstructured":"Ulrich CM, Reed MC, Nijhout HF (2008) Modeling folate, one-carbon metabolism and DNA methylation. Nutr Rev. https:\/\/doi.org\/10.1111\/j.1753-4887.2008.00062.x","journal-title":"Nutr Rev"},{"issue":"1","key":"10894_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12915-023-01525-1","volume":"21","author":"M Stark","year":"2023","unstructured":"Stark M, Raz S, Assaraf YG (2023) Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion. BMC Biol 21(1):1\u201316. https:\/\/doi.org\/10.1186\/s12915-023-01525-1","journal-title":"BMC Biol"},{"key":"10894_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00532-9","author":"R Zhao","year":"2001","unstructured":"Zhao R, Gao F, Goldman ID (2001) Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochem Pharmacol. https:\/\/doi.org\/10.1016\/S0006-2952(01)00532-9","journal-title":"Biochem Pharmacol"},{"key":"10894_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/nature14192","author":"D Sch\u00fcbeler","year":"2015","unstructured":"Sch\u00fcbeler D (2015) Function and information content of DNA methylation. Nature. https:\/\/doi.org\/10.1038\/nature14192","journal-title":"Nature"},{"key":"10894_CR13","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-7-808","author":"S Chattopadhyay","year":"2007","unstructured":"Chattopadhyay S, Tamari R, Min SH et al (2007) Commentary: a case for minimizing folate supplementation in clinical regimens with pemetrexed based on the marked sensitivity of the drug to folate availability. Oncologist. https:\/\/doi.org\/10.1634\/theoncologist.12-7-808","journal-title":"Oncologist"},{"key":"10894_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00884","author":"YJ Menezo","year":"2019","unstructured":"Menezo YJ, Elder K, Clement P (2019) Folic acid: should this supplement be continued? Front Genet. https:\/\/doi.org\/10.3389\/fgene.2019.00884","journal-title":"Front Genet"},{"key":"10894_CR15","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083558","author":"F Gaudet","year":"2003","unstructured":"Gaudet F, Hodgson JG, Eden A et al (2003) Induction of tumors in mice by genomic hypomethylation. Science. https:\/\/doi.org\/10.1126\/science.1083558","journal-title":"Science"},{"key":"10894_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-8989-5_1","volume-title":"DNA methylation and cancer","author":"PC Taberlay","year":"2011","unstructured":"Taberlay PC, Jones PA (2011) DNA methylation and cancer. Springer Basel, Epigenetics and disease. https:\/\/doi.org\/10.1007\/978-3-7643-8989-5_1"},{"key":"10894_CR17","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.000992","author":"KS Crider","year":"2012","unstructured":"Crider KS, Yang TP, Berry RJ et al (2012) Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate\u2019s role. Adv Nutr. https:\/\/doi.org\/10.3945\/an.111.000992","journal-title":"Adv Nutr"},{"key":"10894_CR18","doi-asserted-by":"publisher","DOI":"10.1177\/0884533610392238","author":"GE Mullin","year":"2011","unstructured":"Mullin GE (2011) Folate: is too much of a good thing harmful? Nutr Clin Pract. https:\/\/doi.org\/10.1177\/0884533610392238","journal-title":"Nutr Clin Pract"},{"key":"10894_CR19","doi-asserted-by":"publisher","unstructured":"Cole BF, Baron JA, Sandler RS et al (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 6;297(21):2351-2359. https:\/\/doi.org\/10.1001\/jama.297.21.2351","DOI":"10.1001\/jama.297.21.2351"},{"issue":"2","key":"10894_CR20","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ajcnut.2023.08.015","volume":"119","author":"DE Kok","year":"2024","unstructured":"Kok DE, van Zutphen M, Kampman E et al (2024) Intake and biomarkers of folate and folic acid as determinants of chemotherapy-induced toxicities in patients with colorectal cancer: a cohort study. Am J Clin Nutr 119(2):294\u2013301. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.08.015","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10894_CR21","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/j.1753-4887.2007.tb00275.x","volume":"65","author":"YI Kim","year":"2007","unstructured":"Kim YI (2007) Folic acid fortification and supplementation\u2014good for some but not so good for others. Nutr Rev 65(11):504\u2013511. https:\/\/doi.org\/10.1111\/j.1753-4887.2007.tb00275.x","journal-title":"Nutr Rev"},{"issue":"6","key":"10894_CR22","doi-asserted-by":"publisher","first-page":"e100044","DOI":"10.1371\/journal.pone.0100044","volume":"9","author":"YF Zhang","year":"2014","unstructured":"Zhang YF, Shi WW, Gao HF, Zhou L, Hou AJ et al (2014) Folate intake and the risk of breast cancer: a dose-response meta-analysis of prospective studies. PLoS ONE 9(6):e100044. https:\/\/doi.org\/10.1371\/journal.pone.0100044","journal-title":"PLoS ONE"},{"key":"10894_CR23","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0083-6729(03)01012-4","volume":"66","author":"LH Matherly","year":"2003","unstructured":"Matherly LH, Goldman ID (2003) Membrane transport of folates. Vitam Horm 66:403\u2013456. https:\/\/doi.org\/10.1016\/S0083-6729(03)01012-4","journal-title":"Vitam Horm"},{"key":"10894_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-nutr-072610-145133","volume":"31","author":"R Zhao","year":"2011","unstructured":"Zhao R, Diop-Bove N, Visentin M, Goldman ID (2011) Mechanisms of membrane transport of folates into cells and across epithelia. Annu Rev Nutr 31:177\u2013201. https:\/\/doi.org\/10.1146\/annurev-nutr-072610-145133","journal-title":"Annu Rev Nutr"},{"key":"10894_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1201\/9781420071252.ch1","volume-title":"Folate in health and disease","author":"B Shane","year":"2010","unstructured":"Shane B (2010) Folate chemistry and metabolism. In: Bailey LB (ed) Folate in health and disease, 2nd edn. CRC Press, Boca Raton, pp 1\u201324. https:\/\/doi.org\/10.1201\/9781420071252.ch1","edition":"2"},{"issue":"8","key":"10894_CR26","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.2174\/138920012802002578","volume":"13","author":"R Obeid","year":"2012","unstructured":"Obeid R, Herrmann W (2012) The emerging role of unmetabolized folic acid in human diseases: myth or reality? Curr Drug Metab 13(8):1184\u20131195. https:\/\/doi.org\/10.2174\/138920012802002578","journal-title":"Curr Drug Metab"},{"issue":"8","key":"10894_CR27","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1093\/nutrit\/nux027","volume":"75","author":"MCF de Souza","year":"2017","unstructured":"de Souza MCF, Diniz LM (2017) Folate supplementations for methotrexate therapies in cancer and arthritis: rationales revisited. Nutr Rev 75(8):748\u2013760. https:\/\/doi.org\/10.1093\/nutrit\/nux027","journal-title":"Nutr Rev"},{"issue":"4","key":"10894_CR28","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.drup.2012.06.002","volume":"15","author":"N Gonen","year":"2012","unstructured":"Gonen N, Assaraf YG (2012) Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updates 15(4):183\u2013210. https:\/\/doi.org\/10.1016\/j.drup.2012.06.002","journal-title":"Drug Resist Updates"},{"issue":"3","key":"10894_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.clml.2023.01.005","volume":"24","author":"A Haran","year":"2023","unstructured":"Haran A, Tiwari P, Cohen D et al (2023) Impact of folinic acid dosing on efficacy and toxicity of high-dose methotrexate in central nervous system lymphoma. Clin Lymphoma Myeloma Leuk 24(3):187\u2013193. https:\/\/doi.org\/10.1016\/j.clml.2023.01.005","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"4","key":"10894_CR30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/0115426505020004411","volume":"20","author":"K Robien","year":"2005","unstructured":"Robien K (2005) Folate during antifolate chemotherapy: what we know... and do not know. Nutr Clin Pract 20(4):411\u2013422. https:\/\/doi.org\/10.1177\/0115426505020004411","journal-title":"Nutr Clin Pract"},{"issue":"3","key":"10894_CR31","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/pbc.24081","volume":"59","author":"G Kapoor","year":"2012","unstructured":"Kapoor G, Sinha R, Abedin S (2012) Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country. Pediatr Blood Cancer 59(3):448\u2013453. https:\/\/doi.org\/10.1002\/pbc.24081","journal-title":"Pediatr Blood Cancer"},{"key":"10894_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2192-3","author":"RM Logan","year":"2014","unstructured":"Logan RM, Stringer AM (2014) Chemotherapy-induced mucositis: mechanisms and management. Support Care Cancer. https:\/\/doi.org\/10.1007\/s00520-014-2192-3","journal-title":"Support Care Cancer"},{"issue":"6","key":"10894_CR33","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrgastro.2017.20","volume":"14","author":"JL Alexander","year":"2017","unstructured":"Alexander JL, Wilson ID, Teare J et al (2017) Gut microbiota modulation of chemotherapy efficacy and toxicity. Nat Rev Gastroenterol Hepatol 14(6):356\u2013365. https:\/\/doi.org\/10.1038\/nrgastro.2017.20","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10894_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/COC.0000000000000901","volume":"45","author":"J Smith","year":"2023","unstructured":"Smith J et al (2023) Gastrointestinal effects of chemotherapy. Am J Clin Oncol 45(2):123\u2013129. https:\/\/doi.org\/10.1097\/COC.0000000000000901","journal-title":"Am J Clin Oncol"},{"key":"10894_CR35","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00520-025-09515-5","volume":"33","author":"T Mao","year":"2025","unstructured":"Mao T, Yorke J, Shi Y, Shen N, Wang H, Wong F-K-Y et al (2025) Assessment measures for chemotherapy-induced peripheral neuropathy among pediatric oncology patients: an updated systematic review. Support Care Cancer 33:514. https:\/\/doi.org\/10.1007\/s00520-025-09515-5","journal-title":"Support Care Cancer"},{"issue":"2","key":"10894_CR36","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/ana.22229","volume":"69","author":"M Linnebank","year":"2011","unstructured":"Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, Elger CE (2011) Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol 69(2):352\u2013359. https:\/\/doi.org\/10.1002\/ana.22229","journal-title":"Ann Neurol"},{"issue":"14","key":"10894_CR37","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.3390\/jcm14144819","volume":"14","author":"T Sagawa","year":"2025","unstructured":"Sagawa T, Ishida T, Jobu K, Morisawa S, Akagaki K, Kato T, Maruyama T, Yagi Y, Kihara T, Suzuki S, Endo M, Matsunaga N, Hamada Y (2025) Evaluation of adverse events associated with the sulfamethoxazole\/trimethoprim combination drug. J Clin Med 14(14):4819. https:\/\/doi.org\/10.3390\/jcm14144819","journal-title":"J Clin Med"},{"issue":"4","key":"10894_CR38","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/jcph.1234","volume":"18","author":"R Patel","year":"2020","unstructured":"Patel R et al (2020) Chemotherapy-induced malabsorption. J Clin Pharmacol 18(4):200\u2013210. https:\/\/doi.org\/10.1002\/jcph.1234","journal-title":"J Clin Pharmacol"},{"issue":"5","key":"10894_CR39","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/0272-0590(85)90294-7","volume":"5","author":"SH Duncan","year":"2011","unstructured":"Duncan SH et al (2011) Methotrexate-induced intestinal mucositis delays gastric emptying and gastrointestinal transit of liquids in awake rats. Fundam Appl Toxicol 5(5):991\u2013996. https:\/\/doi.org\/10.1016\/0272-0590(85)90294-7","journal-title":"Fundam Appl Toxicol"},{"issue":"4\u20136","key":"10894_CR40","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.drup.2014.07.002","volume":"17","author":"YG Assaraf","year":"2014","unstructured":"Assaraf YG, Leamon CP, Reddy JA (2014) The folate receptor as a rational therapeutic target for personalized cancer treatment. Drug Resist Updates 17(4\u20136):89\u201395. https:\/\/doi.org\/10.1016\/j.drup.2014.07.002","journal-title":"Drug Resist Updates"},{"key":"10894_CR41","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-230X-12-41","volume":"12","author":"T Koppelmann","year":"2012","unstructured":"Koppelmann T, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I (2012) Dietary L-arginine supplementation reduces methotrexate-induced intestinal mucosal injury in rat. BMC Gastroenterol 12:41. https:\/\/doi.org\/10.1186\/1471-230X-12-41","journal-title":"BMC Gastroenterol"},{"issue":"5","key":"10894_CR42","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ctrv.2007.03.002","volume":"33","author":"RM Logan","year":"2007","unstructured":"Logan RM, Stringer AM, Bowen JM, Yeoh AS, Gibson RJ, Sonis ST, Keefe DM (2007) The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 33(5):448\u2013460. https:\/\/doi.org\/10.1016\/j.ctrv.2007.03.002","journal-title":"Cancer Treat Rev"},{"issue":"2","key":"10894_CR43","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/SPC.0000000000000204","volume":"10","author":"RM Logan","year":"2016","unstructured":"Logan RM, Stringer AM (2016) Mucositis: prevention and management. Curr Opin Support Palliat Care 10(2):125\u2013129. https:\/\/doi.org\/10.1097\/SPC.0000000000000204","journal-title":"Curr Opin Support Palliat Care"},{"issue":"1","key":"10894_CR44","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0163-7258(85)90083-X","volume":"28","author":"ID Goldman","year":"1985","unstructured":"Goldman ID, Matherly LH (1985) The cellular pharmacology of methotrexate. Pharmacol Ther 28(1):77\u2013102. https:\/\/doi.org\/10.1016\/0163-7258(85)90083-X","journal-title":"Pharmacol Ther"},{"issue":"4","key":"10894_CR45","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.3390\/nu13041254","volume":"13","author":"MA Montoro-Huguet","year":"2021","unstructured":"Montoro-Huguet MA, Belloc B, Dom\u00ednguez-Cajal M (2021) Small and large intestine (I): malabsorption of nutrients. Nutrients 13(4):1254. https:\/\/doi.org\/10.3390\/nu13041254","journal-title":"Nutrients"},{"issue":"Suppl. 4","key":"10894_CR46","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1159\/000493670","volume":"73","author":"M DiConstanzo","year":"2018","unstructured":"DiConstanzo M, Berni R (2018) Lactose intolerance: common misunderstandings. Ann Nutr Metab 73(Suppl. 4):30\u201337. https:\/\/doi.org\/10.1159\/000493670","journal-title":"Ann Nutr Metab"},{"key":"10894_CR47","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ibneur.2023.03.010","volume":"14","author":"Z Kravetz","year":"2023","unstructured":"Kravetz Z, Schmidt-Kastner R (2023) New aspects for the brain in Hartnup disease based on mining of high-resolution cellular mRNA expression data for SLC6A19. IBRO Neuroscience Reports 14:393\u2013397. https:\/\/doi.org\/10.1016\/j.ibneur.2023.03.010","journal-title":"IBRO Neuroscience Reports"},{"key":"10894_CR48","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1152\/advan.00094.2009","volume":"34","author":"BE Goodman","year":"2010","unstructured":"Goodman BE (2010) Insights into digestion and absorption of major nutrients in humans. Adv Physiol Educ 34:44\u201353. https:\/\/doi.org\/10.1152\/advan.00094.2009","journal-title":"Adv Physiol Educ"},{"key":"10894_CR49","unstructured":"Cho MS, Kasi A (2020) Zollinger Ellison Syndrome. StatPearls.StatPearls Publishing, Treasure Island. Accessed on 5 May 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459211\/"},{"key":"10894_CR50","volume-title":"Goodman & Gilman's the pharmacological basis of therapeutics","year":"2018","unstructured":"Brunton LL, Hilal-Dandan R, Knollmann BC (eds) (2018) Goodman & Gilman\u2019s the pharmacological basis of therapeutics, 13th edn. McGraw-Hill Education","edition":"13"},{"key":"10894_CR51","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/B978-1-4160-3115-4.50048-2","volume-title":"Medical physiology: a cellular and molecular approach","author":"HJ Binder","year":"2009","unstructured":"Binder HJ, Reuben A (2009) Nutrient digestion and absorption. In: Boron WF, Boulpaep EL (eds) Medical physiology: a cellular and molecular approach. Saunders, Philadelphia, pp 949\u2013979"},{"key":"10894_CR52","first-page":"1788","volume-title":"Sleisenger and Fordtran\u2019s gastrointestinal and liver disease","author":"C Hogenauer","year":"2016","unstructured":"Hogenauer C, Hammer HF (2016) Maldigestion and malabsorption. In: Feldman M, Friedman LS, Brandt LJ (eds) Sleisenger and Fordtran\u2019s gastrointestinal and liver disease, 10th edn. Saunders, Philadelphia, pp 1788\u20131825","edition":"10"},{"key":"10894_CR53","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1146\/annurev.physiol.010908.163145","volume":"71","author":"LG van der Flier","year":"2009","unstructured":"van der Flier LG, Clevers H (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 71:241\u2013260. https:\/\/doi.org\/10.1146\/annurev.physiol.010908.163145","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10894_CR54","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/nu3010118","volume":"3","author":"M Rossi","year":"2011","unstructured":"Rossi M, Amaretti A, Raimondi S (2011) Folate production by probiotic bacteria. Nutrients 3(1):118\u2013134. https:\/\/doi.org\/10.3390\/nu3010118","journal-title":"Nutrients"},{"issue":"10","key":"10894_CR55","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/s41575-019-0173-3","volume":"16","author":"ME Sanders","year":"2019","unstructured":"Sanders ME et al (2019) Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol 16(10):605\u2013616. https:\/\/doi.org\/10.1038\/s41575-019-0173-3","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"10894_CR56","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/nbt.1504","volume":"26","author":"MR Prausnitz","year":"2008","unstructured":"Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26(11):1261\u20131268. https:\/\/doi.org\/10.1038\/nbt.1504","journal-title":"Nat Biotechnol"},{"issue":"2","key":"10894_CR57","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jconrel.2009.06.014","volume":"139","author":"RP Dixit","year":"2009","unstructured":"Dixit RP, Puthli SP (2009) Oral strip technology: overview and future potential. J Control Release 139(2):94\u2013107. https:\/\/doi.org\/10.1016\/j.jconrel.2009.06.014","journal-title":"J Control Release"},{"issue":"1","key":"10894_CR58","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s11095-013-1057-y","volume":"31","author":"GL Amidon","year":"2014","unstructured":"Amidon GL, Lennern\u00e4s H (2014) A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 31(1):97\u2013107. https:\/\/doi.org\/10.1007\/s11095-013-1057-y","journal-title":"Pharm Res"},{"issue":"2","key":"10894_CR59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/MOG.0b013e3283365263","volume":"26","author":"A Rubio-Tapia","year":"2010","unstructured":"Rubio-Tapia A, Murray JA (2010) Celiac disease. Curr Opin Gastroenterol 26(2):116\u2013122","journal-title":"Curr Opin Gastroenterol"},{"issue":"5","key":"10894_CR60","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/nrmicro.2016.17","volume":"14","author":"P Spanogiannopoulos","year":"2016","unstructured":"Spanogiannopoulos P et al (2016) The microbial pharmacists within us: A metagenomic view of xenobiotic metabolism. Nat Rev Microbiol 14(5):273\u2013287","journal-title":"Nat Rev Microbiol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10894-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10894-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10894-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:45:16Z","timestamp":1784011516000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10894-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10894"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10894-6","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"26 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"673"}}