{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:07:43Z","timestamp":1784012863819,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the feasibility and acceptability of a 6-week, self-administered relaxing acupressure intervention in AYAs with clinically significant cancer-related fatigue (CRF) and explore its preliminary impact on CRF severity compared to sham acupressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this pilot randomized controlled trial, 42 post-treatment AYA cancer survivors (PROMIS Fatigue 4a\n                      <jats:italic>T<\/jats:italic>\n                      -score\u2009\u2265\u200955) at least 3 months post-treatment were recruited from a comprehensive cancer center and social media and randomized 2:1 to relaxing or sham acupressure. Participants stimulated five acupoints daily for 27\u00a0min over 6 weeks. PROMIS measures were completed at baseline, 6 weeks, and 10\u00a0weeks. Feasibility outcomes included recruitment, retention, fidelity, adherence, and acceptability. Mixed effects linear regression evaluated changes in CRF over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Recruitment averaged 3.5 participants\/month. Outcome completion was\u2009\u2265\u200969% at baseline, week 6, and week 10. Adherence was variable as 38% of participants completed an average of three or more sessions per week. Fatigue severity significantly decreased from baseline to 6 weeks (control\u2009\u2212\u20098.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0015; acupressure\u2009\u2212\u200910.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and remained improved at 10\u00a0weeks in both groups, with no significant between-group differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Self-administered acupressure is feasible for AYA cancer survivors. Clinically meaningful fatigue reductions occurred in both groups; however, variable adherence and no between-group differences underscore the need to optimize dose and adherence strategies in a future trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Implications for cancer survivors<\/jats:title>\n                    <jats:p>Acupressure is a low-cost, self-directed strategy that may help manage CRF. Future research should work to identify the optimal dose and adherence supports to maximize benefit for AYA survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov Identifier: NCT06442891, registered June 4, 2024.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10917-2","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:00:19Z","timestamp":1782255619000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determining the feasibility of self-administered relaxing acupressure for fatigue among adolescent and young adult cancer survivors"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-5068","authenticated-orcid":false,"given":"Robert","family":"Knoerl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Jardine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Chugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Fecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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