{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:12:41Z","timestamp":1784052761221,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00520-026-10919-0","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:43:05Z","timestamp":1782376985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptom burden and outcomes among patients with early-onset versus average-onset neuroendocrine neoplasms"],"prefix":"10.1007","volume":"34","author":[{"given":"Suriya","family":"Baskar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawyer","family":"Bawek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Samaddar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O\u2019Rorke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Vadehera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Hornstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udhayvir Singh","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"10","key":"10919_CR1","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1590\/1806-9282.63.10.856","volume":"63","author":"F Silveira","year":"2017","unstructured":"Silveira F et al (2017) Neuroendocrine tumors: an epidemiological study of 250 cases at a tertiary hospital. Rev Assoc Med Bras 63(10):856\u2013861","journal-title":"Rev Assoc Med Bras"},{"key":"10919_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12155138","author":"Q Sultana","year":"2023","unstructured":"Sultana Q et al (2023) A comprehensive review on neuroendocrine neoplasms: presentation, pathophysiology and management. J Clin Med. https:\/\/doi.org\/10.3390\/jcm12155138","journal-title":"J Clin Med"},{"issue":"2","key":"10919_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.7861\/clinmed.2023-0044","volume":"23","author":"DJ Cuthbertson","year":"2023","unstructured":"Cuthbertson DJ, Shankland R, Srirajaskanthan R (2023) Diagnosis and management of neuroendocrine tumours. Clin Med (Lond) 23(2):119\u2013124","journal-title":"Clin Med (Lond)"},{"key":"10919_CR4","doi-asserted-by":"publisher","DOI":"10.1530\/ec-23-0331","author":"P Wu","year":"2023","unstructured":"Wu P et al (2023) Epidemiologic trends of and factors associated with overall survival in patients with neuroendocrine tumors over the last two decades in the USA. Endocr Connect. https:\/\/doi.org\/10.1530\/ec-23-0331","journal-title":"Endocr Connect"},{"issue":"8","key":"10919_CR5","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1097\/COC.0000000000000925","volume":"45","author":"O Abdel-Rahman","year":"2022","unstructured":"Abdel-Rahman O, Ghosh S (2022) A real-world study of the incidence and outcomes of early-onset well-differentiated neuroendocrine neoplasms. Am J Clin Oncol 45(8):338\u2013343","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10919_CR6","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1001\/jamaoncol.2024.5937","volume":"11","author":"Y Abboud","year":"2025","unstructured":"Abboud Y et al (2025) Gastroenteropancreatic neuroendocrine tumor incidence by sex and age in the US. JAMA Oncol 11(3):345\u2013349","journal-title":"JAMA Oncol"},{"issue":"6","key":"10919_CR7","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s11764-017-0614-3","volume":"11","author":"DS Stone","year":"2017","unstructured":"Stone DS et al (2017) Young adult cancer survivors and work: a systematic review. J Cancer Surviv 11(6):765\u2013781","journal-title":"J Cancer Surviv"},{"issue":"21","key":"10919_CR8","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1200\/JCO.2017.76.3441","volume":"36","author":"W van Dorp","year":"2018","unstructured":"van Dorp W et al (2018) Reproductive function and outcomes in female survivors of childhood, adolescent, and young adult cancer: a review. J Clin Oncol 36(21):2169\u20132180","journal-title":"J Clin Oncol"},{"issue":"14","key":"10919_CR9","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1200\/JCO.2015.65.5845","volume":"34","author":"C Chao","year":"2016","unstructured":"Chao C et al (2016) Cardiovascular disease risk profiles in survivors of adolescent and young adult (AYA) cancer: the kaiser permanente AYA cancer survivors study. J Clin Oncol 34(14):1626\u20131633","journal-title":"J Clin Oncol"},{"key":"10919_CR10","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ejca.2021.06.020","volume":"154","author":"D Rydbeck","year":"2021","unstructured":"Rydbeck D et al (2021) Younger age at onset of colorectal cancer is associated with increased patient\u2019s delay. Eur J Cancer 154:269\u2013276","journal-title":"Eur J Cancer"},{"key":"10919_CR11","doi-asserted-by":"publisher","first-page":"175883592412922","DOI":"10.1177\/17588359241292271","volume":"16","author":"WY Tan","year":"2024","unstructured":"Tan WY et al (2024) Impact of sex differences on patients with neuroendocrine neoplasms during hospital admission. Ther Adv Med Oncol 16:17588359241292272","journal-title":"Ther Adv Med Oncol"},{"key":"10919_CR12","unstructured":"(HCUP), H.C.a.U.P. Producing National HCUP Estimates - Accessible Version. December 2018; Available from: www.hcup-us.ahrq.gov\/tech_assist\/nationalestimates\/508_course\/508course_2018.jsp. Accessed 30 Mar 2026"},{"issue":"11","key":"10919_CR13","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","volume":"47","author":"M Charlson","year":"1994","unstructured":"Charlson M et al (1994) Validation of a combined comorbidity index. J Clin Epidemiol 47(11):1245\u20131251","journal-title":"J Clin Epidemiol"},{"issue":"6973","key":"10919_CR14","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1136\/bmj.310.6973.170","volume":"310","author":"JM Bland","year":"1995","unstructured":"Bland JM, Altman DG (1995) Multiple significance tests: the Bonferroni method. BMJ 310(6973):170","journal-title":"BMJ"},{"issue":"10","key":"10919_CR15","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1097\/MPA.0000000000001431","volume":"48","author":"C Shen","year":"2019","unstructured":"Shen C et al (2019) Racial Differences in the Incidence and Survival of Patients With Neuroendocrine Tumors. Pancreas 48(10):1373\u20131379","journal-title":"Pancreas"},{"key":"10919_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102411","author":"D Vadehra","year":"2024","unstructured":"Vadehra D et al (2024) Demographic characteristics and survival in young-onset colorectal neuroendocrine neoplasms. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines12102411","journal-title":"Biomedicines"},{"key":"10919_CR17","doi-asserted-by":"publisher","first-page":"1241724","DOI":"10.3389\/fendo.2023.1241724","volume":"14","author":"H Yao","year":"2023","unstructured":"Yao H et al (2023) Epidemiologic trends and survival of early-onset gastroenteropancreatic neuroendocrine neoplasms. Front Endocrinol (Lausanne) 14:1241724","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"10919_CR18","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1002\/cncr.31994","volume":"125","author":"AN Willauer","year":"2019","unstructured":"Willauer AN et al (2019) Clinical and molecular characterization of early-onset colorectal cancer. Cancer 125(12):2002\u20132010","journal-title":"Cancer"},{"issue":"5","key":"10919_CR19","doi-asserted-by":"publisher","first-page":"369","DOI":"10.4103\/0256-4947.55167","volume":"29","author":"MW Saif","year":"2009","unstructured":"Saif MW, Siddiqui IA, Sohail MA (2009) Management of ascites due to gastrointestinal malignancy. Ann Saudi Med 29(5):369\u2013377","journal-title":"Ann Saudi Med"},{"issue":"5","key":"10919_CR20","doi-asserted-by":"publisher","first-page":"2741","DOI":"10.1245\/s10434-020-09566-4","volume":"28","author":"CG Tran","year":"2021","unstructured":"Tran CG, Sherman SK, Howe JR (2021) The landmark series: management of small bowel neuroendocrine tumors. Ann Surg Oncol 28(5):2741\u20132751","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10919_CR21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/SLA.0000000000005941","volume":"279","author":"A Pulvirenti","year":"2024","unstructured":"Pulvirenti A et al (2024) Early-Onset Pancreatic Neuroendocrine Tumors: Clinical Presentation, Pathology Features, and Oncological Outcomes. Ann Surg 279(1):125\u2013131","journal-title":"Ann Surg"},{"issue":"7","key":"10919_CR22","first-page":"747","volume":"30","author":"AN Burnett-Hartman","year":"2019","unstructured":"Burnett-Hartman AN et al (2019) Treatment patterns and survival differ between early-onset and late-onset colorectal cancer patients: the patient outcomes to advance learning network. Cancer Causes Control 30(7):747\u2013755","journal-title":"Cancer Causes Control"},{"key":"10919_CR23","doi-asserted-by":"publisher","first-page":"1139925","DOI":"10.3389\/fonc.2023.1139925","volume":"13","author":"SC Yu","year":"2023","unstructured":"Yu SC et al (2023) The mortality risk in patients with early onset colorectal cancer: the role of comorbidities. Front Oncol 13:1139925","journal-title":"Front Oncol"},{"key":"10919_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1025485","volume":"14","author":"Z Yang","year":"2023","unstructured":"Yang Z et al (2023) Early-onset pancreatic neuroendocrine neoplasms: a distinct disease with improved survival compared with old individuals. Front Endocrinol (Lausanne) 14:1025485","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"10919_CR25","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.3390\/jcm9061777","volume":"9","author":"A Koumarianou","year":"2020","unstructured":"Koumarianou A et al (2020) Pathogenesis and Clinical Management of Mesenteric Fibrosis in Small Intestinal Neuroendocine Neoplasms: A Systematic Review. J Clin Med 9(6):1777","journal-title":"J Clin Med"},{"key":"10919_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ctrv.2016.05.003","volume":"47","author":"S Singh","year":"2016","unstructured":"Singh S et al (2016) Diagnosis and management of gastrointestinal neuroendocrine tumors: An evidence-based Canadian consensus. Cancer Treat Rev 47:32\u201345","journal-title":"Cancer Treat Rev"},{"issue":"10","key":"10919_CR27","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1634\/theoncologist.2019-0112","volume":"24","author":"J Hallet","year":"2019","unstructured":"Hallet J et al (2019) Patterns of symptoms burden in neuroendocrine tumors: a population-based analysis of prospective patient-reported outcomes. Oncologist 24(10):1384\u20131394","journal-title":"Oncologist"},{"issue":"6","key":"10919_CR28","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.3390\/cancers14061428","volume":"14","author":"R Gosain","year":"2022","unstructured":"Gosain R et al (2022) Health-related quality of life (HRQoL) in neuroendocrine tumors: a systematic review. Cancers 14(6):1428","journal-title":"Cancers"},{"issue":"4","key":"10919_CR29","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.3390\/curroncol31040158","volume":"31","author":"VA Baronas","year":"2024","unstructured":"Baronas VA et al (2024) Symptom burden and time from symptom onset to cancer diagnosis in patients with early-onset colorectal cancer: a multicenter retrospective analysis. Curr Oncol 31(4):2133\u20132144","journal-title":"Curr Oncol"},{"issue":"5","key":"10919_CR30","doi-asserted-by":"publisher","first-page":"R163","DOI":"10.1530\/ERC-12-0024","volume":"19","author":"A Frilling","year":"2012","unstructured":"Frilling A et al (2012) Neuroendocrine tumor disease: an evolving landscape. Endocr Relat Cancer 19(5):R163\u2013R185","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"10919_CR31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1200\/JGO.2015.002980","volume":"3","author":"S Singh","year":"2017","unstructured":"Singh S et al (2017) Patient-reported burden of a neuroendocrine tumor (NET) diagnosis: results from the first global survey of patients with NETs. J Global Oncol 3(1):43\u201353","journal-title":"J Global Oncol"},{"issue":"2","key":"10919_CR32","doi-asserted-by":"publisher","first-page":"498","DOI":"10.7150\/jca.50536","volume":"12","author":"Y Wang","year":"2021","unstructured":"Wang Y et al (2021) Sex disparities in the clinical characteristics, synchronous distant metastasis occurrence and prognosis: A pan-cancer analysis. J Cancer 12(2):498\u2013507","journal-title":"J Cancer"},{"issue":"4","key":"10919_CR33","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1002\/cam4.1322","volume":"7","author":"T Akinyemiju","year":"2018","unstructured":"Akinyemiju T et al (2018) Racial\/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer. Cancer Med 7(4):1183\u20131193","journal-title":"Cancer Med"},{"issue":"2","key":"10919_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/pon.505","volume":"10","author":"A Ciaramella","year":"2001","unstructured":"Ciaramella A, Poli P (2001) Assessment of depression among cancer patients: the role of pain, cancer type and treatment. Psychooncology 10(2):156\u2013165","journal-title":"Psychooncology"},{"issue":"4","key":"10919_CR35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1023\/A:1013172913880","volume":"3","author":"LR Snowden","year":"2001","unstructured":"Snowden LR (2001) Barriers to effective mental health services for African Americans. Ment Health Serv Res 3(4):181\u2013187","journal-title":"Ment Health Serv Res"},{"issue":"2","key":"10919_CR36","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/cncr.33903","volume":"128","author":"WC Chen","year":"2022","unstructured":"Chen WC et al (2022) Association of mental health diagnosis with race and all-cause mortality after a cancer diagnosis: Large-scale analysis of electronic health record data. Cancer 128(2):344\u2013352","journal-title":"Cancer"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10919-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10919-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10919-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:02:55Z","timestamp":1784052175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10919-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10919"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10919-0","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"27 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Human ethics and consent to participate declarations","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None","order":3,"name":"Ethics","label":"Prior presentation","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"689"}}