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Understanding infusion-specific barriers and facilitators is essential for designing effective interventions that can be integrated into chemotherapy care. This study explored adult cancer survivors\u2019 perceptions and preferences regarding VR exercise during chemotherapy infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This exploratory concurrent mixed-methods study included community-dwelling adults (\u2265\u200918 years) who had completed primary cancer treatment involving chemotherapy. Participants trialled a commercially available immersive VR exercise program paired with a sensor and seated pedal unit, completed a survey on digital technology confidence and preferences, and took part in a focus group or interview to discuss VR exercise during infusion. Qualitative content analysis was used to analyse transcripts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight cancer survivors (6 female; mean age 63.6\u2009\u00b1\u20098.3 years) participated. Most reported being confident (87%) and comfortable (75%) using digital technologies. All participants enjoyed the VR exercise and indicated they would have used it during chemotherapy if available. Positive perceptions included mental wellbeing benefits, distraction, relaxation, and potential enhancement of drug circulation. Participants also identified negative aspects of the experience and potential barriers to implementation, such as cold caps, risk of cannula dislodgement, space constraints, and infusion\u2011chair suitability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides the first insights into cancer survivors\u2019 perceptions of immersive VR exercise during chemotherapy infusion. Findings highlight both the promise and practical considerations of integrating VR exercise into infusion care and represent an initial step toward developing a tailored VR exercise intervention for use during chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10920-7","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:34:23Z","timestamp":1783150463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult cancer survivors\u2019 perceptions of immersive virtual reality exercise and its utility during chemotherapy infusion: a concurrent mixed method exploratory study"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-9230","authenticated-orcid":false,"given":"Katia","family":"Ferrar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2330-2699","authenticated-orcid":false,"given":"Belinda","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-2234","authenticated-orcid":false,"given":"Thomas","family":"Beltrame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8980-1194","authenticated-orcid":false,"given":"Elizabeth S.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0241-471X","authenticated-orcid":false,"given":"Keng Hao","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-7043","authenticated-orcid":false,"given":"Jonathan J.","family":"Foo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3388-1156","authenticated-orcid":false,"given":"Max K.","family":"Hollis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5664-8031","authenticated-orcid":false,"given":"Emma","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-1642","authenticated-orcid":false,"given":"Bogda","family":"Koczwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-2248","authenticated-orcid":false,"given":"David","family":"Mizrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8216-8792","authenticated-orcid":false,"given":"Jessica","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1164-3899","authenticated-orcid":false,"given":"David","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"issue":"1","key":"10920_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s10926-022-10052-9","volume":"33","author":"TN Wilson","year":"2023","unstructured":"Wilson TN, Nambiema A, Porro B, Descatha A, Aublet-Cuvelier A, Evanoff B, Roquelaure Y (2023) Effectiveness of physical activity interventions on return to work after a cancer diagnosis: a systematic review and meta-analysis. 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Approval was granted by the Ethics Committee of Flinders University(Project #7414).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that author M. Hollis provided informed consent for publication of the image in Fig. 1.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Author Katia Ferrar\u2019s and Emma Kemp\u2019s research roles are funded by Cancer Council SA and Flinders Foundation. David Mizrahi is supported by a Col Reynolds Fellowship from The Kids Cancer Project.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"734"}}