{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:54:43Z","timestamp":1791831283044,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Herzzentrum G\u00f6ttingen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Radiotherapy for head and neck cancer frequently results in radiation-induced xerostomia, a chronic symptom that can persist long-term and compromise oral function and survivorship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional, non-interventional survey was conducted using a mixed recruitment approach (department-based and nationwide online dissemination). Xerostomia prevalence, symptom characteristics, coping strategies, and oral health-related quality of life (OHRQoL) were assessed using a study-specific xerostomia questionnaire and the validated OHIP-G14 instrument. Overall, 253 questionnaires were returned (202 complete and 51 partial), including 163 completed online via LimeSurvey and 39 completed on paper during routine follow-up visits at the tumour clinic of the department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Xerostomia was reported by 90% of respondents; 53.1% described the daily burden as strong\/very strong. Patients with xerostomia had significantly worse OHRQoL than those without (mean OHIP-G14 26.7 vs. 17.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), corresponding to a clinically relevant mean difference of 9.4 points. In multivariable linear regression, xerostomia remained independently associated with worse OHRQoL (B\u2009=\u20098.86,\n                      <jats:italic>p\u2009<\/jats:italic>\n                      &lt;\u20090.001). Functional impairment and oral pain were more pronounced than psychosocial or aesthetic domains, and perceived xerostomia severity correlated with OHIP scores. Commonly used coping strategies included frequent water intake (81%), sugar-free gum\/lozenges (46%), saliva substitutes (43%), and home remedies (e.g., oil or tea) (33%); prescription sialogogues were infrequently used (15%) and perceived as less effective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-radiotherapy xerostomia is highly prevalent and independently associated with clinically meaningful OHRQoL impairment, underscoring the need for optimized counselling and structured supportive care. Management was dominated by low-threshold behavioural strategies, while prescription sialogogues were used by only a minority of respondents and were rated less effective in terms of perceived benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10948-9","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:06:36Z","timestamp":1782515196000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post-radiotherapy xerostomia and quality of life in head and neck cancer patients"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-6758","authenticated-orcid":false,"given":"Georg","family":"Hoene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie Carlotta","family":"Waldzus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Schminke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart Johannes","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Dr\u00f6ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Schliephake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Wolfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"10948_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3390\/medsci11020042","volume":"11","author":"A Barsouk","year":"2023","unstructured":"Barsouk A, Aluru JS, Rawla P et al (2023) Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma. 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