{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T16:43:13Z","timestamp":1786207393705,"version":"build-2736575974"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemotherapy-related fatigue, sleep disturbance, and psychological distress significantly impair quality of life (QoL) in cancer patients. Traditional Chinese medicine (TCM) non-pharmacological therapies are increasingly used as supportive care, yet their comparative effectiveness remains unclear. This study aimed to evaluate and compare five TCM-based interventions for improving QoL and emotional well-being in chemotherapy patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and network meta-analysis was conducted, including randomized controlled trials (RCTs) published through April 2025. Five TCM-based interventions (acupuncture, auricular therapy, manual acupoint therapy, mind\u2013body exercise therapy, and moxibustion) were evaluated. Primary outcomes included QoL, sleep quality, fatigue, general mood, anxiety, and depression. Effect sizes were calculated as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Treatment ranking was determined using surface under the cumulative ranking curve (SUCRA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-five RCTs involving 2025 chemotherapy patients were included. Manual acupoint therapy ranked highest for improving QoL (SUCRA 63.4%; SMD vs. control, 2.29; 95% CI, 0.95 to 3.63) and sleep quality (SUCRA 91.9%; SMD vs. auricular therapy,\u2009\u22129.92; 95% CI,\u2009\u221214.83 to\u2009\u22125.01). Mind\u2013body exercise therapy was most effective for enhancing mood (SUCRA 68.0%; SMD vs. control, 0.72; 95% CI, 0.20 to 1.24) and reducing depression (SUCRA 70.8%; SMD vs. control,\u2009\u22120.92; 95% CI,\u2009\u22121.79 to\u2009\u22120.05). Auricular therapy showed the greatest benefit for fatigue (SUCRA 100%; SMD vs. control,\u2009\u22128.13; 95% CI,\u2009\u221210.15 to\u2009\u22126.11) and anxiety (SUCRA 92.9%; SMD vs. control,\u2009\u22121.53; 95% CI,\u2009\u22122.48 to\u2009\u22120.58).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TCM non-pharmacological therapies demonstrate distinct, symptom-specific efficacy in cancer patients undergoing chemotherapy. Manual acupoint therapy is most effective for QoL and sleep, mind\u2013body exercise therapy for mood and depression, and auricular therapy for fatigue and anxiety. These findings support individualized integration of TCM interventions into supportive cancer care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-10990-7","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:45:46Z","timestamp":1785141946000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative effectiveness of traditional Chinese non-pharmacological therapies for chemotherapy-related symptoms in cancer patients: a systematic review and network meta-analysis"],"prefix":"10.1007","volume":"34","author":[{"given":"Xinzheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"10990_CR1","volume-title":"Disclosure: Anup Kasi declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright \u00a9 2025","author":"MT Amjad","year":"2025","unstructured":"Amjad MT, Chidharla A, Kasi A (2025) Cancer Chemotherapy. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Anusha Chidharla declares no relevant financial relationships with ineligible companies. In: Disclosure: Anup Kasi declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright \u00a9 2025. StatPearls Publishing LLC"},{"issue":"2\u20133","key":"10990_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.14740\/wjon1371","volume":"12","author":"P Prapa","year":"2021","unstructured":"Prapa P, Papathanasiou IV, Bakalis V, Malli F, Papagiannis D, Fradelos EC (2021) Quality of life and psychological distress of lung cancer patients undergoing chemotherapy. World J Oncol 12(2\u20133):61\u201366","journal-title":"World J Oncol"},{"issue":"8","key":"10990_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s12032-021-01544-4","volume":"38","author":"E Ben-Arye","year":"2021","unstructured":"Ben-Arye E, Yakubov Y, Samuels N, Gressel O, Yosipovich A, Schiff E et al (2021) Impact of a combined integrative oncology and palliative care program on quality of life of patients with advanced cancer. Med Oncol (Northwood) 38(8):93","journal-title":"Med Oncol (Northwood)"},{"issue":"1","key":"10990_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/pon.70079","volume":"34","author":"JM Page","year":"2025","unstructured":"Page JM, Morgans AK, Hassett MJ, Haakenstad E, Manni M, McCleary NJ et al (2025) Insomnia prevalence and correlates in cancer patients undergoing treatment. Psycho-Oncol 34(1):e70079","journal-title":"Psycho-Oncol"},{"issue":"2","key":"10990_CR5","doi-asserted-by":"publisher","first-page":"e180","DOI":"10.1016\/S2214-109X(19)30488-7","volume":"8","author":"C de Martel","year":"2020","unstructured":"de Martel C, Georges D, Bray F, Ferlay J, Clifford GM (2020) Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health 8(2):e180\u2013ee90","journal-title":"Lancet Glob Health"},{"issue":"7","key":"10990_CR6","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1001\/jamaoncol.2016.6914","volume":"3","author":"KM Mustian","year":"2017","unstructured":"Mustian KM, Alfano CM, Heckler C, Kleckner AS, Kleckner IR, Leach CR et al (2017) Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol 3(7):961\u2013968","journal-title":"JAMA Oncol"},{"issue":"12","key":"10990_CR7","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1080\/14740338.2018.1546841","volume":"17","author":"JW Wastesson","year":"2018","unstructured":"Wastesson JW, Morin L, Tan ECK, Johnell K (2018) An update on the clinical consequences of polypharmacy in older adults: a narrative review. Expert Opin Drug Saf 17(12):1185\u20131196","journal-title":"Expert Opin Drug Saf"},{"issue":"1","key":"10990_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6259","volume":"33","author":"E Krueger","year":"2024","unstructured":"Krueger E, Secinti E, Stewart JC, Rand KL, Mosher CE (2024) Cognitive-behavioral and mindfulness-based interventions for distress in patients with advanced cancer: A\u00a0meta-analysis. Psycho-Oncol 33(1):e6259","journal-title":"Psycho-Oncol"},{"issue":"5","key":"10990_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5582\/bst.2021.01318","volume":"15","author":"X Zhang","year":"2021","unstructured":"Zhang X, Qiu H, Li C, Cai P, Qi F (2021) The positive role of traditional Chinese medicine as an adjunctive therapy for cancer. Biosci Trends 15(5):283\u2013298","journal-title":"Biosci Trends"},{"key":"10990_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2025.103164","volume":"90","author":"S Zhang","year":"2025","unstructured":"Zhang S, Li Y, Liang Z, Dai J, Huang H, Zhang H et al (2025) Comparing the effects of different non-pharmacological traditional Chinese medicine therapies on cancer survivors: A Bayesian Network Meta-analysis. Complement Ther Med 90:103164","journal-title":"Complement Ther Med"},{"key":"10990_CR11","volume":"106","author":"XW Zhang","year":"2022","unstructured":"Zhang XW, Hou WB, Pu FL, Wang XF, Wang YR, Yang M et al (2022) Acupuncture for cancer-related conditions: an overview of systematic reviews. Phytomed Int J Phytother Phytopharm 106:154430","journal-title":"Phytomed Int J Phytother Phytopharm"},{"issue":"14","key":"10990_CR12","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.1002\/cam4.4020","volume":"10","author":"K Han","year":"2021","unstructured":"Han K, Kim M, Kim EJ, Park YC, Kwon O, Kim AR et al (2021) Moxibustion for treating cancer-related fatigue: a multicenter, assessor-blinded, randomized controlled clinical trial. Cancer Med 10(14):4721\u20134733","journal-title":"Cancer Med"},{"issue":"8","key":"10990_CR13","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1111\/jan.14375","volume":"76","author":"Q Han","year":"2020","unstructured":"Han Q, Yang L, Huang SY, Yeung JWF, Chen XH, Xue H et al (2020) Effectiveness of auricular point therapy for cancer-related fatigue: a systematic review and meta-analysis. J Adv Nurs 76(8):1924\u20131935","journal-title":"J Adv Nurs"},{"key":"10990_CR14","doi-asserted-by":"publisher","first-page":"822","DOI":"10.3389\/fonc.2019.00822","volume":"9","author":"E Ter Veer","year":"2019","unstructured":"Ter Veer E, van Oijen MGH, van Laarhoven HWM (2019) The use of (Network) meta-analysis in clinical oncology. Front Oncol 9:822","journal-title":"Front Oncol"},{"issue":"11","key":"10990_CR15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","volume":"162","author":"B Hutton","year":"2015","unstructured":"Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C et al (2015) The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 162(11):777\u2013784","journal-title":"Ann Intern Med"},{"key":"10990_CR16","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (Clin Res Ed) 372:n71","journal-title":"BMJ (Clin Res Ed)"},{"key":"10990_CR17","doi-asserted-by":"crossref","unstructured":"Higgins JP, Green S (2008) Cochrane handbook for systematic reviews of interventions. J Wiley-Blackwell","DOI":"10.1002\/9780470712184"},{"key":"10990_CR18","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ (Clin Res Ed) 366:l4898","journal-title":"BMJ (Clin Res Ed)"},{"issue":"10","key":"10990_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076654","volume":"8","author":"A Chaimani","year":"2013","unstructured":"Chaimani A, Higgins JP, Mavridis D, Spyridonos P, Salanti G (2013) Graphical tools for network meta-analysis in STATA. PLoS One 8(10):e76654","journal-title":"PLoS One"},{"issue":"3","key":"10990_CR20","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.jpainsymman.2017.10.021","volume":"55","author":"W Zhou","year":"2018","unstructured":"Zhou W, Wan YH, Chen Q, Qiu YR, Luo XM (2018) Effects of Tai chi exercise on cancer-related fatigue in patients with nasopharyngeal carcinoma undergoing chemoradiotherapy: a randomized controlled trial. J Pain Symptom Manag 55(3):737\u2013744","journal-title":"J Pain Symptom Manag"},{"issue":"5","key":"10990_CR21","first-page":"531","volume":"44","author":"M Zhou","year":"2024","unstructured":"Zhou M, Yang S, Chen R, Zhao J, Dai Y, Xu J et al (2024) Heat-sensitive moxibustion combined with tropisetron hydrochloride for chemotherapy-induced nausea and vomiting: a randomized controlled trial. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 44(5):531\u2013536","journal-title":"Zhongguo zhen jiu = Chinese acupuncture & moxibustion."},{"issue":"3","key":"10990_CR22","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.jpainsymman.2015.11.020","volume":"51","author":"LL Zhang","year":"2016","unstructured":"Zhang LL, Wang SZ, Chen HL, Yuan AZ (2016) Tai Chi exercise for cancer-related fatigue in patients with lung cancer undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manag 51(3):504\u2013511","journal-title":"J Pain Symptom Manag"},{"issue":"11","key":"10990_CR23","first-page":"1164","volume":"40","author":"L Zhang","year":"2020","unstructured":"Zhang L, Wang YL, Lou JC, Xia GJ, Xu B, Feng SH et al (2020) Ginger-partitioned moxibustion in prevention of vomiting induced by chemotherapy in advanced malignant bone tumors: a randomized controlled trial. Zhongguo zhen jiu = Chinese Acupuncture & Moxibustion 40(11):1164\u20131168","journal-title":"Zhongguo zhen jiu = Chinese Acupuncture & Moxibustion"},{"issue":"7","key":"10990_CR24","first-page":"574","volume":"45","author":"L Zhang","year":"2020","unstructured":"Zhang L, Wang YL, Fu RY, Li JX, Guo XQ, Xu B et al (2020) Ginger-partitioned moxibustion in the prevention of nausea and vomiting induced by chemotherapy in lung cancer:a randomized controlled trial. Zhen ci yan jiu = Acupuncture research 45(7):574\u2013577","journal-title":"Zhen ci yan jiu = Acupuncture research"},{"key":"10990_CR25","doi-asserted-by":"publisher","first-page":"153473542110191","DOI":"10.1177\/15347354211019103","volume":"20","author":"J Zhang","year":"2021","unstructured":"Zhang J, Qin Z, So TH, Chen H, Lam WL, Yam LL et al (2021) Electroacupuncture plus auricular acupressure for chemotherapy-associated insomnia in breast cancer patients: a pilot randomized controlled trial. Integr Cancer Ther 20:15347354211019103","journal-title":"Integr Cancer Ther"},{"issue":"1","key":"10990_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13058-023-01645-0","volume":"25","author":"J Zhang","year":"2023","unstructured":"Zhang J, Qin Z, So TH, Chang TY, Yang S, Chen H et al (2023) Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial. Breast Cancer Research : BCR 25(1):49","journal-title":"Breast Cancer Research : BCR"},{"issue":"6","key":"10990_CR27","doi-asserted-by":"publisher","first-page":"4837","DOI":"10.3233\/THC-231890","volume":"32","author":"H Yu","year":"2024","unstructured":"Yu H (2024) Analysis of the nursing effect of five-tone therapy combined with acupoint massage on chemotherapy of lung cancer. Technology and health care : official journal of the European Society for Engineering and Medicine 32(6):4837\u20134856","journal-title":"Technology and health care : official journal of the European Society for Engineering and Medicine"},{"key":"10990_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ejon.2016.05.003","volume":"23","author":"ML Yeh","year":"2016","unstructured":"Yeh ML, Chung YC (2016) A randomized controlled trial of qigong on fatigue and sleep quality for non-Hodgkin's lymphoma patients undergoing chemotherapy. European journal of oncology nursing : the official journal of European Oncology Nursing Society. 23:81\u201386","journal-title":"European journal of oncology nursing : the official journal of European Oncology Nursing Society."},{"issue":"9","key":"10990_CR29","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1089\/acm.2020.0531","volume":"27","author":"LH Yang","year":"2021","unstructured":"Yang LH, Duan PB, Hou QM, Wang XQ (2021) Qigong exercise for patients with gastrointestinal cancer undergoing chemotherapy and at high risk for depression: a randomized clinical trial. J Altern Complement Med (New York, NY) 27(9):750\u2013759","journal-title":"J Altern Complement Med (New York, NY)"},{"issue":"1","key":"10990_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s00520-022-07548-8","volume":"31","author":"L Wen","year":"2022","unstructured":"Wen L, Chen X, Cui Y, Zhang M, Bai X (2022) Effects of Baduanjin exercise in nasopharyngeal carcinoma patients after chemoradiotherapy: a randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 31(1):79","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer"},{"issue":"7","key":"10990_CR31","doi-asserted-by":"publisher","first-page":"6079","DOI":"10.1007\/s00520-022-07015-4","volume":"30","author":"X Wei","year":"2022","unstructured":"Wei X, Yuan R, Yang J, Zheng W, Jin Y, Wang M et al (2022) Effects of Baduanjin exercise on cognitive function and cancer-related symptoms in women with breast cancer receiving chemotherapy: a randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 30(7):6079\u20136091","journal-title":"Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer."},{"issue":"4","key":"10990_CR32","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.ctim.2014.05.006","volume":"22","author":"WR Tang","year":"2014","unstructured":"Tang WR, Chen WJ, Yu CT, Chang YC, Chen CM, Wang CH et al (2014) Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: an experimental pilot study. Complement Ther Med 22(4):581\u2013591","journal-title":"Complement Ther Med"},{"issue":"1","key":"10990_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/0193945916680362","volume":"40","author":"J Shin","year":"2018","unstructured":"Shin J, Park H (2018) Effects of auricular acupressure on constipation in patients with breast cancer receiving chemotherapy: a randomized control trial. West J Nurs Res 40(1):67\u201383","journal-title":"West J Nurs Res"},{"key":"10990_CR34","doi-asserted-by":"publisher","first-page":"153473541983650","DOI":"10.1177\/1534735419836501","volume":"18","author":"A Molassiotis","year":"2019","unstructured":"Molassiotis A, Suen LKP, Cheng HL, Mok TSK, Lee SCY, Wang CH et al (2019) A randomized assessor-blinded wait-list-controlled trial to assess the effectiveness of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Integr Cancer Ther 18:1534735419836501","journal-title":"Integr Cancer Ther"},{"issue":"1","key":"10990_CR35","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jpainsymman.2013.03.007","volume":"47","author":"A Molassiotis","year":"2014","unstructured":"Molassiotis A, Russell W, Hughes J, Breckons M, Lloyd-Williams M, Richardson J et al (2014) The effectiveness of acupressure for the control and management of chemotherapy-related acute and delayed nausea: a randomized controlled trial. J Pain Symptom Manag 47(1):12\u201325","journal-title":"J Pain Symptom Manag"},{"issue":"9","key":"10990_CR36","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1159\/000501127","volume":"42","author":"Y Lu","year":"2019","unstructured":"Lu Y, Qu HQ, Chen FY, Li XT, Cai L, Chen S et al (2019) Effect of Baduanjin Qigong exercise on cancer-related fatigue in patients with colorectal cancer undergoing chemotherapy: a randomized controlled trial. Oncol Res Treat 42(9):431\u2013439","journal-title":"Oncol Res Treat"},{"key":"10990_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2022.102219","volume":"61","author":"Q Liu","year":"2022","unstructured":"Liu Q, Wang C, Wang Y, Xu W, Zhan C, Wu J et al (2022) Mindfulness-based stress reduction with acupressure for sleep quality in breast cancer patients with insomnia undergoing chemotherapy: a randomized controlled trial. European journal of oncology nursing : the official journal of European Oncology Nursing Society 61:102219","journal-title":"European journal of oncology nursing : the official journal of European Oncology Nursing Society"},{"issue":"1","key":"10990_CR38","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1136\/bmjspcare-2019-001937","volume":"11","author":"L Lin","year":"2021","unstructured":"Lin L, Zhang Y, Qian HY, Xu JL, Xie CY, Dong B et al (2021) Auricular acupressure for cancer-related fatigue during lung cancer chemotherapy: a randomised trial. BMJ Support Palliat Care 11(1):32\u201339","journal-title":"BMJ Support Palliat Care"},{"issue":"2","key":"10990_CR39","first-page":"E64","volume":"48","author":"MS Jung","year":"2025","unstructured":"Jung MS, Kim M, Sohn EH, Lee JS (2025) The effectiveness and safety of nurse-led auricular acupressure on chemotherapy-induced peripheral neuropathy among patients with breast cancer: a randomized, double-blind. Sham-Controlled Trial Cancer Nursing 48(2):E64\u2013e74","journal-title":"Sham-Controlled Trial Cancer Nursing"},{"key":"10990_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ejon.2015.10.012","volume":"21","author":"SM Huang","year":"2016","unstructured":"Huang SM, Tseng LM, Chien LY, Tai CJ, Chen PH, Hung CT et al (2016) Effects of non-sporting and sporting qigong on frailty and quality of life among breast cancer patients receiving chemotherapy. European journal of oncology nursing : the official journal of European Oncology Nursing Society 21:257\u2013265","journal-title":"European journal of oncology nursing : the official journal of European Oncology Nursing Society"},{"issue":"1","key":"10990_CR41","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s11325-021-02370-8","volume":"26","author":"HTX Hoang","year":"2022","unstructured":"Hoang HTX, Molassiotis A, Chan CW, Vu AH, Bui PT (2022) Pilot randomized sham-controlled trial of self-acupressure to manage the symptom cluster of insomnia, depression, and anxiety in cancer patients undergoing chemotherapy. Sleep Breath = Schlaf & Atmung 26(1):445\u2013456","journal-title":"Sleep Breath = Schlaf & Atmung"},{"issue":"5","key":"10990_CR42","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.21037\/apm-20-1456","volume":"9","author":"Y Ding","year":"2020","unstructured":"Ding Y, Ji L, Hu Y (2020) Effects of tai chi on catheter management and quality of life in tumor patients with PICC at the intermission of chemotherapy: a non-inferiority randomized controlled trial. Ann Palliat Med 9(5):3293\u20133303","journal-title":"Ann Palliat Med"},{"key":"10990_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ijnurstu.2017.01.004","volume":"69","author":"TY Chuang","year":"2017","unstructured":"Chuang TY, Yeh ML, Chung YC (2017) A nurse facilitated mind-body interactive exercise (Chan-Chuang qigong) improves the health status of non-Hodgkin lymphoma patients receiving chemotherapy: Randomised controlled trial. Int J Nurs Stud 69:25\u201333","journal-title":"Int J Nurs Stud"},{"issue":"1","key":"10990_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/acm.2006.6049","volume":"13","author":"A Billhult","year":"2007","unstructured":"Billhult A, Bergbom I, Stener-Victorin E (2007) Massage relieves nausea in women with breast cancer who are undergoing chemotherapy. Journal of alternative and complementary medicine (New York, NY) 13(1):53\u201357","journal-title":"Journal of alternative and complementary medicine (New York, NY)"},{"issue":"7","key":"10990_CR45","first-page":"700","volume":"49","author":"Y Zhuang","year":"2024","unstructured":"Zhuang Y, Yu DD, Ma TT, Wang YX, Wang YY, Luo L et al (2024) Effect of ginger-partitioned moxibustion combined with ringheaded thumb-tack needle stimulation on gastrointestinal reactions of malignant tumor patients undergoing chemotherapy. Zhen ci yan jiu = Acupuncture Research 49(7):700\u2013706","journal-title":"Zhen ci yan jiu = Acupuncture Research"},{"key":"10990_CR46","doi-asserted-by":"publisher","first-page":"6530454","DOI":"10.1155\/2022\/6530454","volume":"2022","author":"X Xu","year":"2022","unstructured":"Xu X, Gu F (2022) Safety and efficacy of mild moxibustion on cancer-related fatigue in non-small-cell lung cancer patients undergoing chemotherapy. Comput Math Methods Med 2022:6530454","journal-title":"Comput Math Methods Med"},{"issue":"2","key":"10990_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2025.103129","volume":"21","author":"Q Xiao","year":"2025","unstructured":"Xiao Q, Liu T, Li J, Sun Z (2025) Auriculotherapy may help to reduce gastrointestinal reactions and improve quality of life post chemotherapy. Explore (New York, NY) 21(2):103129","journal-title":"Explore (New York, NY)"},{"issue":"3","key":"10990_CR48","first-page":"806","volume":"51","author":"SPKS Zhou","year":"2022","unstructured":"Zhou SPKS, Zhou MX, Ma JX, Cai JW (2022) Effect of Baduanjin four-styles combined with emotional nursing on cancer-related fatigue and quality of life in patients with gastrointestinal tumors after chemotherapy. Chongqing Med J 51(3):806\u2013810","journal-title":"Chongqing Med J"},{"issue":"2","key":"10990_CR49","first-page":"115","volume":"25","author":"JLHF Zhang","year":"2024","unstructured":"Zhang JLHF (2024) Effect of Baduanjin combined with traditional Chinese medicine emotional nursing on quality of life in rectal cancer patients undergoing neoadjuvant chemoradiotherapy. Prac Clin Med 25(2):115\u2013117","journal-title":"Prac Clin Med"},{"issue":"3","key":"10990_CR50","first-page":"415","volume":"9","author":"HQXS Xiao","year":"2022","unstructured":"Xiao HQXS (2022) Effect of acupoint massage combined with acupoint application on gastrointestinal reaction and sleep disorder in patients with malignant tumor after chemotherapy. World J Sleep Med 9(3):415\u2013417","journal-title":"World J Sleep Med"},{"issue":"10","key":"10990_CR51","first-page":"169","volume":"30","author":"SWHC Wu","year":"2022","unstructured":"Wu SWHC (2022) Effect of traditional chinese medicine nursing combined with chinese herbal patch and acupoint massage on chemotherapy-induced nausea and vomiting in cancer patients. China & Foreign Medical Treatment 30(10):169\u2013173","journal-title":"China & Foreign Medical Treatment"},{"issue":"4","key":"10990_CR52","first-page":"522","volume":"32","author":"GYYL Peng","year":"2016","unstructured":"Peng GYYL, Tan C, Luo QL, Yang CJ, Yu Y (2016) Effect of pulse acupuncture on the quality of life in patients with advanced nasopharyngeal carcinoma during radiotherapy and chemotherapy. J Guangdong Pharm Univ 32(4):522\u2013526","journal-title":"J Guangdong Pharm Univ"},{"issue":"22","key":"10990_CR53","first-page":"180","volume":"52","author":"M Wang","year":"2020","unstructured":"Wang M (2020) Observation of emotional nursing of chinese medicine combined with point massage for sleep disorders in lung cancer patients undergoing chemotherapy. J New Chin Med 52(22):180\u2013183","journal-title":"JJ New Chin Med"},{"key":"10990_CR54","first-page":"87","volume":"42","author":"MLXJ Chen","year":"2021","unstructured":"Chen MLXJ, Yang JL, Ji YX (2021) Effect of moxibustion combined with auricular point pressure and acupoint patch on cancer-related fatigue and quality of life in lung cancer patients undergoing chemotherapy. Yunnan J Tradit Chin Med 42:87\u201389","journal-title":"Yunnan J Tradit Chin Med"},{"issue":"2","key":"10990_CR55","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.57859","volume":"8","author":"RY Soong","year":"2025","unstructured":"Soong RY, Low CE, Ong V, Sim I, Lee C, Lee F et al (2025) Exercise interventions for depression, anxiety, and quality of life in older adults with cancer: a systematic review and meta-analysis. JAMA Netw Open 8(2):e2457859","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10990_CR56","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13020-025-01105-1","volume":"20","author":"C Yao","year":"2025","unstructured":"Yao C, Zeng X, Zhang S, Xiao B, Sun P, Kong L et al (2025) Acupoint massage: a comprehensive descriptive review of its forms, applications, and underlying mechanisms. Chin Med 20(1):54","journal-title":"Chin Med"},{"issue":"3","key":"10990_CR57","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/wvn.12617","volume":"20","author":"DST Cheung","year":"2023","unstructured":"Cheung DST, Xu X, Smith R, Takemura N, Yeung WF, Chan WL et al (2023) Invasive or noninvasive? A systematic review and network meta-analysis of acupuncture and acupressure to treat sleep disturbance in cancer patients. Worldviews Evid-Based Nurs 20(3):202\u2013211","journal-title":"Worldviews Evid-Based Nurs"},{"issue":"11","key":"10990_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjon.2023.100308","volume":"10","author":"L Bi","year":"2023","unstructured":"Bi L, Gao W, Zhang X, Li N, Han J, Shi M (2023) Efficacy of traditional Chinese medicine external therapy on sleep quality in patients with cancer: A systematic review and network meta-analysis. Asia Pac J Oncol Nurs 10(11):100308","journal-title":"Asia Pac J Oncol Nurs"},{"key":"10990_CR59","doi-asserted-by":"publisher","first-page":"1038945","DOI":"10.3389\/fnins.2022.1038945","volume":"16","author":"YW Li","year":"2022","unstructured":"Li YW, Li W, Wang ST, Gong YN, Dou BM, Lyu ZX et al (2022) The autonomic nervous system: a potential link to the efficacy of acupuncture. Front Neurosci 16:1038945","journal-title":"Front Neurosci"},{"issue":"3","key":"10990_CR60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0319586","volume":"20","author":"DL Keter","year":"2025","unstructured":"Keter DL, Bialosky JE, Brochetti K, Courtney CA, Funabashi M, Karas S et al (2025) The mechanisms of manual therapy: a living review of systematic, narrative, and scoping reviews. PLoS One 20(3):e0319586","journal-title":"PLoS One"},{"key":"10990_CR61","doi-asserted-by":"publisher","first-page":"7607161","DOI":"10.1155\/2020\/7607161","volume":"2020","author":"L Duan","year":"2020","unstructured":"Duan L, Xu Y, Li M (2020) Effects of mind-body exercise in cancer survivors: a systematic review and meta-analysis. Evidence-based complementary and alternative medicine : eCAM 2020:7607161","journal-title":"Evidence-based complementary and alternative medicine : eCAM"},{"issue":"2","key":"10990_CR62","doi-asserted-by":"publisher","DOI":"10.1111\/wvn.70008","volume":"22","author":"J Wen","year":"2025","unstructured":"Wen J, Hui SS, Chin EC, Yang Y, Sit CH (2025) The effectiveness of mind-body exercise on health-related quality of life and mental health during and after breast cancer treatment: an umbrella review of meta-analyses for randomized controlled trials. Worldviews Evid-Based Nurs 22(2):e70008","journal-title":"Worldviews Evid-Based Nurs"},{"key":"10990_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2022.102886","volume":"71","author":"X Gong","year":"2022","unstructured":"Gong X, Rong G, Wang Z, Zhang A, Li X, Wang L (2022) Baduanjin exercise for patients with breast cancer: A systematic review and meta-analysis. Complement Ther Med 71:102886","journal-title":"Complement Ther Med"},{"issue":"1","key":"10990_CR64","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/JCMA.0000000000001014","volume":"87","author":"YY Kung","year":"2024","unstructured":"Kung YY, Shen YC, Li JY, Kao YK, Kuo TBJ, Yang CCH (2024) Effects of mind-body exercise on body constitution and circadian rhythm in people with suboptimal health status. Journal of the Chinese Medical Association : JCMA 87(1):94\u2013102","journal-title":"Journal of the Chinese Medical Association : JCMA"},{"issue":"1","key":"10990_CR65","doi-asserted-by":"publisher","first-page":"10948","DOI":"10.1038\/s41598-023-37309-4","volume":"13","author":"YMY Han","year":"2023","unstructured":"Han YMY, Chan MMY, Choi CXT, Law MCH, Ahorsu DK, Tsang HWH (2023) The neurobiological effects of mind-body exercise: a systematic review and meta-analysis of neuroimaging studies. Sci Rep 13(1):10948","journal-title":"Sci Rep"},{"key":"10990_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2025.112107","volume":"192","author":"P Wu","year":"2025","unstructured":"Wu P, Qian M, Chen X, Zhu M, Liu J (2025) Impact of different exercise types on depression and anxiety in individuals with cancer: A systematic review and network meta-analysis of randomized controlled trials. J Psychosom Res 192:112107","journal-title":"J Psychosom Res"},{"key":"10990_CR67","doi-asserted-by":"publisher","first-page":"153473542412391","DOI":"10.1177\/15347354241239110","volume":"23","author":"B Alhusamiah","year":"2024","unstructured":"Alhusamiah B, Almomani J, Al Omari A, Abu Attallah A, Yousef A, Alshraideh JA et al (2024) The effectiveness of P6 and auricular acupressure as a complimentary therapy in chemotherapy-induced nausea and vomiting among patients with cancer: systematic review. Integr Cancer Ther 23:15347354241239110","journal-title":"Integr Cancer Ther"},{"key":"10990_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2024.103121","volume":"88","author":"SO Silva","year":"2025","unstructured":"Silva SO, Pereira V, Silva ME, Fonseca JFD, Silva M, Camara R et al (2025) Effect of auriculotherapy on anxiety-fatigue and sleep disturbances in cancer patients: a scoping review. Complement Ther Med 88:103121","journal-title":"Complement Ther Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10990-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-10990-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-10990-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T16:02:23Z","timestamp":1786204943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-10990-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":68,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10990"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-10990-7","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"13 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This is a systematic review and meta-analysis; ethics approval and consent to participate are not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. The manuscript does not include the participant\u2019s identification image or other personal or clinical details.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No Generative AI was used in the preparation of this manuscript.","order":4,"name":"Ethics","label":"Generative AI disclosure","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"804"}}