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We aimed to identify predictors of early response and evaluate its implication for 1-year survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 349 hospitalized cancer patients undergoing their first inpatient IPP. Early analgesic response was defined by changes in daily mean NRS scores and morphine equivalent daily dose (MEDD) over a 48-h peri-procedural period. Based on these criteria, patients were categorized into overall responders and non-responders. Independent predictors of this early response were identified using multivariable logistic regression, and 1-year survival outcomes were evaluated using Kaplan\u2013Meier analysis with the log-rank test and multivariable Cox proportional hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 349 patients, overall responders (25.5%) were independently associated with higher baseline NRS (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.63\u20132.83;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower baseline MEDD (OR, 0.95 per 10-mg increase; 95% CI, 0.92\u20130.98;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariable Cox regression, early analgesic response was not independently associated with 1-year mortality (adjusted hazard ratio for non-responders vs. overall responders, 1.26; 95% CI, 0.90\u20131.77;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.176), although univariable analysis indicated a significant survival advantage (log-rank test,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher pain intensity and lower opioid use predict a favorable early analgesic response to IPP, suggesting an optimal therapeutic window for cancer-related pain intervention. Early analgesic response to IPP may serve as an exploratory prognostic indicator in patients with cancer-related pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-11004-2","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:01:17Z","timestamp":1788861677000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early analgesic response to interventional pain procedures in hospitalized patients with cancer-related pain: clinical predictors and exploratory survival analysis"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2671-0791","authenticated-orcid":false,"given":"Joon Hee","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8478-7134","authenticated-orcid":false,"given":"Jiwon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9317-4140","authenticated-orcid":false,"given":"Byunghun","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-4533","authenticated-orcid":false,"given":"Minhye","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-7851","authenticated-orcid":false,"given":"Francis Sahngun","family":"Nahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-3356","authenticated-orcid":false,"given":"Pyung Bok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-3932","authenticated-orcid":false,"given":"Eun Joo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"3","key":"11004_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/cancers15030591","volume":"15","author":"RAH Snijders","year":"2023","unstructured":"Snijders RAH, Brom L, Theunissen M, van den Beuken-van Everdingen MHJ (2023) Update on Prevalence of pain in patients with cancer 2022: a systematic literature review and meta-analysis. 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