{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:42:56Z","timestamp":1786203776670,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00520-026-11044-8","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:50:29Z","timestamp":1785217829000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for chemotherapy-induced dysgeusia in patients receiving dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin therapy: a retrospective observational study"],"prefix":"10.1007","volume":"34","author":[{"given":"Takehiro","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyohito","family":"Oriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riri","family":"Tauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tappei","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"11044_CR1","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s00520-010-0902-1","volume":"18","author":"AJ Hovan","year":"2010","unstructured":"Hovan AJ, Williams PM, Stevenson-Moore P et al (2010) A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer 18:1081\u20131087. https:\/\/doi.org\/10.1007\/s00520-010-0902-1","journal-title":"Support Care Cancer"},{"key":"11044_CR2","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1634\/theoncologist.2009-0333","volume":"15","author":"A Zabernigg","year":"2010","unstructured":"Zabernigg A, Gamper EM, Giesinger JM et al (2010) Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist 15:913\u2013920. https:\/\/doi.org\/10.1634\/theoncologist.2009-0333","journal-title":"Oncologist"},{"key":"11044_CR3","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/annonc\/mdx018","volume":"28","author":"LE Spotten","year":"2017","unstructured":"Spotten LE, Corish CA, Lorton CM et al (2017) Subjective and objective taste and smell changes in cancer. Ann Oncol 28:969\u2013984. https:\/\/doi.org\/10.1093\/annonc\/mdx018","journal-title":"Ann Oncol"},{"key":"11044_CR4","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1007\/BF00364971","volume":"1","author":"S Holmes","year":"1993","unstructured":"Holmes S (1993) Food avoidance in patients undergoing cancer chemotherapy. Support Care Cancer 1:326\u2013330. https:\/\/doi.org\/10.1007\/BF00364971","journal-title":"Support Care Cancer"},{"key":"11044_CR5","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.jpainsymman.2010.06.022","volume":"41","author":"TD Brisbois","year":"2011","unstructured":"Brisbois TD, de Kock IH, Watanabe SM et al (2011) Characterization of chemosensory alterations in advanced cancer reveals specific chemosensory phenotypes impacting dietary intake and quality of life. J Pain Symptom Manage 41:673\u2013683. https:\/\/doi.org\/10.1016\/j.jpainsymman.2010.06.022","journal-title":"J Pain Symptom Manage"},{"key":"11044_CR6","doi-asserted-by":"publisher","first-page":"E79","DOI":"10.1188\/13.Onf.E79-e85","volume":"40","author":"T Kano","year":"2013","unstructured":"Kano T, Kanda K (2013) Development and validation of a chemotherapy-induced taste alteration scale. Oncol Nurs Forum 40:E79-85. https:\/\/doi.org\/10.1188\/13.Onf.E79-e85","journal-title":"Oncol Nurs Forum"},{"key":"11044_CR7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s00415-009-0088-y","volume":"256","author":"BN Landis","year":"2009","unstructured":"Landis BN, Welge-Luessen A, Br\u00e4merson A et al (2009) \u201cTaste strips\u201d - a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol 256:242\u2013248. https:\/\/doi.org\/10.1007\/s00415-009-0088-y","journal-title":"J Neurol"},{"key":"11044_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/00016480260046409","volume":"Suppl 39\u201348","author":"Y Yamauchi","year":"2002","unstructured":"Yamauchi Y, Endo S, Sakai F et al (2002) A new whole-mouth gustatory test procedure. 1. Thresholds and principal components analysis in healthy men and women. Acta Otolaryngol Suppl 39\u201348:39. https:\/\/doi.org\/10.1080\/00016480260046409","journal-title":"Acta Otolaryngol"},{"key":"11044_CR9","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1002\/lio2.1108","volume":"8","author":"EE Blijleven","year":"2023","unstructured":"Blijleven EE, Fuchten D, Dullaart MJ et al (2023) Systematic review: validity, reliability, and diagnostic accuracy of the electrogustometer. Laryngoscope Investig Otolaryngol 8:1068\u20131079. https:\/\/doi.org\/10.1002\/lio2.1108","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"11044_CR10","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57787","volume":"16","author":"N Yadav","year":"2024","unstructured":"Yadav N, Mittal S, Reddy P et al (2024) A subjective assessment of chemotherapy drug-induced taste and smell alteration in non-head and neck cancer patients: a questionnaire-based cross-sectional study. Cureus 16:e57787. https:\/\/doi.org\/10.7759\/cureus.57787","journal-title":"Cureus"},{"key":"11044_CR11","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1007\/s00520-021-06066-3","volume":"29","author":"M Kaizu","year":"2021","unstructured":"Kaizu M, Komatsu H, Yamauchi H et al (2021) Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life. Support Care Cancer 29:5103\u20135114. https:\/\/doi.org\/10.1007\/s00520-021-06066-3","journal-title":"Support Care Cancer"},{"key":"11044_CR12","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1007\/s12282-020-01089-w","volume":"27","author":"Y Denda","year":"2020","unstructured":"Denda Y, Niikura N, Satoh-Kuriwada S et al (2020) Taste alterations in patients with breast cancer following chemotherapy: a cohort study. Breast Cancer 27:954\u2013962. https:\/\/doi.org\/10.1007\/s12282-020-01089-w","journal-title":"Breast Cancer"},{"key":"11044_CR13","doi-asserted-by":"publisher","first-page":"324","DOI":"10.4193\/Rhino10.155","volume":"49","author":"S Boesveldt","year":"2011","unstructured":"Boesveldt S, Lindau ST, McClintock MK et al (2011) Gustatory and olfactory dysfunction in older adults: a national probability study. Rhinology 49:324\u2013330. https:\/\/doi.org\/10.4193\/Rhino10.155","journal-title":"Rhinology"},{"key":"11044_CR14","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1200\/jco.2004.08.149","volume":"22","author":"T Akechi","year":"2004","unstructured":"Akechi T, Okuyama T, Sugawara Y et al (2004) Major depression, adjustment disorders, and post-traumatic stress disorder in terminally ill cancer patients: associated and predictive factors. J Clin Oncol 22:1957\u20131965. https:\/\/doi.org\/10.1200\/jco.2004.08.149","journal-title":"J Clin Oncol"},{"key":"11044_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09215-x","volume":"22","author":"M Endo","year":"2022","unstructured":"Endo M, Matsui K, Akaho R et al (2022) Depressive and anxiety symptoms among Japanese cancer survivors: Japan cancer survivorship research project. BMC Cancer 22:134. https:\/\/doi.org\/10.1186\/s12885-022-09215-x","journal-title":"BMC Cancer"},{"key":"11044_CR16","first-page":"135","volume":"5","author":"K Stolbov\u00e1","year":"1999","unstructured":"Stolbov\u00e1 K, Hahn A, Benes B et al (1999) Gustometry of diabetes mellitus patients and obese patients. Int Tinnitus J 5:135\u2013140","journal-title":"Int Tinnitus J"},{"key":"11044_CR17","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyaf001","author":"T Kawai","year":"2025","unstructured":"Kawai T, Kurokawa Y, Taguchi S et al (2025) Optimization of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin therapy for Japanese patients with urothelial carcinoma. Jpn J Clin Oncol. https:\/\/doi.org\/10.1093\/jjco\/hyaf001","journal-title":"Jpn J Clin Oncol"},{"key":"11044_CR18","doi-asserted-by":"publisher","first-page":"6367","DOI":"10.21873\/anticanres.12995","volume":"38","author":"H Fujii","year":"2018","unstructured":"Fujii H, Hirose C, Ishihara M et al (2018) Improvement of dysgeusia by Polaprezinc, a zinc-L-carnosine, in outpatients receiving cancer chemotherapy. Anticancer Res 38:6367\u20136373. https:\/\/doi.org\/10.21873\/anticanres.12995","journal-title":"Anticancer Res"},{"key":"11044_CR19","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1200\/jco.1990.8.12.1935","volume":"8","author":"WM Hryniuk","year":"1990","unstructured":"Hryniuk WM, Goodyear M (1990) The calculation of received dose intensity. J Clin Oncol 8:1935\u20131937. https:\/\/doi.org\/10.1200\/jco.1990.8.12.1935","journal-title":"J Clin Oncol"},{"key":"11044_CR20","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/s0895-4356(96)00236-3","volume":"49","author":"P Peduzzi","year":"1996","unstructured":"Peduzzi P, Concato J, Kemper E et al (1996) A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 49:1373\u20131379. https:\/\/doi.org\/10.1016\/s0895-4356(96)00236-3","journal-title":"J Clin Epidemiol"},{"key":"11044_CR21","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/01.psy.0000127692.23278.a9","volume":"66","author":"MA Babyak","year":"2004","unstructured":"Babyak MA (2004) What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 66:411\u2013421. https:\/\/doi.org\/10.1097\/01.psy.0000127692.23278.a9","journal-title":"Psychosom Med"},{"key":"11044_CR22","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.21873\/invivo.13283","volume":"37","author":"S Nagata","year":"2023","unstructured":"Nagata S, Korematsu S, Suenaga T et al (2023) Evaluation of chemotherapy-induced dysgeusia in patients with gastrointestinal cancer: a pilot study. In Vivo 37:1894\u20131900. https:\/\/doi.org\/10.21873\/invivo.13283","journal-title":"In Vivo"},{"key":"11044_CR23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1002\/lio2.142","volume":"3","author":"K Hur","year":"2018","unstructured":"Hur K, Choi JS, Zheng M et al (2018) Association of alterations in smell and taste with depression in older adults. Laryngoscope Investig Otolaryngol 3:94\u201399. https:\/\/doi.org\/10.1002\/lio2.142","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"11044_CR24","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.biopsych.2013.05.008","volume":"74","author":"W Swardfager","year":"2013","unstructured":"Swardfager W, Herrmann N, Mazereeuw G et al (2013) Zinc in depression: a meta-analysis. Biol Psychiatry 74:872\u2013878. https:\/\/doi.org\/10.1016\/j.biopsych.2013.05.008","journal-title":"Biol Psychiatry"},{"key":"11044_CR25","doi-asserted-by":"publisher","first-page":"5351","DOI":"10.1007\/s00520-022-06936-4","volume":"30","author":"K Ito","year":"2022","unstructured":"Ito K, Yuki S, Nakatsumi H et al (2022) Multicenter, prospective, observational study of chemotherapy-induced dysgeusia in gastrointestinal cancer. Support Care Cancer 30:5351\u20135359. https:\/\/doi.org\/10.1007\/s00520-022-06936-4","journal-title":"Support Care Cancer"},{"key":"11044_CR26","doi-asserted-by":"publisher","first-page":"768","DOI":"10.2337\/diacare.19.7.768","volume":"19","author":"P Perros","year":"1996","unstructured":"Perros P, MacFarlane TW, Counsell C et al (1996) Altered taste sensation in newly-diagnosed NIDDM. Diabetes Care 19:768\u2013770. https:\/\/doi.org\/10.2337\/diacare.19.7.768","journal-title":"Diabetes Care"},{"key":"11044_CR27","doi-asserted-by":"publisher","unstructured":"Yazla S, Ozmen S, Kiyici S et al (2018) Evaluation of olfaction and taste function in type 2 diabetic patients with and without peripheral neuropathy. Diabetes Metab Res Rev 34.https:\/\/doi.org\/10.1002\/dmrr.2973","DOI":"10.1002\/dmrr.2973"},{"key":"11044_CR28","doi-asserted-by":"publisher","first-page":"656","DOI":"10.18203\/2349-3933.ijam20221346","volume":"9","author":"A Singh","year":"2022","unstructured":"Singh A, Kushwaha J, Giri R (2022) Taste dysfunction in type 2 diabetes mellitus patients with autonomic neuropathy and its relation with HbA1C level and disease duration. Int J Adv Med 9:656. https:\/\/doi.org\/10.18203\/2349-3933.ijam20221346","journal-title":"Int J Adv Med"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-11044-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-11044-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-11044-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T14:55:40Z","timestamp":1786200940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-11044-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["11044"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-11044-8","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"7 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The protocol for this single center retrospective observational study was approved by the ethics committee of the faculty of medicine, the University of Tokyo (Approval number: 2529). The institutional review board granted an opt-out recruitment approach and waived the need for obtaining written informed consent from each patient. We strictly adhered to the Declaration of Helsinki and its latest amendment.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"808"}}