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Comprehensive searches were conducted in PubMed, Embase, Scopus, Web of Science, MEDLINE, LILACS, and gray literature sources, with no date restrictions. Clinical studies evaluating endodontic therapy in irradiated patients were included. Data were charted and narratively synthesized using a Population\u2013Concept\u2013Context framework. Consistent with scoping review methodology, no critical appraisal was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 174 identified records, five studies met the inclusion criteria. Reported success rates ranged from 18 to 100%, with lower rates observed in earlier studies employing outdated techniques. More recent investigations demonstrated high clinical success, improved radiographic stability, and no reported cases of ORN. Across all studies, endodontic therapy was not associated with ORN. However, methodological heterogeneity was noted, particularly regarding outcome definitions and follow-up duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Endodontic therapy appears to be a safe and conservative treatment option for patients with head and neck cancer who underwent radiotherapy and may reduce the need for invasive procedures associated with ORN risk. However, the limited and heterogeneous evidence highlights the need for well-designed prospective studies to support standardized clinical decision-making within supportive oncology care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-11139-2","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:15:57Z","timestamp":1788156957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence supporting endodontic therapy as a safe strategy in patients previously treated with head and neck radiotherapy: a scoping review"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8203-9321","authenticated-orcid":false,"given":"\u00c1lvaro Souza","family":"Wanderley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-1616","authenticated-orcid":false,"given":"Wesley Viana","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6363-5343","authenticated-orcid":false,"given":"Maria Ol\u00edvia","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-3709","authenticated-orcid":false,"given":"Al\u00edcia Marcelly Souza","family":"de Mendon\u00e7a Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-4469","authenticated-orcid":false,"given":"Raylane Farias","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7559-2608","authenticated-orcid":false,"given":"Igor Henrique Morais","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-749X","authenticated-orcid":false,"given":"Lucas Nascimento","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7897-2489","authenticated-orcid":false,"given":"Diana Santana","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-5565","authenticated-orcid":false,"given":"Marlos","family":"Barbosa-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"11139_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1665019","author":"H Sun","year":"2025","unstructured":"Sun H, Yu M, An Z, Liang F, Sun B, Liu Y et al (2025) Global burden of head and neck cancer: epidemiological transitions, inequities, and projections to 2050. 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