{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:11:23Z","timestamp":1790323883991,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00520-026-11152-5","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:40:11Z","timestamp":1787949611000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herpetic reactivation during radiotherapy treatment for gynaecological cancers\u2014a retrospective observational study"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1790-700X","authenticated-orcid":false,"given":"Deepu C","family":"Tom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-5071","authenticated-orcid":false,"given":"Avinash H","family":"Udayashankara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirmala","family":"S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-8553","authenticated-orcid":false,"given":"Hadrian Noel Alexander","family":"F","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1830-0276","authenticated-orcid":false,"given":"Jayalekshmi","family":"R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2678-4993","authenticated-orcid":false,"given":"Sakshi","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-7432","authenticated-orcid":false,"given":"John Michael","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"9","key":"11152_CR1","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1073\/pnas.0610847104","volume":"104","author":"GMGM Verjans","year":"2007","unstructured":"Verjans GMGM, Hintzen RQ, van Dun JM et al (2007) Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia. Proc Natl Acad Sci U S A 104(9):3496\u20133501","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"11152_CR2","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/j.1574-6976.2011.00320.x","volume":"36","author":"MP Nicoll","year":"2012","unstructured":"Nicoll MP, Proen\u00e7a JT, Efstathiou S (2012) The molecular basis of herpes simplex virus latency. FEMS Microbiol Rev 36(3):684\u2013705","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"11152_CR3","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1080\/21505594.2021.1982373","volume":"12","author":"S Zhu","year":"2021","unstructured":"Zhu S, Viejo-Borbolla A (2021) Pathogenesis and virulence of herpes simplex virus. Virulence 12(1):2670\u20132702","journal-title":"Virulence"},{"issue":"3","key":"11152_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.2217\/fvl.10.90","volume":"6","author":"E Eshleman","year":"2011","unstructured":"Eshleman E, Shahzad A, Cohrs RJ (2011) Varicella zoster virus latency. Future Virol 6(3):341\u2013355","journal-title":"Future Virol"},{"issue":"suppl_2","key":"11152_CR5","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1093\/infdis\/jiy403","volume":"218","author":"KJ Laing","year":"2018","unstructured":"Laing KJ, Ouwendijk WJD, Koelle DM et al (2018) Immunobiology of varicella-zoster virus infection. J Infect Dis 218(suppl_2):S68\u2013S74","journal-title":"J Infect Dis"},{"issue":"1","key":"11152_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1600-065X.2011.01074.x","volume":"245","author":"DW White","year":"2012","unstructured":"White DW, Beard RS, Barton ES (2012) Immune modulation during latent herpesvirus infection. Immunol Rev 245(1):189\u2013208","journal-title":"Immunol Rev"},{"key":"11152_CR7","first-page":"1","volume":"523","author":"JB Suzich","year":"2018","unstructured":"Suzich JB, Cliffe AR (2018) Strength in diversity: understanding the pathways to herpes simplex virus reactivation. Virology 523:1\u20134","journal-title":"Virology"},{"key":"11152_CR8","first-page":"699","volume":"15","author":"NT Hasanah","year":"2022","unstructured":"Hasanah NT, Hidayat W (2022) Stress as trigger factor of HSV-1 reactivation causing recurrent intraoral herpes mimicking HAEM: a case report. Int Med Case Rep J 15:699\u2013706","journal-title":"Int Med Case Rep J"},{"issue":"14","key":"11152_CR9","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1101\/gad.190157.112","volume":"26","author":"M Kobayashi","year":"2012","unstructured":"Kobayashi M, Wilson AC, Chao MV et al (2012) Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor. Genes Dev 26(14):1527\u20131532","journal-title":"Genes Dev"},{"issue":"3","key":"11152_CR10","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00277-021-04746-y","volume":"101","author":"L Henze","year":"2022","unstructured":"Henze L, Buhl C, Sandherr M et al (2022) Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus. Ann Hematol 101(3):491\u2013511. https:\/\/doi.org\/10.1007\/s00277-021-04746-y","journal-title":"Ann Hematol"},{"issue":"5","key":"11152_CR11","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/infdis\/jit252","volume":"208","author":"AA Tobian","year":"2013","unstructured":"Tobian AA, Grabowski MK, Serwadda D et al (2013) Reactivation of herpes simplex virus type 2 after initiation of antiretroviral therapy. J Infect Dis 208(5):839\u2013846. https:\/\/doi.org\/10.1093\/infdis\/jit252","journal-title":"J Infect Dis"},{"key":"11152_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jcv.2017.11.004","volume":"98","author":"MK Ramirez-Fort","year":"2018","unstructured":"Ramirez-Fort MK, Zeng J, Feily A et al (2018) Radiotherapy-induced reactivation of neurotrophic human herpes viruses: overview and management. J Clin Virol 98:18\u201327","journal-title":"J Clin Virol"},{"issue":"2","key":"11152_CR13","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s13300-018-0394-4","volume":"9","author":"M Papagianni","year":"2018","unstructured":"Papagianni M, Metallidis S, Tziomalos K (2018) Herpes zoster and diabetes mellitus: a review. Diabetes Ther 9(2):545\u2013550. https:\/\/doi.org\/10.1007\/s13300-018-0394-4","journal-title":"Diabetes Ther"},{"issue":"16","key":"11152_CR14","doi-asserted-by":"publisher","first-page":"e25292","DOI":"10.1097\/MD.0000000000025292","volume":"100","author":"SW Lai","year":"2021","unstructured":"Lai SW, Liu CS, Kuo YH, Lin CL, Hwang BF, Liao KF (2021) The incidence of herpes zoster in patients with diabetes mellitus: a meta-analysis of cohort studies. Medicine (Baltimore) 100(16):e25292. https:\/\/doi.org\/10.1097\/MD.0000000000025292","journal-title":"Medicine (Baltimore)"},{"key":"11152_CR15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.2147\/IDR.S184598","volume":"12","author":"AA Ghweil","year":"2019","unstructured":"Ghweil AA, Helal MM (2019) Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents. Infect Drug Resist 12:759\u2013762. https:\/\/doi.org\/10.2147\/IDR.S184598","journal-title":"Infect Drug Resist"},{"issue":"2","key":"11152_CR16","doi-asserted-by":"publisher","first-page":"2239828","DOI":"10.1080\/07853890.2023.2239828","volume":"55","author":"Y Getaneh","year":"2023","unstructured":"Getaneh Y, Getnet F, Amogne MD, Liao L, Yi F, Shao Y (2023) Burden of hepatitis B virus and syphilis co-infections and its impact on HIV treatment outcome in Ethiopia: nationwide community-based study. Ann Med 55(2):2239828. https:\/\/doi.org\/10.1080\/07853890.2023.2239828","journal-title":"Ann Med"},{"key":"11152_CR17","doi-asserted-by":"publisher","first-page":"e944688","DOI":"10.12659\/MSM.944688","volume":"31","author":"M Wang","year":"2025","unstructured":"Wang M, Yuan Y, Wang J, Yan Y, Yu H (2025) Immune dysregulation in acute herpes zoster: predictive factors for postherpetic neuralgia. Med Sci Monit 31:e944688. https:\/\/doi.org\/10.12659\/MSM.944688","journal-title":"Med Sci Monit"},{"issue":"10","key":"11152_CR18","doi-asserted-by":"publisher","first-page":"ofaf603","DOI":"10.1093\/ofid\/ofaf603","volume":"12","author":"V Ssempijja","year":"2025","unstructured":"Ssempijja V, Callier V, Nason M et al (2025) Herpesviruses reactivation and systemic inflammation before and after initiating antiretroviral therapy among women with HIV in Rakai, Uganda. Open Forum Infect Dis 12(10):ofaf603. https:\/\/doi.org\/10.1093\/ofid\/ofaf603","journal-title":"Open Forum Infect Dis"},{"issue":"6","key":"11152_CR19","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/infdis\/jiv148","volume":"212","author":"S Gianella","year":"2015","unstructured":"Gianella S, Massanella M, Wertheim JO, Smith DM (2015) The sordid affair between human herpesvirus and HIV. J Infect Dis 212(6):845\u2013852. https:\/\/doi.org\/10.1093\/infdis\/jiv148","journal-title":"J Infect Dis"},{"issue":"12","key":"11152_CR20","doi-asserted-by":"publisher","first-page":"e75857","DOI":"10.7759\/cureus.75857","volume":"16","author":"T Aleksiev","year":"2024","unstructured":"Aleksiev T, Popov V, Dobrev H (2024) Radiation-associated herpes zoster: a clinical case. Cureus 16(12):e75857. https:\/\/doi.org\/10.7759\/cureus.75857","journal-title":"Cureus"},{"key":"11152_CR21","doi-asserted-by":"publisher","unstructured":"Oakley C, Epstein JB, Sherlock CH (1997) Reactivation of oral herpes simplex virus: implications for clinical management of herpes simplex virus recurrence during radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84(3):272\u2013278. https:\/\/doi.org\/10.1016\/S1079-2104(97)90342-5","DOI":"10.1016\/S1079-2104(97)90342-5"},{"issue":"3","key":"11152_CR22","doi-asserted-by":"publisher","first-page":"e2437","DOI":"10.1002\/rmv.2437","volume":"33","author":"A Shafiee","year":"2023","unstructured":"Shafiee A, Teymouri Athar MM, Amini MJ et al (2023) Reactivation of herpesviruses during COVID-19: a systematic review and meta-analysis. Rev Med Virol 33(3):e2437. https:\/\/doi.org\/10.1002\/rmv.2437","journal-title":"Rev Med Virol"},{"issue":"9","key":"11152_CR23","doi-asserted-by":"publisher","first-page":"5427","DOI":"10.1002\/jmv.27077","volume":"93","author":"M Khoury","year":"2021","unstructured":"Khoury M, Al-Jasser A, Al-Radi LO et al (2021) COVID-19 pandemic as a risk factor for the reactivation of herpesviruses. J Med Virol 93(9):5427\u20135433. https:\/\/doi.org\/10.1002\/jmv.27077","journal-title":"J Med Virol"},{"issue":"5","key":"11152_CR24","doi-asserted-by":"publisher","first-page":"e2227","DOI":"10.1002\/rmv.2227","volume":"31","author":"AA Al-Qahtani","year":"2021","unstructured":"Al-Qahtani AA, Al-Ahdal MN (2021) Reactivation of herpesviruses during COVID-19: A review. Rev Med Virol 31(5):e2227. https:\/\/doi.org\/10.1002\/rmv.2227","journal-title":"Rev Med Virol"},{"issue":"2","key":"11152_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3855\/jidc.16723","volume":"18","author":"A Gupta","year":"2024","unstructured":"Gupta A, Madan K, Gupta D et al (2024) Clinical features and outcomes of COVID-19 patients with herpesvirus reactivation. J Infect Dev Ctries 18(2):167\u2013173. https:\/\/doi.org\/10.3855\/jidc.16723","journal-title":"J Infect Dev Ctries"},{"issue":"10","key":"11152_CR26","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1093\/infdis\/jiad272","volume":"228","author":"C Riera","year":"2023","unstructured":"Riera C, Mart\u00ednez E, Fern\u00e1ndez-Busquets X et al (2023) Herpes zoster reactivation after mRNA and adenovirus COVID-19 vaccination. J Infect Dis 228(10):1326\u20131330. https:\/\/doi.org\/10.1093\/infdis\/jiad272","journal-title":"J Infect Dis"},{"issue":"2","key":"11152_CR27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.abd.2023.02.001","volume":"98","author":"MCF de Oliveira","year":"2023","unstructured":"de Oliveira MCF, de Almeida MCM, da Silva AC et al (2023) COVID-19 infection and vaccines: potential triggers of herpesvirus reactivation. An Bras Dermatol 98(2):210\u2013214. https:\/\/doi.org\/10.1016\/j.abd.2023.02.001","journal-title":"An Bras Dermatol"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-11152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-11152-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-11152-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:50:54Z","timestamp":1790322654000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00520-026-11152-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["11152"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-11152-5","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"3 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The present study was carried out after a formal Institutional Ethics Committee Clearance at St. John\u2019s National Academy of Health Science, Sarjapur Road, Bengaluru\u2014560034, with IEC Ref No. 209\/2024 dated 21\/08\/2024. The research was conducted in accordance with the Declaration of Helsinki and its amendments.","order":1,"name":"Ethics","label":"Ethics declaration","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted after a formal Institutional Ethics committee clearance. The waiver of consent was approved by the Ethics committee, based on retrospective nature of the study. Hence consent to participate is NOT APPLICABLE.","order":2,"name":"Ethics","label":"Human ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Institutional Ethics Committee, St. John\u2019s Medical College and Hospital, St. John\u2019s National Academy of Health Sciences, Sarjapur Road, Bengaluru \u2013 560034.","order":3,"name":"Ethics","label":"Name of ethics committee","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"907"}}