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However, patients differ substantially in their psychological, physical, functional, interpersonal, and medical needs. Single-score distress screening may not capture this heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed cross-sectional baseline data from 96 adults assessed within an interdisciplinary 72-h fast-track diagnostic program for suspected or newly diagnosed HNC. Five theory-driven, z-standardized domains (psychological distress, physical burden, functional impairment, interpersonal vulnerability, medical complexity) were derived and clustered with k-means. Psychosocial care contacts within 14\u00a0days served as an exploratory external criterion and were not used as clustering inputs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A three-cluster solution yielded (i) low burden (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200958, 60.4%), (ii) psychologically distressed (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924, 25.0%) with elevated distress and comparatively low medical complexity, and (iii) somatic\/functional high burden (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914, 14.6%) characterized by prominent physical and functional burden. Psychosocial care utilization differed only modestly across clusters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Multidimensional profiling in this 72-h HNC pathway yielded clinically interpretable subgroups that may inform needs-based supportive and psychosocial care allocation. Because observed utilization did not map strongly onto profiles, prospective validation is required before clinical implementation\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-11187-8","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:35:21Z","timestamp":1789223721000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Data-driven biopsychosocial profiles to inform early psycho-oncology triage in head and neck cancer"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5252-3976","authenticated-orcid":false,"given":"Jan Ben","family":"Schulze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-8355","authenticated-orcid":false,"given":"Sebastian","family":"Euler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-5129","authenticated-orcid":false,"given":"Roland","family":"von K\u00e4nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-818X","authenticated-orcid":false,"given":"Martina A.","family":"Broglie-D\u00e4ppen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-6657","authenticated-orcid":false,"given":"Christian","family":"Th\u00fcring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-7270","authenticated-orcid":false,"given":"Simon Andreas","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-6772","authenticated-orcid":false,"given":"Gregoire B.","family":"Morand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9655-1776","authenticated-orcid":false,"given":"Cosima Eleanor","family":"Riemenschnitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"issue":"1","key":"11187_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1002\/1099-1611(200101\/02)10:1<19::AID-PON501>3.0.CO;2-6","volume":"10","author":"J Zabora","year":"2001","unstructured":"Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S (2001) The prevalence of psychological distress by cancer site. 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