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Device preference, discomfort, perceived pain control, and reasons for preference were descriptively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      EO-PBMT was preferred by 65.6% of respondents, whereas 34.4% preferred IO-PBMT. Preference for EO-PBMT was mainly associated with greater comfort and avoidance of mouth opening. Discomfort was reported by 43.8% during IO-PBM and by 6.3% during EO-PBMT, with a statistically significant difference between the modalities (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). IO-PBMT was more often perceived to provide better pain control (34.4%), whereas 12.5% favored EO-PBMT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EO-PBMT demonstrated greater caregiver acceptance and lower treatment-related discomfort than IO-PBMT. Although caregivers more frequently perceived IO-PBMT as providing better pain control, these subjective perceptions did not correspond to differences in the clinical occurrence or severity of OM between treatment modalities. EO-PBMT therefore represents a feasible and well-accepted approach for supportive care in pediatric oncology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-11227-3","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:50:54Z","timestamp":1790139054000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acceptance and perceived efficacy of intraoral versus extraoral photobiomodulation for oral mucositis prevention in pediatric patients"],"prefix":"10.1007","volume":"34","author":[{"given":"Isabela de Oliveira Plugge","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Leal Klein","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela","family":"Schuartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara Albonei Dudeque","family":"Pianovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurindo Moacir","family":"Sassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna da Fonseca","family":"Wastner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Rodrigues","family":"de Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"2","key":"11227_CR1","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/ipd.12718","volume":"31","author":"JB Valer","year":"2021","unstructured":"Valer JB, Curra M, Gabriel AF, Schmidt TR, Ferreira MBC, Roesler R, Evangelista JMC, Martins MAT, Gregianin L, Martins MD (2021) Oral mucositis in childhood cancer patients receiving high-dose methotrexate: prevalence, relationship with other toxicities and methotrexate elimination. 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