{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:47:37Z","timestamp":1792090057762,"version":"4.4.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Support Care Cancer"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00520-026-11246-0","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:55:33Z","timestamp":1789775733000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integration of early palliative care in cancer treatment: a meta-analysis of 39 randomized controlled trials on clinical outcomes and management optimization"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7229-0100","authenticated-orcid":false,"given":"Zhenyang","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4485-7491","authenticated-orcid":false,"given":"Yuqi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"issue":"8","key":"11246_CR1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1056\/nejmoa1000678","volume":"363","author":"JS Temel","year":"2010","unstructured":"Temel JS, Greer JA, Muzikansky A et al (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363(8):733\u2013742. https:\/\/doi.org\/10.1056\/nejmoa1000678","journal-title":"N Engl J Med"},{"issue":"6880","key":"11246_CR2","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1136\/bmj.306.6880.752","volume":"306","author":"W Scheithauer","year":"1993","unstructured":"Scheithauer W, Rosen H, Kornek GV et al (1993) Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ 306(6880):752\u2013755. https:\/\/doi.org\/10.1136\/bmj.306.6880.752","journal-title":"BMJ"},{"issue":"13","key":"11246_CR3","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1200\/jco.2011.39.4585","volume":"30","author":"JH Kang","year":"2012","unstructured":"Kang JH, Lee SI, Lim DH et al (2012) Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone. J Clin Oncol 30(13):1513\u20131518. https:\/\/doi.org\/10.1200\/jco.2011.39.4585","journal-title":"J Clin Oncol"},{"issue":"3","key":"11246_CR4","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/jme.10.3.124","volume":"10","author":"KC Calman","year":"1984","unstructured":"Calman KC (1984) Quality of life in cancer patients\u2013an hypothesis. J Med Ethics 10(3):124\u2013127. https:\/\/doi.org\/10.1136\/jme.10.3.124","journal-title":"J Med Ethics"},{"issue":"5","key":"11246_CR5","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1200\/jco.1984.2.5.472","volume":"2","author":"H Schipper","year":"1984","unstructured":"Schipper H, Clinch J, Mcmurray A et al (1984) Measuring the quality of life of cancer patients: the functional living index-cancer: development and validation. J Clin Oncol 2(5):472\u2013483. https:\/\/doi.org\/10.1200\/jco.1984.2.5.472","journal-title":"J Clin Oncol"},{"issue":"5","key":"11246_CR6","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1089\/jpm.2018.0338","volume":"22","author":"A Sarradon-Eck","year":"2019","unstructured":"Sarradon-Eck A, Besle S, Troian J et al (2019) Understanding the barriers to introducing early palliative care for patients with advanced cancer: a qualitative study. J Palliat Med 22(5):508\u2013516. https:\/\/doi.org\/10.1089\/jpm.2018.0338","journal-title":"J Palliat Med"},{"issue":"4","key":"11246_CR7","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1590\/s1413-81232007000400015","volume":"12","author":"D Schout","year":"2007","unstructured":"Schout D, Novaes HMD (2007) From records to indicators: the management of health care information production in hospitals. Ciencia Saude Coletiva 12(4):935\u2013944. https:\/\/doi.org\/10.1590\/s1413-81232007000400015","journal-title":"Ciencia Saude Coletiva"},{"issue":"4","key":"11246_CR8","doi-asserted-by":"publisher","first-page":"e238","DOI":"10.1200\/jop.2017.025221","volume":"14","author":"BS Gannavarapu","year":"2018","unstructured":"Gannavarapu BS, Lau SKM, Carter K et al (2018) Prevalence and survival impact of pretreatment cancer-associated weight loss: a tool for guiding early palliative care. J Oncol Pract 14(4):e238\u2013e250. https:\/\/doi.org\/10.1200\/jop.2017.025221","journal-title":"J Oncol Pract"},{"issue":"1","key":"11246_CR9","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/0269216317739806","volume":"32","author":"J Mcdonald","year":"2017","unstructured":"Mcdonald J, Swami N, Pope A et al (2017) Caregiver quality of life in advanced cancer: qualitative results from a trial of early palliative care. Palliat Med 32(1):69\u201378. https:\/\/doi.org\/10.1177\/0269216317739806","journal-title":"Palliat Med"},{"issue":"8","key":"11246_CR10","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1200\/jco.2016.70.5046","volume":"35","author":"JS Temel","year":"2016","unstructured":"Temel JS, Greer JA, El-Jawahri A et al (2016) Effects of early integrated palliative care in patients with lung and GI cancer: a randomized clinical trial. J Clin Oncol 35(8):834\u2013841. https:\/\/doi.org\/10.1200\/jco.2016.70.5046","journal-title":"J Clin Oncol"},{"issue":"13","key":"11246_CR11","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1200\/jco.2014.58.6362","volume":"33","author":"MA Bakitas","year":"2015","unstructured":"Bakitas MA, Tosteson TD, Li Z et al (2015) Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol 33(13):1438\u20131445. https:\/\/doi.org\/10.1200\/jco.2014.58.6362","journal-title":"J Clin Oncol"},{"issue":"8","key":"11246_CR12","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1089\/jpm.2015.0476","volume":"19","author":"JA Greer","year":"2016","unstructured":"Greer JA, Tramontano AC, Mcmahon PM et al (2016) Cost analysis of a randomized trial of early palliative care in patients with metastatic nonsmall-cell lung cancer. J Palliat Med 19(8):842\u2013848. https:\/\/doi.org\/10.1089\/jpm.2015.0476","journal-title":"J Palliat Med"},{"issue":"6","key":"11246_CR13","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13620","volume":"31","author":"B Huo","year":"2022","unstructured":"Huo B, Song Y, Chang L et al (2022) Effects of early palliative care on patients with incurable cancer: a meta-analysis and systematic review. Eur J Cancer Care 31(6):e13620. https:\/\/doi.org\/10.1111\/ecc.13620","journal-title":"Eur J Cancer Care"},{"issue":"9","key":"11246_CR14","doi-asserted-by":"publisher","first-page":"820","DOI":"10.7326\/0003-4819-127-9-199711010-00008","volume":"127","author":"J Lau","year":"1997","unstructured":"Lau J, Ioannidis JP, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127(9):820\u2013826. https:\/\/doi.org\/10.7326\/0003-4819-127-9-199711010-00008","journal-title":"Ann Intern Med"},{"key":"11246_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1471-2288-8-56","volume":"8","author":"J Ma","year":"2008","unstructured":"Ma J, Liu W, Hunter A et al (2008) Performing meta-analysis with incomplete statistical information in clinical trials. BMC Med Res Methodol 8:56. https:\/\/doi.org\/10.1186\/1471-2288-8-56","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"11246_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-024-02356-6","volume":"24","author":"A Abbas","year":"2024","unstructured":"Abbas A, Hefnawy MT, Negida A (2024) Meta-analysis accelerator: a comprehensive tool for statistical data conversion in systematic reviews with meta-analysis. BMC Med Res Methodol 24(1):243. https:\/\/doi.org\/10.1186\/s12874-024-02356-6","journal-title":"BMC Med Res Methodol"},{"issue":"2","key":"11246_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1177\/096228029300200202","volume":"2","author":"JL Fleiss","year":"1993","unstructured":"Fleiss JL (1993) The statistical basis of meta-analysis. Stat Methods Med Res 2(2):121\u2013145. https:\/\/doi.org\/10.1177\/096228029300200202","journal-title":"Stat Methods Med Res"},{"issue":"1","key":"11246_CR18","doi-asserted-by":"publisher","first-page":"75","DOI":"10.2307\/1164953","volume":"13","author":"S Wasserman","year":"1988","unstructured":"Wasserman S, Hedges LV, Olkin I (1988) Statistical methods for meta-analysis. J Educ Stat 13(1):75\u201375. https:\/\/doi.org\/10.2307\/1164953","journal-title":"J Educ Stat"},{"issue":"6","key":"11246_CR19","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/sim.650","volume":"20","author":"SE Brockwell","year":"2001","unstructured":"Brockwell SE, Gordon IR (2001) A comparison of statistical methods for meta-analysis. Stat Med 20(6):825\u2013840. https:\/\/doi.org\/10.1002\/sim.650","journal-title":"Stat Med"},{"issue":"1","key":"11246_CR20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1258\/1355819021927674","volume":"7","author":"J Higgins","year":"2002","unstructured":"Higgins J, Thompson S, Deeks J et al (2002) Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice. J Health Serv Res Policy 7(1):51\u201361. https:\/\/doi.org\/10.1258\/1355819021927674","journal-title":"J Health Serv Res Policy"},{"issue":"4","key":"11246_CR21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5662\/wjm.v2.i4.27","volume":"2","author":"GA Kelley","year":"2012","unstructured":"Kelley GA, Kelley KS (2012) Statistical models for meta-analysis: a brief tutorial. World J Methodol 2(4):27\u201332. https:\/\/doi.org\/10.5662\/wjm.v2.i4.27","journal-title":"World J Methodol"},{"issue":"2","key":"11246_CR22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1037\/1082-989x.11.2.193","volume":"11","author":"TB Huedo-Medina","year":"2006","unstructured":"Huedo-Medina TB, S\u00e1nchez-Meca J, Mar\u00edn-Mart\u00ednez F et al (2006) Assessing heterogeneity in meta-analysis: Q statistic or I2 index. Psychol Methods 11(2):193\u2013206. https:\/\/doi.org\/10.1037\/1082-989x.11.2.193","journal-title":"Psychol Methods"},{"issue":"11","key":"11246_CR23","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JPT Higgins","year":"2002","unstructured":"Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539\u20131558. https:\/\/doi.org\/10.1002\/sim.1186","journal-title":"Stat Med"},{"issue":"5","key":"11246_CR24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365\u2013376. https:\/\/doi.org\/10.1093\/jnci\/85.5.365","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"11246_CR25","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1001\/jama.2009.1198","volume":"302","author":"M Bakitas","year":"2009","unstructured":"Bakitas M, Lyons KD, Hegel MT et al (2009) Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the project ENABLE II randomized controlled trial. JAMA 302(7):741\u2013749. https:\/\/doi.org\/10.1001\/jama.2009.1198","journal-title":"JAMA"},{"issue":"4","key":"11246_CR26","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1200\/jco.2004.06.078","volume":"22","author":"G Velikova","year":"2004","unstructured":"Velikova G, Booth L, Smith AB et al (2004) Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. J Clin Oncol 22(4):714\u2013724. https:\/\/doi.org\/10.1200\/jco.2004.06.078","journal-title":"J Clin Oncol"},{"issue":"4","key":"11246_CR27","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1037\/1082-989x.9.4.426","volume":"9","author":"LV Hedges","year":"2004","unstructured":"Hedges LV, Pigott TD (2004) The power of statistical tests for moderators in meta-analysis. Psychol Methods 9(4):426\u2013445. https:\/\/doi.org\/10.1037\/1082-989x.9.4.426","journal-title":"Psychol Methods"},{"issue":"13","key":"11246_CR28","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1002\/1097-0258(20000715)19:13<1707::aid-sim491>3.0.co;2-p","volume":"19","author":"EA Engels","year":"2000","unstructured":"Engels EA, Schmid CH, Terrin N et al (2000) Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses. Stat Med 19(13):1707\u20131728. https:\/\/doi.org\/10.1002\/1097-0258(20000715)19:13%3c1707::aid-sim491%3e3.0.co;2-p","journal-title":"Stat Med"},{"issue":"12","key":"11246_CR29","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.6004\/jnccn.2014.0177","volume":"12","author":"JR Bauman","year":"2014","unstructured":"Bauman JR, Temel JS (2014) The integration of early palliative care with oncology care: the time has come for a new tradition. J Natl Compr Canc Netw 12(12):1763\u20131771","journal-title":"J Natl Compr Canc Netw"},{"issue":"4","key":"11246_CR30","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/cco.0b013e3283622c5e","volume":"25","author":"J Gaertner","year":"2013","unstructured":"Gaertner J, Weing\u00e4rtner V, Wolf J et al (2013) Early palliative care for patients with advanced cancer: how to make it work. Curr Opin Oncol 25(4):342\u2013352. https:\/\/doi.org\/10.1097\/cco.0b013e3283622c5e","journal-title":"Curr Opin Oncol"},{"issue":"3","key":"11246_CR31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1037\/met0000025","volume":"20","author":"MALMV Assen","year":"2014","unstructured":"Assen MALMV, Aert RCMV, Wicherts JM (2014) Meta-analysis using effect size distributions of only statistically significant studies. Psychol Methods 20(3):293\u2013309. https:\/\/doi.org\/10.1037\/met0000025","journal-title":"Psychol Methods"},{"issue":"4","key":"11246_CR32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/cco.0b013e328352ea20","volume":"24","author":"J Gaertner","year":"2012","unstructured":"Gaertner J, Wolf J, Voltz R (2012) Early palliative care for patients with metastatic cancer. Curr Opin Oncol 24(4):357\u2013362. https:\/\/doi.org\/10.1097\/cco.0b013e328352ea20","journal-title":"Curr Opin Oncol"},{"issue":"4","key":"11246_CR33","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1001\/jamainternmed.2013.1874","volume":"173","author":"J Yoong","year":"2013","unstructured":"Yoong J, Park ER, Greer JA et al (2013) Early palliative care in advanced lung cancer: a qualitative study. JAMA Intern Med 173(4):283\u2013290. https:\/\/doi.org\/10.1001\/jamainternmed.2013.1874","journal-title":"JAMA Intern Med"},{"issue":"1","key":"11246_CR34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1634\/theoncologist.2015-0232","volume":"21","author":"RD Nipp","year":"2015","unstructured":"Nipp RD, Greer JA, El-Jawahri A et al (2015) Age and gender moderate the impact of early palliative care in metastatic non-small cell lung cancer. Oncologist 21(1):119\u2013126. https:\/\/doi.org\/10.1634\/theoncologist.2015-0232","journal-title":"Oncologist"},{"issue":"12","key":"11246_CR35","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1634\/theoncologist.2017-0227","volume":"22","author":"A El-Jawahri","year":"2017","unstructured":"El-Jawahri A, Greer JA, Pirl WF et al (2017) Effects of early integrated palliative care on caregivers of patients with lung and gastrointestinal cancer: a randomized clinical trial. Oncologist 22(12):1528\u20131534. https:\/\/doi.org\/10.1634\/theoncologist.2017-0227","journal-title":"Oncologist"},{"issue":"4","key":"11246_CR36","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1191\/0269216306pm1156oa","volume":"20","author":"P Schofield","year":"2006","unstructured":"Schofield P, Carey M, Love A et al (2006) \u201cWould you like to talk about your future treatment options\u201d? Discussing the transition from curative cancer treatment to palliative care. Palliat Med 20(4):397\u2013406. https:\/\/doi.org\/10.1191\/0269216306pm1156oa","journal-title":"Palliat Med"},{"key":"11246_CR37","volume-title":"Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine","author":"DB Petitti","year":"1994","unstructured":"Petitti DB (1994) Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine. Oxford University Press, New York"},{"issue":"1","key":"11246_CR38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1177\/2515245919885611","volume":"3","author":"BM Wiernik","year":"2020","unstructured":"Wiernik BM, Dahlke JA (2020) Obtaining unbiased results in meta-analysis: the importance of correcting for statistical artifacts. Adv Methods Pract Psychol Sci 3(1):94\u2013123. https:\/\/doi.org\/10.1177\/2515245919885611","journal-title":"Adv Methods Pract Psychol Sci"},{"issue":"3","key":"11246_CR39","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1634\/theoncologist.2016-0227","volume":"22","author":"AM Romano","year":"2017","unstructured":"Romano AM, Gade KE, Nielsen G et al (2017) Early palliative care reduces end-of-life intensive care unit (ICU) use but not ICU course in patients with advanced cancer. Oncologist 22(3):318\u2013323. https:\/\/doi.org\/10.1634\/theoncologist.2016-0227","journal-title":"Oncologist"},{"issue":"2","key":"11246_CR40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1002\/sim.6342","volume":"34","author":"Z Jin","year":"2014","unstructured":"Jin Z, Zhou X, He J (2014) Statistical methods for dealing with publication bias in meta-analysis. Stat Med 34(2):343\u2013360. https:\/\/doi.org\/10.1002\/sim.6342","journal-title":"Stat Med"},{"issue":"3","key":"11246_CR41","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1037\/1082-989x.8.3.243","volume":"8","author":"LD Cohn","year":"2003","unstructured":"Cohn LD, Becker BJ (2003) How meta-analysis increases statistical power. Psychol Methods 8(3):243\u2013253. https:\/\/doi.org\/10.1037\/1082-989x.8.3.243","journal-title":"Psychol Methods"},{"issue":"4","key":"11246_CR42","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1177\/0962280210392008","volume":"21","author":"E Kontopantelis","year":"2010","unstructured":"Kontopantelis E, Reeves D (2010) Performance of statistical methods for meta-analysis when true study effects are non-normally distributed: a simulation study. Stat Methods Med Res 21(4):409\u2013426. https:\/\/doi.org\/10.1177\/0962280210392008","journal-title":"Stat Methods Med Res"},{"issue":"29","key":"11246_CR43","doi-asserted-by":"publisher","first-page":"6093","DOI":"10.1002\/sim.3428","volume":"27","author":"BJ Biggerstaff","year":"2008","unstructured":"Biggerstaff BJ, Jackson D (2008) The exact distribution of Cochran\u2019s heterogeneity statistic in one-way random effects meta-analysis. Stat Med 27(29):6093\u20136110. https:\/\/doi.org\/10.1002\/sim.3428","journal-title":"Stat Med"},{"issue":"11","key":"11246_CR44","doi-asserted-by":"publisher","first-page":"e2341928","DOI":"10.1001\/jamanetworkopen.2023.41928","volume":"6","author":"VV Bansal","year":"2023","unstructured":"Bansal VV, Kim D, Reddy B et al (2023) Early integrated palliative care within a surgical oncology clinic. JAMA Netw Open 6(11):e2341928. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.41928","journal-title":"JAMA Netw Open"},{"issue":"9","key":"11246_CR45","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1200\/jco.18.02123","volume":"38","author":"D Hui","year":"2020","unstructured":"Hui D, Bruera E (2020) Models of palliative care delivery for patients with cancer. J Clin Oncol 38(9):852\u2013865. https:\/\/doi.org\/10.1200\/jco.18.02123","journal-title":"J Clin Oncol"},{"issue":"19","key":"11246_CR46","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1200\/jco.24.00542","volume":"42","author":"JJ Sanders","year":"2024","unstructured":"Sanders JJ, Temin S, Ghoshal A et al (2024) Palliative care for patients with cancer: ASCO guideline update. J Clin Oncol 42(19):2336\u20132357. https:\/\/doi.org\/10.1200\/jco.24.00542","journal-title":"J Clin Oncol"},{"issue":"11","key":"11246_CR47","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/s0277-9536(99)00045-3","volume":"48","author":"MA Sprangers","year":"1999","unstructured":"Sprangers MA, Schwartz CE (1999) Integrating response shift into health-related quality of life research: a theoretical model. Soc Sci Med 48(11):1507\u20131515. https:\/\/doi.org\/10.1016\/s0277-9536(99)00045-3","journal-title":"Soc Sci Med"},{"key":"11246_CR48","doi-asserted-by":"publisher","first-page":"783","DOI":"10.3389\/fonc.2019.00783","volume":"9","author":"G Ilie","year":"2019","unstructured":"Ilie G, Bradfield J, Moodie L et al (2019) The role of response-shift in studies assessing quality of life outcomes among cancer patients: a systematic review. Front Oncol 9:783. https:\/\/doi.org\/10.3389\/fonc.2019.00783","journal-title":"Front Oncol"},{"issue":"9","key":"11246_CR49","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1007\/s00520-018-4156-7","volume":"26","author":"AS Aburub","year":"2018","unstructured":"Aburub AS, Gagnon B, Ahmed S et al (2018) Impact of reconceptualization response shift on rating of quality of life over time among people with advanced cancer. Support Care Cancer 26(9):3063\u20133071. https:\/\/doi.org\/10.1007\/s00520-018-4156-7","journal-title":"Support Care Cancer"},{"key":"11246_CR50","doi-asserted-by":"publisher","first-page":"1439655","DOI":"10.3389\/fpsyg.2025.1439655","volume":"16","author":"A Hinz","year":"2025","unstructured":"Hinz A, Wedding U, Schulte T et al (2025) Assessment of quality of life in cancer patients using anchoring vignettes: comparisons between mixed cancer patients, patients receiving palliative care, and the general population. Front Psychol 16:1439655. https:\/\/doi.org\/10.3389\/fpsyg.2025.1439655","journal-title":"Front Psychol"},{"issue":"10","key":"11246_CR51","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1007\/s11136-019-02248-z","volume":"28","author":"BD Rapkin","year":"2019","unstructured":"Rapkin BD, Schwartz CE (2019) Advancing quality-of-life research by deepening our understanding of response shift: a unifying theory of appraisal. Qual Life Res 28(10):2623\u20132630. https:\/\/doi.org\/10.1007\/s11136-019-02248-z","journal-title":"Qual Life Res"},{"issue":"12","key":"11246_CR52","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1007\/s11136-021-02766-9","volume":"30","author":"R Sawatzky","year":"2021","unstructured":"Sawatzky R, Kwon JY, Barclay R et al (2021) Implications of response shift for micro-, meso-, and macro-level healthcare decision-making using results of patient-reported outcome measures. Qual Life Res 30(12):3343\u20133357. https:\/\/doi.org\/10.1007\/s11136-021-02766-9","journal-title":"Qual Life Res"},{"issue":"6","key":"11246_CR53","doi-asserted-by":"publisher","first-page":"CD011129","DOI":"10.1002\/14651858.CD011129.pub2","volume":"6","author":"MW Haun","year":"2017","unstructured":"Haun MW, Estel S, R\u00fccker G et al (2017) Early palliative care for adults with advanced cancer. Cochrane Database Syst Rev 6(6):CD011129. https:\/\/doi.org\/10.1002\/14651858.CD011129.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"11246_CR54","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/s1470-2045(18)30060-3","volume":"19","author":"G Vanbutsele","year":"2018","unstructured":"Vanbutsele G, Pardon K, Van Belle S et al (2018) Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial. Lancet Oncol 19(3):394\u2013404. https:\/\/doi.org\/10.1016\/s1470-2045(18)30060-3","journal-title":"Lancet Oncol"},{"issue":"10","key":"11246_CR55","doi-asserted-by":"publisher","first-page":"e2440977","DOI":"10.1001\/jamanetworkopen.2024.40977","volume":"7","author":"SJ Mah","year":"2024","unstructured":"Mah SJ, Carter Ramirez DM, Schnarr K et al (2024) Timing of palliative care, end-of-life quality indicators, and health resource utilization. JAMA Netw Open 7(10):e2440977. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.40977","journal-title":"JAMA Netw Open"},{"issue":"4","key":"11246_CR56","doi-asserted-by":"publisher","first-page":"e325","DOI":"10.1016\/j.jpainsymman.2024.07.008","volume":"68","author":"CJ Oswalt","year":"2024","unstructured":"Oswalt CJ, Nakatani MM, Troy J et al (2024) Timing of palliative care consultation impacts end of life care outcomes in metastatic non-small cell lung cancer. J Pain Symptom Manage 68(4):e325\u2013e332. https:\/\/doi.org\/10.1016\/j.jpainsymman.2024.07.008","journal-title":"J Pain Symptom Manage"},{"issue":"1","key":"11246_CR57","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.70128","volume":"224","author":"C Schilling","year":"2018","unstructured":"Schilling C, Wawryk O, Collins A et al (2018) Early palliative care and quality of end-of-life care for people with terminal cancer, Victoria, 2018-2023: a retrospective, population-based cohort study. Med J Aust 224(1):e70128. https:\/\/doi.org\/10.5694\/mja2.70128","journal-title":"Med J Aust"},{"issue":"7","key":"11246_CR58","doi-asserted-by":"publisher","first-page":"e211829","DOI":"10.1001\/jamahealthforum.2021.1829","volume":"2","author":"JS Weissman","year":"2021","unstructured":"Weissman JS, Reich AJ, Prigerson HG et al (2021) Association of advance care planning visits with intensity of health care for Medicare beneficiaries with serious illness at the end of life. JAMA Health Forum 2(7):e211829. https:\/\/doi.org\/10.1001\/jamahealthforum.2021.1829","journal-title":"JAMA Health Forum"},{"issue":"5","key":"11246_CR59","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.71908","volume":"15","author":"L Rautakorpi","year":"2026","unstructured":"Rautakorpi L, N\u00e5hls NS, Saarto T et al (2026) Assessing the impact of specialist palliative care on healthcare utilisation at the end of life among patients with pancreatic cancer: a nationwide register-based cohort study. Cancer Med 15(5):e71908. https:\/\/doi.org\/10.1002\/cam4.71908","journal-title":"Cancer Med"},{"issue":"2","key":"11246_CR60","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jclinepi.2007.03.012","volume":"61","author":"D Revicki","year":"2008","unstructured":"Revicki D, Hays RD, Cella D, Sloan J (2008) Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes. J Clin Epidemiol 61(2):102\u2013109. https:\/\/doi.org\/10.1016\/j.jclinepi.2007.03.012","journal-title":"J Clin Epidemiol"},{"issue":"5","key":"11246_CR61","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1097\/01.mlr.0000062554.74615.4c","volume":"41","author":"GR Norman","year":"2003","unstructured":"Norman GR, Sloan JA, Wyrwich KW (2003) Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care 41(5):582\u2013592. https:\/\/doi.org\/10.1097\/01.mlr.0000062554.74615.4c","journal-title":"Med Care"},{"issue":"6","key":"11246_CR62","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/s0885-3924(02)00529-8","volume":"24","author":"D Cella","year":"2002","unstructured":"Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE (2002) Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage 24(6):547\u2013561. https:\/\/doi.org\/10.1016\/s0885-3924(02)00529-8","journal-title":"J Pain Symptom Manage"}],"container-title":["Supportive Care in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-11246-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-11246-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00520-026-11246-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:48:56Z","timestamp":1792086536000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00520-026-11246-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["11246"],"URL":"https:\/\/doi.org\/10.1007\/s00520-026-11246-0","relation":{},"ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]},"assertion":[{"value":"15 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article is based on data from previously published randomised controlled trials and does not contain any new studies with human participants or animals performed by any of the authors. All included studies received prior ethics approval from their respective institutional review boards.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"990"}}