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This study aimed to identify gastrointestinal symptom profiles over the first-year post-surgery and to explore changes over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed between 2013 and 2024 who underwent esophagectomy or gastrectomy for nonmetastatic esophageal or gastric cancer were selected. Longitudinal self-reported gastrointestinal symptom data were linked to patient and tumor characteristics. K-means clustering based on symptom severity scores was performed at baseline and at every three months up to 12\u00a0months postoperatively. Generalized Linear Mixed Models assessed associations between patient characteristics and symptom profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1462 patients who underwent\u00a0esophagectomy and 434 who underwent\u00a0gastrectomy, three symptom severity profiles, mild, moderate, and severe, were identified for each period. These profiles reflected increasing symptom severity rather than distinct symptom patterns. The mild symptom profile was the most common (esophagectomy: 42.5\u2009~\u200960.5%; gastrectomy: 53.9\u2009~\u200973.5% across time periods). Most patients remained in the same profile over time. Amongst others, female sex (esophagectomy: OR\u2009=\u20091.67; 95% CI:1.30\u20132.14, gastrectomy: OR\u2009=\u20091.54; 95% CI:1.07\u20132.23) and receiving neoadjuvant chemotherapy (esophagectomy: OR\u2009=\u20091.91; 95% CI:1.22\u20132.99, gastrectomy: OR\u2009=\u20092.39; 95% CI:1.55\u20133.67) were associated with a higher likelihood of moderate\/severe symptom profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Three stable gastrointestinal symptom severity profiles were identified during the first postoperative year, supporting risk-stratified monitoring after upper gastrointestinal cancer surgery. Early identification of patients at risk for persistent moderate-to-severe gastrointestinal symptoms may facilitate timely supportive care and improve survivorship outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-11293-7","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:13:54Z","timestamp":1791375234000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal symptom profiles after resection of esophageal or gastric cancer"],"prefix":"10.1007","volume":"34","author":[{"given":"Yipei","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Katsimpokis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice N.","family":"van Erning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grard A. 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The study proposal was approved by the privacy board of the NCR and the scientific committee of the Dutch Upper-GI Cancer Group (DUCG), medical ethical approval was not required. This study was designed in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines [\n                      \n                      ].","order":1,"name":"Ethics","label":"Ethics statements","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"D. Katsimpokis reports research funding from AstraZeneca. G.A.P. Nieuwenhuijzen reports a relationship with Medtronic that includes consulting or advisory roles; and a relationship with CZ Assurance Company that includes funding grants. H.W.M. van Laarhoven reports research funding and\/or medication or material supply from Amgen, Auristone, BMS, Incyte, Merck, Create Medicine, ORCA, and Servier; consulting or advisory roles with Amgen, Amphera, Astellas, AstraZeneca, BeiGene, BMS, Boehringer, Daiichi, MSD, and Create Medicine; and speaker roles for AstraZeneca, BMS, Congress Care, Daiichi, Medtalks, Uitgeverij JAAP, and Travel Congress Management; unrestricted research funding from the Dutch Cancer Society, NWO\/ZonMw, and the European Research Council. S.S. Gisbertz reports relationships with Medicaroid, Johnson & Johnson, and Olympus that include consulting or advisory roles. R.E. Pouw reports relationships with Boston Scientific, Medtronic, MicroTech Europe, and Cook Medical that include consulting or advisory roles; relationships with Olympus, Fujifilm, and Pentax that include speaking and lecture fees; and a relationship with Moeller Medical that includes funding grants. R.H.A. Verhoeven reports a relationship with Daiichi Sankyo that includes consulting or advisory roles, and relationships with Amgen and Bristol Myers Squibb that include funding grants. The other authors declare no conflicts of interest.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1069"}}