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The intervention involved supervised aerobic exercise training 2\u20133\u00a0days per week before surgery. Usual care involved standard cancer treatment. Feasibility was assessed through recruitment, attendance, adherence, and attrition rates. Safety was evaluated via adverse event monitoring. Exploratory analyses evaluated group-by-time changes in cardiorespiratory fitness, health-related quality of life, and fatigue from baseline to the pre-surgery and post-surgery assessment timepoints, with 30-day post-operative outcomes (complications and length of stay) also collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 47 potentially eligible patients approached and screened, 23 were recruited and randomised, and completed baseline assessments. Twenty participants (prehabilitation\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911, usual care\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) completed the pre- and T1 and T2 assessments. Participants attended an average of 5.25\u2009\u00b1\u20092.16 prehabilitation sessions. Attendance, adherence, completeness, and attrition rates were 91.3%, 82.6%, 85.7%, and 13%, respectively. Five adverse events were recorded in the prehabilitation group (fatigue,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093; muscular pain in the extremities,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092); all were grade 1. No significant group-by-time interactions were observed for cardiorespiratory fitness, health-related quality of life, or fatigue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among participants who commenced prehabilitation, attendance, adherence, and completeness were 91.3%, 82.6%, and 85.7%, respectively. No serious adverse events were observed. Exploratory clinical outcome estimates were imprecise and did not support firm conclusions regarding intervention effectiveness. Recruitment limitations and the small heterogeneous sample also preclude broader conclusions regarding feasibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00520-026-11356-9","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:10:30Z","timestamp":1792573830000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and safety of an exercise-based prehabilitation intervention before cancer surgery: a pilot randomised controlled trial"],"prefix":"10.1007","volume":"34","author":[{"given":"Declan T.","family":"Hennessy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Wong","family":"Shee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Rawstorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Wallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"issue":"3","key":"11356_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2022","unstructured":"Bray F, Laversanne M, Sung H et al (2022) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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