{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:12:45Z","timestamp":1764173565798},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In pancreatic lithiasis in elderly autopsy cases, the stones are small and the pancreatic duct is changed very slightly when viewed by simple X\u2010ray film, pancreatic ductography and gross appearance. Histologically, a slight fibrous increase is seen very locally, but findings consistent with chronic pancreatitis are not found throughout the whole pancreas. However, marked, diffuse and irregular dilatation of the pancreatic duct is frequently found in operative cases with chronic pancreatitis and pancreatic stones. These findings show that the changes seen with aging and with chronic pancreatitis can be distinguished based on the findings of pancreatic ductography. Mucin production in epithelia in intraductal papillary\u2010mucinous neoplasm (IPMN) may not be strongly associated with the pathogenesis of pancreatic lithiasis. Pancreatic lithiasis may be related to squamous cell metaplasia. IPMN and dilatation of the pancreatic duct are closely associated with mucin production. An increase in intraductal pressure of the pancreatic duct may be somewhat related to the mechanism of stone formation. The incidental co\u2010existence of pancreatic epithelia with pancreatic lithiasis in patients with chronic pancreatitis and the development of IPMN may also be possible. IPMN and pancreatic lithiasis may be related through the mechanism(s) of their pathogenesis, their synergism and the pathogenesis of stone formation. The relation between mucinous metaplasia and stone formation is slight and, therefore, there may be only a weak correlation between IPMN and pancreatic stones. This may explain why there are few reports of the co\u2010existence of IPMN and pancreatic stones (Kimura in Kan Tan Sui 58:485\u2013492, 2009).<\/jats:p>","DOI":"10.1007\/s00534-009-0180-9","type":"journal-article","created":{"date-parts":[[2009,9,24]],"date-time":"2009-09-24T11:53:20Z","timestamp":1253793200000},"page":"776-781","source":"Crossref","is-referenced-by-count":7,"title":["Pancreatic lithiasis and intraductal papillary\u2010mucinous neoplasm with special reference to the pathogenesis of lithiasis"],"prefix":"10.1002","volume":"17","author":[{"given":"Wataru","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Gastroenterological, General and Breast and Thyroid Surgery (First Department of Surgery) Yamagata University Faculty of Medicine  2\u20102\u20102 Iida\u2010Nishi Yamagata Yamagata 990\u20109585 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784942"},{"key":"e_1_2_6_3_1","first-page":"517","article-title":"Histological study on pathogenesis of sites of isolated islets of Langerhans and their course to the terminal state","volume":"84","author":"Kimura W","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90419-0"},{"key":"e_1_2_6_5_1","first-page":"22","article-title":"Diagnostic criteria for chronic pancreatitis","volume":"10","author":"Japanese Committee of Investigation of Diagnostic Criteria for Chronic Pancreatitis","year":"1995","journal-title":"Jpn J Panc Soc."},{"key":"e_1_2_6_6_1","first-page":"348","article-title":"Four cases of mucin producing cancer of the pancreas\u2014with special reference to special findings of the papilla of Vater","volume":"20","author":"Murakami Y Ohhashi","year":"1982","journal-title":"Prog Dig Endosc"},{"key":"e_1_2_6_7_1","first-page":"549","article-title":"Pancreatic lithiasis and dilatation of the pancreatic ducts in the aged","volume":"24","author":"Kimura W","year":"1997","journal-title":"Shokakika."},{"key":"e_1_2_6_8_1","first-page":"61","article-title":"Acute pancreatitis, pancreatic lithiasis and dilatation of the pancreatic ducts","volume":"10","author":"Kimura W","year":"1998","journal-title":"Ronen Shokakibyo"},{"key":"e_1_2_6_9_1","first-page":"692","article-title":"Duct\u2010ectatic type of mucin producing tumor of the pancreas\u2014new concept of pancreatic neoplasia","volume":"43","author":"Kimura W","year":"1996","journal-title":"Hepatogastroenterology."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199804000-00025"},{"key":"e_1_2_6_11_1","first-page":"5","article-title":"Intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN) of the pancreas","volume":"12","author":"Kimura W","year":"2009","journal-title":"Clin Dig Organs"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02482811"},{"key":"e_1_2_6_13_1","first-page":"501","article-title":"Intra\u2010ductal papillary mucinous tumor (IPMT) with pancreato lithiasis. 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