{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:57:39Z","timestamp":1784257059044,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,11,26]],"date-time":"2009-11-26T00:00:00Z","timestamp":1259193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Hilar cholangiocarcinoma and intrahepatic cholangiocarcinoma involving the hepatic hilus are defined as \u201cperihilar cholangiocarcinoma\u201d. The principle of surgical treatment is hemi\u2010hepatectomy or trisectionectomy of the liver, caudate lobectomy, and resection of the extrahepatic bile duct for complete resection of the tumor. The aim of this study was to review the outcomes of major hepatectomy for perihilar cholangiocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Kaplan\u2013Meier method and the Cox proportional hazards model, we analyzed the results in 125 patients with perihilar cholangiocarcinoma who had undergone major hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Right hepatectomy, right trisectionectomy, left hepatectomy, and left trisectionectomy were performed in 66, 8, 49, and 2 patients, respectively. Curative resection was achieved in 79 patients (63.2%). Mortality and morbidity rates were 8.0 and 48.7%, respectively. The overall 1\u2010, 3\u2010, and 5\u2010year survival rates of all patients were 73.2, 36.7, and 34.7%, respectively. The median survival was 26.8 months. Multivariate analysis showed that the independent prognostic factors for overall survival were gender, histopathological grading, curative resection, and American Joint Committee on Cancer (AJCC)\/International Union Against Cancer (UICC) pT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Major hepatectomy for perihilar cholangiocarcinoma was acceptable and showed satisfactory outcomes. For long\u2010term survival in these patients, the surgeon should aim for complete resection of the tumor with negative margins.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-009-0206-3","type":"journal-article","created":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T10:15:23Z","timestamp":1259144123000},"page":"463-469","source":"Crossref","is-referenced-by-count":78,"title":["Major hepatectomy for perihilar cholangiocarcinoma"],"prefix":"10.1002","volume":"17","author":[{"given":"Michiaki","family":"Unno","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery, Department of Surgery Tohoku University Graduate School of Medicine  1\u20101, Seiryo\u2010machi, Aoba\u2010ku Sendai 980\u20108574 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Katayose","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery, Department of Surgery Tohoku University Graduate 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