{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:42Z","timestamp":1770815862807,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T00:00:00Z","timestamp":1258588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We introduce recent advances in surgical techniques and perioperative management in liver resection for hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our approaches to further enhancing the efficacy of resection for HCC, based on our presentation at \u201cThe 6th International Meeting of Hepatocellular Carcinoma: Eastern and Western Experiences\u201d held in Seoul in December 2008, are presented, along with a review of recent advances in this field reported from eastern Asia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our series, liver resection enabled a 5\u2010year overall survival rate of close to 60%, even among patients with multiple HCCs and those with portal hypertension in a background of Child\u2010Pugh class A cirrhosis. Favorable long\u2010term results were obtained by the precise evaluation of liver function using the indocyanine green (ICG) test and the application of perioperative treatments for gastroesophageal varices and severe thrombocytopenia. Furthermore, promising novel techniques have been applied to increase the efficacy of HCC resection, including the preoperative simulation of liver resection, using three\u2010dimensional computed tomography, a \u201cpeeling\u2010off\u201d technique for resecting HCC with macroscopic portal venous tumor thrombus, ICG\u2010fluorescent imaging, predeposit autologous plasma transfusion, and laparoscopic liver resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The safety and accuracy of liver resection for HCC has been continuously enhanced by advances in surgical techniques and perioperative care. Given that the resection of HCC offers a satisfactory overall survival rate for patients with portal hypertension and those with oligonodular multiple tumors, the surgical indications can now be expanded to include such second\u2010best candidates.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-009-0231-2","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T11:45:40Z","timestamp":1258544740000},"page":"389-393","source":"Crossref","is-referenced-by-count":25,"title":["Surgical technique: new advances for expanding indications and increasing safety in liver resection for HCC"],"prefix":"10.1002","volume":"17","author":[{"given":"Takeaki","family":"Ishizawa","sequence":"first","affiliation":[{"name":"Hepato\u2010Biliary\u2010Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine University of Tokyo  7\u20103\u20101 Hongo, Bunkyo\u2010ku Tokyo 113\u20108655 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