{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:16:42Z","timestamp":1792145802614,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T00:00:00Z","timestamp":1271289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Gallbladder cancer occurs frequently in patients with pancreaticobiliary maljunction due to pancreatobiliary reflux. Pancreatobiliary reflux is also detected in some patients with a relatively long common channel. This study aimed to clarify the correlation between pancreatobiliary reflux and the length of a common channel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and three patients, in whom both the length of a common channel and amylase level in the bile were measured, were enrolled from nine centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bile amylase level was correlated with the length of a common channel (<jats:italic>p<\/jats:italic> &lt; 0.01). The minimum length of a common channel that could induce a markedly elevated amylase level in the bile (&gt;1,000 mg\/dl) was determined as 5 mm. We redefined high confluence of pancreatobiliary ducts (HCPBD) as cases with a common channel \u22655 mm, in which the communication between the pancreatic and bile ducts was occluded with the sphincter contraction. Gallbladder cancer was found in 20% of 56 redefined HCPBD patients. Bile amylase level &gt;1,000 mg\/dl and biliopancreatic reflux were detected in 79 and 95% of the patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with a common channel \u22655 mm (redefined HCPBD) should be monitored for the development of gallbladder cancer, as they frequently showed significant pancreatobiliary reflux.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-010-0282-4","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T03:25:57Z","timestamp":1271215557000},"page":"865-870","source":"Crossref","is-referenced-by-count":19,"title":["Pancreatobiliary reflux and the length of a common channel"],"prefix":"10.1002","volume":"17","author":[{"given":"Terumi","family":"Kamisawa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Tokyo Metropolitan Komagome Hospital  3\u201018\u201022 Honkomagome, Bunkyo\u2010ku Tokyo 113\u20108677 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Surgery Fukuoka University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Toho University Ohmori Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kitasato University  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goro","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokyo Metropolitan Komagome Hospital  Tokyo 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