{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:00:46Z","timestamp":1788188446322,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T00:00:00Z","timestamp":1274832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:sc>18<\/jats:sc>F\u2010fluorodeoxyglucose positron emission tomography (FDG\u2010PET) is used in the differential diagnosis and staging of extrahepatic bile duct cancer (EBDC), but its prognostic value has not been fully elucidated. In this study, we investigated the prognostic value of FDG\u2010PET in EBDC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 73 consecutive patients with EBDC, of whom 48 underwent surgical resection for EBDC. The effects of clinicopathological factors including the standardized uptake value (SUV) of the primary lesion and lymph node metastasis detected by FDG\u2010PET (PET\u2010N) on overall survival were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all 73 patients, multivariate analysis showed that surgical resection (risk ratio 2.5, 95% confidence interval [CI] 1.17\u20135.35,<jats:italic>p<\/jats:italic> = 0.018) and the SUV (2.0, 1.07\u20133.91,<jats:italic>p<\/jats:italic> = 0.030) were independent predictors of survival. In the 48 patients who underwent surgical resection, multivariate analysis revealed that perineural invasion (risk ratio 3.2, 95% CI 1.28\u20137.93,<jats:italic>p<\/jats:italic> = 0.012), pathologic lymph node metastasis (3.4, 1.27\u20139.17,<jats:italic>p<\/jats:italic> = 0.015), and PET\u2010N (4.0, 1.10\u201315.25,<jats:italic>p<\/jats:italic> = 0.036) were independent predictors of overall survival. In the 25 patients without surgical resection, the SUV showed a significant relationship with overall survival (<jats:italic>p<\/jats:italic> = 0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that the SUV of the primary lesion is a useful prognostic factor in patients with EBDC, and the prognosis for patients with PET\u2010N remains very poor despite surgical resection.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-010-0293-1","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T05:28:25Z","timestamp":1274765305000},"page":"39-46","source":"Crossref","is-referenced-by-count":31,"title":["Prognostic value of<scp>18<\/scp>F\u2010fluorodeoxyglucose positron emission tomography in patients with extrahepatic bile duct cancer"],"prefix":"10.1002","volume":"18","author":[{"given":"Koji","family":"Kitamura","sequence":"first","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Higashi","sequence":"additional","affiliation":[{"name":"Shiga Medical Center Research Institute  5\u20104\u201030 Moriyama Moriyama Shiga 524\u20108524 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Mitsubishi Kyoto Hospital  1 Katsuragosho\u2010cho, Nishikyo\u2010ku Kyoto 615\u20108087 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Taura","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yasuchika","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichiro","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Ikai","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[{"name":"Department of Surgery Graduate School of Medicine Kyoto University  54 Kawahara\u2010cho, Shogoin, Sakyo\u2010ku Kyoto 606\u20108507 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67530-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.040"},{"issue":"7","key":"e_1_2_5_4_1","first-page":"939","article-title":"Cancers of the gallbladder and biliary ducts","volume":"16","author":"Yee K","year":"2002","journal-title":"Oncology (Williston Park)."},{"issue":"8","key":"e_1_2_5_5_1","first-page":"1049","article-title":"Gallbladder and biliary tract carcinoma: a comprehensive update, part 2","volume":"18","author":"Daines WP","year":"2004","journal-title":"Oncology (Williston Park)."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411807"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920915)70:6<1498::AID-CNCR2820700609>3.0.CO;2-C"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-8389(05)70319-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/snuc.2002.29272"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23912"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280316"},{"issue":"8","key":"e_1_2_5_12_1","first-page":"731","article-title":"Positron emission tomography and cholangiocarcinoma in primary sclerosing cholangitis","volume":"37","author":"Widjaja A","year":"1999","journal-title":"Z Gastroenterol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05173.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.07.002"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0852-z"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2003.10.003"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1656-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0791-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9001-y"},{"key":"e_1_2_5_20_1","volume-title":"Classification of biliary tract carcinoma","author":"Japanese Society of Biliary Surgery","year":"2004"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.10017"},{"issue":"9","key":"e_1_2_5_22_1","first-page":"1337","article-title":"Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study","volume":"38","author":"Higashi T","year":"1997","journal-title":"J Nucl Med."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.01.010"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21356"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200112000-00002"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-0880-8"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600114"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(00)00535-2"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.265055208"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01710.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.05.012"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098109"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199803000-00013"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000160817.94472.fd"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050092"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200103000-00013"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1279-5"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(01)00005-1"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02211.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000129491.43855.6b"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20906"}],"container-title":["Journal of Hepato-Biliary-Pancreatic Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1007%2Fs00534-010-0293-1","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00534-010-0293-1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1007\/s00534-010-0293-1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00534-010-0293-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T12:49:19Z","timestamp":1694436559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00534-010-0293-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,26]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1007\/s00534-010-0293-1"],"URL":"https:\/\/doi.org\/10.1007\/s00534-010-0293-1","archive":["Portico"],"relation":{},"ISSN":["1868-6974","1868-6982"],"issn-type":[{"value":"1868-6974","type":"print"},{"value":"1868-6982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,26]]}}}