{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:29:45Z","timestamp":1770506985115,"version":"3.49.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,8,7]],"date-time":"2010-08-07T00:00:00Z","timestamp":1281139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Pylorus\u2010preserving pancreaticoduodenectomy (PPPD) is the treatment of choice for benign or premalignant pancreatic head lesions. Duodenum\u2010preserving pancreatic head resection (DPPHR) has been reported in only 132 patients. This study aimed to compare the long\u2010term results of DPPHR and PPPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent DPPHR or PPPD for benign or borderline disease between 1991 and 2008 were followed up until December 2009 or their death. Endocrine and exocrine pancreatic functions were evaluated at their last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients underwent DPPHR (Group 1) and 37 PPPD (Group 2). They were followed for a mean of 100 and 135 months, respectively. Group 1 had a higher complication rate (81.5 vs. 40.5%) and pancreatic fistula rate (40.1 vs. 18.9%). Hospital mortality was 0 and 2.7%, respectively. Two patients died 3.3 and 97 months after DPPHR. Significantly more Group 2 patients needed medical treatment for benign cholangitis (<jats:italic>p<\/jats:italic> &lt; 0.0001). Insulin\u2010dependent diabetes mellitus was observed in six Group 1 and 15 Group 2 patients (<jats:italic>p<\/jats:italic> = 0.077). Ten Group 1 and 21 Group 2 patients are taking pancreatic enzymes (<jats:italic>p<\/jats:italic> = 0.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DPPHR for benign or premalignant lesions is a difficult procedure with a higher complication rate than PPPD, but was without mortality. Preserving the entire duodenum and a normal biliary tree allows better long\u2010term results.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-010-0317-x","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T12:17:24Z","timestamp":1281097044000},"page":"94-102","source":"Crossref","is-referenced-by-count":41,"title":["Duodenum\u2010preserving versus pylorus\u2010preserving pancreatic head resection for benign and premalignant lesions"],"prefix":"10.1002","volume":"18","author":[{"given":"Sergio","family":"Pedrazzoli","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, IV Surgical Clinic University of Padova  Ospedale Giustinianeo, Via Giustiniani 2 35128 Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio Alen","family":"Canton","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, IV Surgical Clinic University of Padova  Ospedale Giustinianeo, Via Giustiniani 2 35128 Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Sperti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, IV Surgical Clinic University of Padova  Ospedale Giustinianeo, Via Giustiniani 2 35128 Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,8,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"467","article-title":"Duodenum\u2010preserving resection of the head of the pancreas in patients with severe chronic pancreatitis","volume":"97","author":"Beger HG","year":"1985","journal-title":"Surgery."},{"key":"e_1_2_7_3_1","first-page":"356","article-title":"Duodenum\u2010preserving pancreatoduodenostomy. 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