{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T06:41:45Z","timestamp":1694500905538},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,13]],"date-time":"2011-04-13T00:00:00Z","timestamp":1302652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>We have invented multi\u2010piercing surgery (MPS) which could potentially solve the triangular formation loss and device clashing which occur in single\u2010port surgery (SPS), as well as restricted visual field, organ damage by needle\u2010type instruments, and impaired removal of a resected organ from the body which occur in needlescopic surgery (NS). MPS is natural orifice translumenal endoscopic surgery (NOTES)\u2010assisted NS. We used 3\u2010mm diameter robots as needle\u2010type instruments for MPS to examine the possibility of local immune cell therapy and regenerative therapy using stem cells for pancreatic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In MPS using two robots, the therapeutic cell suspension was injected into a target region of pancreas in two pigs. Both retention of a capsule of liquid cell suspension and invasive level were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Triangular formation could be ensured. The use of small\u2010diameter robots allowed (1) the surgical separation of the pancreas and the retroperitoneum, and (2) the formation of the capsule containing the immune cell and stem cell suspension. The endoscope for NOTES provided a clear visual field and also assisted the removal of a resected organ from the body. The visual field of the endoscope could be oriented well by using an electromagnetic navigation system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MPS using small\u2010diameter robots could potentially solve the issues inherent in SPS and NS and could allow minimally invasive local immune cell and stem cell therapy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-011-0384-7","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T08:06:48Z","timestamp":1302595608000},"page":"499-505","source":"Crossref","is-referenced-by-count":8,"title":["Ultra\u2010minimally invasive local immune cell therapy and regenerative therapy by multi\u2010piercing surgery for abdominal solid tumor: therapeutic simulation by natural orifice translumenal endoscopic surgery\u2010assisted needlescopic surgery using 3\u2010mm diameter robots"],"prefix":"10.1002","volume":"18","author":[{"given":"Takeshi","family":"Ohdaira","sequence":"first","affiliation":[{"name":"Department of Advanced Medicine and Innovative Technology Kyshu University Hospital  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka Fukuoka 812\u20108582 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine and Innovative Technology Kyshu University Hospital  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka Fukuoka 812\u20108582 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine and Innovative Technology Kyshu University Hospital  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka Fukuoka 812\u20108582 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumu","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine and Innovative Technology Kyshu University Hospital  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka Fukuoka 812\u20108582 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munenori","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine and Innovative Technology Kyshu University Hospital  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka Fukuoka 812\u20108582 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ieiri","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine and Innovative Technology Kyshu University Hospital  3\u20101\u20101 Maidashi, Higashi\u2010ku Fukuoka Fukuoka 812\u20108582 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