{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:00:33Z","timestamp":1790290833312,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T00:00:00Z","timestamp":1303948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Rifampicin has been used for the treatment of patients with jaundice and pruritus. This study evaluated the effect of rifampicin on the expression of different detoxification systems and bile acid transporters during in\u2010vivo and in\u2010vitro experimental models of cholestasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rifampicin was administered to glycochenodeoxycholic acid (GCDCA)\u2010treated human hepatocytes and bile duct\u2010obstructed rats. Different parameters related to cell death, and the expression of phase I and II drug metabolizing enzymes (DME) and bile acid transporters were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The induction of hepatocellular injury induced by cholestasis was associated with a reduction in cytochrome P4503A4 (CYP3A4), CYP7A1, and UDP\u2010glucuronosyltransferase 2B4 (UGT2B4) expression, as well as an increase in import (Na<jats:sup>+<\/jats:sup>\u2010taurocholate co\u2010transporting polypeptide, NTCP) system expression. The beneficial properties of rifampicin were associated with an increase in DME and export bile acid systems (multidrug resistance\u2010associated protein 4, MRP4, and bile acid export pump to bile duct, BSEP) expression, as well as a reduction in NTCP expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The beneficial effect of rifampicin in cholestasis is associated with an increase in DME expression involved in toxic, bile acid and cholesterol metabolism, as well as a reduction in the bile acid importing system in hepatocytes.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-011-0396-3","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T05:17:19Z","timestamp":1303881439000},"page":"740-750","source":"Crossref","is-referenced-by-count":19,"title":["Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids"],"prefix":"10.1002","volume":"18","author":[{"given":"Ra\u00fal","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Liver Research Unit Hospital Universitario Reina Sof\u00eda, IMIBIC (Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba) Av. Men\u00e9ndez Pidal s\/n 14004 C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of General Surgery \u201cValle de los Pedroches\u201d General Hospital Pozoblanco C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ferr\u00edn","sequence":"additional","affiliation":[{"name":"Liver Research Unit Hospital Universitario Reina Sof\u00eda, IMIBIC (Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba) Av. Men\u00e9ndez Pidal s\/n 14004 C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"L\u00f3pez\u2010Cillero","sequence":"additional","affiliation":[{"name":"Surgery Department IMIBIC (Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba), \u201cReina Sofia\u201d University Hospital C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Surgery Department IMIBIC (Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba), \u201cReina Sofia\u201d University Hospital C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, \u201cVirgen del Roc\u00edo\u201d University Hospital (IBiS) Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Rufi\u00e1n","sequence":"additional","affiliation":[{"name":"Surgery Department IMIBIC (Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba), \u201cReina Sofia\u201d University Hospital C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Padillo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, \u201cVirgen del Roc\u00edo\u201d University Hospital (IBiS) Seville Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"De la Mata","sequence":"additional","affiliation":[{"name":"Gastroenterology Department IMIBIC (Instituto Maim\u00f3nides para la Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba), \u201cReina Sofia\u201d University Hospital C\u00f3rdoba Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J. 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