{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:26:03Z","timestamp":1792146363156,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,9]],"date-time":"2011-07-09T00:00:00Z","timestamp":1310169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hepato Biliary Pancreat"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our purpose was to assess the clinicopathological features and surgical outcomes of combined hepatocellular\u2010cholangiocarcinoma (HCC\u2010CC) in an Asian center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1998 and 2009, 27 patients were diagnosed with combined HCC\u2010CC at our hospital. Their medical records were reviewed and clinicopathological data retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 27 patients included 24 (88.9%) males and 3 (11.1%) females with a mean age of 58.26 \u00b1 11.18 years. Cirrhosis was present in 10 patients (37.0%), and 12 patients had hepatitis C or hepatitis B virus infection. Serum alpha fetoprotein was &gt;20 ng\/ml in 7 of the 19 patients in whom it was measured (36.8%). Twenty\u2010five patients underwent hepatic resections and 2 received liver transplantations. Five (18.5%) patients had separate HCC and CC within the same liver (type I), 21 (77.8%) had tumors with mixed components (type II), and 1 patient had a type III tumor (3.7%). Of 22 patients with immunohistochemical data, 19 (86.4%) were cytokeratin (CK) 7\u2010positive, 20 (90.9%) were CK19\u2010positive, and 4 (18.2%) were CK20\u2010positive. Mean follow\u2010up was 25.8 months. The 1\u2010 and 2\u2010year survival rates were 72.5 and 49.4%, respectively. The 1\u2010 and 2\u2010year disease\u2010free survival rates were 54.2 and 41.3%, respectively. Symptoms at the time of diagnosis, and regional lymph node metastases, were associated with higher mortality and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymph node metastasis and positive resection margins are important factors affecting HCC\u2010CC surgical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00534-011-0417-2","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T17:09:10Z","timestamp":1310144950000},"page":"361-369","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and pathological analysis of 27 patients with combined hepatocellular\u2010cholangiocarcinoma in an Asian center"],"prefix":"10.1002","volume":"19","author":[{"given":"Qian","family":"Zhan","sequence":"first","affiliation":[{"name":"General Surgical Department Ruijin Hospital Affiliated to Shanghai Jiaotong University  197 Ruijin Er Road Shanghai 200025 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